Details for: RSRC1

Gene ID: 51319

Symbol: RSRC1

Ensembl ID: ENSG00000174891

Description: arginine and serine rich coiled-coil 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 346.5230
    Cell Significance Index: -53.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 227.0511
    Cell Significance Index: -57.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 134.0330
    Cell Significance Index: -63.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.0285
    Cell Significance Index: -52.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.7498
    Cell Significance Index: -59.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.6692
    Cell Significance Index: -52.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.3854
    Cell Significance Index: -60.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.3598
    Cell Significance Index: -57.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.5124
    Cell Significance Index: -56.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.1529
    Cell Significance Index: -63.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.9731
    Cell Significance Index: -32.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7786
    Cell Significance Index: 37.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4569
    Cell Significance Index: 137.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9275
    Cell Significance Index: 382.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8364
    Cell Significance Index: 127.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8346
    Cell Significance Index: 298.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6686
    Cell Significance Index: 334.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5663
    Cell Significance Index: 30.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2579
    Cell Significance Index: 451.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0790
    Cell Significance Index: 194.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0609
    Cell Significance Index: 115.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0445
    Cell Significance Index: 29.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9640
    Cell Significance Index: 666.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8971
    Cell Significance Index: 110.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8015
    Cell Significance Index: 61.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6980
    Cell Significance Index: 26.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6785
    Cell Significance Index: 30.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5843
    Cell Significance Index: 80.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5330
    Cell Significance Index: 235.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4181
    Cell Significance Index: 228.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4151
    Cell Significance Index: 27.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3905
    Cell Significance Index: 24.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3819
    Cell Significance Index: 719.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3764
    Cell Significance Index: 8.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3748
    Cell Significance Index: 238.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3721
    Cell Significance Index: 24.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3528
    Cell Significance Index: 34.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3288
    Cell Significance Index: 42.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3027
    Cell Significance Index: 19.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2769
    Cell Significance Index: 510.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2563
    Cell Significance Index: 394.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2121
    Cell Significance Index: 96.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1913
    Cell Significance Index: 2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1804
    Cell Significance Index: 6.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1686
    Cell Significance Index: 7.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1682
    Cell Significance Index: 7.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1549
    Cell Significance Index: 7.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1475
    Cell Significance Index: 17.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1273
    Cell Significance Index: 114.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1214
    Cell Significance Index: 2.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0956
    Cell Significance Index: 2.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0910
    Cell Significance Index: 123.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0323
    Cell Significance Index: 1.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0074
    Cell Significance Index: 0.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0331
    Cell Significance Index: -24.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0580
    Cell Significance Index: -43.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0595
    Cell Significance Index: -44.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0598
    Cell Significance Index: -3.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0755
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0768
    Cell Significance Index: -13.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0770
    Cell Significance Index: -14.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0861
    Cell Significance Index: -6.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0988
    Cell Significance Index: -55.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1116
    Cell Significance Index: -69.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1130
    Cell Significance Index: -11.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1296
    Cell Significance Index: -16.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1817
    Cell Significance Index: -26.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1893
    Cell Significance Index: -54.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2969
    Cell Significance Index: -7.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3172
    Cell Significance Index: -66.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3346
    Cell Significance Index: -34.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3520
    Cell Significance Index: -40.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3658
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3700
    Cell Significance Index: -43.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3755
    Cell Significance Index: -19.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4058
    Cell Significance Index: -10.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4659
    Cell Significance Index: -6.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5609
    Cell Significance Index: -14.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5942
    Cell Significance Index: -7.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6213
    Cell Significance Index: -16.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6266
    Cell Significance Index: -4.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6331
    Cell Significance Index: -50.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7055
    Cell Significance Index: -18.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7425
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7763
    Cell Significance Index: -24.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7977
    Cell Significance Index: -27.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8017
    Cell Significance Index: -11.5300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8086
    Cell Significance Index: -10.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8154
    Cell Significance Index: -23.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8202
    Cell Significance Index: -21.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8259
    Cell Significance Index: -18.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8379
    Cell Significance Index: -51.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9079
    Cell Significance Index: -15.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9819
    Cell Significance Index: -23.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9855
    Cell Significance Index: -28.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0271
    Cell Significance Index: -21.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0404
    Cell Significance Index: -52.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.0553
    Cell Significance Index: -7.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0618
    Cell Significance Index: -22.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RSRC1 is a coiled-coil protein with a high content of arginine and serine residues, which suggests its involvement in protein-protein interactions and possibly in the regulation of mRNA splicing. The gene exhibits high expression levels in various cell types, including hematopoietic cells, smooth muscle fibers, and immune cells. This widespread expression hints at RSRC1's role in maintaining cellular homeostasis and regulating cellular processes. **Pathways and Functions:** The functional implications of RSRC1 are multifaceted and involve several signaling pathways. The gene's association with alternative mRNA splicing via the spliceosome suggests its role in RNA processing and regulation. Additionally, RSRC1's involvement in cytoplasmic and nuclear transport mechanisms implies its potential role in regulating the movement of proteins and RNAs within the cell. Furthermore, RSRC1's expression in immune cells and its association with T-cell development and function suggest its involvement in immune regulation. **Key Pathways:** 1. **Alternative mRNA splicing via spliceosome:** RSRC1's involvement in this process suggests its role in regulating RNA processing and potentially in the development of alternative protein isoforms. 2. **Nuclear speck:** The presence of RSRC1 in nuclear specks, a type of nuclear structure involved in RNA processing and protein regulation, implies its role in regulating gene expression and cellular processes. 3. **Nucleocytoplasmic transport:** RSRC1's involvement in this process suggests its potential role in regulating the movement of proteins and RNAs between the nucleus and cytoplasm. 4. **Protein binding:** The high content of arginine and serine residues in RSRC1 suggests its ability to interact with other proteins, potentially regulating protein-protein interactions and signaling pathways. **Clinical Significance:** Despite its widespread expression, the clinical significance of RSRC1 remains unclear. However, its involvement in immune regulation and its expression in various cell types suggest potential roles in disease. For example, alterations in RSRC1 expression or function may contribute to immune disorders, such as autoimmune diseases or immunodeficiencies. Further research is needed to elucidate the functional implications of RSRC1 and its potential role in human disease. In conclusion, RSRC1 is a gene with a complex and multifaceted role in cellular processes. Its involvement in alternative mRNA splicing, nuclear speck formation, nucleocytoplasmic transport, and protein binding suggests its potential role in regulating gene expression, cellular homeostasis, and immune function. Further research is needed to fully elucidate the functional implications of RSRC1 and its potential role in human disease.

Genular Protein ID: 464357967

Symbol: RSRC1_HUMAN

Name: Serine/Arginine-related protein 53

UniProtKB Accession Codes:

Q96IZ7 A8K2R9 Q96QK2 Q9NZE5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 5 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15798186

Title: A novel SR-related protein is required for the second step of pre-mRNA splicing.

PubMed ID: 15798186

DOI: 10.1128/mcb.25.8.2969-2980.2005

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 29522154

Title: RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3.

PubMed ID: 29522154

DOI: 10.1093/brain/awy045

PubMed ID: 28640246

Title: GWAS signals revisited using human knockouts.

PubMed ID: 28640246

DOI: 10.1038/gim.2017.78

Sequence Information:

  • Length: 334
  • Mass: 38677
  • Checksum: DF31CC8C953E790A
  • Sequence:
    • MGRRSSDTEE ESRSKRKKKH RRRSSSSSSS DSRTYSRKKG GRKSRSKSRS WSRDLQPRSH 
SYDRRRRHRS SSSSSYGSRR KRSRSRSRGR GKSYRVQRSR SKSRTRRSRS RPRLRSHSRS 
SERSSHRRTR SRSRDRERRK GRDKEKREKE KDKGKDKELH NIKRGESGNI KAGLEHLPPA 
EQAKARLQLV LEAAAKADEA LKAKERNEEE AKRRKEEDQA TLVEQVKRVK EIEAIESDSF 
VQQTFRSSKE VKKSVEPSEV KQATSTSGPA SAVADPPSTE KEIDPTSIPT AIKYQDDNSL 
AHPNLFIEKA DAEEKWFKRL IALRQERLMG SPVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.