RPL26L1 | ENSG00000037241 | NCBI 51121

Details for: RPL26L1

Gene ID: 51121

Symbol: RPL26L1

Ensembl ID: ENSG00000037241

Description: ribosomal protein L26 like 1

Associated with

Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation
(R-HSA-72766)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasmic translation
(GO:0002181)
Cytosolic large ribosomal subunit
(GO:0022625)
Extracellular exosome
(GO:0070062)
Protein binding
(GO:0005515)
Ribosomal large subunit biogenesis
(GO:0042273)
Rna binding
(GO:0003723)
Structural constituent of ribosome
(GO:0003735)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 101.4449
Cell Significance Index: -41.7900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 83.7071
Cell Significance Index: -39.5200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 71.0557
Cell Significance Index: -36.5500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 58.9101
Cell Significance Index: -39.5300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.5837
Cell Significance Index: -33.7100
Cell Name: abnormal cell (CL0001061)
Fold Change: 2.3599
Cell Significance Index: 241.0700
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.0834
Cell Significance Index: 53.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.0228
Cell Significance Index: 121.4400
Cell Name: kidney cell (CL1000497)
Fold Change: 1.8699
Cell Significance Index: 14.9300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.5866
Cell Significance Index: 33.2100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.4644
Cell Significance Index: 15.9200
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.3813
Cell Significance Index: 36.3200
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.1852
Cell Significance Index: 17.8600
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1306
Cell Significance Index: 617.4500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0202
Cell Significance Index: 125.4500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0038
Cell Significance Index: 46.8000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9961
Cell Significance Index: 70.4500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8805
Cell Significance Index: 158.7300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7957
Cell Significance Index: 9.0400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7953
Cell Significance Index: 351.6300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7804
Cell Significance Index: 40.5400
Cell Name: peg cell (CL4033014)
Fold Change: 0.7497
Cell Significance Index: 17.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7475
Cell Significance Index: 102.6500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7226
Cell Significance Index: 25.1100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7075
Cell Significance Index: 83.4300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6962
Cell Significance Index: 18.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6716
Cell Significance Index: 31.5700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6274
Cell Significance Index: 46.7600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.5929
Cell Significance Index: 4.9800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5826
Cell Significance Index: 17.1100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5729
Cell Significance Index: 396.2400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5458
Cell Significance Index: 37.7500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5392
Cell Significance Index: 4.9700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.5074
Cell Significance Index: 65.5500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4589
Cell Significance Index: 58.8300
Cell Name: germ cell (CL0000586)
Fold Change: 0.3986
Cell Significance Index: 3.0100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3826
Cell Significance Index: 17.3400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3328
Cell Significance Index: 7.2100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3009
Cell Significance Index: 19.4200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2704
Cell Significance Index: 51.4600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2664
Cell Significance Index: 240.5500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2105
Cell Significance Index: 13.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1367
Cell Significance Index: 13.5200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.1193
Cell Significance Index: 34.3400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1102
Cell Significance Index: 22.1100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0688
Cell Significance Index: 52.0900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0277
Cell Significance Index: 0.7400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0213
Cell Significance Index: 0.7500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0130
Cell Significance Index: 9.5600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0084
Cell Significance Index: 1.6600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0084
Cell Significance Index: 3.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0044
Cell Significance Index: 0.2300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0149
Cell Significance Index: -28.0100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0260
Cell Significance Index: -0.3900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0264
Cell Significance Index: -48.7700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0313
Cell Significance Index: -48.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0355
Cell Significance Index: -6.0700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0371
Cell Significance Index: -50.4200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0401
Cell Significance Index: -29.7000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0473
Cell Significance Index: -30.0700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0616
Cell Significance Index: -34.7500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0685
Cell Significance Index: -42.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0812
Cell Significance Index: -36.8600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0934
Cell Significance Index: -10.7000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1105
Cell Significance Index: -17.9700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1456
Cell Significance Index: -3.1000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2117
Cell Significance Index: -6.7800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2144
Cell Significance Index: -45.1500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2510
Cell Significance Index: -36.4900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2520
Cell Significance Index: -6.7400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2565
Cell Significance Index: -3.2900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2665
Cell Significance Index: -4.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2720
Cell Significance Index: -21.5400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3607
Cell Significance Index: -22.1700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3625
Cell Significance Index: -6.7000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3733
Cell Significance Index: -10.7000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3763
Cell Significance Index: -39.1800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3971
Cell Significance Index: -11.7000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4507
Cell Significance Index: -34.5900
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.4659
Cell Significance Index: -4.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4969
Cell Significance Index: -6.7800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5123
Cell Significance Index: -28.7500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5556
Cell Significance Index: -37.3600
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.5864
Cell Significance Index: -8.2300
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.6180
Cell Significance Index: -8.3400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6231
Cell Significance Index: -6.4500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6325
Cell Significance Index: -38.7800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6573
Cell Significance Index: -16.4300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7023
Cell Significance Index: -12.4100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7304
Cell Significance Index: -19.5700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8076
Cell Significance Index: -20.7600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.8246
Cell Significance Index: -5.0800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8393
Cell Significance Index: -30.8100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8408
Cell Significance Index: -5.0800
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.8418
Cell Significance Index: -5.2700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8455
Cell Significance Index: -37.4000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.8974
Cell Significance Index: -25.8600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9691
Cell Significance Index: -33.9500
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.9834
Cell Significance Index: -8.4500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9948
Cell Significance Index: -37.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** RPL26L1 is a conserved ribosomal protein that belongs to the L26 family of ribosomal proteins. It is a component of the 60S subunit of the eukaryotic ribosome, which is responsible for the translation of mRNAs into proteins. The gene is highly expressed in cells undergoing rapid growth and development, such as embryonic stem cells and smooth muscle fibers. RPL26L1 also plays a role in the regulation of protein synthesis, particularly under conditions of stress or amino acid deficiency. **Pathways and Functions:** RPL26L1 is involved in various cellular processes, including: 1. **Translation:** RPL26L1 is a crucial component of the 60S subunit, which is responsible for the elongation of protein synthesis. It interacts with other ribosomal proteins and factors to regulate the translation process. 2. **Stress Response:** RPL26L1 is induced in response to stress, such as amino acid deficiency, and plays a role in the regulation of protein synthesis during this time. 3. **Developmental Biology:** RPL26L1 is highly expressed in embryonic stem cells and smooth muscle fibers, suggesting its role in cellular differentiation and development. 4. **Immune Response:** RPL26L1 is expressed in immune cells, such as peripheral blood mononuclear cells and CD8-alpha-beta-positive T cells, suggesting its involvement in immune function. 5. **Ribosome Biogenesis:** RPL26L1 is involved in the regulation of ribosome biogenesis, particularly in the formation of the 60S subunit. **Clinical Significance:** Dysregulation of RPL26L1 has been implicated in various diseases, including: 1. **Infectious Diseases:** RPL26L1 is involved in the translation of viral mRNAs, suggesting its potential role in the pathogenesis of infectious diseases, such as influenza. 2. **Cancer:** Alterations in RPL26L1 expression have been observed in various types of cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** RPL26L1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RPL26L1 is a multifunctional gene that plays a critical role in various cellular processes, including translation, stress response, and development. Its dysregulation has significant implications for our understanding of disease, and further research is needed to fully elucidate its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

60S ribosomal protein L26-like 1

Genular Protein ID: 3741434990

Symbol: RL26L_HUMAN

Name: 60S ribosomal protein L26-like 1

UniProtKB Accession Codes:

Q9UNX3 B3KY82 D3DQM0

Database IDs:

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 145
Mass: 17256
Checksum: 090D4CAB4E3F4F36
Sequence:

MKFNPFVTSD RSKNRKRHFN APSHVRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG 
HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE 
RKAKSRQVGK EKGKYKEELI EKMQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPL26L1

Associated with

Cells (max top 100)

Other Information

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

Initial characterization of the human central proteome. PubMed ID: 21269460

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733