Details for: THAP4

Gene ID: 51078

Symbol: THAP4

Ensembl ID: ENSG00000176946

Description: THAP domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.3018
    Cell Significance Index: -20.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.1198
    Cell Significance Index: -18.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.7161
    Cell Significance Index: -19.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.3015
    Cell Significance Index: -21.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 32.6666
    Cell Significance Index: -21.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.4191
    Cell Significance Index: -19.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8676
    Cell Significance Index: -22.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8728
    Cell Significance Index: -21.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8800
    Cell Significance Index: -18.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6690
    Cell Significance Index: -22.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4094
    Cell Significance Index: 19.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3038
    Cell Significance Index: 67.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1429
    Cell Significance Index: 31.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8782
    Cell Significance Index: 142.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8417
    Cell Significance Index: 38.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7819
    Cell Significance Index: 54.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7673
    Cell Significance Index: 153.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6808
    Cell Significance Index: 14.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6468
    Cell Significance Index: 128.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5963
    Cell Significance Index: 107.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4590
    Cell Significance Index: 56.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4382
    Cell Significance Index: 239.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3562
    Cell Significance Index: 48.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3526
    Cell Significance Index: 16.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3366
    Cell Significance Index: 120.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3359
    Cell Significance Index: 148.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3057
    Cell Significance Index: 30.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2920
    Cell Significance Index: 21.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2562
    Cell Significance Index: 16.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2547
    Cell Significance Index: 229.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2251
    Cell Significance Index: 42.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2204
    Cell Significance Index: 15.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2063
    Cell Significance Index: 6.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2007
    Cell Significance Index: 5.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1970
    Cell Significance Index: 15.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1853
    Cell Significance Index: 23.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1844
    Cell Significance Index: 9.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1782
    Cell Significance Index: 30.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1781
    Cell Significance Index: 9.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1702
    Cell Significance Index: 5.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1624
    Cell Significance Index: 19.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1624
    Cell Significance Index: 18.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1369
    Cell Significance Index: 2.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1336
    Cell Significance Index: 3.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1283
    Cell Significance Index: 6.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1089
    Cell Significance Index: 13.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1081
    Cell Significance Index: 1.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0902
    Cell Significance Index: 1.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0857
    Cell Significance Index: 3.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0762
    Cell Significance Index: 4.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0605
    Cell Significance Index: 2.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0469
    Cell Significance Index: 34.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0401
    Cell Significance Index: 1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0270
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 12.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0018
    Cell Significance Index: 1.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0035
    Cell Significance Index: -2.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0070
    Cell Significance Index: -4.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0267
    Cell Significance Index: -3.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0414
    Cell Significance Index: -3.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0497
    Cell Significance Index: -10.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0578
    Cell Significance Index: -1.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0652
    Cell Significance Index: -18.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0704
    Cell Significance Index: -8.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0718
    Cell Significance Index: -4.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0730
    Cell Significance Index: -4.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0843
    Cell Significance Index: -4.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1022
    Cell Significance Index: -2.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1256
    Cell Significance Index: -14.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1272
    Cell Significance Index: -3.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1273
    Cell Significance Index: -2.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1563
    Cell Significance Index: -4.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1615
    Cell Significance Index: -3.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1876
    Cell Significance Index: -2.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2017
    Cell Significance Index: -21.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2202
    Cell Significance Index: -6.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2206
    Cell Significance Index: -4.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2239
    Cell Significance Index: -5.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2696
    Cell Significance Index: -16.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3005
    Cell Significance Index: -8.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3011
    Cell Significance Index: -5.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3247
    Cell Significance Index: -4.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3343
    Cell Significance Index: -9.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3543
    Cell Significance Index: -7.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3835
    Cell Significance Index: -3.9700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3873
    Cell Significance Index: -2.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4214
    Cell Significance Index: -13.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4360
    Cell Significance Index: -4.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THAP4 is characterized by its ability to bind to DNA, heme, and metal ions, which are essential for its function. The protein's structure and function are attributed to its THAP domain, a conserved domain found in several proteins involved in cellular processes. The expression of THAP4 is widespread, with significant presence in cells involved in hematopoiesis, immune response, and epithelial barrier function. The protein's expression profile suggests its involvement in various cellular processes, including proliferation, differentiation, and survival. **Pathways and Functions:** THAP4 is implicated in several cellular pathways, including nitric oxide metabolism, peroxynitrite isomerase activity, and tyrosine metabolism. The protein's ability to bind to nitric oxide and peroxynitrite isomerase activity suggests its role in regulating nitric oxide levels and mitigating oxidative stress. Additionally, THAP4's involvement in tyrosine metabolism implies its potential role in signaling pathways and cellular regulation. The protein's expression in hematopoietic progenitor cells and mast cells further supports its involvement in immune response and inflammation. **Clinical Significance:** The clinical significance of THAP4 is an area of ongoing research. Given its widespread expression and involvement in cellular processes, alterations in THAP4 expression levels may contribute to various diseases, including autoimmune disorders, cancer, and inflammatory conditions. For instance, dysregulation of THAP4 expression in hematopoietic progenitor cells may lead to impaired immune function and increased susceptibility to infections. Furthermore, THAP4's role in epithelial barrier function suggests its potential involvement in gastrointestinal disorders, such as inflammatory bowel disease. In conclusion, THAP4 is a multifunctional protein that exhibits a unique combination of characteristics, including DNA binding, heme binding, and metal ion binding capabilities. Its widespread expression in various cell types and involvement in multiple cellular pathways suggest its potential role in various diseases. Further research is necessary to fully elucidate the clinical significance of THAP4 and its potential applications in disease diagnosis and treatment. **Recommendations for Future Research:** 1. Investigate the role of THAP4 in specific disease models, such as autoimmune disorders and cancer. 2. Elucidate the molecular mechanisms underlying THAP4's involvement in nitric oxide metabolism and peroxynitrite isomerase activity. 3. Explore the potential therapeutic applications of THAP4 in disease diagnosis and treatment. 4. Investigate the expression profile of THAP4 in different tissues and cell types to better understand its role in various cellular processes. By continuing to investigate the complex role of THAP4, researchers can gain a deeper understanding of its functions and potential applications in human disease.

Genular Protein ID: 938121848

Symbol: THAP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY91 Q53NU7 Q6GRN0 Q6IPJ3 Q9NW26 Q9Y325

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30524950

Title: Human nitrobindin: the first example of an all-beta-barrel ferric heme-protein that catalyzes peroxynitrite detoxification.

PubMed ID: 30524950

DOI: 10.1002/2211-5463.12534

PubMed ID: 32295384

Title: Mycobacterial and Human Nitrobindins: Structure and Function.

PubMed ID: 32295384

DOI: 10.1089/ars.2019.7874

PubMed ID: 21387410

Title: Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens.

PubMed ID: 21387410

DOI: 10.1002/prot.22944

Sequence Information:

  • Length: 577
  • Mass: 62890
  • Checksum: 40660A5ACDD0A7C3
  • Sequence:
    • MVICCAAVNC SNRQGKGEKR AVSFHRFPLK DSKRLIQWLK AVQRDNWTPT KYSFLCSEHF 
TKDSFSKRLE DQHRLLKPTA VPSIFHLTEK KRGAGGHGRT RRKDASKATG GVRGHSSAAT 
SRGAAGWSPS SSGNPMAKPE SRRLKQAALQ GEATPRAAQE AASQEQAQQA LERTPGDGLA 
TMVAGSQGKA EASATDAGDE SATSSIEGGV TDKSGISMDD FTPPGSGACK FIGSLHSYSF 
SSKHTRERPS VPREPIDRKR LKKDVEPSCS GSSLGPDKGL AQSPPSSSLT ATPQKPSQSP 
SAPPADVTPK PATEAVQSEH SDASPMSINE VILSASGACK LIDSLHSYCF SSRQNKSQVC 
CLREQVEKKN GELKSLRQRV SRSDSQVRKL QEKLDELRRV SVPYPSSLLS PSREPPKMNP 
VVEPLSWMLG TWLSDPPGAG TYPTLQPFQY LEEVHISHVG QPMLNFSFNS FHPDTRKPMH 
RECGFIRLKP DTNKVAFVSA QNTGVVEVEE GEVNGQELCI ASHSIARISF AKEPHVEQIT 
RKFRLNSEGK LEQTVSMATT TQPMTQHLHV TYKKVTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.