Details for: AMZ2

Gene ID: 51321

Symbol: AMZ2

Ensembl ID: ENSG00000196704

Description: archaelysin family metallopeptidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 158.7320
    Cell Significance Index: -24.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.1516
    Cell Significance Index: -23.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.3582
    Cell Significance Index: -28.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.1958
    Cell Significance Index: -26.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.1025
    Cell Significance Index: -29.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.3671
    Cell Significance Index: -28.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.4943
    Cell Significance Index: -26.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9067
    Cell Significance Index: -27.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7032
    Cell Significance Index: -23.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0463
    Cell Significance Index: -27.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0511
    Cell Significance Index: -16.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7147
    Cell Significance Index: -8.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7056
    Cell Significance Index: 36.3300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1621
    Cell Significance Index: 8.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0506
    Cell Significance Index: 63.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7504
    Cell Significance Index: 122.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7340
    Cell Significance Index: 86.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6643
    Cell Significance Index: 19.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5354
    Cell Significance Index: 27.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5201
    Cell Significance Index: 104.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5170
    Cell Significance Index: 66.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5160
    Cell Significance Index: 27.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4978
    Cell Significance Index: 13.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4597
    Cell Significance Index: 31.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4467
    Cell Significance Index: 841.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4307
    Cell Significance Index: 52.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4193
    Cell Significance Index: 75.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4069
    Cell Significance Index: 367.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3550
    Cell Significance Index: 7.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3259
    Cell Significance Index: 44.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3212
    Cell Significance Index: 175.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3001
    Cell Significance Index: 13.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2744
    Cell Significance Index: 7.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2546
    Cell Significance Index: 161.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2467
    Cell Significance Index: 3.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2190
    Cell Significance Index: 16.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2139
    Cell Significance Index: 94.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1775
    Cell Significance Index: 33.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1726
    Cell Significance Index: 29.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1512
    Cell Significance Index: 14.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1449
    Cell Significance Index: 9.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1413
    Cell Significance Index: 50.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1410
    Cell Significance Index: 3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1191
    Cell Significance Index: 4.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1107
    Cell Significance Index: 1.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1025
    Cell Significance Index: 2.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0820
    Cell Significance Index: 56.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0802
    Cell Significance Index: 10.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0658
    Cell Significance Index: 13.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0525
    Cell Significance Index: 3.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0221
    Cell Significance Index: 1.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0181
    Cell Significance Index: 1.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0179
    Cell Significance Index: 0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0131
    Cell Significance Index: 0.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0022
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0151
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0200
    Cell Significance Index: -2.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0570
    Cell Significance Index: -12.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0607
    Cell Significance Index: -1.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0852
    Cell Significance Index: -2.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0936
    Cell Significance Index: -2.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0975
    Cell Significance Index: -28.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1072
    Cell Significance Index: -12.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1168
    Cell Significance Index: -1.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1244
    Cell Significance Index: -14.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1380
    Cell Significance Index: -4.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1429
    Cell Significance Index: -2.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1517
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1770
    Cell Significance Index: -20.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1837
    Cell Significance Index: -12.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2009
    Cell Significance Index: -12.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2058
    Cell Significance Index: -4.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2101
    Cell Significance Index: -16.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2425
    Cell Significance Index: -4.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2470
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2819
    Cell Significance Index: -22.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2853
    Cell Significance Index: -16.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3287
    Cell Significance Index: -14.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3630
    Cell Significance Index: -4.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4294
    Cell Significance Index: -16.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4655
    Cell Significance Index: -28.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4745
    Cell Significance Index: -13.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5152
    Cell Significance Index: -16.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5211
    Cell Significance Index: -16.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5425
    Cell Significance Index: -15.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5599
    Cell Significance Index: -18.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5685
    Cell Significance Index: -20.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5738
    Cell Significance Index: -16.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5746
    Cell Significance Index: -20.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Patterns:** AMZ2 is significantly expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, mucosal type mast cells, smooth muscle fibers of the ileum, peripheral blood mononuclear cells, ciliated cells of the bronchus, orthochromatic erythroblasts, CD8-positive, alpha-beta regulatory T cells, and stromal cells of bone marrow. This widespread expression suggests a multifaceted role in various cellular processes. 2. **Metallopeptidase Activity:** AMZ2 possesses metallopeptidase activity, which implies its ability to catalyze the hydrolysis of peptide bonds in metal-bound substrates. This enzymatic activity is crucial for protein degradation and cellular homeostasis. 3. **Metal Ion Binding:** The gene's association with metal ion binding suggests its potential involvement in the regulation of metal-dependent enzymatic activities. **Pathways and Functions:** 1. **Cellular Component:** AMZ2 is associated with the cellular component, indicating its role in maintaining cellular structure and function. 2. **Metal Ion Binding:** Metal ion binding is a critical function of AMZ2, which may involve the regulation of metal-dependent enzymatic activities. 3. **Metallopeptidase Activity:** AMZ2's metallopeptidase activity is essential for protein degradation and cellular homeostasis. 4. **Proteolysis:** The gene's involvement in proteolysis suggests its role in regulating protein turnover and cellular signaling pathways. **Clinical Significance:** 1. **Immune Regulation:** AMZ2's expression in regulatory T cells and other immune cells suggests its potential role in immune regulation and tolerance. 2. **Cancer and Inflammation:** The gene's involvement in proteolysis and metal ion binding may have implications for cancer progression and inflammation. 3. **Neurological Disorders:** AMZ2's expression in ciliated cells of the bronchus and other cell types raises questions about its potential involvement in neurological disorders, such as neurodegenerative diseases. 4. **Disease Association:** Further research is needed to establish the relationship between AMZ2 and various diseases, including cancer, autoimmune disorders, and neurological conditions. In conclusion, the AMZ2 gene is a complex and multifaceted molecule with far-reaching implications for immune regulation, cellular homeostasis, and disease. Further studies are necessary to unravel the intricacies of this gene's function and its potential applications in the diagnosis and treatment of various diseases.

Genular Protein ID: 1329708381

Symbol: AMZ2_HUMAN

Name: Archaemetzincin-2

UniProtKB Accession Codes:

Q86W34 A6NLD9 B3KR44 Q5XKF1 Q9NZE2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 8 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 18 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15972818

Title: Identification and characterization of human archaemetzincin-1 and - 2, two novel members of a family of metalloproteases widely distributed in Archaea.

PubMed ID: 15972818

DOI: 10.1074/jbc.m504533200

PubMed ID: 30808005

Title:

PubMed ID: 30808005

DOI: 10.1074/jbc.w118.007328

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17074343

Title: Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue.

PubMed ID: 17074343

DOI: 10.1016/j.fertnstert.2006.04.039

Sequence Information:

  • Length: 360
  • Mass: 41263
  • Checksum: D74E7F7CE7873CBF
  • Sequence:
    • MQIIRHSEQT LKTALISKNP VLVSQYEKLN AGEQRLMNEA FQPASDLFGP ITLHSPSDWI 
TSHPEAPQDF EQFFSDPYRK TPSPNKRSIY IQSIGSLGNT RIISEEYIKW LTGYCKAYFY 
GLRVKLLEPV PVSVTRCSFR VNENTHNLQI HAGDILKFLK KKKPEDAFCV VGITMIDLYP 
RDSWNFVFGQ ASLTDGVGIF SFARYGSDFY SMHYKGKVKK LKKTSSSDYS IFDNYYIPEI 
TSVLLLRSCK TLTHEIGHIF GLRHCQWLAC LMQGSNHLEE ADRRPLNLCP ICLHKLQCAV 
GFSIVERYKA LVRWIDDESS DTPGATPEHS HEDNGNLPKP VEAFKEWKEW IIKCLAVLQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.