Details for: GOLGA7

Gene ID: 51125

Symbol: GOLGA7

Ensembl ID: ENSG00000147533

Description: golgin A7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 267.7678
    Cell Significance Index: -41.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.0171
    Cell Significance Index: -40.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.7381
    Cell Significance Index: -48.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.5594
    Cell Significance Index: -46.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.3706
    Cell Significance Index: -38.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.2085
    Cell Significance Index: -43.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.6490
    Cell Significance Index: -46.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.9168
    Cell Significance Index: -39.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.5788
    Cell Significance Index: -45.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.7839
    Cell Significance Index: -46.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4041
    Cell Significance Index: -30.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4250
    Cell Significance Index: -32.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5149
    Cell Significance Index: 173.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2282
    Cell Significance Index: 133.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2203
    Cell Significance Index: 73.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8819
    Cell Significance Index: 121.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7722
    Cell Significance Index: 22.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7337
    Cell Significance Index: 10.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6281
    Cell Significance Index: 29.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6109
    Cell Significance Index: 16.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5898
    Cell Significance Index: 260.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5462
    Cell Significance Index: 109.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5344
    Cell Significance Index: 291.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5336
    Cell Significance Index: 11.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5304
    Cell Significance Index: 24.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5291
    Cell Significance Index: 52.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4669
    Cell Significance Index: 59.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4639
    Cell Significance Index: 57.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4630
    Cell Significance Index: 16.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4552
    Cell Significance Index: 23.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4541
    Cell Significance Index: 23.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4289
    Cell Significance Index: 77.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4256
    Cell Significance Index: 84.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4179
    Cell Significance Index: 11.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3674
    Cell Significance Index: 10.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3476
    Cell Significance Index: 2.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3442
    Cell Significance Index: 55.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3403
    Cell Significance Index: 21.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3185
    Cell Significance Index: 41.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2841
    Cell Significance Index: 21.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2712
    Cell Significance Index: 19.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2452
    Cell Significance Index: 221.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1925
    Cell Significance Index: 69.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1850
    Cell Significance Index: 21.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1824
    Cell Significance Index: 31.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1374
    Cell Significance Index: 3.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1143
    Cell Significance Index: 21.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1021
    Cell Significance Index: 70.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1020
    Cell Significance Index: 6.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0748
    Cell Significance Index: 0.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0344
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0095
    Cell Significance Index: -17.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0220
    Cell Significance Index: -16.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0236
    Cell Significance Index: -43.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0317
    Cell Significance Index: -48.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0383
    Cell Significance Index: -3.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0408
    Cell Significance Index: -55.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0413
    Cell Significance Index: -1.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0441
    Cell Significance Index: -27.9900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0553
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0562
    Cell Significance Index: -31.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0645
    Cell Significance Index: -3.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0768
    Cell Significance Index: -34.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0985
    Cell Significance Index: -20.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1191
    Cell Significance Index: -13.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1278
    Cell Significance Index: -36.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1355
    Cell Significance Index: -15.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1650
    Cell Significance Index: -3.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1728
    Cell Significance Index: -10.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1803
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1891
    Cell Significance Index: -21.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2430
    Cell Significance Index: -35.3300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2849
    Cell Significance Index: -2.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2909
    Cell Significance Index: -7.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2951
    Cell Significance Index: -19.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3013
    Cell Significance Index: -9.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3441
    Cell Significance Index: -7.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3479
    Cell Significance Index: -26.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3949
    Cell Significance Index: -22.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3954
    Cell Significance Index: -10.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3993
    Cell Significance Index: -4.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4311
    Cell Significance Index: -34.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4462
    Cell Significance Index: -46.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4490
    Cell Significance Index: -7.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4866
    Cell Significance Index: -5.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4879
    Cell Significance Index: -13.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4912
    Cell Significance Index: -6.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4939
    Cell Significance Index: -30.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5748
    Cell Significance Index: -9.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6398
    Cell Significance Index: -13.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6488
    Cell Significance Index: -29.4100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7208
    Cell Significance Index: -10.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7665
    Cell Significance Index: -19.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7716
    Cell Significance Index: -34.1300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8440
    Cell Significance Index: -11.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9293
    Cell Significance Index: -35.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9911
    Cell Significance Index: -10.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GOLGA7 is a Golgi-associated protein that belongs to the Golgins family, which is essential for maintaining the structure and function of the Golgi apparatus. It exhibits characteristics of both the Golgi-associated subfamily A (GAS) and the Golgins family, making it a unique protein with distinct functions. GOLGA7 is a palmitoylated protein, which allows it to interact with other proteins and participate in various cellular processes. **Pathways and Functions:** GOLGA7 is involved in multiple cellular pathways, including: 1. **Protein targeting to membrane:** GOLGA7 facilitates the targeting of proteins to the Golgi membrane, which is essential for protein maturation, modification, and secretion. 2. **Signal transduction:** GOLGA7 interacts with various signaling molecules, including MAPKs and Raf, to regulate signal transduction pathways. 3. **Immune regulation:** GOLGA7 is expressed in immune cells, such as neutrophils and peripheral blood mononuclear cells, and plays a role in regulating immune responses, including neutrophil degranulation and immune cell activation. 4. **Viral infection pathways:** GOLGA7 has been implicated in the regulation of viral infections, including SARS-CoV-2, by interacting with viral proteins and regulating viral replication. 5. **Golgi to plasma membrane transport:** GOLGA7 participates in the transport of proteins from the Golgi apparatus to the plasma membrane, which is essential for maintaining cellular homeostasis. **Clinical Significance:** GOLGA7's involvement in immune regulation and disease mechanisms has significant clinical implications. Alterations in GOLGA7 expression or function may contribute to various diseases, including: 1. **Autoimmune disorders:** Dysregulation of GOLGA7 expression may contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** GOLGA7's role in regulating protein targeting and signal transduction may be exploited by cancer cells to promote tumor growth and metastasis. 3. **Viral infections:** GOLGA7's interaction with viral proteins may influence the outcome of viral infections, such as SARS-CoV-2, and contribute to disease severity. In conclusion, GOLGA7 is a multifaceted protein that plays a critical role in regulating various cellular processes, including immune responses and disease mechanisms. Further research is needed to fully elucidate the functions of GOLGA7 and its implications in human disease.

Genular Protein ID: 3949628918

Symbol: GOGA7_HUMAN

Name: Golgin subfamily A member 7

UniProtKB Accession Codes:

Q7Z5G4 D3DSX9 J3KQ24 Q96EQ4 Q9P1S0 Q9Y5U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 15 GO 11 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14522980

Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.

PubMed ID: 14522980

DOI: 10.1074/jbc.m310014200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16000296

Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

PubMed ID: 16000296

DOI: 10.1074/jbc.m504113200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 137
  • Mass: 15824
  • Checksum: 00280547DE3702A3
  • Sequence:
    • MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL NNLYAEAEKL 
GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ NEKIYAPQGL LLTDPIERGL 
RVIEITIYED RGMSSGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.