Details for: PBX2

Gene ID: 5089

Symbol: PBX2

Ensembl ID: ENSG00000204304

Description: PBX homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.7576
    Cell Significance Index: -17.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.7436
    Cell Significance Index: -17.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.0307
    Cell Significance Index: -21.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.6269
    Cell Significance Index: -18.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.0758
    Cell Significance Index: -20.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.2198
    Cell Significance Index: -18.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3533
    Cell Significance Index: -18.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8485
    Cell Significance Index: -21.0300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.2076
    Cell Significance Index: 154.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9112
    Cell Significance Index: -19.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9265
    Cell Significance Index: -12.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3126
    Cell Significance Index: -7.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5458
    Cell Significance Index: 180.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3629
    Cell Significance Index: 70.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2393
    Cell Significance Index: 1118.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0565
    Cell Significance Index: 14.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0515
    Cell Significance Index: 16.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9103
    Cell Significance Index: 99.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5221
    Cell Significance Index: 27.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4872
    Cell Significance Index: 13.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4761
    Cell Significance Index: 65.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4504
    Cell Significance Index: 89.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4018
    Cell Significance Index: 8.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3861
    Cell Significance Index: 11.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3754
    Cell Significance Index: 10.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3459
    Cell Significance Index: 42.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3361
    Cell Significance Index: 148.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3278
    Cell Significance Index: 59.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3156
    Cell Significance Index: 2.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2938
    Cell Significance Index: 20.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2876
    Cell Significance Index: 6.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2792
    Cell Significance Index: 18.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2767
    Cell Significance Index: 55.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2605
    Cell Significance Index: 142.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1814
    Cell Significance Index: 8.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1631
    Cell Significance Index: 31.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1571
    Cell Significance Index: 11.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1501
    Cell Significance Index: 2.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1478
    Cell Significance Index: 18.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1396
    Cell Significance Index: 6.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1336
    Cell Significance Index: 2.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1224
    Cell Significance Index: 3.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1089
    Cell Significance Index: 39.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0701
    Cell Significance Index: 6.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0604
    Cell Significance Index: 2.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0510
    Cell Significance Index: 2.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0402
    Cell Significance Index: 1.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0333
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0317
    Cell Significance Index: 5.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0247
    Cell Significance Index: 17.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0187
    Cell Significance Index: 2.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0011
    Cell Significance Index: 2.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -1.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0032
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0077
    Cell Significance Index: -0.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0178
    Cell Significance Index: -11.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0226
    Cell Significance Index: -1.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0295
    Cell Significance Index: -16.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0308
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0335
    Cell Significance Index: -15.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0387
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0395
    Cell Significance Index: -24.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0432
    Cell Significance Index: -4.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0487
    Cell Significance Index: -3.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0543
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0590
    Cell Significance Index: -4.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0618
    Cell Significance Index: -8.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0706
    Cell Significance Index: -20.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1027
    Cell Significance Index: -21.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1097
    Cell Significance Index: -2.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1123
    Cell Significance Index: -2.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1312
    Cell Significance Index: -1.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1363
    Cell Significance Index: -1.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1415
    Cell Significance Index: -8.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1791
    Cell Significance Index: -18.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1898
    Cell Significance Index: -4.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1993
    Cell Significance Index: -12.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2167
    Cell Significance Index: -17.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2170
    Cell Significance Index: -6.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2227
    Cell Significance Index: -2.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2491
    Cell Significance Index: -7.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2689
    Cell Significance Index: -11.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2861
    Cell Significance Index: -6.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2917
    Cell Significance Index: -10.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3187
    Cell Significance Index: -2.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3399
    Cell Significance Index: -2.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3518
    Cell Significance Index: -15.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3840
    Cell Significance Index: -6.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3968
    Cell Significance Index: -10.2000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4049
    Cell Significance Index: -5.6800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4057
    Cell Significance Index: -2.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4190
    Cell Significance Index: -12.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4259
    Cell Significance Index: -15.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PBX2 is a homeobox gene that belongs to the PBX family of transcription factors. It contains a highly conserved homeobox domain, which is essential for its DNA-binding activity. The PBX2 protein exhibits a unique structure, consisting of a homeobox domain, a C-terminal repression domain, and an N-terminal transcription activation domain. This modular architecture allows PBX2 to regulate gene expression through both transcriptional activation and repression. **Pathways and Functions:** PBX2 is involved in various cellular processes, including: 1. **Transcriptional Regulation**: PBX2 acts as a transcriptional regulator by binding to specific DNA sequences, thereby modulating the expression of target genes. It interacts with RNA polymerase II and other transcriptional co-factors to regulate the transcription of developmental genes. 2. **Cell Proliferation and Differentiation**: PBX2 regulates the expression of genes involved in cell proliferation and differentiation, thereby influencing the development of various tissues and organs. 3. **Apoptosis**: PBX2 has been shown to regulate apoptosis by modulating the expression of pro-apoptotic and anti-apoptotic genes. 4. **Immune Response**: PBX2 is expressed in classical monocytes, suggesting its role in immune response and inflammation. **Signaling Pathways:** PBX2 interacts with various signaling pathways, including: 1. **Wnt/β-catenin Signaling**: PBX2 regulates the expression of Wnt/β-catenin target genes, which are involved in cell proliferation, differentiation, and survival. 2. **Notch Signaling**: PBX2 interacts with Notch receptors to regulate the expression of Notch target genes. 3. **PI3K/AKT Signaling**: PBX2 modulates the expression of PI3K/AKT target genes, which are involved in cell survival and proliferation. **Clinical Significance:** Dysregulation of PBX2 has been implicated in various human diseases, including: 1. **Cancer**: PBX2 is often deregulated in cancer cells, leading to uncontrolled cell proliferation and tumor formation. 2. **Neurological Disorders**: PBX2 mutations have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Immunological Disorders**: PBX2 is involved in immune response and inflammation, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis. In conclusion, PBX2 is a crucial transcriptional regulator involved in various developmental processes and disease pathways. Its dysregulation has significant implications for human health, highlighting the need for further research into the molecular mechanisms underlying PBX2-mediated gene regulation.

Genular Protein ID: 2956108614

Symbol: PBX2_HUMAN

Name: Pre-B-cell leukemia transcription factor 2

UniProtKB Accession Codes:

P40425 A2BFJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 7 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1682799

Title: PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

PubMed ID: 1682799

DOI: 10.1128/mcb.11.12.6149-6157.1991

PubMed ID: 7759099

Title: The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein.

PubMed ID: 7759099

DOI: 10.1016/0888-7543(95)80007-9

PubMed ID: 7835890

Title: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.

PubMed ID: 7835890

DOI: 10.1006/geno.1994.1517

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7910944

Title: Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

PubMed ID: 7910944

DOI: 10.1128/mcb.14.6.3938-3948.1994

PubMed ID: 10825160

Title: Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.

PubMed ID: 10825160

DOI: 10.1074/jbc.m001323200

PubMed ID: 12609849

Title: Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.

PubMed ID: 12609849

DOI: 10.1182/blood-2002-02-0380

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 430
  • Mass: 45881
  • Checksum: EF2FFA158C4DAF68
  • Sequence:
    • MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI 
MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN 
MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE 
QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR 
FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI 
RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP 
GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG 
PGSVHSDTSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.