GCNT4 | ENSG00000176928 | NCBI 51301

Details for: GCNT4

Gene ID: 51301

Symbol: GCNT4

Ensembl ID: ENSG00000176928

Description: glucosaminyl (N-acetyl) transferase 4

Associated with

Metabolism of proteins
(R-HSA-392499)
O-linked glycosylation
(R-HSA-5173105)
O-linked glycosylation of mucins
(R-HSA-913709)
Post-translational protein modification
(R-HSA-597592)
Acetylglucosaminyltransferase activity
(GO:0008375)
Beta-1,3-galactosyl-o-glycosyl-glycoprotein beta-1,6-n-acetylglucosaminyltransferase activity
(GO:0003829)
Carbohydrate metabolic process
(GO:0005975)
Golgi membrane
(GO:0000139)
Inter-male aggressive behavior
(GO:0002121)
Kidney morphogenesis
(GO:0060993)
N-acetyllactosaminide beta-1,6-n-acetylglucosaminyltransferase activity
(GO:0008109)
Neutrophil homeostasis
(GO:0001780)
O-glycan processing
(GO:0016266)
Protein o-linked glycosylation
(GO:0006493)
Thyroid hormone metabolic process
(GO:0042403)
Tissue morphogenesis
(GO:0048729)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 51.3677
Cell Significance Index: -7.9900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.5009
Cell Significance Index: -7.9900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 6.7767
Cell Significance Index: -6.4700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.4804
Cell Significance Index: -7.9900
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.6878
Cell Significance Index: 26.9500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.6395
Cell Significance Index: 84.5400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.0324
Cell Significance Index: -8.0200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.9030
Cell Significance Index: -5.8500
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.7398
Cell Significance Index: 28.6700
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.0741
Cell Significance Index: 7.1300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9832
Cell Significance Index: 37.2300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9629
Cell Significance Index: 20.8600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8532
Cell Significance Index: 37.7400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7406
Cell Significance Index: 38.4700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6513
Cell Significance Index: 18.7700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6388
Cell Significance Index: 38.3500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6351
Cell Significance Index: 103.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6097
Cell Significance Index: 60.3200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5911
Cell Significance Index: 533.6900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5484
Cell Significance Index: 5.0500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4983
Cell Significance Index: 54.2000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4947
Cell Significance Index: 7.4600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4710
Cell Significance Index: 84.9000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4458
Cell Significance Index: 54.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4408
Cell Significance Index: 11.7700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3855
Cell Significance Index: 5.2600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3674
Cell Significance Index: 10.0000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2936
Cell Significance Index: 20.3100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2334
Cell Significance Index: 6.6900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2184
Cell Significance Index: 41.5600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1134
Cell Significance Index: 8.0200
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: 0.1088
Cell Significance Index: 1.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0952
Cell Significance Index: 2.3800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0883
Cell Significance Index: 10.2900
Cell Name: decidual cell (CL2000002)
Fold Change: 0.0798
Cell Significance Index: 1.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0719
Cell Significance Index: 14.4200
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.0693
Cell Significance Index: 0.3300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0527
Cell Significance Index: 23.2900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0497
Cell Significance Index: 1.0300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0362
Cell Significance Index: 0.7700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0318
Cell Significance Index: 3.6400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0218
Cell Significance Index: 7.8300
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: 0.0192
Cell Significance Index: 0.2100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0186
Cell Significance Index: 12.8700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0171
Cell Significance Index: 0.6000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0129
Cell Significance Index: 24.3600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0088
Cell Significance Index: 4.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0067
Cell Significance Index: 4.2500
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.0065
Cell Significance Index: 0.0800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0015
Cell Significance Index: 2.6800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0002
Cell Significance Index: -0.0900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0022
Cell Significance Index: -3.3600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0030
Cell Significance Index: -0.4300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0035
Cell Significance Index: -2.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0037
Cell Significance Index: -2.0800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0041
Cell Significance Index: -3.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0058
Cell Significance Index: -7.8200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0073
Cell Significance Index: -0.3300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0100
Cell Significance Index: -7.6000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0115
Cell Significance Index: -0.3000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0168
Cell Significance Index: -10.5200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0178
Cell Significance Index: -3.0400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0186
Cell Significance Index: -1.1400
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0190
Cell Significance Index: -2.4300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0207
Cell Significance Index: -0.5900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0208
Cell Significance Index: -2.8500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0248
Cell Significance Index: -7.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0288
Cell Significance Index: -2.9400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0309
Cell Significance Index: -6.1300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0364
Cell Significance Index: -7.6700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0557
Cell Significance Index: -7.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0589
Cell Significance Index: -6.1300
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0609
Cell Significance Index: -1.0500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0730
Cell Significance Index: -5.6000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0731
Cell Significance Index: -3.6900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0773
Cell Significance Index: -2.1600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0780
Cell Significance Index: -3.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0867
Cell Significance Index: -6.8700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0901
Cell Significance Index: -10.6200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0908
Cell Significance Index: -6.7700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1106
Cell Significance Index: -4.0600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1139
Cell Significance Index: -7.6600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1219
Cell Significance Index: -6.3500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1229
Cell Significance Index: -7.9300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1230
Cell Significance Index: -7.7500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1287
Cell Significance Index: -7.2200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1289
Cell Significance Index: -7.9200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1330
Cell Significance Index: -2.3500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1387
Cell Significance Index: -5.6800
Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.1413
Cell Significance Index: -1.9800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1498
Cell Significance Index: -4.7700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1504
Cell Significance Index: -7.0700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1576
Cell Significance Index: -5.1600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1615
Cell Significance Index: -1.8400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1616
Cell Significance Index: -5.6600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1642
Cell Significance Index: -8.6200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1662
Cell Significance Index: -2.4900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1746
Cell Significance Index: -8.1400
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.1967
Cell Significance Index: -1.0300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1993
Cell Significance Index: -4.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** GCNT4 is a type II transmembrane glycosyltransferase that belongs to the glycosaminyl (N-acetyl) transferase family. It is specifically involved in the transfer of N-acetylglucosamine (GlcNAc) to serine or threonine residues on target proteins, resulting in the formation of O-glycans. These glycosylated proteins play a critical role in various biological processes, including cell signaling, adhesion, and immune responses. **Pathways and Functions:** GCNT4 is involved in multiple cellular pathways, including: 1. **O-glycan processing:** GCNT4 is essential for the formation of O-glycans on mucins, which are key components of the protective mucus layer in the respiratory and gastrointestinal tracts. 2. **Immune regulation:** GCNT4 is expressed in various immune cells, including neutrophils, T cells, and dendritic cells, and is involved in the regulation of immune responses, including neutrophil homeostasis and T cell activation. 3. **Cell signaling:** GCNT4 is involved in the regulation of cell signaling pathways, including the Wnt/β-catenin pathway, which is critical for tissue morphogenesis and development. 4. **Protein modification:** GCNT4 is involved in the modification of proteins, including the incorporation of O-glycans into proteins, which can regulate protein function and stability. **Clinical Significance:** Dysregulation of GCNT4 has been implicated in various diseases, including: 1. **Autoimmune diseases:** GCNT4 has been shown to play a critical role in the regulation of immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** GCNT4 has been shown to be overexpressed in various types of cancer, including lung, breast, and colon cancer, and is associated with poor prognosis. 3. **Neurological disorders:** GCNT4 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Gastrointestinal disorders:** GCNT4 has been shown to play a critical role in the regulation of mucins and has been implicated in gastrointestinal disorders, including inflammatory bowel disease. In conclusion, GCNT4 is a crucial enzyme involved in the regulation of immune responses, cell signaling, and protein modification. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of GCNT4 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.