Details for: DCTN4

Gene ID: 51164

Symbol: DCTN4

Ensembl ID: ENSG00000132912

Description: dynactin subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 258.3172
    Cell Significance Index: -40.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.1461
    Cell Significance Index: -40.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.2006
    Cell Significance Index: -43.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.1461
    Cell Significance Index: -35.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.0555
    Cell Significance Index: -40.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.9457
    Cell Significance Index: -43.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.6332
    Cell Significance Index: -35.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.9672
    Cell Significance Index: -41.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7301
    Cell Significance Index: -39.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.1185
    Cell Significance Index: -34.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8057
    Cell Significance Index: -42.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3165
    Cell Significance Index: -20.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2641
    Cell Significance Index: 368.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8604
    Cell Significance Index: 216.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3318
    Cell Significance Index: 267.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1224
    Cell Significance Index: 222.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0580
    Cell Significance Index: 14.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9035
    Cell Significance Index: 162.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8263
    Cell Significance Index: 46.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7947
    Cell Significance Index: 21.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6779
    Cell Significance Index: 243.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6706
    Cell Significance Index: 51.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6529
    Cell Significance Index: 17.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6100
    Cell Significance Index: 421.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5992
    Cell Significance Index: 73.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5975
    Cell Significance Index: 36.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5843
    Cell Significance Index: 16.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5071
    Cell Significance Index: 14.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4707
    Cell Significance Index: 12.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4391
    Cell Significance Index: 19.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3450
    Cell Significance Index: 47.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3440
    Cell Significance Index: 65.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3251
    Cell Significance Index: 22.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2747
    Cell Significance Index: 150.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2644
    Cell Significance Index: 13.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2637
    Cell Significance Index: 116.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2427
    Cell Significance Index: 12.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2412
    Cell Significance Index: 15.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2363
    Cell Significance Index: 213.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2306
    Cell Significance Index: 10.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1980
    Cell Significance Index: 372.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1719
    Cell Significance Index: 6.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1147
    Cell Significance Index: 72.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1137
    Cell Significance Index: 2.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0989
    Cell Significance Index: 11.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0829
    Cell Significance Index: 127.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0688
    Cell Significance Index: 11.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0621
    Cell Significance Index: 114.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0612
    Cell Significance Index: 0.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0604
    Cell Significance Index: 5.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0498
    Cell Significance Index: 22.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0402
    Cell Significance Index: 2.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0255
    Cell Significance Index: 34.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0027
    Cell Significance Index: 0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0085
    Cell Significance Index: -0.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0113
    Cell Significance Index: -0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0158
    Cell Significance Index: -2.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0228
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0289
    Cell Significance Index: -21.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0346
    Cell Significance Index: -25.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0370
    Cell Significance Index: -27.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0450
    Cell Significance Index: -1.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0601
    Cell Significance Index: -6.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0604
    Cell Significance Index: -4.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0622
    Cell Significance Index: -35.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0772
    Cell Significance Index: -48.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0809
    Cell Significance Index: -3.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1236
    Cell Significance Index: -35.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1310
    Cell Significance Index: -2.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1341
    Cell Significance Index: -19.4900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1406
    Cell Significance Index: -1.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1479
    Cell Significance Index: -19.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1672
    Cell Significance Index: -3.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2042
    Cell Significance Index: -15.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2141
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2172
    Cell Significance Index: -45.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3060
    Cell Significance Index: -31.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3100
    Cell Significance Index: -35.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3593
    Cell Significance Index: -10.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3841
    Cell Significance Index: -7.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4375
    Cell Significance Index: -22.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4377
    Cell Significance Index: -14.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4381
    Cell Significance Index: -34.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4506
    Cell Significance Index: -12.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4985
    Cell Significance Index: -10.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5494
    Cell Significance Index: -7.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5554
    Cell Significance Index: -8.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5560
    Cell Significance Index: -19.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6151
    Cell Significance Index: -10.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6287
    Cell Significance Index: -15.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6312
    Cell Significance Index: -17.1800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6877
    Cell Significance Index: -8.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6919
    Cell Significance Index: -42.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7668
    Cell Significance Index: -22.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7824
    Cell Significance Index: -24.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7914
    Cell Significance Index: -25.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8332
    Cell Significance Index: -17.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8524
    Cell Significance Index: -5.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9082
    Cell Significance Index: -24.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DCTN4 is a cytoplasmic protein that belongs to the dynactin family, which is composed of six subunits. The dynactin complex is responsible for the formation of microtubule-associated motor proteins, enabling the movement of vesicles, organelles, and chromosomes along microtubules. DCTN4 is the largest subunit of the dynactin complex and interacts with dynein, a minus-end-directed motor protein, to facilitate the movement of cargo along microtubules. **Pathways and Functions:** DCTN4 is involved in various cellular processes, including: 1. **Cell Motility:** DCTN4 plays a crucial role in regulating cell motility by interacting with dynein to facilitate the movement of vesicles and organelles along microtubules. 2. **Protein Trafficking:** DCTN4 is involved in the regulation of protein trafficking, including the transport of proteins to the Golgi apparatus and subsequent modification. 3. **Cell Division:** DCTN4 is required for proper chromosome segregation during cell division, ensuring accurate chromosome alignment and separation. 4. **Adaptive Immune Response:** DCTN4 has been implicated in the regulation of immune cell migration and function, including the trafficking of T cells and dendritic cells. **Clinical Significance:** DCTN4 has been associated with various immunological disorders, including: 1. **Autoimmune Diseases:** Abnormalities in DCTN4 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** DCTN4 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** DCTN4 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, DCTN4 is a critical component of the dynactin complex, playing a key role in regulating cellular motility, protein trafficking, and cell division. Its dysregulation has been implicated in various immunological disorders, highlighting the need for further research into the molecular mechanisms underlying DCTN4 function and its potential therapeutic applications. **Significantly Expressed Cells:** Polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, smooth muscle fiber of ileum, mucosal type mast cell, peripheral blood mononuclear cell, ileal goblet cell, ciliated cell of the bronchus, orthochromatic erythroblast, CD8-alpha-beta-positive, alpha-beta intraepithelial T cell, CD8-positive, alpha-beta regulatory T cell. **Proteins:** DCTN4_HUMAN (Dynactin subunit 4), Q9NSJ5_HUMAN

Genular Protein ID: 1146311829

Symbol: DCTN4_HUMAN

Name: Dynactin subunit 4

UniProtKB Accession Codes:

Q9UJW0 B3KWW0 D3DQH0 E5RGT5 Q8TAN8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10671518

Title: A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1.

PubMed ID: 10671518

DOI: 10.1074/jbc.275.7.4834

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16554302

Title: Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A.

PubMed ID: 16554302

DOI: 10.1074/jbc.m512745200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 460
  • Mass: 52337
  • Checksum: 2105D6C0A713B11D
  • Sequence:
    • MASLLQSDRV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY CPSCLENMPS 
AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK TTMKKAYYLA CGFCRWTSRD 
VGMADKSVAS GGWQEPENPH TQRMNKLIEY YQQLAQKEKV ERDRKKLARR RNYMPLAFSD 
KYGLGTRLQR PRAGASISTL AGLSLKEGED QKEIKIEPAQ AVDEVEPLPE DYYTRPVNLT 
EVTTLQQRLL QPDFQPVCAS QLYPRHKHLL IKRSLRCRKC EHNLSKPEFN PTSIKFKIQL 
VAVNYIPEVR IMSIPNLRYM KESQVLLTLT NPVENLTHVT LFECEEGDPD DINSTAKVVV 
PPKELVLAGK DAAAEYDELA EPQDFQDDPD IIAFRKANKV GIFIKVTPQR EEGEVTVCFK 
MKHDFKNLAA PIRPIEESDQ GTEVIWLTQH VELSLGPLLP

Genular Protein ID: 4202316597

Symbol: Q9NSJ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NSJ5

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PeptideAtlas 1 PharmGKB 1 RefSeq 3 SMR 1

Sequence Information:

  • Length: 144
  • Mass: 16142
  • Checksum: F8A0563E2F62A5D9
  • Sequence:
    • LRYMKESQVL LTLTNPVENL THVTLFECEE GDPDDINSTA KVVVPPKELV LAGKDAAAEY 
DELAEPQDFQ DDPDIIAFRK ANKVGIFIKV TPQREEGEVT VCFKMKHDFK NLAAPIRPIE 
ESDQGTEVIW LTQHVELSLG PLLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.