Details for: SLC15A3

Gene ID: 51296

Symbol: SLC15A3

Ensembl ID: ENSG00000110446

Description: solute carrier family 15 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.7406
    Cell Significance Index: -11.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.6088
    Cell Significance Index: -10.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.3009
    Cell Significance Index: -12.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3434
    Cell Significance Index: -10.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.2785
    Cell Significance Index: -11.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.7320
    Cell Significance Index: 57.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.6848
    Cell Significance Index: 118.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.6232
    Cell Significance Index: 54.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9194
    Cell Significance Index: -11.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3805
    Cell Significance Index: -5.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2987
    Cell Significance Index: 247.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2985
    Cell Significance Index: 24.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9553
    Cell Significance Index: 49.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8374
    Cell Significance Index: 82.8400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7838
    Cell Significance Index: 4.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6715
    Cell Significance Index: 606.3500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.6603
    Cell Significance Index: 5.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4708
    Cell Significance Index: 51.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4356
    Cell Significance Index: 70.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4057
    Cell Significance Index: 24.3600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.3518
    Cell Significance Index: 2.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2434
    Cell Significance Index: 16.8400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1997
    Cell Significance Index: 2.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0961
    Cell Significance Index: 12.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0514
    Cell Significance Index: 6.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0257
    Cell Significance Index: 3.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0194
    Cell Significance Index: 0.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0156
    Cell Significance Index: 0.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0020
    Cell Significance Index: -0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0064
    Cell Significance Index: -0.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0075
    Cell Significance Index: -0.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0080
    Cell Significance Index: -14.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0093
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0190
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0193
    Cell Significance Index: -14.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0206
    Cell Significance Index: -11.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0223
    Cell Significance Index: -4.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0260
    Cell Significance Index: -11.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0290
    Cell Significance Index: -1.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0311
    Cell Significance Index: -11.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0373
    Cell Significance Index: -10.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0394
    Cell Significance Index: -7.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0394
    Cell Significance Index: -0.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0438
    Cell Significance Index: -1.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0490
    Cell Significance Index: -9.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0526
    Cell Significance Index: -1.8500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0586
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0630
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0649
    Cell Significance Index: -13.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0711
    Cell Significance Index: -10.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0737
    Cell Significance Index: -1.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0780
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0805
    Cell Significance Index: -13.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0943
    Cell Significance Index: -12.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1048
    Cell Significance Index: -5.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1062
    Cell Significance Index: -7.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1091
    Cell Significance Index: -11.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1209
    Cell Significance Index: -13.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1234
    Cell Significance Index: -7.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1313
    Cell Significance Index: -6.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1409
    Cell Significance Index: -9.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1442
    Cell Significance Index: -6.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1569
    Cell Significance Index: -12.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1632
    Cell Significance Index: -4.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1634
    Cell Significance Index: -4.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1652
    Cell Significance Index: -12.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1858
    Cell Significance Index: -12.4900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1909
    Cell Significance Index: -2.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1933
    Cell Significance Index: -10.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1946
    Cell Significance Index: -7.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2011
    Cell Significance Index: -1.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2017
    Cell Significance Index: -12.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2143
    Cell Significance Index: -11.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2155
    Cell Significance Index: -7.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2162
    Cell Significance Index: -10.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2351
    Cell Significance Index: -6.7400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2531
    Cell Significance Index: -2.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2634
    Cell Significance Index: -4.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2782
    Cell Significance Index: -7.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2838
    Cell Significance Index: -8.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2842
    Cell Significance Index: -12.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2975
    Cell Significance Index: -3.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2977
    Cell Significance Index: -10.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3069
    Cell Significance Index: -6.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3138
    Cell Significance Index: -11.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3148
    Cell Significance Index: -6.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3327
    Cell Significance Index: -12.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3383
    Cell Significance Index: -4.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3390
    Cell Significance Index: -11.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3392
    Cell Significance Index: -9.0900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3405
    Cell Significance Index: -4.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** SLC15A3 is a transmembrane transporter that spans the plasma membrane, allowing for the transport of peptides, amino acids, and dipeptides across cellular membranes. 2. **Dipeptide Transport:** SLC15A3 is specifically involved in the transport of dipeptides, which are short chains of two amino acids linked by a peptide bond. 3. **Protein Binding:** The SLC15A3 transporter can bind to various proteins, including nucleotide-binding oligomerization domain-containing 2 (NOD2), which is a key player in the innate immune response. 4. **Cellular Localization:** SLC15A3 is expressed in various cell types, including immune cells, epithelial cells, and hematopoietic cells. **Pathways and Functions:** 1. **Dipeptide Import Across Plasma Membrane:** SLC15A3 plays a crucial role in the import of dipeptides across the plasma membrane, which is essential for the synthesis of proteins and the regulation of cellular signaling pathways. 2. **Innate Immune Response:** The SLC15A3 transporter can interact with NOD2, a key player in the innate immune response, to regulate the transport of dipeptides and influence the activation of immune cells. 3. **Peptide Transport:** SLC15A3 is involved in the transport of peptides across cellular membranes, which is essential for the regulation of protein synthesis and cell signaling pathways. 4. **Proton/Oligopeptide Cotransporters:** SLC15A3 can also function as a proton/oligopeptide cotransporter, regulating the transport of protons and peptides across cellular membranes. **Clinical Significance:** 1. **Immune System Disorders:** Abnormalities in SLC15A3 expression or function may contribute to immune system disorders, such as inflammatory bowel disease and autoimmune disorders. 2. **Cancer:** The SLC15A3 transporter has been implicated in the regulation of peptide transport in cancer cells, which may influence tumor growth and metastasis. 3. **Neurological Disorders:** SLC15A3 has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease, due to its role in protein transport and signaling pathways. 4. **Dietary Implications:** The SLC15A3 transporter plays a crucial role in the absorption of amino acids and peptides from the gut, which is essential for maintaining proper nutrition and immune function. In conclusion, SLC15A3 is a crucial gene that regulates peptide transport and immune response. Its dysregulation may contribute to various diseases, including immune system disorders, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms of SLC15A3 and its clinical significance.

Genular Protein ID: 1455013191

Symbol: S15A3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IY34 Q9P2X9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 31073693

Title: The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells.

PubMed ID: 31073693

DOI: 10.1007/s00726-019-02739-w

PubMed ID: 31254495

Title: Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells.

PubMed ID: 31254495

DOI: 10.1016/j.xphs.2019.06.016

Sequence Information:

  • Length: 581
  • Mass: 63560
  • Checksum: 56768D2963DB13D4
  • Sequence:
    • MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL 
NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA 
TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT 
SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA 
FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA 
LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT 
SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL 
EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL 
YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G

Genular Protein ID: 1065064127

Symbol: A0A7P0T8H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7P0T8H0

Database IDs:

ARBA 8 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 535
  • Mass: 58402
  • Checksum: 41660F3E56980833
  • Sequence:
    • MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL 
NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA 
TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT 
SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA 
FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA 
LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT 
SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL 
EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF AEEEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.