Details for: MRTO4

Gene ID: 51154

Symbol: MRTO4

Ensembl ID: ENSG00000053372

Description: MRT4 homolog, ribosome maturation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.3234
    Cell Significance Index: -21.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.6537
    Cell Significance Index: -19.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.6590
    Cell Significance Index: -26.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.9838
    Cell Significance Index: -26.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.4874
    Cell Significance Index: -25.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5633
    Cell Significance Index: -22.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6522
    Cell Significance Index: -26.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5288
    Cell Significance Index: -13.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5701
    Cell Significance Index: 40.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3500
    Cell Significance Index: 157.3300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2961
    Cell Significance Index: 14.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.0490
    Cell Significance Index: 74.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8916
    Cell Significance Index: 23.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8769
    Cell Significance Index: 142.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8047
    Cell Significance Index: 439.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7722
    Cell Significance Index: 49.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7377
    Cell Significance Index: 101.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7353
    Cell Significance Index: 50.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7034
    Cell Significance Index: 311.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6058
    Cell Significance Index: 31.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5979
    Cell Significance Index: 107.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5919
    Cell Significance Index: 16.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5471
    Cell Significance Index: 70.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5312
    Cell Significance Index: 65.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4935
    Cell Significance Index: 17.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4573
    Cell Significance Index: 13.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4415
    Cell Significance Index: 20.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4331
    Cell Significance Index: 82.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4181
    Cell Significance Index: 82.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3913
    Cell Significance Index: 8.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3648
    Cell Significance Index: 104.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3588
    Cell Significance Index: 42.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3547
    Cell Significance Index: 4.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3404
    Cell Significance Index: 9.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3356
    Cell Significance Index: 25.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3180
    Cell Significance Index: 6.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3013
    Cell Significance Index: 60.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2735
    Cell Significance Index: 12.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2727
    Cell Significance Index: 7.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2578
    Cell Significance Index: 6.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2489
    Cell Significance Index: 11.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2394
    Cell Significance Index: 165.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2259
    Cell Significance Index: 2.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2136
    Cell Significance Index: 27.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2133
    Cell Significance Index: 3.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1504
    Cell Significance Index: 135.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1471
    Cell Significance Index: 2.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1459
    Cell Significance Index: 3.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1428
    Cell Significance Index: 9.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1235
    Cell Significance Index: 44.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1195
    Cell Significance Index: 3.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0734
    Cell Significance Index: 1.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0690
    Cell Significance Index: 1.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0451
    Cell Significance Index: 4.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0347
    Cell Significance Index: 5.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0306
    Cell Significance Index: 0.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0220
    Cell Significance Index: 0.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0065
    Cell Significance Index: 4.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0111
    Cell Significance Index: -20.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0145
    Cell Significance Index: -22.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0311
    Cell Significance Index: -19.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0338
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0339
    Cell Significance Index: -25.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0366
    Cell Significance Index: -3.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0455
    Cell Significance Index: -25.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0492
    Cell Significance Index: -22.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0500
    Cell Significance Index: -31.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0661
    Cell Significance Index: -7.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0911
    Cell Significance Index: -5.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0968
    Cell Significance Index: -5.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1074
    Cell Significance Index: -3.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1269
    Cell Significance Index: -7.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1278
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1523
    Cell Significance Index: -32.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1760
    Cell Significance Index: -10.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2001
    Cell Significance Index: -13.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2038
    Cell Significance Index: -2.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2050
    Cell Significance Index: -15.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2499
    Cell Significance Index: -26.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2686
    Cell Significance Index: -21.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2764
    Cell Significance Index: -1.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3531
    Cell Significance Index: -15.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3753
    Cell Significance Index: -3.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4313
    Cell Significance Index: -22.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4417
    Cell Significance Index: -16.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4577
    Cell Significance Index: -11.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5025
    Cell Significance Index: -14.8000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5069
    Cell Significance Index: -6.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5082
    Cell Significance Index: -8.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5649
    Cell Significance Index: -12.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5756
    Cell Significance Index: -21.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5973
    Cell Significance Index: -7.6500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5996
    Cell Significance Index: -6.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6080
    Cell Significance Index: -21.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6247
    Cell Significance Index: -9.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6361
    Cell Significance Index: -20.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRTO4 is a gene that encodes a protein involved in ribosome biogenesis, a process critical for protein synthesis. The gene is highly expressed in cells of hematopoietic origin, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and pro-T cells. MRTO4 is also expressed in smooth muscle cells, ileal goblet cells, and epithelial cells of the stomach, suggesting its widespread importance in cellular homeostasis. The protein encoded by MRTO4 is a homolog of the MRT4 protein, which is known to play a role in ribosome maturation and assembly. **Pathways and Functions:** MRTO4 is involved in several key pathways, including: 1. **Ribosomal large subunit biogenesis:** MRTO4 is essential for the assembly of the 60S ribosomal subunit, which is a critical component of the ribosome. 2. **Ribosome maturation:** MRTO4 is involved in the maturation of ribosomes, ensuring that they are properly assembled and functional. 3. **Nuclear-transcribed mRNA catabolic process:** MRTO4 is also involved in the degradation of nuclear-transcribed mRNA, a process that helps regulate protein synthesis. 4. **Protein binding:** MRTO4 is capable of binding to various proteins, including ribosomal proteins and other cellular proteins. **Clinical Significance:** Dysregulation of MRTO4 has been implicated in various diseases, including: 1. **Anemia:** Mutations in the MRTO4 gene have been associated with anemia, a condition characterized by a deficiency in red blood cells or hemoglobin. 2. **Immunodeficiency:** Alterations in MRTO4 expression have been linked to immunodeficiency disorders, including severe combined immunodeficiency (SCID). 3. **Cancer:** MRTO4 has been implicated in the development and progression of various cancers, including leukemia and lymphoma. In conclusion, MRTO4 is a critical gene involved in ribosome biogenesis and cellular homeostasis. Its dysregulation has significant implications for human health, and further research is needed to fully understand its role in disease. As an immunologist, it is essential to consider the importance of MRTO4 in the context of immune cell development and function, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 837304834

Symbol: MRT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UKD2 B3KNB3 Q5TG55 Q96SS6 Q9BPV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 33 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 33 PDBsum 33 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 20083226

Title: Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain.

PubMed ID: 20083226

DOI: 10.1016/j.biocel.2010.01.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35393574

Title: Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor.

PubMed ID: 35393574

DOI: 10.1038/s41589-022-01003-9

Sequence Information:

  • Length: 239
  • Mass: 27560
  • Checksum: F1BFF6E566FF942F
  • Sequence:
    • MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN SKLKDIRNAW 
KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKRLRGEV GLLFTNRTKE EVNEWFTKYT 
EMDYARAGNK AAFTVSLDPG PLEQFPHSME PQLRQLGLPT ALKRGVVTLL SDYEVCKEGD 
VLTPEQARVL KLFGYEMAEF KVTIKYMWDS QSGRFQQMGD DLPESASEST EESDSEDDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.