Details for: PLEKHO1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 212.8320
Cell Significance Index: -33.1100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 115.6348
Cell Significance Index: -29.3300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 76.2325
Cell Significance Index: -30.9700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 75.8278
Cell Significance Index: -35.8000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 67.0412
Cell Significance Index: -34.4900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 33.0351
Cell Significance Index: -31.5400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.8420
Cell Significance Index: -33.1000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.1055
Cell Significance Index: -29.7500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.4160
Cell Significance Index: -33.2100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.2702
Cell Significance Index: -18.1000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.9083
Cell Significance Index: -24.2900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.1767
Cell Significance Index: 217.5600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.7133
Cell Significance Index: 77.7800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.2107
Cell Significance Index: 142.6300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.5068
Cell Significance Index: 40.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.4700
Cell Significance Index: 27.1700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.0408
Cell Significance Index: 21.7900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0317
Cell Significance Index: 35.8500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0037
Cell Significance Index: 137.8400 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.7469
Cell Significance Index: 3.9300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6145
Cell Significance Index: 123.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5474
Cell Significance Index: 104.1700 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4737
Cell Significance Index: 5.1500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4526
Cell Significance Index: 162.3500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4442
Cell Significance Index: 27.3100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4346
Cell Significance Index: 24.3900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2722
Cell Significance Index: 120.3600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2550
Cell Significance Index: 230.2700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2094
Cell Significance Index: 20.7200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1791
Cell Significance Index: 22.9600 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1771
Cell Significance Index: 3.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1631
Cell Significance Index: 4.7000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1462
Cell Significance Index: 79.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1455
Cell Significance Index: 66.0400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1336
Cell Significance Index: 10.2600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1177
Cell Significance Index: 81.4200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1081
Cell Significance Index: 12.7500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1059
Cell Significance Index: 21.0200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1057
Cell Significance Index: 17.1900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0723
Cell Significance Index: 2.5400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0569
Cell Significance Index: 2.9900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0030
Cell Significance Index: -5.6200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0081
Cell Significance Index: -6.0100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0128
Cell Significance Index: -0.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0177
Cell Significance Index: -1.9300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0213
Cell Significance Index: -39.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0219
Cell Significance Index: -13.6800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0251
Cell Significance Index: -38.5700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0291
Cell Significance Index: -39.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0343
Cell Significance Index: -4.4400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0432
Cell Significance Index: -32.6700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0440
Cell Significance Index: -27.9200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0453
Cell Significance Index: -33.1800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0476
Cell Significance Index: -26.8200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0771
Cell Significance Index: -9.4800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0806
Cell Significance Index: -13.7600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0823
Cell Significance Index: -1.4100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0942
Cell Significance Index: -2.2600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1008
Cell Significance Index: -21.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1190
Cell Significance Index: -34.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1194
Cell Significance Index: -21.5300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1195
Cell Significance Index: -2.5900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1198
Cell Significance Index: -8.9300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1228
Cell Significance Index: -3.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1426
Cell Significance Index: -6.7000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1563
Cell Significance Index: -4.2600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1698
Cell Significance Index: -17.3500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1746
Cell Significance Index: -20.3500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1817
Cell Significance Index: -26.4100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2011
Cell Significance Index: -14.2200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2098
Cell Significance Index: -24.0400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2177
Cell Significance Index: -14.6400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2254
Cell Significance Index: -23.4700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2287
Cell Significance Index: -13.7300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2391
Cell Significance Index: -16.5400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2627
Cell Significance Index: -6.7100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2744
Cell Significance Index: -6.8600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2777
Cell Significance Index: -31.7000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2861
Cell Significance Index: -12.9700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3000
Cell Significance Index: -9.6100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3126
Cell Significance Index: -13.8300 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.3162
Cell Significance Index: -1.4600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3611
Cell Significance Index: -22.1400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3767
Cell Significance Index: -4.2800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3929
Cell Significance Index: -3.3000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4589
Cell Significance Index: -23.8400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4654
Cell Significance Index: -10.1900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4835
Cell Significance Index: -18.3100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5060
Cell Significance Index: -14.4400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5165
Cell Significance Index: -15.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5206
Cell Significance Index: -32.8100 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.5347
Cell Significance Index: -3.8400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5658
Cell Significance Index: -26.3800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5899
Cell Significance Index: -12.5200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5948
Cell Significance Index: -12.8500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7060
Cell Significance Index: -19.7300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7536
Cell Significance Index: -24.0000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7602
Cell Significance Index: -26.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7728
Cell Significance Index: -25.3000 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.7779
Cell Significance Index: -4.7000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4287484491
Symbol: PKHO1_HUMAN
Name: Pleckstrin homology domain-containing family O member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10799509
Title: Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.
PubMed ID: 10799509
PubMed ID: 15706351
Title: Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.
PubMed ID: 15706351
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11483580
Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.
PubMed ID: 11483580
DOI: 10.1101/gr.175501
PubMed ID: 11827170
Title: Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners.
PubMed ID: 11827170
PubMed ID: 15254037
Title: The pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane.
PubMed ID: 15254037
PubMed ID: 14729969
Title: Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.
PubMed ID: 14729969
PubMed ID: 15831458
Title: The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein.
PubMed ID: 15831458
PubMed ID: 16325375
Title: CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.
PubMed ID: 16325375
PubMed ID: 16987810
Title: The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.
PubMed ID: 16987810
PubMed ID: 17942896
Title: Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.
PubMed ID: 17942896
PubMed ID: 17197158
Title: The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.
PubMed ID: 17197158
Sequence Information:
- Length: 409
- Mass: 46237
- Checksum: 5077D6B559EB9F78
- Sequence:
MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG DQLYISEKEV KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS KQPGNTAPNL IFLAVSPEEK ESWINALNSA ITRAKNRILD EVTVEEDSYL AHPTRDRAKI QHSRRPPTRG HLMAVASTST SDGMLTLDLI QEEDPSPEEP TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL SRPWEKTDKG ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ LLLETERLLG EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP HSQYRKSLM
Genular Protein ID: 2471910111
Symbol: Q5T4P9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 226
- Mass: 25363
- Checksum: F80825F62AFAC08D
- Sequence:
MLTLDLIQEE DPSPEEPTSC AESFRVDLDK SVAQLAGSRR RADSDRIQPS ADRASSLSRP WEKTDKGATY TPQAPKKLTP TEKGRCASLE EILSQRDAAS ARTLQLRAEE PPTPALPNPG QLSRIQDLVA RKLEETQELL AEVQGLGDGK RKAKDPPRSP PDSESEQLLL ETERLLGEAS SNWSQAKRVL QEVRELRDLY RQMDLQTPDS HLRQTTPHSQ YRKSLM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.