Details for: PLEKHO1

Gene ID: 51177

Symbol: PLEKHO1

Ensembl ID: ENSG00000023902

Description: pleckstrin homology domain containing O1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 212.8320
    Cell Significance Index: -33.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.6348
    Cell Significance Index: -29.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.2325
    Cell Significance Index: -30.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.8278
    Cell Significance Index: -35.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0412
    Cell Significance Index: -34.4900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0351
    Cell Significance Index: -31.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8420
    Cell Significance Index: -33.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1055
    Cell Significance Index: -29.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4160
    Cell Significance Index: -33.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2702
    Cell Significance Index: -18.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9083
    Cell Significance Index: -24.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.1767
    Cell Significance Index: 217.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7133
    Cell Significance Index: 77.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2107
    Cell Significance Index: 142.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.5068
    Cell Significance Index: 40.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4700
    Cell Significance Index: 27.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0408
    Cell Significance Index: 21.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0317
    Cell Significance Index: 35.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0037
    Cell Significance Index: 137.8400
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7469
    Cell Significance Index: 3.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6145
    Cell Significance Index: 123.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5474
    Cell Significance Index: 104.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4737
    Cell Significance Index: 5.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4526
    Cell Significance Index: 162.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4442
    Cell Significance Index: 27.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4346
    Cell Significance Index: 24.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2722
    Cell Significance Index: 120.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2550
    Cell Significance Index: 230.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2094
    Cell Significance Index: 20.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1791
    Cell Significance Index: 22.9600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1771
    Cell Significance Index: 3.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1631
    Cell Significance Index: 4.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1462
    Cell Significance Index: 79.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1455
    Cell Significance Index: 66.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1336
    Cell Significance Index: 10.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1177
    Cell Significance Index: 81.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1081
    Cell Significance Index: 12.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1059
    Cell Significance Index: 21.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1057
    Cell Significance Index: 17.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0723
    Cell Significance Index: 2.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0569
    Cell Significance Index: 2.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0177
    Cell Significance Index: -1.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0213
    Cell Significance Index: -39.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0251
    Cell Significance Index: -38.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0291
    Cell Significance Index: -39.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0343
    Cell Significance Index: -4.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0432
    Cell Significance Index: -32.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0440
    Cell Significance Index: -27.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0453
    Cell Significance Index: -33.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0476
    Cell Significance Index: -26.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0771
    Cell Significance Index: -9.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0806
    Cell Significance Index: -13.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0823
    Cell Significance Index: -1.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0942
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1008
    Cell Significance Index: -21.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1190
    Cell Significance Index: -34.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1194
    Cell Significance Index: -21.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1195
    Cell Significance Index: -2.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1198
    Cell Significance Index: -8.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1228
    Cell Significance Index: -3.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1426
    Cell Significance Index: -6.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1563
    Cell Significance Index: -4.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1698
    Cell Significance Index: -17.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1746
    Cell Significance Index: -20.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1817
    Cell Significance Index: -26.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2011
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2098
    Cell Significance Index: -24.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2177
    Cell Significance Index: -14.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2254
    Cell Significance Index: -23.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2287
    Cell Significance Index: -13.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2391
    Cell Significance Index: -16.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2627
    Cell Significance Index: -6.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2744
    Cell Significance Index: -6.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2777
    Cell Significance Index: -31.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2861
    Cell Significance Index: -12.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3000
    Cell Significance Index: -9.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3126
    Cell Significance Index: -13.8300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3162
    Cell Significance Index: -1.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3611
    Cell Significance Index: -22.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3767
    Cell Significance Index: -4.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3929
    Cell Significance Index: -3.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4589
    Cell Significance Index: -23.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4654
    Cell Significance Index: -10.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4835
    Cell Significance Index: -18.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5060
    Cell Significance Index: -14.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5165
    Cell Significance Index: -15.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5206
    Cell Significance Index: -32.8100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.5347
    Cell Significance Index: -3.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5658
    Cell Significance Index: -26.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5899
    Cell Significance Index: -12.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5948
    Cell Significance Index: -12.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7060
    Cell Significance Index: -19.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7536
    Cell Significance Index: -24.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7602
    Cell Significance Index: -26.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7728
    Cell Significance Index: -25.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7779
    Cell Significance Index: -4.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLEKHO1 is a member of the pleckstrin homology domain-containing protein family, characterized by its unique pleckstrin homology domain (PHD) motif. This domain is crucial for binding to phospholipids and proteins, influencing various cellular processes. PLEKHO1 is predominantly expressed in hematopoietic cells, smooth muscle cells, and immune cells, highlighting its importance in tissue development and immune function. **Pathways and Functions:** PLEKHO1 is involved in several key cellular pathways, including: 1. **Lamellipodium morphogenesis:** PLEKHO1 plays a critical role in regulating the formation and dynamics of lamellipodia, the protrusive structures essential for cell migration and adhesion. 2. **Myoblast fusion:** PLEKHO1 is essential for the fusion of myoblasts, the precursor cells that differentiate into muscle fibers. 3. **Regulation of cell shape:** PLEKHO1's PHD motif enables it to interact with phospholipids, influencing cell morphology and cytoskeletal organization. 4. **Protein binding:** PLEKHO1 interacts with various proteins, modulating signaling pathways and influencing cellular behavior. **Clinical Significance:** PLEKHO1's involvement in immune cell function and tissue development highlights its potential as a therapeutic target in various diseases. Alterations in PLEKHO1 expression have been linked to: 1. **Autoimmune disorders:** Dysregulation of PLEKHO1 in immune cells may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Muscular dystrophy:** PLEKHO1's role in myoblast fusion and muscle development makes it a potential target for the treatment of muscular dystrophy. 3. **Cancer:** PLEKHO1's involvement in cell migration and invasion suggests its potential as a prognostic marker and therapeutic target in various cancers. In conclusion, PLEKHO1 is a multifaceted gene that plays a crucial role in regulating cellular processes, from cell morphology and migration to immune function and tissue development. Further research into PLEKHO1's mechanisms of action and its clinical significance will provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 4287484491

Symbol: PKHO1_HUMAN

Name: Pleckstrin homology domain-containing family O member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10799509

Title: Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2.

PubMed ID: 10799509

DOI: 10.1074/jbc.275.19.14295

PubMed ID: 15706351

Title: Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis.

PubMed ID: 15706351

DOI: 10.1038/sj.emboj.7600532

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11483580

Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PubMed ID: 11483580

DOI: 10.1101/gr.175501

PubMed ID: 11827170

Title: Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners.

PubMed ID: 11827170

DOI: 10.1023/a:1013188101465

PubMed ID: 15254037

Title: The pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane.

PubMed ID: 15254037

DOI: 10.1074/jbc.m407628200

PubMed ID: 14729969

Title: Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.

PubMed ID: 14729969

DOI: 10.1128/mcb.24.3.1245-1255.2004

PubMed ID: 15831458

Title: The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein.

PubMed ID: 15831458

DOI: 10.1128/mcb.25.9.3519-3534.2005

PubMed ID: 16325375

Title: CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.

PubMed ID: 16325375

DOI: 10.1016/j.cellsig.2005.10.017

PubMed ID: 16987810

Title: The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.

PubMed ID: 16987810

DOI: 10.1074/jbc.m607595200

PubMed ID: 17942896

Title: Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo.

PubMed ID: 17942896

DOI: 10.1158/0008-5472.can-07-1050

PubMed ID: 17197158

Title: The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.

PubMed ID: 17197158

DOI: 10.1016/j.cellsig.2006.11.002

Sequence Information:

  • Length: 409
  • Mass: 46237
  • Checksum: 5077D6B559EB9F78
  • Sequence:
  • MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG DQLYISEKEV 
    KDEKNIQEVF DLSDYEKCEE LRKSKSRSKK NHSKFTLAHS KQPGNTAPNL IFLAVSPEEK 
    ESWINALNSA ITRAKNRILD EVTVEEDSYL AHPTRDRAKI QHSRRPPTRG HLMAVASTST 
    SDGMLTLDLI QEEDPSPEEP TSCAESFRVD LDKSVAQLAG SRRRADSDRI QPSADRASSL 
    SRPWEKTDKG ATYTPQAPKK LTPTEKGRCA SLEEILSQRD AASARTLQLR AEEPPTPALP 
    NPGQLSRIQD LVARKLEETQ ELLAEVQGLG DGKRKAKDPP RSPPDSESEQ LLLETERLLG 
    EASSNWSQAK RVLQEVRELR DLYRQMDLQT PDSHLRQTTP HSQYRKSLM

Genular Protein ID: 2471910111

Symbol: Q5T4P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 226
  • Mass: 25363
  • Checksum: F80825F62AFAC08D
  • Sequence:
  • MLTLDLIQEE DPSPEEPTSC AESFRVDLDK SVAQLAGSRR RADSDRIQPS ADRASSLSRP 
    WEKTDKGATY TPQAPKKLTP TEKGRCASLE EILSQRDAAS ARTLQLRAEE PPTPALPNPG 
    QLSRIQDLVA RKLEETQELL AEVQGLGDGK RKAKDPPRSP PDSESEQLLL ETERLLGEAS 
    SNWSQAKRVL QEVRELRDLY RQMDLQTPDS HLRQTTPHSQ YRKSLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.