Details for: RAB9B

Gene ID: 51209

Symbol: RAB9B

Ensembl ID: ENSG00000123570

Description: RAB9B, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.1258
    Cell Significance Index: -10.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.5868
    Cell Significance Index: -9.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.9903
    Cell Significance Index: -9.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.2606
    Cell Significance Index: -10.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.3199
    Cell Significance Index: 80.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1988
    Cell Significance Index: 26.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0072
    Cell Significance Index: 202.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6529
    Cell Significance Index: 24.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6382
    Cell Significance Index: 28.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5687
    Cell Significance Index: 16.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5275
    Cell Significance Index: 23.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4795
    Cell Significance Index: 32.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4578
    Cell Significance Index: 9.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3786
    Cell Significance Index: 37.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3347
    Cell Significance Index: 5.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3110
    Cell Significance Index: 111.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3043
    Cell Significance Index: 23.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3034
    Cell Significance Index: 15.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2981
    Cell Significance Index: 18.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2647
    Cell Significance Index: 2.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2417
    Cell Significance Index: 14.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2226
    Cell Significance Index: 24.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2174
    Cell Significance Index: 196.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2049
    Cell Significance Index: 4.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2010
    Cell Significance Index: 32.6800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1604
    Cell Significance Index: 1.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1543
    Cell Significance Index: 3.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1483
    Cell Significance Index: 102.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1266
    Cell Significance Index: 2.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0826
    Cell Significance Index: 1.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0821
    Cell Significance Index: 5.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0677
    Cell Significance Index: 3.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0571
    Cell Significance Index: 3.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0450
    Cell Significance Index: 1.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0205
    Cell Significance Index: 0.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0102
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0026
    Cell Significance Index: 0.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0021
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0023
    Cell Significance Index: -1.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0036
    Cell Significance Index: -1.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0077
    Cell Significance Index: -1.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0108
    Cell Significance Index: -1.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0154
    Cell Significance Index: -3.2400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0238
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0245
    Cell Significance Index: -0.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0262
    Cell Significance Index: -4.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0284
    Cell Significance Index: -8.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0356
    Cell Significance Index: -4.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0417
    Cell Significance Index: -0.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0420
    Cell Significance Index: -1.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0425
    Cell Significance Index: -1.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0458
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0555
    Cell Significance Index: -6.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0585
    Cell Significance Index: -8.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0615
    Cell Significance Index: -7.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0620
    Cell Significance Index: -6.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0632
    Cell Significance Index: -1.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0660
    Cell Significance Index: -8.5300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0712
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0715
    Cell Significance Index: -8.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0725
    Cell Significance Index: -8.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0781
    Cell Significance Index: -1.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0782
    Cell Significance Index: -4.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0818
    Cell Significance Index: -9.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0882
    Cell Significance Index: -1.7700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0893
    Cell Significance Index: -0.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1031
    Cell Significance Index: -7.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1198
    Cell Significance Index: -9.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1223
    Cell Significance Index: -3.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1260
    Cell Significance Index: -3.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1276
    Cell Significance Index: -1.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1287
    Cell Significance Index: -1.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1296
    Cell Significance Index: -8.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1306
    Cell Significance Index: -9.7300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1326
    Cell Significance Index: -1.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1342
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1424
    Cell Significance Index: -4.9900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1513
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1564
    Cell Significance Index: -4.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1664
    Cell Significance Index: -4.1500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1708
    Cell Significance Index: -2.0700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1729
    Cell Significance Index: -1.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1739
    Cell Significance Index: -3.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1769
    Cell Significance Index: -4.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1777
    Cell Significance Index: -8.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1781
    Cell Significance Index: -2.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1871
    Cell Significance Index: -5.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2088
    Cell Significance Index: -3.3500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2155
    Cell Significance Index: -1.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2193
    Cell Significance Index: -7.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2278
    Cell Significance Index: -6.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2340
    Cell Significance Index: -2.7300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2353
    Cell Significance Index: -5.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB9B is a small GTPase that belongs to the RAS superfamily, which includes RAS, RAB, and RHO GTPases. RAB9B is specifically localized to the Golgi apparatus, endosomes, and lysosomes, where it plays a crucial role in regulating membrane trafficking and protein transport. Its expression is widespread across various cell types, including hematopoietic cells, smooth muscle fibers, and neurons. **Pathways and Functions** RAB9B is involved in several key signaling pathways, including: 1. **Retrograde transport**: RAB9B regulates the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus and lysosomes. 2. **Membrane trafficking**: RAB9B modulates the movement of vesicles and proteins between the Golgi apparatus, endosomes, and lysosomes. 3. **Immune response**: RAB9B plays a role in the regulation of phagocytic vesicle formation and neutrophil degranulation, which are essential for the innate immune response. 4. **Signaling by RHO GTPases**: RAB9B interacts with RHO GTPases to regulate signaling pathways involved in cellular processes such as cytoskeleton organization and cell migration. **Clinical Significance** RAB9B has been implicated in various diseases and disorders, including: 1. **Immune disorders**: Mutations in RAB9B have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: Overexpression of RAB9B has been observed in certain types of cancer, including breast and lung cancer. 3. **Neurological disorders**: RAB9B has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, RAB9B is a critical regulator of membrane trafficking and immune response, and its dysregulation has been implicated in various diseases and disorders. Further research is needed to fully understand the role of RAB9B in human health and disease. **Significantly expressed cells** Polychromatophilic erythroblast Hematopoietic oligopotent progenitor cell Smooth muscle fiber of ileum Orthochromatic erythroblast Intestinal tuft cell Purkinje cell L2/3-6 intratelencephalic projecting glutamatergic neuron Direct pathway medium spiny neuron Indirect pathway medium spiny neuron Hippocampal pyramidal neuron

Genular Protein ID: 3325558161

Symbol: RAB9B_HUMAN

Name: Ras-related protein Rab-9B

UniProtKB Accession Codes:

Q9NP90 B2R8M0 Q52LX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11043518

Title: cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region.

PubMed ID: 11043518

DOI: 10.1007/s100380070025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20048159

Title: Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.

PubMed ID: 20048159

DOI: 10.1074/jbc.m109.069088

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 22637480

Title: RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.

PubMed ID: 22637480

DOI: 10.1074/jbc.m112.362558

Sequence Information:

  • Length: 201
  • Mass: 22719
  • Checksum: B35EDA8E8358C49C
  • Sequence:
    • MSGKSLLLKV ILLGDGGVGK SSLMNRYVTN KFDSQAFHTI GVEFLNRDLE VDGRFVTLQI 
WDTAGQERFK SLRTPFYRGA DCCLLTFSVD DRQSFENLGN WQKEFIYYAD VKDPEHFPFV 
VLGNKVDKED RQVTTEEAQT WCMENGDYPY LETSAKDDTN VTVAFEEAVR QVLAVEEQLE 
HCMLGHTIDL NSGSKAGSSC C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.