Details for: UTP18

Gene ID: 51096

Symbol: UTP18

Ensembl ID: ENSG00000011260

Description: UTP18 small subunit processome component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.6572
    Cell Significance Index: -25.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.6230
    Cell Significance Index: -22.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.0912
    Cell Significance Index: -26.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.6525
    Cell Significance Index: -30.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.6005
    Cell Significance Index: -31.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.4000
    Cell Significance Index: -26.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.7397
    Cell Significance Index: -29.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2017
    Cell Significance Index: -24.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6735
    Cell Significance Index: -30.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2181
    Cell Significance Index: -22.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0398
    Cell Significance Index: -11.0300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.4423
    Cell Significance Index: 10.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3915
    Cell Significance Index: 83.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1236
    Cell Significance Index: 15.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1011
    Cell Significance Index: 29.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9745
    Cell Significance Index: 158.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8414
    Cell Significance Index: 43.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8348
    Cell Significance Index: 167.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7801
    Cell Significance Index: 20.8300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.7144
    Cell Significance Index: 10.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5770
    Cell Significance Index: 114.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5635
    Cell Significance Index: 38.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5302
    Cell Significance Index: 95.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5225
    Cell Significance Index: 36.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5216
    Cell Significance Index: 230.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5214
    Cell Significance Index: 33.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5011
    Cell Significance Index: 23.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4562
    Cell Significance Index: 56.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4332
    Cell Significance Index: 59.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4157
    Cell Significance Index: 227.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4111
    Cell Significance Index: 48.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3847
    Cell Significance Index: 11.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3799
    Cell Significance Index: 4.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3679
    Cell Significance Index: 47.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3609
    Cell Significance Index: 249.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3604
    Cell Significance Index: 129.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2700
    Cell Significance Index: 5.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2630
    Cell Significance Index: 7.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2173
    Cell Significance Index: 10.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1785
    Cell Significance Index: 13.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1604
    Cell Significance Index: 20.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1436
    Cell Significance Index: 4.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1209
    Cell Significance Index: 2.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1182
    Cell Significance Index: 6.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1177
    Cell Significance Index: 3.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1150
    Cell Significance Index: 11.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0787
    Cell Significance Index: 2.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0589
    Cell Significance Index: 53.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0421
    Cell Significance Index: 79.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0390
    Cell Significance Index: 7.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0239
    Cell Significance Index: 15.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0185
    Cell Significance Index: 0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0162
    Cell Significance Index: 24.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0160
    Cell Significance Index: 29.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0040
    Cell Significance Index: 0.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0038
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0280
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0337
    Cell Significance Index: -5.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0362
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0385
    Cell Significance Index: -3.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0479
    Cell Significance Index: -27.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0487
    Cell Significance Index: -0.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0541
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0552
    Cell Significance Index: -34.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0709
    Cell Significance Index: -1.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0729
    Cell Significance Index: -4.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0777
    Cell Significance Index: -2.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0861
    Cell Significance Index: -24.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1272
    Cell Significance Index: -2.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1415
    Cell Significance Index: -7.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1510
    Cell Significance Index: -10.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1536
    Cell Significance Index: -17.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1572
    Cell Significance Index: -33.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1694
    Cell Significance Index: -7.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1788
    Cell Significance Index: -1.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1930
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1997
    Cell Significance Index: -22.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2512
    Cell Significance Index: -26.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2695
    Cell Significance Index: -14.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2831
    Cell Significance Index: -22.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2849
    Cell Significance Index: -7.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2891
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3556
    Cell Significance Index: -11.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3715
    Cell Significance Index: -7.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3782
    Cell Significance Index: -6.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4161
    Cell Significance Index: -25.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4237
    Cell Significance Index: -9.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4275
    Cell Significance Index: -11.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5316
    Cell Significance Index: -11.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5563
    Cell Significance Index: -28.1100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5700
    Cell Significance Index: -7.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5970
    Cell Significance Index: -10.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6065
    Cell Significance Index: -17.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Small subunit processome component**: UTP18 is a critical component of the small subunit processome, a complex involved in the biogenesis of the ribosomal small subunit. 2. **RNA processing**: UTP18 is associated with the U3 small nucleolar RNA and is involved in the processing and modification of rRNA in both the nucleus and cytosol. 3. **Significant expression in hematopoietic cells**: UTP18 is significantly expressed in cells of hematopoietic origin, including erythroblasts, oligopotent progenitor cells, and T cells. 4. **Association with RNA binding proteins**: UTP18 is associated with PWP2P, a protein that is part of the 90S preribosome subcomplex. **Pathways and Functions** 1. **RNA processing in the nucleolus and cytosol**: UTP18 is involved in the processing and modification of rRNA in both the nucleus and cytosol, highlighting its role in regulating rRNA biogenesis. 2. **Ribosomal small subunit biogenesis**: UTP18 is a component of the small subunit processome, which is involved in the biogenesis of the ribosomal small subunit. 3. **Metabolism of RNA**: UTP18 is involved in the processing and modification of rRNA, highlighting its role in regulating RNA metabolism. 4. **Protein binding**: UTP18 is associated with PWP2P, a protein that is part of the 90S preribosome subcomplex, highlighting its role in protein binding. **Clinical Significance** 1. **Hematopoietic disorders**: UTP18 expression in hematopoietic cells highlights its potential role in regulating rRNA biogenesis and protein synthesis in hematopoietic disorders, such as leukemia and lymphoma. 2. **RNA processing disorders**: UTP18's involvement in RNA processing pathways highlights its potential role in disorders associated with impaired RNA processing, such as myelodysplastic syndromes. 3. **Cancer research**: UTP18's association with PWP2P and its role in protein binding highlight its potential role in cancer research, particularly in understanding the regulation of protein synthesis in cancer cells. In conclusion, the UTP18 gene is a critical component of the small subunit processome and is involved in the processing and modification of rRNA in both the nucleus and cytosol. Its significant expression in hematopoietic cells and association with RNA binding proteins highlight its potential role in regulating rRNA biogenesis and protein synthesis. Further research is needed to fully understand the clinical significance of UTP18 and its potential role in hematopoietic disorders and cancer research.

Genular Protein ID: 393834574

Symbol: UTP18_HUMAN

Name: U3 small nucleolar RNA-associated protein 18 homolog

UniProtKB Accession Codes:

Q9Y5J1 Q9H4N6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 556
  • Mass: 62004
  • Checksum: 800139F974F4EDF6
  • Sequence:
    • MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA 
IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE NDEDALLRRL RGPRVQEHED 
SGDSEVENEA KGNFPPQKKP VWVDEEDEDE EMVDMMNNRF RKDMMKNASE SKLSKDNLKK 
RLKEEFQHAM GGVPAWAETT KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN 
CQHANAERPT VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK 
ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS PDGSFLLING 
IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS SGDGEVYVWD VNSRKCLNRF 
VDEGSLYGLS IATSRNGQYV ACGSNCGVVN IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT 
FNPTTEILAI ASEKMKEAVR LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN 
EKGKALMYRL HHYSDF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.