Details for: PBX3

Gene ID: 5090

Symbol: PBX3

Ensembl ID: ENSG00000167081

Description: PBX homeobox 3

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Animal organ morphogenesis
    (GO:0009887)
  • Anterior compartment pattern formation
    (GO:0007387)
  • Brain development
    (GO:0007420)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dorsal spinal cord development
    (GO:0021516)
  • Embryonic organ development
    (GO:0048568)
  • Eye development
    (GO:0001654)
  • Neuron development
    (GO:0048666)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Posterior compartment specification
    (GO:0007388)
  • Regulation of respiratory gaseous exchange by nervous system process
    (GO:0002087)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory gaseous exchange by respiratory system
    (GO:0007585)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 288.3084
    Cell Significance Index: -44.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 175.4432
    Cell Significance Index: -44.5000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.4065
    Cell Significance Index: -43.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.9663
    Cell Significance Index: -45.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.6754
    Cell Significance Index: -36.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8269
    Cell Significance Index: -36.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.9235
    Cell Significance Index: -45.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4996
    Cell Significance Index: -44.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.5717
    Cell Significance Index: -34.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5736
    Cell Significance Index: -45.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.2246
    Cell Significance Index: 159.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.1384
    Cell Significance Index: 183.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.1367
    Cell Significance Index: 61.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.0812
    Cell Significance Index: 236.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.7256
    Cell Significance Index: 58.2600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.6246
    Cell Significance Index: 27.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2937
    Cell Significance Index: 128.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9379
    Cell Significance Index: 695.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8239
    Cell Significance Index: 361.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3698
    Cell Significance Index: 38.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2392
    Cell Significance Index: 857.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2027
    Cell Significance Index: 75.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1358
    Cell Significance Index: 24.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0945
    Cell Significance Index: 27.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.0238
    Cell Significance Index: 1576.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8165
    Cell Significance Index: 80.7700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7939
    Cell Significance Index: 11.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6578
    Cell Significance Index: 1238.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6577
    Cell Significance Index: 106.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6434
    Cell Significance Index: 7.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5972
    Cell Significance Index: 119.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5391
    Cell Significance Index: 34.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5043
    Cell Significance Index: 455.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4588
    Cell Significance Index: 846.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3889
    Cell Significance Index: 528.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3739
    Cell Significance Index: 5.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3703
    Cell Significance Index: 45.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3637
    Cell Significance Index: 65.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3417
    Cell Significance Index: 21.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3017
    Cell Significance Index: 6.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2925
    Cell Significance Index: 31.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2642
    Cell Significance Index: 30.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1945
    Cell Significance Index: 26.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1157
    Cell Significance Index: 73.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0905
    Cell Significance Index: 40.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0852
    Cell Significance Index: 16.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0608
    Cell Significance Index: 0.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0571
    Cell Significance Index: 7.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0561
    Cell Significance Index: 25.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0087
    Cell Significance Index: 0.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0003
    Cell Significance Index: 0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0251
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0302
    Cell Significance Index: -17.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0318
    Cell Significance Index: -19.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0415
    Cell Significance Index: -1.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0426
    Cell Significance Index: -31.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0503
    Cell Significance Index: -3.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0565
    Cell Significance Index: -42.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0572
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0581
    Cell Significance Index: -9.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1186
    Cell Significance Index: -7.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1261
    Cell Significance Index: -6.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1302
    Cell Significance Index: -37.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1306
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1354
    Cell Significance Index: -13.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1925
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2079
    Cell Significance Index: -23.8200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2169
    Cell Significance Index: -3.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2174
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2269
    Cell Significance Index: -1.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2303
    Cell Significance Index: -5.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2443
    Cell Significance Index: -25.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2696
    Cell Significance Index: -19.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2830
    Cell Significance Index: -32.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3003
    Cell Significance Index: -35.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3058
    Cell Significance Index: -39.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3317
    Cell Significance Index: -17.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3812
    Cell Significance Index: -12.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4362
    Cell Significance Index: -29.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4378
    Cell Significance Index: -32.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4601
    Cell Significance Index: -21.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4899
    Cell Significance Index: -38.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4916
    Cell Significance Index: -22.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4920
    Cell Significance Index: -6.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5061
    Cell Significance Index: -8.5300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5399
    Cell Significance Index: -3.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6009
    Cell Significance Index: -16.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6121
    Cell Significance Index: -14.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6633
    Cell Significance Index: -13.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6643
    Cell Significance Index: -9.8100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.7051
    Cell Significance Index: -6.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7255
    Cell Significance Index: -38.0900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7511
    Cell Significance Index: -6.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7597
    Cell Significance Index: -4.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7661
    Cell Significance Index: -26.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7955
    Cell Significance Index: -10.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** PBX3 is a member of the PBX homeobox family, which is known for its role in transcriptional regulation. As a transcription factor, PBX3 binds to specific DNA sequences, influencing the expression of target genes. 2. **Developmental Processes:** PBX3 is involved in various developmental pathways, including brain development, organogenesis, and locomotory behavior. Its expression is crucial for the proper formation and function of the nervous system. 3. **Immune Cell Association:** PBX3 is significantly expressed in neuronal cells, suggesting its potential role in the development and function of immune cells, such as dendritic cells and T cells. 4. **Cell Type-Specific Expression:** PBX3's expression is restricted to specific cell types, including neuron-associated cells, granule cells, lens epithelial cells, and others involved in the nervous system and immune response. **Pathways and Functions:** 1. **Transcriptional Regulation:** PBX3 regulates the expression of target genes through its interaction with RNA polymerase II and other transcriptional regulators. 2. **Developmental Pathways:** PBX3 is involved in brain development, organogenesis, and locomotory behavior, highlighting its role in shaping the nervous system and immune response. 3. **Immune Cell Development:** PBX3's expression in neuronal cells suggests its potential role in immune cell development, including the development of dendritic cells and T cells. 4. **Neurodevelopmental Disorders:** Alterations in PBX3 expression have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** PBX3's involvement in neurodevelopmental disorders highlights its potential as a therapeutic target for the treatment of these conditions. 2. **Immune System Dysregulation:** PBX3's expression in immune cells suggests its potential role in immune system dysregulation, which is a hallmark of various autoimmune and inflammatory disorders. 3. **Cancer:** Alterations in PBX3 expression have been linked to cancer, including brain tumors and leukemia, highlighting its potential as a biomarker and therapeutic target. 4. **Personalized Medicine:** PBX3's involvement in various developmental and immune processes makes it a promising candidate for personalized medicine approaches, where genetic variants are used to tailor treatment strategies to individual patients. In conclusion, PBX3 is a complex gene that plays a pivotal role in developmental and immune processes. Its involvement in transcriptional regulation, brain development, and immune cell development highlights its potential as a therapeutic target for various diseases, including neurodevelopmental disorders, immune system dysregulation, and cancer. Further research is needed to fully elucidate the mechanisms by which PBX3 influences these processes and to explore its potential as a biomarker and therapeutic target.

Genular Protein ID: 768111084

Symbol: PBX3_HUMAN

Name: Pre-B-cell leukemia transcription factor 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1682799

Title: PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

PubMed ID: 1682799

DOI: 10.1128/mcb.11.12.6149-6157.1991

PubMed ID: 11579467

Title: Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities.

PubMed ID: 11579467

DOI: 10.1002/gcc.1190

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7910944

Title: Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

PubMed ID: 7910944

DOI: 10.1128/mcb.14.6.3938-3948.1994

PubMed ID: 10825160

Title: Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.

PubMed ID: 10825160

DOI: 10.1074/jbc.m001323200

Sequence Information:

  • Length: 434
  • Mass: 47190
  • Checksum: 81987E4C80C22069
  • Sequence:
  • MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS 
    LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV 
    SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH 
    VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR 
    NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 
    QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD 
    SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS 
    PTEGPGSVHS DTSN

Genular Protein ID: 1782396198

Symbol: Q96AL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 367
  • Mass: 39924
  • Checksum: 0FE7B826B9983265
  • Sequence:
  • EKTGLSIRGA QEEDPPDPQL MRLDNMLLAE GVSGPEKGGG SAAAAAAAAA SGGSSDNSIE 
    HSDYRAKLTQ IRQIYHTELE KYEQACNEFT THVMNLLREQ SRTRPISPKE IERMVGIIHR 
    KFSSIQMQLK QSTCEAVMIL RSRFLDARRK RRNFSKQATE ILNEYFYSHL SNPYPSEEAK 
    EELAKKCSIT VSQSLVKDPK ERGSKGSDIQ PTSVVSNWFG NKRIRYKKNI GKFQEEANLY 
    AAKTAVTAAH AVAAAVQNNQ TNSPTTPNSG SSGSFNLPNS GDMFMNMQSL NGDSYQGSQV 
    GANVQSQVDT LRHVINQTGG YSDGLGGNSL YSPHNLNANG GWQDATTPSS VTSPTEGPGS 
    VHSDTSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.