Details for: ZMYND10

Gene ID: 51364

Symbol: ZMYND10

Ensembl ID: ENSG00000004838

Description: zinc finger MYND-type containing 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 30.8592
    Cell Significance Index: -4.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.5156
    Cell Significance Index: -4.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 13.3998
    Cell Significance Index: -5.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.3875
    Cell Significance Index: -4.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.0310
    Cell Significance Index: -4.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.7706
    Cell Significance Index: -3.6000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.3564
    Cell Significance Index: 23.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8016
    Cell Significance Index: 18.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7904
    Cell Significance Index: 431.6400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.4660
    Cell Significance Index: 4.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4097
    Cell Significance Index: 25.8200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4036
    Cell Significance Index: 5.6000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.3925
    Cell Significance Index: 3.8400
  • Cell Name: primary cultured cell (CL0000001)
    Fold Change: 0.3423
    Cell Significance Index: 1.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2779
    Cell Significance Index: 4.5800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.2475
    Cell Significance Index: 2.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1306
    Cell Significance Index: 2.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0952
    Cell Significance Index: 1.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0831
    Cell Significance Index: 15.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0682
    Cell Significance Index: 47.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0330
    Cell Significance Index: 29.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0321
    Cell Significance Index: 0.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0242
    Cell Significance Index: 0.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0184
    Cell Significance Index: 3.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0140
    Cell Significance Index: 1.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0106
    Cell Significance Index: 1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0059
    Cell Significance Index: 0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0019
    Cell Significance Index: 0.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0019
    Cell Significance Index: 0.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -1.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0029
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0036
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0044
    Cell Significance Index: -3.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0052
    Cell Significance Index: -1.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0060
    Cell Significance Index: -0.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0073
    Cell Significance Index: -4.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0086
    Cell Significance Index: -1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0122
    Cell Significance Index: -1.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0128
    Cell Significance Index: -0.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0171
    Cell Significance Index: -1.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0215
    Cell Significance Index: -2.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0218
    Cell Significance Index: -0.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0256
    Cell Significance Index: -3.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0256
    Cell Significance Index: -3.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0259
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0266
    Cell Significance Index: -5.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0283
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0285
    Cell Significance Index: -0.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0346
    Cell Significance Index: -2.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0349
    Cell Significance Index: -2.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0357
    Cell Significance Index: -4.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0375
    Cell Significance Index: -2.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0386
    Cell Significance Index: -2.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0416
    Cell Significance Index: -2.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0435
    Cell Significance Index: -5.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0471
    Cell Significance Index: -4.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0523
    Cell Significance Index: -3.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0541
    Cell Significance Index: -4.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0628
    Cell Significance Index: -4.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0664
    Cell Significance Index: -3.4600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0671
    Cell Significance Index: -0.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0685
    Cell Significance Index: -3.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0699
    Cell Significance Index: -1.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0714
    Cell Significance Index: -4.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0790
    Cell Significance Index: -4.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0818
    Cell Significance Index: -3.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0868
    Cell Significance Index: -4.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0963
    Cell Significance Index: -4.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0990
    Cell Significance Index: -3.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1029
    Cell Significance Index: -3.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1042
    Cell Significance Index: -1.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1068
    Cell Significance Index: -3.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1095
    Cell Significance Index: -4.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1130
    Cell Significance Index: -4.2800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1162
    Cell Significance Index: -1.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1186
    Cell Significance Index: -3.8000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1211
    Cell Significance Index: -1.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1239
    Cell Significance Index: -3.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1279
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1301
    Cell Significance Index: -4.2600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1409
    Cell Significance Index: -1.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1439
    Cell Significance Index: -7.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1454
    Cell Significance Index: -3.8900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1493
    Cell Significance Index: -1.5400
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1497
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1529
    Cell Significance Index: -3.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1582
    Cell Significance Index: -4.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZMYND10 is a MYND-type zinc finger protein, characterized by its unique zinc finger domain, which is crucial for protein-protein interactions and binding to specific DNA sequences. The gene's expression is predominantly observed in cells with cilia, such as ciliated epithelial cells, bronchial ciliated cells, and peg cells, highlighting its involvement in cilia assembly and function. ZMYND10 is also implicated in protein folding and localization to the cilium, suggesting a broader role in protein quality control and cellular organization. **Pathways and Functions:** The ZMYND10 gene is involved in the following pathways and processes: 1. **Motile Cilium Assembly**: ZMYND10 plays a crucial role in the positive regulation of motile cilium assembly, a process essential for maintaining proper respiratory function and immune system homeostasis. 2. **Protein Binding**: ZMYND10 interacts with other proteins, such as dynein axonemal particles and dynein arms, to regulate cilia assembly and function. 3. **Protein Folding**: ZMYND10 is involved in protein folding and localization to the cilium, suggesting a broader role in protein quality control and cellular organization. 4. **Metal Ion Binding**: ZMYND10 binds to metal ions, which is essential for its protein-protein interactions and DNA binding. **Clinical Significance:** Dysregulation of ZMYND10 has been implicated in various diseases, including: 1. **Primary Ciliary Dyskinesia (PCD)**: ZMYND10 mutations have been identified in patients with PCD, a rare genetic disorder characterized by respiratory and immune system dysfunction. 2. **Respiratory Infections**: Impaired cilia function due to ZMYND10 dysfunction can lead to increased susceptibility to respiratory infections. 3. **Ciliary Epithelial Cell Dysfunction**: ZMYND10's role in cilia assembly and function suggests that its dysfunction can also impact ciliary epithelial cell function, leading to various respiratory and immune system disorders. In conclusion, the ZMYND10 gene is a critical component of the cilia assembly and regulation machinery, and its dysregulation can have significant clinical implications. Further research is necessary to fully elucidate the mechanisms by which ZMYND10 regulates cilia function and to explore its therapeutic potential in treating diseases associated with cilia dysfunction.

Genular Protein ID: 1804283329

Symbol: ZMY10_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75800 A6NK41 B3KU54 O14570 O75801 Q53FE6 Q8N4R6 Q8NDN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11085536

Title: The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.

PubMed ID: 11085536

PubMed ID: 23891469

Title: ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.

PubMed ID: 23891469

DOI: 10.1016/j.ajhg.2013.06.007

PubMed ID: 23891471

Title: Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.

PubMed ID: 23891471

DOI: 10.1016/j.ajhg.2013.07.009

PubMed ID: 25186273

Title: Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.

PubMed ID: 25186273

DOI: 10.1183/09031936.00052014

PubMed ID: 29601588

Title: ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.

PubMed ID: 29601588

DOI: 10.1371/journal.pgen.1007316

Sequence Information:

  • Length: 440
  • Mass: 50344
  • Checksum: 510D41074C956CA3
  • Sequence:
    • MGDLELLLPG EAEVLVRGLR SFPLREMGSE GWNQQHENLE KLNMQAILDA TVSQGEPIQE 
LLVTHGKVPT LVEELIAVEM WKQKVFPVFC RVEDFKPQNT FPIYMVVHHE ASIINLLETV 
FFHKEVCESA EDTVLDLVDY CHRKLTLLVA QSGCGGPPEG EGSQDSNPMQ ELQKQAELME 
FEIALKALSV LRYITDCVDS LSLSTLSRML STHNLPCLLV ELLEHSPWSR REGGKLQQFE 
GSRWHTVAPS EQQKLSKLDG QVWIALYNLL LSPEAQARYC LTSFAKGRLL KLRAFLTDTL 
LDQLPNLAHL QSFLAHLTLT ETQPPKKDLV LEQIPEIWER LERENRGKWQ AIAKHQLQHV 
FSPSEQDLRL QARRWAETYR LDVLEAVAPE RPRCAYCSAE ASKRCSRCQN EWYCCRECQV 
KHWEKHGKTC VLAAQGDRAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.