Details for: PDZD11

Gene ID: 51248

Symbol: PDZD11

Ensembl ID: ENSG00000120509

Description: PDZ domain containing 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 144.6525
    Cell Significance Index: -22.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.3237
    Cell Significance Index: -22.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.9443
    Cell Significance Index: -23.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.9931
    Cell Significance Index: -24.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.9760
    Cell Significance Index: -23.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.0048
    Cell Significance Index: -24.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.4468
    Cell Significance Index: -25.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4634
    Cell Significance Index: -25.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3236
    Cell Significance Index: -16.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8637
    Cell Significance Index: -18.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4428
    Cell Significance Index: 238.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1857
    Cell Significance Index: 131.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.7753
    Cell Significance Index: 14.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2841
    Cell Significance Index: 11.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2186
    Cell Significance Index: 198.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1308
    Cell Significance Index: 23.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0915
    Cell Significance Index: 56.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8066
    Cell Significance Index: 6.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6561
    Cell Significance Index: 41.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6512
    Cell Significance Index: 355.6400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6344
    Cell Significance Index: 6.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6301
    Cell Significance Index: 6.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6097
    Cell Significance Index: 13.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5651
    Cell Significance Index: 66.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5504
    Cell Significance Index: 28.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5358
    Cell Significance Index: 101.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5246
    Cell Significance Index: 94.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5195
    Cell Significance Index: 71.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5165
    Cell Significance Index: 15.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5139
    Cell Significance Index: 63.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5057
    Cell Significance Index: 6.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4909
    Cell Significance Index: 22.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4776
    Cell Significance Index: 22.2700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4677
    Cell Significance Index: 5.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4580
    Cell Significance Index: 29.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4200
    Cell Significance Index: 10.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4199
    Cell Significance Index: 4.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4053
    Cell Significance Index: 51.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3884
    Cell Significance Index: 5.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3875
    Cell Significance Index: 10.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3513
    Cell Significance Index: 26.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3248
    Cell Significance Index: 143.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2984
    Cell Significance Index: 10.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2655
    Cell Significance Index: 18.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2322
    Cell Significance Index: 6.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2294
    Cell Significance Index: 5.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2244
    Cell Significance Index: 29.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2116
    Cell Significance Index: 5.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2092
    Cell Significance Index: 20.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1825
    Cell Significance Index: 5.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1704
    Cell Significance Index: 8.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0604
    Cell Significance Index: 1.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0492
    Cell Significance Index: 9.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0262
    Cell Significance Index: 0.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0176
    Cell Significance Index: 0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0149
    Cell Significance Index: 11.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0146
    Cell Significance Index: 2.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0135
    Cell Significance Index: 0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0068
    Cell Significance Index: 4.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0056
    Cell Significance Index: -0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0065
    Cell Significance Index: -2.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0101
    Cell Significance Index: -18.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0122
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0198
    Cell Significance Index: -30.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0233
    Cell Significance Index: -31.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0368
    Cell Significance Index: -20.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0449
    Cell Significance Index: -28.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0465
    Cell Significance Index: -7.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0477
    Cell Significance Index: -13.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0505
    Cell Significance Index: -22.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0667
    Cell Significance Index: -1.4200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0905
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1176
    Cell Significance Index: -13.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1280
    Cell Significance Index: -18.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1316
    Cell Significance Index: -15.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1379
    Cell Significance Index: -29.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1398
    Cell Significance Index: -2.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1846
    Cell Significance Index: -4.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1946
    Cell Significance Index: -11.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1983
    Cell Significance Index: -15.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2457
    Cell Significance Index: -25.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2929
    Cell Significance Index: -7.8400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2934
    Cell Significance Index: -2.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2974
    Cell Significance Index: -8.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3067
    Cell Significance Index: -1.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3071
    Cell Significance Index: -18.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3156
    Cell Significance Index: -24.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3217
    Cell Significance Index: -18.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3401
    Cell Significance Index: -22.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3637
    Cell Significance Index: -3.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4546
    Cell Significance Index: -13.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4613
    Cell Significance Index: -6.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4776
    Cell Significance Index: -8.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4937
    Cell Significance Index: -7.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5153
    Cell Significance Index: -18.9200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5526
    Cell Significance Index: -3.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDZD11 is a single-coding gene that belongs to the PDZ domain family, characterized by its unique PDZ (PSD-95/Discs Large/Zonula Occludens-1) domain. This domain is essential for protein-protein interactions, facilitating the assembly of protein complexes and regulating cellular processes. PDZD11 expression is significantly elevated in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and embryonic stem cells, indicating its importance in development and immune system maturation. **Pathways and Functions:** PDZD11 is involved in multiple cellular pathways, including adherens junction, antimicrobial peptides, biotin transport and metabolism, and ion channel transport. Its role in regulating immune responses is mediated through its involvement in the innate immune system, where it interacts with antimicrobial peptides and ion influx/efflux at the host-pathogen interface. Additionally, PDZD11 plays a crucial role in the assembly of pore complexes, which are essential for the transport of small molecules across cell membranes. **Clinical Significance:** The dysregulation of PDZD11 has been implicated in various diseases, including autoimmune disorders, where immune system dysregulation leads to the development of chronic inflammation. Mutations in PDZD11 have also been associated with developmental abnormalities, including those affecting the hematopoietic system. Furthermore, its role in regulating cellular adhesion and ion transport makes it a potential target for the treatment of diseases characterized by impaired cellular function, such as neurodegenerative disorders. **Implications for Immunology and Cellular Biology:** The study of PDZD11 has significant implications for our understanding of immune system regulation and cellular homeostasis. Its role in the innate immune system and its involvement in multiple cellular pathways highlight the complexity of immune responses and the need for further investigation into the mechanisms underlying PDZD11 function. Additionally, the identification of PDZD11 as a potential therapeutic target for autoimmune disorders and developmental abnormalities underscores the importance of this gene in maintaining cellular and immune system homeostasis. **Future Directions:** Future research should focus on elucidating the specific mechanisms by which PDZD11 regulates immune responses and cellular adhesion. Additionally, the development of therapeutic strategies targeting PDZD11 may provide new avenues for the treatment of autoimmune disorders and developmental abnormalities. The study of PDZD11 will also contribute to our understanding of the intricate relationships between immune system regulation, cellular homeostasis, and disease development, ultimately informing the development of novel therapeutic approaches for a range of diseases.

Genular Protein ID: 158930388

Symbol: PDZ11_HUMAN

Name: PDZ domain-containing protein 11

UniProtKB Accession Codes:

Q5EBL8 D3DVU3 Q6UWE1 Q9P0Q1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12763866

Title: Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.

PubMed ID: 12763866

DOI: 10.1111/j.1749-6632.2003.tb07230.x

PubMed ID: 16051599

Title: A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis.

PubMed ID: 16051599

DOI: 10.1074/jbc.m505889200

PubMed ID: 21183659

Title: Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter.

PubMed ID: 21183659

DOI: 10.1152/ajpgi.00530.2010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30463011

Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.

PubMed ID: 30463011

DOI: 10.1016/j.celrep.2018.10.088

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 140
  • Mass: 16131
  • Checksum: 601216B821A36DCE
  • Sequence:
    • MDSRIPYDDY PVVFLPAYEN PPAWIPPHER VHHPDYNNEL TQFLPRTITL KKPPGAQLGF 
NIRGGKASQL GIFISKVIPD SDAHRAGLQE GDQVLAVNDV DFQDIEHSKA VEILKTAREI 
SMRVRFFPYN YHRQKERTVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.