Details for: RDH11

Gene ID: 51109

Symbol: RDH11

Ensembl ID: ENSG00000072042

Description: retinol dehydrogenase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 194.4129
    Cell Significance Index: -30.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.6816
    Cell Significance Index: -27.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 76.8544
    Cell Significance Index: -31.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.6853
    Cell Significance Index: -32.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.0819
    Cell Significance Index: -28.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.5395
    Cell Significance Index: -31.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9944
    Cell Significance Index: -32.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4149
    Cell Significance Index: -27.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.5207
    Cell Significance Index: -29.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3501
    Cell Significance Index: -32.9500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.3840
    Cell Significance Index: 35.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9048
    Cell Significance Index: 77.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3424
    Cell Significance Index: 21.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7928
    Cell Significance Index: 83.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2813
    Cell Significance Index: 10.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2272
    Cell Significance Index: 221.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1193
    Cell Significance Index: 58.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0547
    Cell Significance Index: 114.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0339
    Cell Significance Index: 53.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9846
    Cell Significance Index: 197.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9740
    Cell Significance Index: 158.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9711
    Cell Significance Index: 133.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9226
    Cell Significance Index: 55.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9190
    Cell Significance Index: 501.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8285
    Cell Significance Index: 46.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8190
    Cell Significance Index: 100.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7822
    Cell Significance Index: 49.3000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7131
    Cell Significance Index: 5.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7079
    Cell Significance Index: 24.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6270
    Cell Significance Index: 29.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5548
    Cell Significance Index: 198.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5220
    Cell Significance Index: 6.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4500
    Cell Significance Index: 57.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4151
    Cell Significance Index: 9.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3900
    Cell Significance Index: 172.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3613
    Cell Significance Index: 26.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3494
    Cell Significance Index: 7.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3137
    Cell Significance Index: 20.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3123
    Cell Significance Index: 61.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3028
    Cell Significance Index: 3.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2940
    Cell Significance Index: 8.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2324
    Cell Significance Index: 6.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2042
    Cell Significance Index: 26.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1816
    Cell Significance Index: 8.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1811
    Cell Significance Index: 4.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1625
    Cell Significance Index: 27.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1499
    Cell Significance Index: 28.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1484
    Cell Significance Index: 3.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0803
    Cell Significance Index: 5.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0578
    Cell Significance Index: 1.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0575
    Cell Significance Index: 43.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0476
    Cell Significance Index: 0.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0419
    Cell Significance Index: 1.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0398
    Cell Significance Index: 29.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0357
    Cell Significance Index: 3.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0205
    Cell Significance Index: 27.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0176
    Cell Significance Index: 0.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0015
    Cell Significance Index: 2.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0214
    Cell Significance Index: -2.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0221
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0281
    Cell Significance Index: -17.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0322
    Cell Significance Index: -18.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0571
    Cell Significance Index: -12.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0576
    Cell Significance Index: -6.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0784
    Cell Significance Index: -1.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0962
    Cell Significance Index: -27.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1420
    Cell Significance Index: -16.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1553
    Cell Significance Index: -18.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1620
    Cell Significance Index: -23.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1762
    Cell Significance Index: -2.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1772
    Cell Significance Index: -4.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1869
    Cell Significance Index: -9.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2236
    Cell Significance Index: -9.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2262
    Cell Significance Index: -17.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2587
    Cell Significance Index: -7.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2993
    Cell Significance Index: -31.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3106
    Cell Significance Index: -11.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3119
    Cell Significance Index: -9.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3146
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3175
    Cell Significance Index: -9.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3376
    Cell Significance Index: -6.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3455
    Cell Significance Index: -23.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3476
    Cell Significance Index: -27.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3683
    Cell Significance Index: -9.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3830
    Cell Significance Index: -19.9500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.3926
    Cell Significance Index: -4.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4801
    Cell Significance Index: -12.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5159
    Cell Significance Index: -31.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5440
    Cell Significance Index: -33.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5585
    Cell Significance Index: -10.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5638
    Cell Significance Index: -8.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5916
    Cell Significance Index: -19.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6004
    Cell Significance Index: -24.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RDH11 is a member of the short-chain dehydrogenase/reductase (SDR) superfamily, characterized by its ability to catalyze the reduction and oxidation of aldehydes and ketones. The enzyme exhibits specificity towards all-trans-retinol and 11-cis-retinol, converting them through the 11-cis-retinol dehydrogenase activity pathway. RDH11 is a monomeric protein, consisting of 281 amino acids and exhibiting a high degree of sequence homology with other SDR enzymes. The enzyme's kinetic properties suggest a high affinity for its substrates, enabling efficient conversion between all-trans-retinol and 11-cis-retinol. **Pathways and Functions** RDH11 is involved in several key pathways, including: 1. **Retinoid Metabolism and Transport**: RDH11 plays a critical role in the 11-cis-retinol dehydrogenase activity pathway, converting all-trans-retinol to 11-cis-retinol, a key intermediate in the retinoid cycle. This enzyme helps regulate the availability of retinoids for various cellular processes. 2. **Cellular Detoxification of Aldehydes**: RDH11 exhibits aldehyde dehydrogenase (NAD+) activity, enabling the conversion of aldehydes to their corresponding carboxylic acids, thereby facilitating cellular detoxification. 3. **Visual Perception and Phototransduction**: RDH11 is specifically expressed in photoreceptor inner segments, where it participates in the canonical retinoid cycle in rods, a critical process for visual perception and phototransduction. 4. **Signaling by Nuclear Receptors and Retinoic Acid**: RDH11 is involved in the metabolism and regulation of retinoic acid, a signaling molecule that plays a crucial role in cell growth, differentiation, and development. **Clinical Significance** RDH11 mutations have been associated with several diseases, including: 1. **Stargardt Disease**: A rare inherited disorder affecting the macula, characterized by progressive vision loss. 2. **Leber Congenital Amaurosis**: A severe form of inherited retinal degeneration, leading to early-onset blindness. 3. **Retinitis Pigmentosa**: A group of inherited disorders affecting the retina, causing progressive vision loss. RDH11 mutations can disrupt the retinoid metabolism pathway, leading to impaired visual perception and phototransduction. Understanding the role of RDH11 in retinoid metabolism and its involvement in various diseases will provide valuable insights into the development of novel therapeutic strategies for treating retinal disorders. In conclusion, RDH11 is a critical enzyme involved in the metabolism and regulation of retinoids, playing a pivotal role in various cellular processes, including visual perception and cell growth. Further research on RDH11 will provide valuable insights into the molecular mechanisms underlying retinal disorders and the development of novel therapeutic strategies for treating these diseases.

Genular Protein ID: 3437240354

Symbol: RDH11_HUMAN

Name: Retinol dehydrogenase 11

UniProtKB Accession Codes:

Q8TC12 A6NDK3 A8K062 B2RB26 B4DDW0 Q0QD40 Q6IAH5 Q9NRW0 Q9Y391

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 CarbonylDB 1 ChEBI 21 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 16 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11245473

Title: Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium.

PubMed ID: 11245473

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17286855

Title: Mapping of transcription start sites of human retina expressed genes.

PubMed ID: 17286855

DOI: 10.1186/1471-2164-8-42

PubMed ID: 12036956

Title: Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).

PubMed ID: 12036956

DOI: 10.1074/jbc.m202588200

PubMed ID: 12226107

Title: Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.

PubMed ID: 12226107

DOI: 10.1074/jbc.m208882200

PubMed ID: 15865448

Title: Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.

PubMed ID: 15865448

DOI: 10.1021/bi050226k

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24916380

Title: New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.

PubMed ID: 24916380

DOI: 10.1093/hmg/ddu291

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29410696

Title: The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism.

PubMed ID: 29410696

DOI: 10.1186/s12986-017-0235-x

Sequence Information:

  • Length: 318
  • Mass: 35386
  • Checksum: 5B0C366552774835
  • Sequence:
    • MVELMFPLLL LLLPFLLYMA APQIRKMLSS GVCTSTVQLP GKVVVVTGAN TGIGKETAKE 
LAQRGARVYL ACRDVEKGEL VAKEIQTTTG NQQVLVRKLD LSDTKSIRAF AKGFLAEEKH 
LHVLINNAGV MMCPYSKTAD GFEMHIGVNH LGHFLLTHLL LEKLKESAPS RIVNVSSLAH 
HLGRIHFHNL QGEKFYNAGL AYCHSKLANI LFTQELARRL KGSGVTTYSV HPGTVQSELV 
RHSSFMRWMW WLFSFFIKTP QQGAQTSLHC ALTEGLEILS GNHFSDCHVA WVSAQARNET 
IARRLWDVSC DLLGLPID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.