Details for: RSL24D1

Gene ID: 51187

Symbol: RSL24D1

Ensembl ID: ENSG00000137876

Description: ribosomal L24 domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 434.9217
    Cell Significance Index: -67.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 206.4583
    Cell Significance Index: -85.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.5825
    Cell Significance Index: -48.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 175.1108
    Cell Significance Index: -71.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 172.4128
    Cell Significance Index: -81.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 157.4890
    Cell Significance Index: -81.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 121.4267
    Cell Significance Index: -81.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 75.6225
    Cell Significance Index: -72.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.9926
    Cell Significance Index: -78.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.6444
    Cell Significance Index: -63.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.4594
    Cell Significance Index: -84.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.3729
    Cell Significance Index: -53.3600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.0876
    Cell Significance Index: 53.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.5263
    Cell Significance Index: 129.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.1511
    Cell Significance Index: 86.8900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.9572
    Cell Significance Index: 43.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.8912
    Cell Significance Index: 182.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7837
    Cell Significance Index: 30.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.4162
    Cell Significance Index: 89.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.9667
    Cell Significance Index: 103.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.9591
    Cell Significance Index: 382.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9333
    Cell Significance Index: 402.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.8826
    Cell Significance Index: 17.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.6103
    Cell Significance Index: 184.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4630
    Cell Significance Index: 67.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4598
    Cell Significance Index: 158.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4542
    Cell Significance Index: 1340.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4367
    Cell Significance Index: 43.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2165
    Cell Significance Index: 272.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1729
    Cell Significance Index: 960.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0768
    Cell Significance Index: 154.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7385
    Cell Significance Index: 19.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7048
    Cell Significance Index: 307.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6725
    Cell Significance Index: 77.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6100
    Cell Significance Index: 84.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5541
    Cell Significance Index: 183.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5072
    Cell Significance Index: 193.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2451
    Cell Significance Index: 15.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2265
    Cell Significance Index: 36.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1118
    Cell Significance Index: 76.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8557
    Cell Significance Index: 7.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7797
    Cell Significance Index: 133.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7464
    Cell Significance Index: 214.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5546
    Cell Significance Index: 54.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5493
    Cell Significance Index: 104.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5262
    Cell Significance Index: 11.4000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4332
    Cell Significance Index: 2.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3788
    Cell Significance Index: 19.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3740
    Cell Significance Index: 75.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3483
    Cell Significance Index: 9.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3340
    Cell Significance Index: 17.4000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2854
    Cell Significance Index: 2.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2574
    Cell Significance Index: 51.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0828
    Cell Significance Index: 62.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0699
    Cell Significance Index: 1.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0292
    Cell Significance Index: 1.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0163
    Cell Significance Index: 5.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0149
    Cell Significance Index: 0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0157
    Cell Significance Index: -29.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0236
    Cell Significance Index: -14.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0441
    Cell Significance Index: -4.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0522
    Cell Significance Index: -96.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0584
    Cell Significance Index: -32.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0605
    Cell Significance Index: -93.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0723
    Cell Significance Index: -98.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0965
    Cell Significance Index: -61.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1582
    Cell Significance Index: -71.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1666
    Cell Significance Index: -35.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2689
    Cell Significance Index: -6.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2797
    Cell Significance Index: -5.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2988
    Cell Significance Index: -10.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3217
    Cell Significance Index: -14.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3539
    Cell Significance Index: -40.5400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4258
    Cell Significance Index: -48.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4405
    Cell Significance Index: -51.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4849
    Cell Significance Index: -70.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5811
    Cell Significance Index: -16.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6521
    Cell Significance Index: -3.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6793
    Cell Significance Index: -53.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7299
    Cell Significance Index: -18.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7570
    Cell Significance Index: -13.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7592
    Cell Significance Index: -21.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7955
    Cell Significance Index: -82.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8119
    Cell Significance Index: -45.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8274
    Cell Significance Index: -26.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9292
    Cell Significance Index: -62.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9305
    Cell Significance Index: -57.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9984
    Cell Significance Index: -14.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0019
    Cell Significance Index: -76.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0795
    Cell Significance Index: -18.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0804
    Cell Significance Index: -14.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0912
    Cell Significance Index: -65.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2053
    Cell Significance Index: -32.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2607
    Cell Significance Index: -10.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3272
    Cell Significance Index: -81.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.4356
    Cell Significance Index: -8.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5287
    Cell Significance Index: -15.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5585
    Cell Significance Index: -40.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RLP24D1 is a ribosomal biogenesis gene that encodes a protein with a L24 domain, which is a conserved motif found in ribosomal proteins. The gene is associated with various cellular processes, including nucleolus formation, ribosomal large subunit biogenesis, and translation. Its expression is widespread, with notable presence in polychromatophilic erythroblast, embryonic stem cells, and hematopoietic oligopotent progenitor cells. The gene's cellular localization and expression patterns suggest its involvement in regulating protein synthesis and cell growth. **Pathways and Functions:** RLP24D1 is involved in several key pathways, including: 1. **Ribosomal large subunit biogenesis**: This process involves the assembly of ribosomal components, which is essential for protein synthesis. RLP24D1 likely plays a role in this process by regulating the expression of ribosomal proteins. 2. **Nucleolus formation**: The nucleolus is a structure within the nucleus responsible for ribosome production. RLP24D1 may contribute to nucleolus formation by regulating the expression of ribosomal genes. 3. **Protein binding**: The L24 domain in RLP24D1 protein may interact with other proteins, influencing their activity and function. 4. **Translation**: RLP24D1 may regulate translation by controlling the expression of ribosomal components or by interacting with translation factors. **Clinical Significance:** RLP24D1's involvement in ribosomal biogenesis and protein synthesis makes it a potential target for therapeutic interventions in diseases characterized by impaired protein synthesis, such as cancer, neurodegenerative disorders, and immunodeficiency diseases. Further research is needed to elucidate the specific functions of RLP24D1 and its role in disease pathology. Additionally, the gene's expression patterns in various cell types suggest its potential as a biomarker for disease diagnosis or monitoring. In conclusion, RSL24D1 is a gene with significant implications for our understanding of ribosomal biogenesis and protein synthesis. Further research is necessary to fully elucidate its functions and clinical significance, but its potential as a therapeutic target or biomarker warrants further investigation.

Genular Protein ID: 4255916822

Symbol: RLP24_HUMAN

Name: Probable ribosome biogenesis protein RLP24

UniProtKB Accession Codes:

Q9UHA3 B2RD72 Q561V8 Q8N6S8 Q96B04 Q96C76 Q96HJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 24 EMDB 37 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 37 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 35354024

Title: Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.

PubMed ID: 35354024

DOI: 10.1016/j.celrep.2022.110597

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 163
  • Mass: 19621
  • Checksum: 1E5D9ECFFCF678D1
  • Sequence:
    • MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG 
KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK 
VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.