Details for: ZNF706

Gene ID: 51123

Symbol: ZNF706

Ensembl ID: ENSG00000120963

Description: zinc finger protein 706

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 536.5642
    Cell Significance Index: -83.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 296.3018
    Cell Significance Index: -75.1600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 243.7931
    Cell Significance Index: -100.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 204.9044
    Cell Significance Index: -96.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 197.7073
    Cell Significance Index: -80.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 180.0402
    Cell Significance Index: -92.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 144.4513
    Cell Significance Index: -96.9300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 85.1643
    Cell Significance Index: -81.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.4576
    Cell Significance Index: -90.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.4180
    Cell Significance Index: -70.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.5729
    Cell Significance Index: -93.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.6961
    Cell Significance Index: -69.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.1872
    Cell Significance Index: -31.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1017
    Cell Significance Index: 98.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.0419
    Cell Significance Index: 144.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0243
    Cell Significance Index: 130.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9797
    Cell Significance Index: 56.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8034
    Cell Significance Index: 232.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7211
    Cell Significance Index: 128.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6983
    Cell Significance Index: 750.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6116
    Cell Significance Index: 159.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5571
    Cell Significance Index: 191.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5561
    Cell Significance Index: 42.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4412
    Cell Significance Index: 169.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4011
    Cell Significance Index: 252.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3940
    Cell Significance Index: 761.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3932
    Cell Significance Index: 279.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2610
    Cell Significance Index: 173.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1419
    Cell Significance Index: 409.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0175
    Cell Significance Index: 9.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9137
    Cell Significance Index: 181.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9105
    Cell Significance Index: 42.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8267
    Cell Significance Index: 24.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7972
    Cell Significance Index: 136.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7943
    Cell Significance Index: 86.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7217
    Cell Significance Index: 19.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6086
    Cell Significance Index: 31.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6031
    Cell Significance Index: 37.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5735
    Cell Significance Index: 29.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5673
    Cell Significance Index: 8.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5171
    Cell Significance Index: 34.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4700
    Cell Significance Index: 424.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3985
    Cell Significance Index: 51.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3732
    Cell Significance Index: 71.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1547
    Cell Significance Index: 107.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1542
    Cell Significance Index: 2.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1194
    Cell Significance Index: 2.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0927
    Cell Significance Index: 174.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0166
    Cell Significance Index: -25.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0216
    Cell Significance Index: -1.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0240
    Cell Significance Index: -44.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0352
    Cell Significance Index: -25.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0483
    Cell Significance Index: -36.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0551
    Cell Significance Index: -74.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0662
    Cell Significance Index: -6.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0668
    Cell Significance Index: -41.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0823
    Cell Significance Index: -37.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1216
    Cell Significance Index: -68.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1882
    Cell Significance Index: -3.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2017
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2253
    Cell Significance Index: -47.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2544
    Cell Significance Index: -29.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2636
    Cell Significance Index: -11.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2655
    Cell Significance Index: -76.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3017
    Cell Significance Index: -23.1500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3767
    Cell Significance Index: -4.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3887
    Cell Significance Index: -10.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3892
    Cell Significance Index: -56.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4221
    Cell Significance Index: -15.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4344
    Cell Significance Index: -12.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4552
    Cell Significance Index: -53.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4993
    Cell Significance Index: -8.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5444
    Cell Significance Index: -9.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5607
    Cell Significance Index: -12.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6133
    Cell Significance Index: -34.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6592
    Cell Significance Index: -41.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6999
    Cell Significance Index: -17.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7006
    Cell Significance Index: -79.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7007
    Cell Significance Index: -31.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7437
    Cell Significance Index: -23.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8172
    Cell Significance Index: -85.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8217
    Cell Significance Index: -23.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9144
    Cell Significance Index: -72.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9219
    Cell Significance Index: -24.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0584
    Cell Significance Index: -14.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2434
    Cell Significance Index: -76.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3558
    Cell Significance Index: -28.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.4569
    Cell Significance Index: -34.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5140
    Cell Significance Index: -90.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5386
    Cell Significance Index: -39.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7598
    Cell Significance Index: -43.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8248
    Cell Significance Index: -11.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9362
    Cell Significance Index: -57.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1043
    Cell Significance Index: -60.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.1117
    Cell Significance Index: -45.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.1354
    Cell Significance Index: -68.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.1454
    Cell Significance Index: -70.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1804
    Cell Significance Index: -80.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator**: ZNF706 is a transcription factor that binds to specific DNA sequences, influencing gene expression by either activating or repressing transcription. 2. **Metal Ion Binding**: ZNF706 contains a zinc finger domain, which allows it to bind to metal ions, facilitating its interaction with DNA and other proteins. 3. **Tissue-Specific Expression**: ZNF706 is expressed in various cell types, including hematopoietic cells, stem cells, and epithelial cells, suggesting its involvement in multiple physiological processes. 4. **Regulatory Functions**: ZNF706 has been implicated in the regulation of translation, gene expression, and DNA-templated transcription, highlighting its versatility in influencing cellular behavior. **Pathways and Functions:** 1. **Negative Regulation of DNA-templated Transcription**: ZNF706 acts as a transcriptional repressor, influencing the expression of genes involved in cell growth, differentiation, and survival. 2. **Negative Regulation of Stem Cell Population Maintenance**: ZNF706 contributes to the regulation of stem cell populations, ensuring proper cell fate determination and preventing excessive proliferation. 3. **Regulation of Translation**: ZNF706 modulates the translation of specific mRNAs, influencing protein synthesis and cellular behavior. 4. **Gene Expression (transcription)**: ZNF706 regulates the expression of genes involved in various biological processes, including immune response, cell growth, and differentiation. **Clinical Significance:** 1. **Immune Regulation**: ZNF706's role in regulating immune responses, particularly in hematopoietic cells, underscores its potential as a therapeutic target for immune-related disorders. 2. **Cancer**: The involvement of ZNF706 in cancer progression and metastasis highlights its potential as a diagnostic biomarker or therapeutic target. 3. **Regenerative Medicine**: ZNF706's function in stem cell maintenance and differentiation suggests its potential as a tool for regenerative medicine, particularly in tissue engineering and organ transplantation. 4. **Infectious Diseases**: The expression of ZNF706 in various cell types and its role in regulating immune responses make it an attractive target for the development of novel therapeutic strategies against infectious diseases. In conclusion, ZNF706 is a multifaceted transcription factor that plays a crucial role in regulating immune responses, stem cell maintenance, and gene expression. Further research is necessary to fully elucidate its functions and clinical significance, but its potential as a therapeutic target and diagnostic biomarker makes it an area of interest for immunologists and researchers alike.

Genular Protein ID: 2688760550

Symbol: ZN706_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y5V0 A8K362

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 7 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 76
  • Mass: 8498
  • Checksum: 3EDEABD9FFE529FF
  • Sequence:
    • MARGQQKIQS QQKNAKKQAG QKKKQGHDQK AAAKAALIYT CTVCRTQMPD PKTFKQHFES 
KHPKTPLPPE LADVQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.