Details for: METTL25B

Gene ID: 51093

Symbol: METTL25B

Ensembl ID: ENSG00000143303

Description: methyltransferase like 25B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 103.6997
    Cell Significance Index: -16.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.9624
    Cell Significance Index: -15.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.8156
    Cell Significance Index: -15.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.3420
    Cell Significance Index: -17.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.6825
    Cell Significance Index: -14.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.8731
    Cell Significance Index: -14.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.8448
    Cell Significance Index: -17.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3664
    Cell Significance Index: -17.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4939
    Cell Significance Index: -7.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6216
    Cell Significance Index: 160.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0554
    Cell Significance Index: 14.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0074
    Cell Significance Index: 60.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9924
    Cell Significance Index: 107.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7867
    Cell Significance Index: 127.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7521
    Cell Significance Index: 39.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5867
    Cell Significance Index: 16.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5417
    Cell Significance Index: 14.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5344
    Cell Significance Index: 36.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5308
    Cell Significance Index: 11.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4408
    Cell Significance Index: 12.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4181
    Cell Significance Index: 18.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3706
    Cell Significance Index: 73.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3683
    Cell Significance Index: 9.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3054
    Cell Significance Index: 14.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2872
    Cell Significance Index: 7.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2860
    Cell Significance Index: 4.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2832
    Cell Significance Index: 17.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2463
    Cell Significance Index: 134.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2397
    Cell Significance Index: 48.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2381
    Cell Significance Index: 42.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2265
    Cell Significance Index: 27.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2221
    Cell Significance Index: 28.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1417
    Cell Significance Index: 62.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1413
    Cell Significance Index: 26.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1367
    Cell Significance Index: 10.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1340
    Cell Significance Index: 4.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1277
    Cell Significance Index: 17.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1272
    Cell Significance Index: 3.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1077
    Cell Significance Index: 7.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1035
    Cell Significance Index: 71.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0986
    Cell Significance Index: 35.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0966
    Cell Significance Index: 4.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0760
    Cell Significance Index: 3.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0568
    Cell Significance Index: 1.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0456
    Cell Significance Index: 41.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0442
    Cell Significance Index: 0.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0438
    Cell Significance Index: 2.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0377
    Cell Significance Index: 0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0337
    Cell Significance Index: 4.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0290
    Cell Significance Index: 3.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0192
    Cell Significance Index: 36.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0112
    Cell Significance Index: 7.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0112
    Cell Significance Index: 1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0101
    Cell Significance Index: 0.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0079
    Cell Significance Index: 0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0077
    Cell Significance Index: 11.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0061
    Cell Significance Index: 11.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0035
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0083
    Cell Significance Index: -6.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0154
    Cell Significance Index: -1.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0215
    Cell Significance Index: -2.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0257
    Cell Significance Index: -14.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0266
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0303
    Cell Significance Index: -18.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0322
    Cell Significance Index: -1.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0323
    Cell Significance Index: -0.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0387
    Cell Significance Index: -0.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0463
    Cell Significance Index: -13.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0488
    Cell Significance Index: -1.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0536
    Cell Significance Index: -0.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0591
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0869
    Cell Significance Index: -18.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1433
    Cell Significance Index: -2.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1586
    Cell Significance Index: -16.5100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1824
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1854
    Cell Significance Index: -14.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1895
    Cell Significance Index: -1.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1926
    Cell Significance Index: -5.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1930
    Cell Significance Index: -12.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2199
    Cell Significance Index: -13.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2355
    Cell Significance Index: -1.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2428
    Cell Significance Index: -6.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2496
    Cell Significance Index: -7.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2579
    Cell Significance Index: -4.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2618
    Cell Significance Index: -11.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2657
    Cell Significance Index: -1.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2714
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2855
    Cell Significance Index: -8.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2993
    Cell Significance Index: -12.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3054
    Cell Significance Index: -2.5700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3191
    Cell Significance Index: -4.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3207
    Cell Significance Index: -6.2600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3252
    Cell Significance Index: -2.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** METTL25B is significantly expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, smooth muscle fibers of the ileum, mucosal type mast cells, ciliated cells of the bronchus, orthochromatic erythroblasts, stromal cells of bone marrow, CD8-positive alpha-beta regulatory T cells, and colon goblet cells. This widespread expression suggests a non-specific or general role in cellular regulation. 2. **Methyltransferase Activity:** METTL25B exhibits a methyltransferase-like activity, which implies that it may contribute to the methylation of RNA molecules, particularly in the context of rRNA (adenine-N6,N6-dimethyltransferase) activity. 3. **Protein Structure:** The protein encoded by METTL25B, MT25B_HUMAN (RRNAD1), contains a non-canonical methyltransferase domain. This domain is distinct from the classical methyltransferase domains found in other enzymes, suggesting that METTL25B may have evolved a novel mechanism for RNA methylation. **Pathways and Functions:** 1. **RNA Methylation:** METTL25B's methyltransferase-like activity suggests that it may be involved in the methylation of rRNA molecules. This process could play a crucial role in regulating ribosome biogenesis, translation efficiency, and cellular homeostasis. 2. **Gene Regulation:** The expression of METTL25B in various tissues and cell types suggests that it may regulate gene expression in response to specific cellular cues. This could involve the methylation of regulatory RNAs, such as microRNAs or long non-coding RNAs, to modulate gene expression. 3. **Cellular Differentiation:** METTL25B's expression in hematopoietic cells and stem cells suggests that it may play a role in regulating cellular differentiation and proliferation. The methylation of RNA molecules could influence the expression of genes involved in cell fate decisions. **Clinical Significance:** 1. **Cancer Association:** The expression of METTL25B in various types of cancer cells, including hematological malignancies and solid tumors, suggests that it may be involved in tumorigenesis. Further studies are needed to elucidate the role of METTL25B in cancer development and progression. 2. **Regulatory T Cells:** The expression of METTL25B in CD8-positive alpha-beta regulatory T cells suggests that it may play a role in modulating immune responses. Further studies are needed to investigate the functional significance of METTL25B in immune regulation. 3. **Neurological Disorders:** The expression of METTL25B in ciliated cells of the bronchus and other epithelial cells suggests that it may be involved in the regulation of cellular homeostasis in the respiratory tract. Further studies are needed to investigate the role of METTL25B in neurological disorders, such as respiratory diseases and neurodegenerative disorders. In conclusion, METTL25B is a gene with a complex and multifaceted role in human biology. Further studies are needed to elucidate the functional significance of METTL25B, particularly in the context of cancer, immune regulation, and neurological disorders.

Genular Protein ID: 3823036037

Symbol: MT25B_HUMAN

Name: Protein RRNAD1

UniProtKB Accession Codes:

Q96FB5 D3DVC7 Q4VX71 Q5SZ03 Q9Y358

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 475
  • Mass: 52981
  • Checksum: 36B0552C8CD0582F
  • Sequence:
    • MPGISARGLS HEGRKQLAVN LTRVLALYRS ILDAYIIEFF TDNLWDTLPC SWQEALDGLK 
PPQLATMLLG MPGEGEVVRY RSVWPLTLLA LKSTACALAF TRMPGFQTPS EFLENPSQSS 
RLTAPFRKHV RPKKQHEIRR LGELVKKLSD FTGCTQVVDV GSGQGHLSRF MALGLGLMVK 
SIEGDQRLVE RAQRLDQELL QALEKEEKRN PQVVQTSPRH SPHHVVRWVD PTALCEELLL 
PLENPCQGRA RLLLTGLHAC GDLSVALLRH FSCCPEVVAL ASVGCCYMKL SDPGGYPLSQ 
WVAGLPGYEL PYRLREGACH ALEEYAERLQ KAGPGLRTHC YRAALETVIR RARPELRRPG 
VQGIPRVHEL KIEEYVQRGL QRVGLDPQLP LNLAALQAHV AQENRVVAFF SLALLLAPLV 
ETLILLDRLL YLQEQGFHAE LLPIFSPELS PRNLVLVATK MPLGQALSVL ETEDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.