Details for: METTL9

Gene ID: 51108

Symbol: METTL9

Ensembl ID: ENSG00000197006

Description: methyltransferase 9, His-X-His N1(pi)-histidine

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 322.8643
    Cell Significance Index: -50.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.7396
    Cell Significance Index: -53.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.0281
    Cell Significance Index: -62.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 149.6221
    Cell Significance Index: -70.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.0606
    Cell Significance Index: -67.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 105.6895
    Cell Significance Index: -70.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 66.5415
    Cell Significance Index: -63.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.5233
    Cell Significance Index: -61.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.6792
    Cell Significance Index: -47.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.5609
    Cell Significance Index: -65.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9896
    Cell Significance Index: -46.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8191
    Cell Significance Index: -21.4900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 7.8582
    Cell Significance Index: 195.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.5958
    Cell Significance Index: 28.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4387
    Cell Significance Index: 51.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1727
    Cell Significance Index: 75.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9187
    Cell Significance Index: 208.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4907
    Cell Significance Index: 34.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4605
    Cell Significance Index: 797.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4317
    Cell Significance Index: 176.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4153
    Cell Significance Index: 1277.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3773
    Cell Significance Index: 276.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3746
    Cell Significance Index: 188.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3735
    Cell Significance Index: 247.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2978
    Cell Significance Index: 67.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1124
    Cell Significance Index: 20.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0314
    Cell Significance Index: 48.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0266
    Cell Significance Index: 11.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0204
    Cell Significance Index: 72.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0004
    Cell Significance Index: 442.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9452
    Cell Significance Index: 153.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9397
    Cell Significance Index: 64.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9044
    Cell Significance Index: 12.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8344
    Cell Significance Index: 106.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8166
    Cell Significance Index: 21.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7942
    Cell Significance Index: 37.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7760
    Cell Significance Index: 40.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7646
    Cell Significance Index: 151.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7476
    Cell Significance Index: 48.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7225
    Cell Significance Index: 53.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6091
    Cell Significance Index: 6.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5559
    Cell Significance Index: 71.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4737
    Cell Significance Index: 327.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4305
    Cell Significance Index: 11.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4066
    Cell Significance Index: 47.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3933
    Cell Significance Index: 141.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3804
    Cell Significance Index: 64.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3374
    Cell Significance Index: 7.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2859
    Cell Significance Index: 54.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2612
    Cell Significance Index: 7.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1813
    Cell Significance Index: 9.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1134
    Cell Significance Index: 213.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0845
    Cell Significance Index: 8.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0541
    Cell Significance Index: 2.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0340
    Cell Significance Index: 0.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0339
    Cell Significance Index: 1.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0333
    Cell Significance Index: 24.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0166
    Cell Significance Index: 0.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0157
    Cell Significance Index: 0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0067
    Cell Significance Index: 10.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0063
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0266
    Cell Significance Index: -19.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0299
    Cell Significance Index: -22.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0334
    Cell Significance Index: -21.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0382
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0406
    Cell Significance Index: -25.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0605
    Cell Significance Index: -8.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0625
    Cell Significance Index: -6.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0663
    Cell Significance Index: -30.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0780
    Cell Significance Index: -43.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0947
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1122
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1315
    Cell Significance Index: -27.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1359
    Cell Significance Index: -6.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1989
    Cell Significance Index: -57.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2339
    Cell Significance Index: -14.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2723
    Cell Significance Index: -7.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2870
    Cell Significance Index: -8.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2894
    Cell Significance Index: -33.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3314
    Cell Significance Index: -38.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3850
    Cell Significance Index: -3.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4224
    Cell Significance Index: -10.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4484
    Cell Significance Index: -11.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4724
    Cell Significance Index: -36.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4985
    Cell Significance Index: -39.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4986
    Cell Significance Index: -56.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5270
    Cell Significance Index: -16.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5340
    Cell Significance Index: -55.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6064
    Cell Significance Index: -24.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7497
    Cell Significance Index: -19.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7532
    Cell Significance Index: -16.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7688
    Cell Significance Index: -13.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8128
    Cell Significance Index: -23.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8246
    Cell Significance Index: -9.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0873
    Cell Significance Index: -13.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1322
    Cell Significance Index: -36.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1431
    Cell Significance Index: -70.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1448
    Cell Significance Index: -37.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** METTL9 is a methyltransferase enzyme that catalyzes the transfer of a methyl group to histidine residues, specifically the N1 position. This enzymatic activity is essential for the post-translational modification of proteins and the regulation of various cellular processes. 2. **Histidine N1-π-histidine motif:** The unique histidine N1-π-histidine motif present in the METTL9 protein is crucial for its enzymatic activity. This motif allows for the specific transfer of a methyl group to histidine residues, enabling the regulation of protein function and cellular processes. 3. **Widespread Cellular Expression:** METTL9 is significantly expressed in various cell types, including hematopoietic cells, epithelial cells, immune cells, and smooth muscle fibers. This widespread expression suggests its potential role in regulating cellular processes across different tissues and cell types. **Pathways and Functions:** 1. **Methylation:** METTL9 is involved in the methylation of histidine residues, which is a post-translational modification that regulates protein function and cellular processes. 2. **Protein-l-histidine n-pros-methyltransferase activity:** METTL9 exhibits a unique enzymatic activity that allows for the transfer of a methyl group to histidine residues, enabling the regulation of protein function and cellular processes. 3. **Protein binding:** METTL9 interacts with other proteins, including histidine-containing proteins, to regulate protein function and cellular processes. 4. **Endoplasmic reticulum:** METTL9 is localized to the endoplasmic reticulum, where it regulates protein folding and modification. 5. **Mitochondrion:** METTL9 is also localized to the mitochondrion, where it regulates mitochondrial function and cellular processes. **Clinical Significance:** 1. **Cancer:** Aberrant expression of METTL9 has been observed in various types of cancer, including leukemia, lymphoma, and breast cancer. This suggests its potential role in cancer development and progression. 2. **Immune system:** METTL9 is expressed in immune cells, including T cells and B cells, where it regulates immune responses and cellular processes. 3. **Neurological disorders:** METTL9 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it regulates protein function and cellular processes. 4. **Cardiovascular disease:** METTL9 has been linked to cardiovascular disease, where it regulates protein function and cellular processes involved in cardiovascular disease. In conclusion, METTL9 is a multifunctional enzyme that plays a crucial role in regulating cellular processes, including methylation, protein binding, and signal transduction. Its widespread cellular expression and involvement in various cellular processes suggest its potential role in regulating human disease, including cancer, immune system disorders, and neurological and cardiovascular diseases. Further research is needed to fully elucidate the role of METTL9 in human disease and to explore its therapeutic potential.

Genular Protein ID: 3084154684

Symbol: METL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H1A3 Q8NBT8 Q9BWJ7 Q9H1A2 Q9Y390

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11132146

Title: The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function.

PubMed ID: 11132146

DOI: 10.1007/s002510000259

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 34562450

Title: siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.

PubMed ID: 34562450

DOI: 10.1016/j.jbc.2021.101230

PubMed ID: 33563959

Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.

PubMed ID: 33563959

DOI: 10.1038/s41467-020-20670-7

Sequence Information:

  • Length: 318
  • Mass: 36536
  • Checksum: 81DEF9CC78342229
  • Sequence:
    • MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR KENHQWYVCN 
REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY HSFVSSVFSL FMSRTSINGL 
LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL DLGAGDGEVT KIMSPHFEEI YATELSETMI 
WQLQKKKYRV LGINEWQNTG FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL 
VLPFHPYVEN VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD 
MYNDYYVLDD AVFVLKPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.