Details for: APH1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 263.6532
Cell Significance Index: -41.0100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 131.7598
Cell Significance Index: -33.4200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 122.0058
Cell Significance Index: -50.2600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 106.6566
Cell Significance Index: -43.3300 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 100.6518
Cell Significance Index: -47.5200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 91.7406
Cell Significance Index: -47.1900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 70.8397
Cell Significance Index: -47.5400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.9624
Cell Significance Index: -44.3400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.9421
Cell Significance Index: -34.6700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.4849
Cell Significance Index: -45.3200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.2427
Cell Significance Index: -31.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.4099
Cell Significance Index: -11.8400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.9349
Cell Significance Index: 56.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.7753
Cell Significance Index: 37.1600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.7392
Cell Significance Index: 47.3400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5821
Cell Significance Index: 21.5900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2282
Cell Significance Index: 168.6700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.1574
Cell Significance Index: 136.4900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.1303
Cell Significance Index: 29.7200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.1280
Cell Significance Index: 84.0700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.0908
Cell Significance Index: 13.9700 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0700
Cell Significance Index: 138.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0247
Cell Significance Index: 53.2300 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.0183
Cell Significance Index: 8.1300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0115
Cell Significance Index: 35.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9759
Cell Significance Index: 45.5000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9715
Cell Significance Index: 119.4600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9623
Cell Significance Index: 425.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9332
Cell Significance Index: 509.6500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.9290
Cell Significance Index: 10.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9282
Cell Significance Index: 167.3200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9026
Cell Significance Index: 146.8100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8626
Cell Significance Index: 61.0100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8607
Cell Significance Index: 40.4500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7993
Cell Significance Index: 9.0800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7524
Cell Significance Index: 20.1300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7099
Cell Significance Index: 15.3800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5995
Cell Significance Index: 38.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.5727
Cell Significance Index: 73.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5010
Cell Significance Index: 99.4200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4829
Cell Significance Index: 8.9300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.4724
Cell Significance Index: 4.3500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.4149
Cell Significance Index: 4.3000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.2700
Cell Significance Index: 4.1000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2667
Cell Significance Index: 7.6900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2608
Cell Significance Index: 49.6400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2500
Cell Significance Index: 24.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1730
Cell Significance Index: 5.5400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1293
Cell Significance Index: 25.9300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0515
Cell Significance Index: 1.4400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0457
Cell Significance Index: 31.6100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0454
Cell Significance Index: 1.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0368
Cell Significance Index: 13.2100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0351
Cell Significance Index: 1.5900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0287
Cell Significance Index: 0.4800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0264
Cell Significance Index: 20.0100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0056
Cell Significance Index: 0.1500 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0018
Cell Significance Index: 0.1800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0001
Cell Significance Index: 0.2300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0060
Cell Significance Index: -4.4300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0214
Cell Significance Index: -3.6500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0295
Cell Significance Index: -54.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0364
Cell Significance Index: -56.0900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0382
Cell Significance Index: -0.6800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0432
Cell Significance Index: -58.7500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0447
Cell Significance Index: -1.5700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0534
Cell Significance Index: -39.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0539
Cell Significance Index: -34.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0699
Cell Significance Index: -39.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0829
Cell Significance Index: -51.7500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0987
Cell Significance Index: -44.7900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1539
Cell Significance Index: -17.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1630
Cell Significance Index: -46.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1853
Cell Significance Index: -21.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1948
Cell Significance Index: -28.3200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2303
Cell Significance Index: -5.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2525
Cell Significance Index: -53.1800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2643
Cell Significance Index: -16.6600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2648
Cell Significance Index: -6.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2678
Cell Significance Index: -14.0600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2916
Cell Significance Index: -7.4500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3076
Cell Significance Index: -6.5500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4323
Cell Significance Index: -45.0200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4827
Cell Significance Index: -29.6700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5252
Cell Significance Index: -40.3000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5302
Cell Significance Index: -41.9900 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -0.5415
Cell Significance Index: -3.3500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5910
Cell Significance Index: -39.7400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6403
Cell Significance Index: -35.9300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6461
Cell Significance Index: -19.0300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6863
Cell Significance Index: -4.6500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7648
Cell Significance Index: -11.4600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7774
Cell Significance Index: -47.6600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.8057
Cell Significance Index: -41.9700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.8213
Cell Significance Index: -11.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8874
Cell Significance Index: -39.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.9694
Cell Significance Index: -35.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.0582
Cell Significance Index: -40.0700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.0765
Cell Significance Index: -27.6700 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -1.0862
Cell Significance Index: -6.8000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2266872274
Symbol: APH1A_HUMAN
Name: Gamma-secretase subunit APH-1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12297508
Title: Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
PubMed ID: 12297508
PubMed ID: 10810093
Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
PubMed ID: 10810093
DOI: 10.1101/gr.10.5.703
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12110170
Title: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
PubMed ID: 12110170
PubMed ID: 12522139
Title: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
PubMed ID: 12522139
PubMed ID: 12471034
Title: APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
PubMed ID: 12471034
PubMed ID: 12763021
Title: APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity.
PubMed ID: 12763021
PubMed ID: 12740439
Title: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
PubMed ID: 12740439
PubMed ID: 12679784
PubMed ID: 14593096
Title: Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex.
PubMed ID: 14593096
PubMed ID: 19369254
Title: APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
PubMed ID: 19369254
PubMed ID: 25043039
Title: Three-dimensional structure of human gamma-secretase.
PubMed ID: 25043039
DOI: 10.1038/nature13567
PubMed ID: 26623517
Title: Sampling the conformational space of the catalytic subunit of human gamma-secretase.
PubMed ID: 26623517
DOI: 10.7554/elife.11182
PubMed ID: 26280335
PubMed ID: 30598546
Title: Structural basis of Notch recognition by human gamma-secretase.
PubMed ID: 30598546
PubMed ID: 30630874
Title: Recognition of the amyloid precursor protein by human gamma-secretase.
PubMed ID: 30630874
Sequence Information:
- Length: 265
- Mass: 28996
- Checksum: 8E37984A1DECC263
- Sequence:
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ RSLLCRRQED SRVMVYSALR IPPED
Genular Protein ID: 366537363
Symbol: B4DUG7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 190
- Mass: 20250
- Checksum: 7C8F464511739F65
- Sequence:
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGKA DEGLASLSED GRSPISIRQM AYVSGLSFGI ISGVFSVINI LADALGPGVV GIHGDSPYYF LTSAFLTAAI ILLHTFWGVV FFDACERRRY WALGLVVGSH LLTSGLTFLN PWYEASLLPI YAVTVSMGLW AFITAGGSLR SIQRSLLCKD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.