Details for: RRP15

Gene ID: 51018

Symbol: RRP15

Ensembl ID: ENSG00000067533

Description: ribosomal RNA processing 15 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.5601
    Cell Significance Index: -23.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.8539
    Cell Significance Index: -24.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 65.1782
    Cell Significance Index: -26.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.0390
    Cell Significance Index: -29.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.6297
    Cell Significance Index: -24.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6195
    Cell Significance Index: -24.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.6610
    Cell Significance Index: -27.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3361
    Cell Significance Index: -25.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6456
    Cell Significance Index: -30.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7362
    Cell Significance Index: -20.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3185
    Cell Significance Index: -11.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.0863
    Cell Significance Index: 49.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6840
    Cell Significance Index: 166.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6602
    Cell Significance Index: 99.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4203
    Cell Significance Index: 11.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2820
    Cell Significance Index: 139.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2173
    Cell Significance Index: 241.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1141
    Cell Significance Index: 30.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8423
    Cell Significance Index: 168.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8272
    Cell Significance Index: 96.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8185
    Cell Significance Index: 361.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8161
    Cell Significance Index: 57.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7608
    Cell Significance Index: 93.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6466
    Cell Significance Index: 88.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6433
    Cell Significance Index: 18.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6302
    Cell Significance Index: 113.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6227
    Cell Significance Index: 43.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6054
    Cell Significance Index: 98.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4904
    Cell Significance Index: 30.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4314
    Cell Significance Index: 55.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4291
    Cell Significance Index: 19.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3819
    Cell Significance Index: 28.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3633
    Cell Significance Index: 9.7000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3555
    Cell Significance Index: 5.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3517
    Cell Significance Index: 18.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3364
    Cell Significance Index: 303.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3301
    Cell Significance Index: 180.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3241
    Cell Significance Index: 116.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3070
    Cell Significance Index: 14.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2668
    Cell Significance Index: 2.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2625
    Cell Significance Index: 33.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2269
    Cell Significance Index: 12.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2269
    Cell Significance Index: 10.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1899
    Cell Significance Index: 36.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1891
    Cell Significance Index: 5.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1839
    Cell Significance Index: 3.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1618
    Cell Significance Index: 12.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1476
    Cell Significance Index: 2.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1383
    Cell Significance Index: 8.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1185
    Cell Significance Index: 13.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1135
    Cell Significance Index: 7.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1058
    Cell Significance Index: 3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0447
    Cell Significance Index: 1.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0316
    Cell Significance Index: 1.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0169
    Cell Significance Index: 0.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0092
    Cell Significance Index: 0.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0054
    Cell Significance Index: 10.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0049
    Cell Significance Index: 3.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 4.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0015
    Cell Significance Index: 2.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0164
    Cell Significance Index: -10.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0237
    Cell Significance Index: -4.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0309
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0329
    Cell Significance Index: -14.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0329
    Cell Significance Index: -24.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0457
    Cell Significance Index: -25.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0503
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0530
    Cell Significance Index: -33.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0784
    Cell Significance Index: -22.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0939
    Cell Significance Index: -0.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1047
    Cell Significance Index: -4.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1079
    Cell Significance Index: -5.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1296
    Cell Significance Index: -18.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1474
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1493
    Cell Significance Index: -17.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1559
    Cell Significance Index: -32.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1566
    Cell Significance Index: -8.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1635
    Cell Significance Index: -6.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1867
    Cell Significance Index: -4.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1891
    Cell Significance Index: -2.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2027
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2505
    Cell Significance Index: -19.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2780
    Cell Significance Index: -28.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2804
    Cell Significance Index: -4.8100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2979
    Cell Significance Index: -3.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3319
    Cell Significance Index: -4.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3429
    Cell Significance Index: -6.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3463
    Cell Significance Index: -2.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3502
    Cell Significance Index: -8.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3834
    Cell Significance Index: -12.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3916
    Cell Significance Index: -9.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4001
    Cell Significance Index: -9.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4197
    Cell Significance Index: -9.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4270
    Cell Significance Index: -2.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4458
    Cell Significance Index: -13.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4494
    Cell Significance Index: -27.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RRP15 is a gene that has been identified in humans and other organisms as a homolog of the ribosomal RNA processing 15 protein. The protein encoded by this gene, RRP15-Human, shares similarities with other RRP15-like proteins found in various eukaryotic organisms. RRP15 is primarily expressed in cells involved in hematopoiesis, immune responses, and tissue development. Its expression is observed in a range of cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and embryonic stem cells. Notably, RRP15 is also expressed in smooth muscle fibers of the ileum, mucosal type mast cells, and ciliated cells of the bronchus. **Pathways and Functions** RRP15 is involved in the maturation of 5.8s rRNA, a critical step in the assembly of the large ribosomal subunit. This process is essential for protein synthesis, cell growth, and proliferation. RRP15 has been shown to interact with other proteins involved in rRNA processing, including the RRP15-like protein (RRP15L). The RRP15-RRP15L complex is thought to play a key role in the regulation of rRNA processing and the assembly of the ribosome. Beyond its role in rRNA processing, RRP15 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and immune responses. Its expression has been observed in cells involved in immune responses, including CD8-alpha-beta-positive, alpha-beta intraepithelial T cells and regulatory T cells. **Clinical Significance** The clinical significance of RRP15 is an area of ongoing research. While its role in rRNA processing is well established, its involvement in other cellular processes and its expression in immune cells suggest that it may play a role in various diseases. For example, alterations in RRP15 expression have been observed in certain types of cancer, including leukemia and lymphoma. Additionally, RRP15 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Further research is needed to fully understand the clinical significance of RRP15 and its potential role in disease pathogenesis. In conclusion, RRP15 is a gene that plays a critical role in the maturation of 5.8s rRNA and is involved in various cellular processes, including cell proliferation, differentiation, and survival. Its expression is observed in a diverse range of cell types, including hematopoietic stem cells, embryonic stem cells, and immune cells. Further research is needed to fully understand the clinical significance of RRP15 and its potential role in disease pathogenesis.

Genular Protein ID: 3049224135

Symbol: RRP15_HUMAN

Name: RRP15-like protein

UniProtKB Accession Codes:

Q9Y3B9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 4 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 282
  • Mass: 31484
  • Checksum: 3FB1E3D861FB938F
  • Sequence:
    • MAAAAPDSRV SEEENLKKTP KKKMKMVTGA VASVLEDEAT DTSDSEGSCG SEKDHFYSDD 
DAIEADSEGD AEPCDKENEN DGESSVGTNM GWADAMAKVL NKKTPESKPT ILVKNKKLEK 
EKEKLKQERL EKIKQRDKRL EWEMMCRVKP DVVQDKETER NLQRIATRGV VQLFNAVQKH 
QKNVDEKVKE AGSSMRKRAK LISTVSKKDF ISVLRGMDGS TNETASSRKK PKAKQTEVKS 
EEGPGWTILR DDFMMGASMK DWDKESDGPD DSRPESASDS DT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.