Details for: POP5

Gene ID: 51367

Symbol: POP5

Ensembl ID: ENSG00000167272

Description: POP5 homolog, ribonuclease P/MRP subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.5233
    Cell Significance Index: -21.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.7723
    Cell Significance Index: -17.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.3866
    Cell Significance Index: -25.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.9267
    Cell Significance Index: -25.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.3611
    Cell Significance Index: -25.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.9868
    Cell Significance Index: -25.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.2359
    Cell Significance Index: -24.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6117
    Cell Significance Index: -26.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5186
    Cell Significance Index: -16.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4982
    Cell Significance Index: -12.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.3210
    Cell Significance Index: 427.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2744
    Cell Significance Index: -9.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8861
    Cell Significance Index: 113.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6571
    Cell Significance Index: 180.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3012
    Cell Significance Index: 211.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2223
    Cell Significance Index: 142.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1773
    Cell Significance Index: 54.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9939
    Cell Significance Index: 13.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9450
    Cell Significance Index: 49.0900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8337
    Cell Significance Index: 57.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8064
    Cell Significance Index: 21.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7987
    Cell Significance Index: 51.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7324
    Cell Significance Index: 16.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7267
    Cell Significance Index: 131.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6919
    Cell Significance Index: 85.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6673
    Cell Significance Index: 364.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6353
    Cell Significance Index: 74.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5969
    Cell Significance Index: 263.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5956
    Cell Significance Index: 42.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5267
    Cell Significance Index: 475.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4824
    Cell Significance Index: 21.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4538
    Cell Significance Index: 13.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4496
    Cell Significance Index: 4.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4355
    Cell Significance Index: 59.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3767
    Cell Significance Index: 74.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3577
    Cell Significance Index: 7.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3346
    Cell Significance Index: 42.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3203
    Cell Significance Index: 11.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3175
    Cell Significance Index: 14.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3037
    Cell Significance Index: 3.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2503
    Cell Significance Index: 13.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2426
    Cell Significance Index: 18.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2271
    Cell Significance Index: 14.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1979
    Cell Significance Index: 25.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1850
    Cell Significance Index: 5.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1848
    Cell Significance Index: 37.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1561
    Cell Significance Index: 29.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1559
    Cell Significance Index: 4.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1413
    Cell Significance Index: 3.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1280
    Cell Significance Index: 3.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1071
    Cell Significance Index: 2.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0638
    Cell Significance Index: 22.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0452
    Cell Significance Index: 1.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0357
    Cell Significance Index: 26.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0233
    Cell Significance Index: 17.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0150
    Cell Significance Index: 27.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0124
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0065
    Cell Significance Index: 9.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0067
    Cell Significance Index: -0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0090
    Cell Significance Index: -0.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0136
    Cell Significance Index: -0.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0149
    Cell Significance Index: -9.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0185
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0235
    Cell Significance Index: -4.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0236
    Cell Significance Index: -16.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0315
    Cell Significance Index: -23.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0387
    Cell Significance Index: -21.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0415
    Cell Significance Index: -18.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0472
    Cell Significance Index: -29.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0502
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0577
    Cell Significance Index: -8.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0700
    Cell Significance Index: -20.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0755
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1232
    Cell Significance Index: -9.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1391
    Cell Significance Index: -29.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1404
    Cell Significance Index: -16.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1490
    Cell Significance Index: -9.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1864
    Cell Significance Index: -10.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1965
    Cell Significance Index: -15.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2399
    Cell Significance Index: -2.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2413
    Cell Significance Index: -25.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2741
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2783
    Cell Significance Index: -18.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3322
    Cell Significance Index: -6.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3396
    Cell Significance Index: -9.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4118
    Cell Significance Index: -12.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4169
    Cell Significance Index: -18.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4173
    Cell Significance Index: -4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4184
    Cell Significance Index: -25.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4833
    Cell Significance Index: -4.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4851
    Cell Significance Index: -18.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5524
    Cell Significance Index: -14.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5529
    Cell Significance Index: -15.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5534
    Cell Significance Index: -20.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6029
    Cell Significance Index: -19.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6094
    Cell Significance Index: -21.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6117
    Cell Significance Index: -10.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The POP5 gene encodes a subunit of the ribonuclease P/MRP complex, which consists of two main subunits: POP5 and POP6. The POP5 subunit is responsible for the catalytic activity of the complex, specifically the removal of the 5'-leader sequence from tRNA precursors. This process is essential for the maturation of tRNA molecules, which are required for protein synthesis. The POP5 subunit also interacts with other proteins and RNAs to regulate the activity of the RNase P complex. **Pathways and Functions:** The POP5 gene is involved in several key pathways, including: 1. **RNA processing:** The POP5 subunit plays a critical role in the maturation of tRNA precursors, which is essential for protein synthesis. 2. **Immune regulation:** The POP5 subunit is highly expressed in immune cells, including T cells and monocytes, and is involved in the regulation of immune responses. 3. **Cell cycle regulation:** The POP5 subunit is also involved in the regulation of cell cycle progression, particularly in the G1 phase. 4. **Stem cell maintenance:** The POP5 subunit is expressed in embryonic stem cells and is required for their maintenance and differentiation. **Clinical Significance:** Dysregulation of the POP5 gene has been implicated in several diseases, including: 1. **Cancer:** The POP5 subunit is overexpressed in several types of cancer, including leukemia and lymphoma. 2. **Autoimmune disorders:** The POP5 subunit is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative diseases:** The POP5 subunit is also involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the POP5 gene is a critical component of the ribonuclease P/MRP complex, which plays a key role in RNA processing and immune regulation. Its dysregulation has been implicated in several diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which the POP5 gene regulates these processes and to explore its potential as a therapeutic target.

Genular Protein ID: 2671875999

Symbol: POP5_HUMAN

Name: Ribonuclease P/MRP protein subunit POP5

UniProtKB Accession Codes:

Q969H6 A6NL80 Q53FS5 Q9Y2Q6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 Ensembl 2 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11413139

Title: hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases.

PubMed ID: 11413139

DOI: 10.1074/jbc.m103399200

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15096576

Title: Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.

PubMed ID: 15096576

DOI: 10.1093/nar/gkh539

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 16723659

Title: Differential association of protein subunits with the human RNase MRP and RNase P complexes.

PubMed ID: 16723659

DOI: 10.1261/rna.2293906

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 28115465

Title: Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

PubMed ID: 28115465

DOI: 10.1101/gad.286963.116

PubMed ID: 30454648

Title: Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.

PubMed ID: 30454648

DOI: 10.1016/j.cell.2018.10.003

Sequence Information:

  • Length: 163
  • Mass: 18820
  • Checksum: DF436E60B3DD50C1
  • Sequence:
    • MVRFKHRYLL CELVSDDPRC RLSLDDRVLS SLVRDTIARV HGTFGAAACS IGFAVRYLNA 
YTGIVLLRCR KEFYQLVWSA LPFITYLENK GHRYPCFFNT LHVGGTIRTC QKFLIQYNRR 
QLLILLQNCT DEGEREAIQK SVTRSCLLEE EEESGEEAAE AME

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.