Details for: ZDHHC3

Gene ID: 51304

Symbol: ZDHHC3

Ensembl ID: ENSG00000163812

Description: zinc finger DHHC-type palmitoyltransferase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.5198
    Cell Significance Index: -21.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.8496
    Cell Significance Index: -31.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.5948
    Cell Significance Index: -35.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.1649
    Cell Significance Index: -30.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.0303
    Cell Significance Index: -33.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.3142
    Cell Significance Index: -35.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.7572
    Cell Significance Index: -30.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.8322
    Cell Significance Index: -31.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1320
    Cell Significance Index: -32.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6162
    Cell Significance Index: -34.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9083
    Cell Significance Index: -24.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8681
    Cell Significance Index: -17.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5784
    Cell Significance Index: 133.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8258
    Cell Significance Index: 24.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3231
    Cell Significance Index: 162.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3172
    Cell Significance Index: 12.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2923
    Cell Significance Index: 232.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0999
    Cell Significance Index: 29.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0452
    Cell Significance Index: 28.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9910
    Cell Significance Index: 21.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8543
    Cell Significance Index: 24.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8379
    Cell Significance Index: 37.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7482
    Cell Significance Index: 150.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6539
    Cell Significance Index: 34.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5981
    Cell Significance Index: 118.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5812
    Cell Significance Index: 79.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4856
    Cell Significance Index: 22.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4785
    Cell Significance Index: 11.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4690
    Cell Significance Index: 76.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4527
    Cell Significance Index: 247.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3817
    Cell Significance Index: 168.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3684
    Cell Significance Index: 132.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3265
    Cell Significance Index: 25.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3075
    Cell Significance Index: 58.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2942
    Cell Significance Index: 222.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2771
    Cell Significance Index: 19.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2584
    Cell Significance Index: 28.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2567
    Cell Significance Index: 30.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2347
    Cell Significance Index: 23.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2168
    Cell Significance Index: 10.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2072
    Cell Significance Index: 143.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2011
    Cell Significance Index: 5.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1519
    Cell Significance Index: 137.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1510
    Cell Significance Index: 25.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1503
    Cell Significance Index: 3.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1457
    Cell Significance Index: 10.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1070
    Cell Significance Index: 3.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0868
    Cell Significance Index: 11.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0829
    Cell Significance Index: 2.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0752
    Cell Significance Index: 9.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0352
    Cell Significance Index: 66.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0115
    Cell Significance Index: 7.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0035
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0107
    Cell Significance Index: -7.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0112
    Cell Significance Index: -7.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0422
    Cell Significance Index: -19.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0570
    Cell Significance Index: -5.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0641
    Cell Significance Index: -9.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0813
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0971
    Cell Significance Index: -20.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1003
    Cell Significance Index: -28.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1078
    Cell Significance Index: -6.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1084
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1107
    Cell Significance Index: -12.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1150
    Cell Significance Index: -7.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1215
    Cell Significance Index: -7.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1291
    Cell Significance Index: -1.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1485
    Cell Significance Index: -4.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1684
    Cell Significance Index: -19.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1798
    Cell Significance Index: -11.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1915
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2228
    Cell Significance Index: -25.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2255
    Cell Significance Index: -11.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2289
    Cell Significance Index: -4.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2922
    Cell Significance Index: -7.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3084
    Cell Significance Index: -32.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3115
    Cell Significance Index: -13.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3279
    Cell Significance Index: -5.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3640
    Cell Significance Index: -7.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3694
    Cell Significance Index: -29.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3978
    Cell Significance Index: -10.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4091
    Cell Significance Index: -15.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4376
    Cell Significance Index: -22.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4831
    Cell Significance Index: -29.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4839
    Cell Significance Index: -11.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4858
    Cell Significance Index: -14.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4946
    Cell Significance Index: -7.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5042
    Cell Significance Index: -11.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5284
    Cell Significance Index: -13.5000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5441
    Cell Significance Index: -10.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6026
    Cell Significance Index: -17.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6150
    Cell Significance Index: -17.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6853
    Cell Significance Index: -10.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6976
    Cell Significance Index: -7.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7240
    Cell Significance Index: -7.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZDHHC3 is a palmitoyltransferase enzyme that catalyzes the post-translational modification of cysteine residues, adding palmitoyl groups to specific proteins. This modification is crucial for protein localization, stability, and activity. ZDHHC3 belongs to the DHHC family of palmitoyltransferases, which are involved in various cellular processes, including cell signaling, protein-protein interactions, and immune regulation. **Pathways and Functions:** ZDHHC3 is implicated in multiple signaling pathways, including: 1. **Endoplasmic Reticulum and Golgi Apparatus:** ZDHHC3 is involved in the regulation of protein localization and sorting within the endoplasmic reticulum and Golgi apparatus. 2. **Infectious Disease:** ZDHHC3 is associated with the regulation of viral infection pathways, including the maturation of spike proteins in SARS-CoV-2. 3. **Golgi Membrane and Lipoprotein Localization:** ZDHHC3 is involved in the localization of lipoproteins to the Golgi membrane, which is essential for lipid metabolism and cellular homeostasis. 4. **Protein-Cysteine S-Palmitoylation:** ZDHHC3 is responsible for the palmitoylation of cysteine residues on specific proteins, which is crucial for protein stability, localization, and activity. 5. **Positive Regulation of Receptor Localization to Synapse:** ZDHHC3 is involved in the regulation of synaptic transmission and receptor localization to the synapse. **Clinical Significance:** ZDHHC3 has been found to be significantly expressed in various tissues, including hematopoietic cells, smooth muscle fibers, and epithelial cells. Its dysregulation has been implicated in various diseases, including: 1. **Infectious Diseases:** ZDHHC3's role in viral infection pathways makes it a potential target for the development of antiviral therapies. 2. **Cancer:** ZDHHC3's involvement in protein localization and stability may contribute to cancer progression and metastasis. 3. **Neurological Disorders:** ZDHHC3's role in synaptic transmission and receptor localization may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Conclusion:** In conclusion, ZDHHC3 is a multifaceted enzyme that plays a crucial role in various cellular processes, including immune regulation, signaling pathways, and disease mechanisms. Further research is needed to fully understand the complexities of ZDHHC3's function and its implications in human health and disease. As an immunologist, it is essential to continue studying ZDHHC3 to uncover its potential as a therapeutic target for various diseases.

Genular Protein ID: 12373049

Symbol: ZDHC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NYG2 Q53A17 Q96BL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 Rhea 12 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16647879

Title: Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.

PubMed ID: 16647879

DOI: 10.1016/j.bbalip.2006.03.010

PubMed ID: 19001095

Title: Identification of G protein alpha subunit-palmitoylating enzyme.

PubMed ID: 19001095

DOI: 10.1128/mcb.01144-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21926431

Title: Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals.

PubMed ID: 21926431

DOI: 10.1074/jbc.m111.272369

PubMed ID: 22240897

Title: Regulation in the targeting of TRAIL receptor 1 to cell surface via GODZ for TRAIL sensitivity in tumor cells.

PubMed ID: 22240897

DOI: 10.1038/cdd.2011.209

PubMed ID: 22314500

Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.

PubMed ID: 22314500

DOI: 10.1007/s00018-012-0924-6

PubMed ID: 23034182

Title: Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system.

PubMed ID: 23034182

DOI: 10.1091/mbc.e12-05-0336

PubMed ID: 26535572

Title: Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.

PubMed ID: 26535572

DOI: 10.1371/journal.pone.0140661

PubMed ID: 35893977

Title: Structural exploration on palmitoyltransferase DHHC3 from Homo sapiens.

PubMed ID: 35893977

DOI: 10.3390/polym14153013

PubMed ID: 38169466

Title: Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice.

PubMed ID: 38169466

DOI: 10.1038/s41467-023-43650-z

Sequence Information:

  • Length: 299
  • Mass: 34170
  • Checksum: 345A960FCB46E0E1
  • Sequence:
    • MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV TWFLVLYAEF 
VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT DPGAVPKGNA TKEFIESLQL 
KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI RKMDHHCPWV NNCVGENNQK YFVLFTMYIA 
LISLHALIMV GFHFLHCFEE DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH 
SICTDETGIE QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV

Genular Protein ID: 1253984643

Symbol: F8W6M3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W6M3

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 4 RuleBase 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

Sequence Information:

  • Length: 333
  • Mass: 37865
  • Checksum: 4545F5DA0AF9F0D2
  • Sequence:
    • MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV TWFLVLYAEF 
VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT DPVRTCTEMA FTLLGRGASF 
PEKLDKPVSG RSKCLLGAVP KGNATKEFIE SLQLKPGQVV YKCPKCCSIK PDRAHHCSVC 
KRCIRKMDHH CPWVNNCVGE NNQKYFVLFT MYIALISLHA LIMVGFHFLH CFEEDWTKCS 
SFSPPTTVIL LILLCFEGLL FLIFTSVMFG TQVHSICTDE TGIEQLKKEE RRWAKKTKWM 
NMKAVFGHPF SLGWASPFAT PDQGKADPYQ YVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.