Details for: DESI2

Gene ID: 51029

Symbol: DESI2

Ensembl ID: ENSG00000121644

Description: desumoylating isopeptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.9080
    Cell Significance Index: -35.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.5410
    Cell Significance Index: -35.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.2199
    Cell Significance Index: -39.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 80.2201
    Cell Significance Index: -32.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.7313
    Cell Significance Index: -39.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.3967
    Cell Significance Index: -32.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3579
    Cell Significance Index: -37.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.7932
    Cell Significance Index: -36.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5437
    Cell Significance Index: -37.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4032
    Cell Significance Index: -25.8100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.4660
    Cell Significance Index: -16.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6964
    Cell Significance Index: 275.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2415
    Cell Significance Index: 33.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1841
    Cell Significance Index: 1069.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1729
    Cell Significance Index: 127.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9250
    Cell Significance Index: 12.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8479
    Cell Significance Index: 168.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7994
    Cell Significance Index: 21.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7949
    Cell Significance Index: 30.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7612
    Cell Significance Index: 152.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6547
    Cell Significance Index: 28.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6369
    Cell Significance Index: 87.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6176
    Cell Significance Index: 17.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5856
    Cell Significance Index: 72.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5807
    Cell Significance Index: 68.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5707
    Cell Significance Index: 39.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5503
    Cell Significance Index: 99.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5327
    Cell Significance Index: 290.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4995
    Cell Significance Index: 12.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4963
    Cell Significance Index: 38.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4620
    Cell Significance Index: 29.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4270
    Cell Significance Index: 19.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4010
    Cell Significance Index: 143.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3780
    Cell Significance Index: 167.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3669
    Cell Significance Index: 19.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3454
    Cell Significance Index: 34.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3384
    Cell Significance Index: 18.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3329
    Cell Significance Index: 230.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2243
    Cell Significance Index: 11.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2014
    Cell Significance Index: 38.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1958
    Cell Significance Index: 12.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1798
    Cell Significance Index: 8.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1698
    Cell Significance Index: 12.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1561
    Cell Significance Index: 7.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1508
    Cell Significance Index: 19.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1029
    Cell Significance Index: 46.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0863
    Cell Significance Index: 162.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0763
    Cell Significance Index: 117.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0403
    Cell Significance Index: 0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0321
    Cell Significance Index: 24.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0258
    Cell Significance Index: 47.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0220
    Cell Significance Index: 0.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0150
    Cell Significance Index: 0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0145
    Cell Significance Index: 9.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0106
    Cell Significance Index: 14.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0033
    Cell Significance Index: 0.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0069
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0404
    Cell Significance Index: -5.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0422
    Cell Significance Index: -31.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0451
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0515
    Cell Significance Index: -8.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0590
    Cell Significance Index: -1.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0649
    Cell Significance Index: -36.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0698
    Cell Significance Index: -43.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0702
    Cell Significance Index: -1.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0780
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0847
    Cell Significance Index: -8.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0894
    Cell Significance Index: -0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1092
    Cell Significance Index: -15.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1113
    Cell Significance Index: -32.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1123
    Cell Significance Index: -13.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1345
    Cell Significance Index: -2.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1498
    Cell Significance Index: -4.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1899
    Cell Significance Index: -14.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1964
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2020
    Cell Significance Index: -42.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2046
    Cell Significance Index: -5.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2220
    Cell Significance Index: -14.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2285
    Cell Significance Index: -8.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2331
    Cell Significance Index: -26.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2527
    Cell Significance Index: -13.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2676
    Cell Significance Index: -27.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2732
    Cell Significance Index: -6.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3129
    Cell Significance Index: -9.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3390
    Cell Significance Index: -5.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3617
    Cell Significance Index: -7.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3758
    Cell Significance Index: -29.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3920
    Cell Significance Index: -5.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4458
    Cell Significance Index: -6.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4750
    Cell Significance Index: -29.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4935
    Cell Significance Index: -24.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5058
    Cell Significance Index: -13.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5205
    Cell Significance Index: -11.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5969
    Cell Significance Index: -13.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6181
    Cell Significance Index: -5.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7483
    Cell Significance Index: -22.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7653
    Cell Significance Index: -19.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7843
    Cell Significance Index: -24.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cysteine-type deubiquitinase activity:** DESI2 possesses cysteine-type deubiquitinase activity, which allows it to remove K48- and K63-linked ubiquitin chains from target proteins. 2. **Multifunctional enzyme:** DESI2 has been implicated in various cellular processes, including proteolysis, long-chain fatty acyl-coa hydrolase activity, and macromolecule depalmitoylation. 3. **Cell type-specific expression:** DESI2 is significantly expressed in polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and immune cells, such as alpha-beta intraepithelial T cells and regulatory T cells. **Pathways and Functions:** 1. **Immune regulation:** DESI2 may play a role in regulating immune responses by modulating the activity of immune cells, such as T cells and mast cells. 2. **Cellular homeostasis:** DESI2 may contribute to maintaining cellular homeostasis by regulating the expression and activity of proteins involved in various cellular processes. 3. **Proteolysis:** DESI2 may participate in proteolytic processes, such as the removal of desumoylation marks from proteins, which could have implications for protein stability and function. 4. **Long-chain fatty acyl-coa hydrolase activity:** DESI2's long-chain fatty acyl-coa hydrolase activity may be involved in lipid metabolism and cellular energy homeostasis. **Clinical Significance:** 1. **Immunological disorders:** Alterations in DESI2 expression or activity may contribute to the development of immunological disorders, such as autoimmune diseases or immune deficiencies. 2. **Cancer:** DESI2's role in regulating cellular homeostasis and immune responses may also be relevant to cancer development and progression. 3. **Neurological disorders:** DESI2's involvement in protein degradation and cellular homeostasis may also have implications for neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, DESI2 is a multifunctional enzyme that plays a significant role in various cellular processes, including immune regulation, cellular homeostasis, and proteolysis. Further research is needed to fully elucidate the functions of DESI2 and its potential implications for human disease.

Genular Protein ID: 3421066060

Symbol: DESI2_HUMAN

Name: Desumoylating isopeptidase 2

UniProtKB Accession Codes:

Q9BSY9 B1APK6 Q5VVC6 Q9NYS2 Q9Y3E4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 4 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28483520

Title: PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family.

PubMed ID: 28483520

DOI: 10.1016/j.bbrc.2017.04.161

PubMed ID: 35427157

Title: Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration.

PubMed ID: 35427157

DOI: 10.1126/sciadv.abj8633

Sequence Information:

  • Length: 194
  • Mass: 21444
  • Checksum: 9EADC1A33642EFFF
  • Sequence:
    • MGANQLVVLN VYDMYWMNEY TSSIGIGVFH SGIEVYGREF AYGGHPYPFS GIFEISPGNA 
SELGETFKFK EAVVLGSTDF LEDDIEKIVE ELGKEYKGNA YHLMHKNCNH FSSALSEILC 
GKEIPRWINR LAYFSSCIPF LQSCLPKEWL TPAALQSSVS QELQDELEEA EDAAASASVA 
STAAGSRPGR HTKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.