Details for: GLOD4

Gene ID: 51031

Symbol: GLOD4

Ensembl ID: ENSG00000167699

Description: glyoxalase domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.8285
    Cell Significance Index: -33.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 118.3551
    Cell Significance Index: -30.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 89.8901
    Cell Significance Index: -37.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 83.9612
    Cell Significance Index: -39.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.8693
    Cell Significance Index: -33.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.8746
    Cell Significance Index: -38.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.9518
    Cell Significance Index: -33.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.7391
    Cell Significance Index: -37.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8377
    Cell Significance Index: -38.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6086
    Cell Significance Index: -25.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7976
    Cell Significance Index: -23.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0483
    Cell Significance Index: -8.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2438
    Cell Significance Index: 378.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3128
    Cell Significance Index: 45.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1009
    Cell Significance Index: 8.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9386
    Cell Significance Index: 115.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9044
    Cell Significance Index: 147.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8910
    Cell Significance Index: 23.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8820
    Cell Significance Index: 61.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8591
    Cell Significance Index: 154.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8282
    Cell Significance Index: 452.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7504
    Cell Significance Index: 6.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7389
    Cell Significance Index: 52.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7085
    Cell Significance Index: 313.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6878
    Cell Significance Index: 35.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6868
    Cell Significance Index: 36.0600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6724
    Cell Significance Index: 7.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6564
    Cell Significance Index: 14.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6480
    Cell Significance Index: 88.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5229
    Cell Significance Index: 24.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4856
    Cell Significance Index: 97.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4781
    Cell Significance Index: 22.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4604
    Cell Significance Index: 5.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4566
    Cell Significance Index: 28.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4497
    Cell Significance Index: 12.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3991
    Cell Significance Index: 360.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3794
    Cell Significance Index: 75.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3760
    Cell Significance Index: 7.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3754
    Cell Significance Index: 27.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3720
    Cell Significance Index: 16.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3670
    Cell Significance Index: 9.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3572
    Cell Significance Index: 21.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3302
    Cell Significance Index: 42.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3125
    Cell Significance Index: 36.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2651
    Cell Significance Index: 8.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2636
    Cell Significance Index: 34.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2207
    Cell Significance Index: 79.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2200
    Cell Significance Index: 21.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1569
    Cell Significance Index: 26.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1522
    Cell Significance Index: 28.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1424
    Cell Significance Index: 9.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0954
    Cell Significance Index: 1.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0755
    Cell Significance Index: 2.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0733
    Cell Significance Index: 50.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0729
    Cell Significance Index: 0.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0404
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0283
    Cell Significance Index: 53.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0273
    Cell Significance Index: 19.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0135
    Cell Significance Index: 24.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0100
    Cell Significance Index: 15.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0026
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0096
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0141
    Cell Significance Index: -10.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0152
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0209
    Cell Significance Index: -13.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0340
    Cell Significance Index: -3.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0398
    Cell Significance Index: -22.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0605
    Cell Significance Index: -27.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0613
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0723
    Cell Significance Index: -15.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0836
    Cell Significance Index: -9.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0887
    Cell Significance Index: -25.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1195
    Cell Significance Index: -17.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1593
    Cell Significance Index: -2.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1801
    Cell Significance Index: -4.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2062
    Cell Significance Index: -10.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2086
    Cell Significance Index: -5.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2214
    Cell Significance Index: -1.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2228
    Cell Significance Index: -3.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2352
    Cell Significance Index: -5.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2441
    Cell Significance Index: -27.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2462
    Cell Significance Index: -6.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2593
    Cell Significance Index: -19.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2818
    Cell Significance Index: -22.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3062
    Cell Significance Index: -17.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3524
    Cell Significance Index: -36.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3880
    Cell Significance Index: -26.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4672
    Cell Significance Index: -12.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5321
    Cell Significance Index: -32.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5543
    Cell Significance Index: -24.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6294
    Cell Significance Index: -18.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6483
    Cell Significance Index: -24.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6571
    Cell Significance Index: -18.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6736
    Cell Significance Index: -8.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7713
    Cell Significance Index: -4.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8277
    Cell Significance Index: -23.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GLOD4 exhibits a specific glyoxalase domain, a structural motif involved in detoxifying methylglyoxal, a potent reactive aldehyde. The protein is highly expressed in various cell types, including hematopoietic cells, stem cells, and epithelial cells, suggesting its involvement in cellular development, maintenance, and immune function. The diverse expression profiles of GLOD4 across different tissues and cell types underscore its multifaceted role in maintaining cellular homeostasis. **Pathways and Functions:** GLOD4 is implicated in several cellular pathways, including: 1. **Cadherin binding**: GLOD4 interacts with cadherin proteins, which are essential for cell-cell adhesion and tissue structure. This interaction may regulate cell migration, differentiation, and survival. 2. **Extracellular exosome**: GLOD4 is secreted by various cells, including epithelial cells and immune cells, forming extracellular vesicles that can influence cellular behavior and tissue function. 3. **Mitochondrion**: The glyoxalase domain of GLOD4 is involved in protecting mitochondria from oxidative damage, ensuring the proper functioning of these organelles. The functions of GLOD4 are multifaceted, including: 1. **Detoxification**: GLOD4 helps to detoxify methylglyoxal, a reactive aldehyde that can cause cellular damage. 2. **Cellular development**: GLOD4 is essential for the development and maintenance of various cell types, including hematopoietic cells and epithelial cells. 3. **Immune regulation**: GLOD4 is expressed in immune cells, suggesting its role in regulating immune responses and maintaining tissue homeostasis. **Clinical Significance:** GLOD4 dysregulation has been implicated in various diseases, including: 1. **Cancer**: Altered expression of GLOD4 has been observed in various types of cancer, suggesting its role in tumor development and progression. 2. **Neurodegenerative diseases**: GLOD4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where oxidative stress and mitochondrial dysfunction play key roles. 3. **Autoimmune disorders**: GLOD4 may play a role in autoimmune diseases, such as rheumatoid arthritis and lupus, where immune dysregulation is a hallmark. In conclusion, GLOD4 is a multifunctional protein that plays a crucial role in immune regulation, cellular development, and tissue homeostasis. Further research is needed to elucidate the mechanisms underlying GLOD4 function and its implications for human disease.

Genular Protein ID: 1972241028

Symbol: GLOD4_HUMAN

Name: Glyoxalase domain-containing protein 4

UniProtKB Accession Codes:

Q9HC38 D3DTG9 D3DTH1 Q96B89 Q9H3J8 Q9HC37 Q9NVN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11642406

Title: Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocellular carcinoma.

PubMed ID: 11642406

DOI: 10.1038/sj.cr.7290088

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12897971

Title: Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method.

PubMed ID: 12897971

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 313
  • Mass: 34793
  • Checksum: 43DB04159153F07C
  • Sequence:
    • MAARRALHFV FKVGNRFQTA RFYRDVLGMK VESCSVARLE CSGAISAHCS DYTRITEDSF 
SKPYDGKWSK TMVGFGPEDD HFVAELTYNY GVGDYKLGND FMGITLASSQ AVSNARKLEW 
PLTEVAEGVF ETEAPGGYKF YLQNRSLPQS DPVLKVTLAV SDLQKSLNYW CNLLGMKIYE 
KDEEKQRALL GYADNQCKLE LQGVKGGVDH AAAFGRIAFS CPQKELPDLE DLMKRENQKI 
LTPLVSLDTP GKATVQVVIL ADPDGHEICF VGDEAFRELS KMDPEGSKLL DDAMAADKSD 
EWFAKHNKPK ASG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.