Details for: GOLT1B

Gene ID: 51026

Symbol: GOLT1B

Ensembl ID: ENSG00000111711

Description: golgi transport 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 181.8121
    Cell Significance Index: -28.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.6311
    Cell Significance Index: -30.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.6096
    Cell Significance Index: -31.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.7712
    Cell Significance Index: -26.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.5577
    Cell Significance Index: -31.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.6884
    Cell Significance Index: -32.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.1751
    Cell Significance Index: -26.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8509
    Cell Significance Index: -30.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6086
    Cell Significance Index: -25.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6050
    Cell Significance Index: -26.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9523
    Cell Significance Index: -31.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5367
    Cell Significance Index: 44.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4185
    Cell Significance Index: 284.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2710
    Cell Significance Index: 1147.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8683
    Cell Significance Index: 141.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7667
    Cell Significance Index: 10.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6311
    Cell Significance Index: 226.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5868
    Cell Significance Index: 27.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5333
    Cell Significance Index: 14.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5332
    Cell Significance Index: 20.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5152
    Cell Significance Index: 15.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4757
    Cell Significance Index: 21.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4452
    Cell Significance Index: 30.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3947
    Cell Significance Index: 78.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3736
    Cell Significance Index: 51.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3388
    Cell Significance Index: 61.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3083
    Cell Significance Index: 6.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2839
    Cell Significance Index: 155.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2248
    Cell Significance Index: 4.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2132
    Cell Significance Index: 26.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2088
    Cell Significance Index: 39.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2057
    Cell Significance Index: 20.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1967
    Cell Significance Index: 9.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1940
    Cell Significance Index: 85.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1868
    Cell Significance Index: 11.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1772
    Cell Significance Index: 30.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1575
    Cell Significance Index: 11.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1450
    Cell Significance Index: 17.1000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1416
    Cell Significance Index: 0.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1371
    Cell Significance Index: 94.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1306
    Cell Significance Index: 16.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0937
    Cell Significance Index: 2.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0796
    Cell Significance Index: 5.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0538
    Cell Significance Index: 2.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0450
    Cell Significance Index: 5.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0410
    Cell Significance Index: 55.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0343
    Cell Significance Index: 64.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0194
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0004
    Cell Significance Index: 0.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0002
    Cell Significance Index: 0.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0035
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0130
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0149
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0197
    Cell Significance Index: -12.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0254
    Cell Significance Index: -1.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0279
    Cell Significance Index: -20.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0307
    Cell Significance Index: -4.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0334
    Cell Significance Index: -2.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0344
    Cell Significance Index: -0.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0367
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0386
    Cell Significance Index: -21.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0397
    Cell Significance Index: -1.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0697
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0743
    Cell Significance Index: -15.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0883
    Cell Significance Index: -25.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0966
    Cell Significance Index: -5.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0969
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1148
    Cell Significance Index: -13.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1155
    Cell Significance Index: -2.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1311
    Cell Significance Index: -2.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1319
    Cell Significance Index: -3.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1454
    Cell Significance Index: -9.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1554
    Cell Significance Index: -18.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1874
    Cell Significance Index: -9.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1921
    Cell Significance Index: -3.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1982
    Cell Significance Index: -5.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2179
    Cell Significance Index: -24.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2649
    Cell Significance Index: -27.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2706
    Cell Significance Index: -6.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3125
    Cell Significance Index: -10.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3590
    Cell Significance Index: -28.4300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3631
    Cell Significance Index: -2.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3687
    Cell Significance Index: -9.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3988
    Cell Significance Index: -8.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4403
    Cell Significance Index: -5.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4507
    Cell Significance Index: -11.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4599
    Cell Significance Index: -16.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4612
    Cell Significance Index: -15.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4660
    Cell Significance Index: -14.8400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4808
    Cell Significance Index: -2.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5159
    Cell Significance Index: -31.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5247
    Cell Significance Index: -13.1200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5253
    Cell Significance Index: -6.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5269
    Cell Significance Index: -14.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5292
    Cell Significance Index: -10.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GOLT1B is a member of the vesicle transport protein family, which plays a crucial role in the movement of vesicles between the endoplasmic reticulum (ER) and the Golgi apparatus. The protein is characterized by its ability to interact with other proteins and lipids to facilitate vesicle transport, a process that is essential for cellular homeostasis and immune function. GOLT1B is specifically expressed in cells involved in immune responses, such as hematopoietic cells, epithelial cells, and immune cells. **Pathways and Functions:** GOLT1B is involved in various cellular processes, including: 1. **Endoplasmic reticulum to Golgi vesicle-mediated transport**: GOLT1B facilitates the transport of vesicles from the ER to the Golgi apparatus, a process that is essential for protein modification, sorting, and packaging. 2. **Golgi membrane transport**: GOLT1B is involved in the transport of vesicles between the Golgi apparatus and the plasma membrane, a process that is crucial for cell-cell communication and immune responses. 3. **Retrograde transport**: GOLT1B is also involved in retrograde transport, a process that involves the transport of vesicles from the Golgi apparatus back to the ER. 4. **Positive regulation of canonical NF-κB signaling**: GOLT1B has been shown to interact with proteins involved in NF-κB signaling, a key pathway involved in immune responses and inflammation. **Clinical Significance:** The dysregulation of GOLT1B has been implicated in various diseases, including: 1. **Autoimmune disorders**: Alterations in GOLT1B expression have been observed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: GOLT1B has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 3. **Neurological disorders**: GOLT1B has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GOLT1B plays a critical role in cellular transport and signaling, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which GOLT1B regulates immune responses and to explore its potential as a therapeutic target for disease treatment. **Recommendations for Future Research:** 1. **Investigate the molecular mechanisms underlying GOLT1B's role in immune responses**: Further studies are needed to elucidate the specific molecular mechanisms by which GOLT1B regulates immune responses and signaling. 2. **Explore the therapeutic potential of GOLT1B**: GOLT1B's role in various diseases has been implicated, and further research is needed to explore its potential as a therapeutic target for disease treatment. 3. **Investigate the expression and function of GOLT1B in different tissues and cell types**: Further studies are needed to fully understand the expression and function of GOLT1B in different tissues and cell types.

Genular Protein ID: 2495767419

Symbol: GOT1B_HUMAN

Name: Vesicle transport protein GOT1B

UniProtKB Accession Codes:

Q9Y3E0 B2R4R4 Q54A40 Q6I9W6 Q9P1R9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10406798

Title: Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex.

PubMed ID: 10406798

DOI: 10.1093/emboj/18.14.3934

PubMed ID: 12414650

Title: Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes.

PubMed ID: 12414650

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 138
  • Mass: 15426
  • Checksum: 2EB85823C34EFAFA
  • Sequence:
    • MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI GLERTFRFFF 
QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG FFPVVVGFIR RVPVLGSLLN 
LPGIRSFVDK VGESNNMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.