Details for: ATRAID

Gene ID: 51374

Symbol: ATRAID

Ensembl ID: ENSG00000138085

Description: all-trans retinoic acid induced differentiation factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 367.9959
    Cell Significance Index: -57.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.8228
    Cell Significance Index: -47.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.0954
    Cell Significance Index: -57.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.1614
    Cell Significance Index: -60.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.1837
    Cell Significance Index: -58.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 91.4277
    Cell Significance Index: -61.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.4641
    Cell Significance Index: -62.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2403
    Cell Significance Index: -64.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.5273
    Cell Significance Index: -44.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9388
    Cell Significance Index: -37.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5300
    Cell Significance Index: -16.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.2537
    Cell Significance Index: 44.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7898
    Cell Significance Index: 176.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1142
    Cell Significance Index: 84.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0216
    Cell Significance Index: 69.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.9727
    Cell Significance Index: 23.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6376
    Cell Significance Index: 362.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1382
    Cell Significance Index: 56.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1251
    Cell Significance Index: 383.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.1088
    Cell Significance Index: 44.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0117
    Cell Significance Index: 247.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9574
    Cell Significance Index: 18.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8158
    Cell Significance Index: 23.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7992
    Cell Significance Index: 20.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7751
    Cell Significance Index: 132.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7214
    Cell Significance Index: 220.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6739
    Cell Significance Index: 914.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5159
    Cell Significance Index: 78.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3932
    Cell Significance Index: 98.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3586
    Cell Significance Index: 600.6600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3294
    Cell Significance Index: 7.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1795
    Cell Significance Index: 55.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0421
    Cell Significance Index: 134.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0045
    Cell Significance Index: 29.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9859
    Cell Significance Index: 34.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8748
    Cell Significance Index: 9.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8160
    Cell Significance Index: 132.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7984
    Cell Significance Index: 136.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6939
    Cell Significance Index: 44.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4637
    Cell Significance Index: 54.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4219
    Cell Significance Index: 7.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3678
    Cell Significance Index: 16.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3610
    Cell Significance Index: 9.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3492
    Cell Significance Index: 9.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2634
    Cell Significance Index: 52.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2187
    Cell Significance Index: 41.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1675
    Cell Significance Index: 4.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1082
    Cell Significance Index: 81.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1027
    Cell Significance Index: 6.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1012
    Cell Significance Index: 74.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0890
    Cell Significance Index: 2.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0828
    Cell Significance Index: 1.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0156
    Cell Significance Index: 0.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0130
    Cell Significance Index: 1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0037
    Cell Significance Index: -0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0118
    Cell Significance Index: -22.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0325
    Cell Significance Index: -20.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0360
    Cell Significance Index: -66.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0439
    Cell Significance Index: -67.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0545
    Cell Significance Index: -37.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0549
    Cell Significance Index: -74.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0558
    Cell Significance Index: -20.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0674
    Cell Significance Index: -42.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0676
    Cell Significance Index: -13.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0694
    Cell Significance Index: -39.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1062
    Cell Significance Index: -22.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1148
    Cell Significance Index: -52.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1164
    Cell Significance Index: -33.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1313
    Cell Significance Index: -15.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1751
    Cell Significance Index: -3.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1834
    Cell Significance Index: -21.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2430
    Cell Significance Index: -8.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2710
    Cell Significance Index: -2.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2882
    Cell Significance Index: -9.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2897
    Cell Significance Index: -7.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3437
    Cell Significance Index: -49.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4104
    Cell Significance Index: -46.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4226
    Cell Significance Index: -11.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4372
    Cell Significance Index: -8.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4706
    Cell Significance Index: -26.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5295
    Cell Significance Index: -41.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5452
    Cell Significance Index: -14.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5805
    Cell Significance Index: -7.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6045
    Cell Significance Index: -3.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6067
    Cell Significance Index: -63.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6978
    Cell Significance Index: -53.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7062
    Cell Significance Index: -28.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7614
    Cell Significance Index: -46.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7819
    Cell Significance Index: -16.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7869
    Cell Significance Index: -9.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8485
    Cell Significance Index: -42.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8990
    Cell Significance Index: -60.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9951
    Cell Significance Index: -61.0100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.1102
    Cell Significance Index: -6.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1657
    Cell Significance Index: -34.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1808
    Cell Significance Index: -16.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2029
    Cell Significance Index: -30.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.2427
    Cell Significance Index: -17.4300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -1.2737
    Cell Significance Index: -7.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ATRAID is a gene with a single nucleotide sequence (ENSG00000138085). Its expression is widespread across various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, and epithelial cells. The protein encoded by ATRAID, ARAID_HUMAN, is a transcription factor that regulates gene expression and interacts with various cellular components, including the nuclear envelope, lysosomal membrane, and plasma membrane. **Pathways and Functions:** ATRAID is involved in several cellular pathways, including: 1. **Cell Differentiation:** ATRAID plays a crucial role in regulating cell differentiation, particularly in hematopoietic cells and epithelial cells. It influences the transition of cells from a proliferative to a differentiated state, which is essential for tissue development and homeostasis. 2. **Gene Expression:** ATRAID regulates gene expression by interacting with transcription factors and influencing the expression of specific genes involved in cellular differentiation, proliferation, and survival. 3. **Bone Mineralization:** ATRAID is involved in the regulation of bone mineralization, a process that is critical for bone development and homeostasis. It promotes the differentiation of osteoblasts, the cells responsible for bone formation. 4. **Osteoblast Differentiation:** ATRAID is a key regulator of osteoblast differentiation, influencing the expression of genes involved in bone formation and mineralization. 5. **Protein Catabolic Process:** ATRAID is also involved in regulating protein catabolic processes, which are essential for maintaining cellular homeostasis and preventing protein degradation. **Clinical Significance:** ATRAID's involvement in cellular processes has significant implications for various diseases, including: 1. **Leukemia:** ATRAID is expressed in hematopoietic cells and has been implicated in the pathogenesis of leukemia. Its dysregulation may contribute to the development of leukemia by promoting cell proliferation and preventing differentiation. 2. **Bone Disorders:** ATRAID's involvement in bone mineralization and osteoblast differentiation makes it a potential therapeutic target for diseases related to bone disorders, such as osteoporosis and bone cancer. 3. **Immune System Disorders:** ATRAID's expression in immune cells, including T cells and dendritic cells, suggests that it may play a role in the regulation of immune responses and the development of immune-related disorders. In conclusion, ATRAID is a multifunctional gene that plays a critical role in regulating cellular processes, including cell differentiation, gene expression, and bone mineralization. Its dysregulation has significant implications for various diseases, making it a potential therapeutic target for the development of novel treatments. Further research is needed to fully elucidate the role of ATRAID in human health and disease.

Genular Protein ID: 1523901612

Symbol: ARAID_HUMAN

Name: All-trans retinoic acid-induced differentiation factor

UniProtKB Accession Codes:

Q6UW56 A8C1S2 A8K779 Q96FF6 Q96RT2 Q9Y2R7 Q9Y5L7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10948432

Title: Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes.

PubMed ID: 10948432

DOI: 10.2144/00292st06

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17524364

Title: Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1.

PubMed ID: 17524364

DOI: 10.1016/j.bbrc.2007.05.049

PubMed ID: 17387583

Title: Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB.

PubMed ID: 17387583

DOI: 10.1007/s11010-007-9440-7

PubMed ID: 21723284

Title: NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation.

PubMed ID: 21723284

DOI: 10.1016/j.febslet.2011.06.024

PubMed ID: 29745899

Title: Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

PubMed ID: 29745899

DOI: 10.7554/elife.36620

Sequence Information:

  • Length: 229
  • Mass: 24747
  • Checksum: CF051C5E886BCFF1
  • Sequence:
    • MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF YCKTTRELML 
HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL QANPLKGDLA NTFRGFTQLQ 
TLILPQHVNC PGGINAWNTI TSYIDNQICQ GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ 
CVCADGFHGY KCMRQGSFSL LMFFGILGAT TLSVSILLWA TQRRKAKTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.