Details for: MEMO1

Gene ID: 51072

Symbol: MEMO1

Ensembl ID: ENSG00000162959

Description: mediator of cell motility 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.1246
    Cell Significance Index: -15.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.1418
    Cell Significance Index: -14.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.5563
    Cell Significance Index: -14.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.4402
    Cell Significance Index: -16.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.3863
    Cell Significance Index: -14.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.4311
    Cell Significance Index: -16.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7450
    Cell Significance Index: -15.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2524
    Cell Significance Index: -16.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6302
    Cell Significance Index: -11.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.8579
    Cell Significance Index: 68.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.6845
    Cell Significance Index: 58.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5176
    Cell Significance Index: -5.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1176
    Cell Significance Index: 130.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4336
    Cell Significance Index: 38.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2285
    Cell Significance Index: 26.2600
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.8812
    Cell Significance Index: 7.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6714
    Cell Significance Index: 9.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6121
    Cell Significance Index: 36.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5926
    Cell Significance Index: 16.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5918
    Cell Significance Index: 16.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5583
    Cell Significance Index: 504.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4974
    Cell Significance Index: 54.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4349
    Cell Significance Index: 87.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4095
    Cell Significance Index: 66.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3860
    Cell Significance Index: 20.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3398
    Cell Significance Index: 64.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3196
    Cell Significance Index: 37.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3078
    Cell Significance Index: 19.8600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2952
    Cell Significance Index: 2.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2933
    Cell Significance Index: 34.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2832
    Cell Significance Index: 8.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2387
    Cell Significance Index: 7.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2303
    Cell Significance Index: 15.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2271
    Cell Significance Index: 4.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2176
    Cell Significance Index: 39.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2057
    Cell Significance Index: 9.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1978
    Cell Significance Index: 70.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1610
    Cell Significance Index: 19.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1593
    Cell Significance Index: 2.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1482
    Cell Significance Index: 7.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1405
    Cell Significance Index: 9.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1246
    Cell Significance Index: 24.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1228
    Cell Significance Index: 16.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1187
    Cell Significance Index: 3.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1163
    Cell Significance Index: 3.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1050
    Cell Significance Index: 6.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0956
    Cell Significance Index: 52.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0915
    Cell Significance Index: 40.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0822
    Cell Significance Index: 2.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0784
    Cell Significance Index: 7.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0606
    Cell Significance Index: 3.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0598
    Cell Significance Index: 7.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0552
    Cell Significance Index: 1.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0385
    Cell Significance Index: 0.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0179
    Cell Significance Index: 0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0137
    Cell Significance Index: 0.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0125
    Cell Significance Index: 1.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0102
    Cell Significance Index: -0.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0174
    Cell Significance Index: -13.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0181
    Cell Significance Index: -13.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0235
    Cell Significance Index: -10.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0242
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0258
    Cell Significance Index: -4.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0263
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0311
    Cell Significance Index: -2.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0349
    Cell Significance Index: -1.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0370
    Cell Significance Index: -5.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0453
    Cell Significance Index: -4.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0499
    Cell Significance Index: -14.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0506
    Cell Significance Index: -1.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0521
    Cell Significance Index: -2.4300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0552
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0618
    Cell Significance Index: -7.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0640
    Cell Significance Index: -1.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0687
    Cell Significance Index: -5.1200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0701
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0752
    Cell Significance Index: -1.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0789
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0823
    Cell Significance Index: -17.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0843
    Cell Significance Index: -3.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1054
    Cell Significance Index: -1.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1097
    Cell Significance Index: -2.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1249
    Cell Significance Index: -2.6500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1382
    Cell Significance Index: -1.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1384
    Cell Significance Index: -2.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1399
    Cell Significance Index: -4.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1492
    Cell Significance Index: -9.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1506
    Cell Significance Index: -15.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1675
    Cell Significance Index: -2.8700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1762
    Cell Significance Index: -2.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1922
    Cell Significance Index: -6.1200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1932
    Cell Significance Index: -2.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MEMO1 is a cytoskeletal protein that interacts with the actin cytoskeleton, influencing cell motility and morphology. Its expression is tightly regulated, with dynamic changes observed in response to various cellular stimuli. MEMO1 exhibits a high degree of specificity, interacting with distinct partners to modulate its activity. This gene is also implicated in the regulation of microtubule-based processes, indicating a broader role in cellular organization and movement. **Pathways and Functions** MEMO1 is integral to several key signaling pathways that regulate cell motility and movement. Notably, its interaction with the ErbB2 receptor tyrosine kinase and the regulation of microtubule-based processes highlight the complexity of its role in cellular organization. The protein's involvement in the regulation of the actin cytoskeleton and its dynamic reorganization during cell migration underscore its critical function in cellular movement. Furthermore, MEMO1's expression in hematopoietic progenitor cells and immune cells suggests its involvement in the development and function of these cell types. **Clinical Significance** The dysregulation of MEMO1 has been implicated in various diseases, including cancer and autoimmune disorders. In cancer, altered MEMO1 expression has been linked to tumor progression, invasion, and metastasis. In autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, MEMO1's role in regulating immune cell function and tissue repair has been implicated in disease pathogenesis. The identification of specific MEMO1 mutations and variants has also provided insights into the genetic basis of these diseases, highlighting the potential for targeted therapeutic interventions. In conclusion, MEMO1 is a multifunctional gene that plays a critical role in regulating cellular movement and organization. Its involvement in various signaling pathways and its expression in diverse cell types underscore its importance in maintaining tissue homeostasis and preventing disease. Further research into the complexities of MEMO1's function and regulation will provide valuable insights into the molecular mechanisms underlying cellular movement and disease pathogenesis.

Genular Protein ID: 952255292

Symbol: MEMO1_HUMAN

Name: Protein MEMO1

UniProtKB Accession Codes:

Q9Y316 B4DLS0 D6W575 Q5R2V8 Q5R2V9 Q6NSL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11707072

Title: From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.

PubMed ID: 11707072

DOI: 10.1006/geno.2001.6640

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15156151

Title: Memo mediates ErbB2-driven cell motility.

PubMed ID: 15156151

DOI: 10.1038/ncb1134

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18045866

Title: Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.

PubMed ID: 18045866

DOI: 10.1074/jbc.m703523200

Sequence Information:

  • Length: 297
  • Mass: 33733
  • Checksum: E315FD5587776211
  • Sequence:
    • MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA 
HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE 
RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP 
SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH 
NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH

Genular Protein ID: 1871288577

Symbol: A8K3Y8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3Y8

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 1 HAMAP 1 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1

Sequence Information:

  • Length: 297
  • Mass: 33752
  • Checksum: 4DAAAD1429C723BB
  • Sequence:
    • MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA GYTYCGSCAA 
HAYKQVDPSI TRRIFILGPS HRVPLSRCAL SSVDIYRTPL YDLRIDQKIY GELWKTGMFE 
RMSLQTDEDE HSIEMHLPYT AKAMESHKDE FTIIPVLVGA LSESKEQEFG KLFSKYLADP 
SNLFVVSSDF CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH 
NTICGRHPIG VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.