Details for: ATP6V1D

Gene ID: 51382

Symbol: ATP6V1D

Ensembl ID: ENSG00000100554

Description: ATPase H+ transporting V1 subunit D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 278.1828
    Cell Significance Index: -43.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 187.3497
    Cell Significance Index: -47.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.3740
    Cell Significance Index: -47.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.6794
    Cell Significance Index: -51.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.8997
    Cell Significance Index: -42.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.6349
    Cell Significance Index: -47.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.7635
    Cell Significance Index: -51.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2632
    Cell Significance Index: -42.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.4766
    Cell Significance Index: -47.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0222
    Cell Significance Index: -45.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1461
    Cell Significance Index: -51.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.7050
    Cell Significance Index: -32.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5672
    Cell Significance Index: -18.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.4570
    Cell Significance Index: 519.4100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.3290
    Cell Significance Index: 35.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0448
    Cell Significance Index: 18.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7314
    Cell Significance Index: 89.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6734
    Cell Significance Index: 87.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2942
    Cell Significance Index: 233.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1166
    Cell Significance Index: 137.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0083
    Cell Significance Index: 550.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9798
    Cell Significance Index: 196.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9411
    Cell Significance Index: 25.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8571
    Cell Significance Index: 23.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7509
    Cell Significance Index: 35.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6914
    Cell Significance Index: 32.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6844
    Cell Significance Index: 31.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6289
    Cell Significance Index: 86.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5304
    Cell Significance Index: 105.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4664
    Cell Significance Index: 59.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4651
    Cell Significance Index: 205.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4635
    Cell Significance Index: 34.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4367
    Cell Significance Index: 156.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4107
    Cell Significance Index: 40.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3887
    Cell Significance Index: 24.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3792
    Cell Significance Index: 48.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3245
    Cell Significance Index: 8.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3176
    Cell Significance Index: 20.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3165
    Cell Significance Index: 24.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2825
    Cell Significance Index: 19.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2086
    Cell Significance Index: 4.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1728
    Cell Significance Index: 4.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1563
    Cell Significance Index: 4.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1554
    Cell Significance Index: 10.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1472
    Cell Significance Index: 101.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1461
    Cell Significance Index: 27.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1436
    Cell Significance Index: 16.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1108
    Cell Significance Index: 208.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0977
    Cell Significance Index: 2.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0620
    Cell Significance Index: 45.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0609
    Cell Significance Index: 3.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0446
    Cell Significance Index: 82.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0361
    Cell Significance Index: 55.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0275
    Cell Significance Index: 4.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0147
    Cell Significance Index: 0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0073
    Cell Significance Index: 5.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0026
    Cell Significance Index: 3.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0010
    Cell Significance Index: 0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0307
    Cell Significance Index: -13.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0513
    Cell Significance Index: -28.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0613
    Cell Significance Index: -6.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0780
    Cell Significance Index: -2.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0823
    Cell Significance Index: -1.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0857
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0922
    Cell Significance Index: -19.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0977
    Cell Significance Index: -2.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1312
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1323
    Cell Significance Index: -15.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1447
    Cell Significance Index: -41.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1664
    Cell Significance Index: -24.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1676
    Cell Significance Index: -2.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1808
    Cell Significance Index: -3.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2231
    Cell Significance Index: -4.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2261
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2319
    Cell Significance Index: -26.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2652
    Cell Significance Index: -21.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3102
    Cell Significance Index: -4.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3124
    Cell Significance Index: -13.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3248
    Cell Significance Index: -6.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3322
    Cell Significance Index: -10.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3355
    Cell Significance Index: -8.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4009
    Cell Significance Index: -15.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4313
    Cell Significance Index: -26.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4326
    Cell Significance Index: -8.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4458
    Cell Significance Index: -46.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4656
    Cell Significance Index: -5.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4782
    Cell Significance Index: -10.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4895
    Cell Significance Index: -14.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5868
    Cell Significance Index: -16.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6195
    Cell Significance Index: -32.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6206
    Cell Significance Index: -18.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7272
    Cell Significance Index: -9.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8189
    Cell Significance Index: -50.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8222
    Cell Significance Index: -12.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8681
    Cell Significance Index: -5.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9286
    Cell Significance Index: -23.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9350
    Cell Significance Index: -25.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9505
    Cell Significance Index: -13.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proton transport**: The VATD protein is a key component of the V-ATPase complex, responsible for transporting protons across cellular membranes, thereby regulating cellular pH homeostasis. 2. **Cellular localization**: The VATD protein is predominantly expressed in cells involved in immune responses, such as neutrophils, mast cells, and epithelial cells lining the gastrointestinal tract. 3. **Hematopoietic expression**: The VATD gene is also expressed in cells involved in hematopoiesis, including hematopoietic oligopotent progenitor cells and polychromatophilic erythroblasts. 4. **Regulation of cellular processes**: The VATD protein is involved in various cellular processes, including immune responses, cellular responses to stress, and regulation of macroautophagy. **Pathways and Functions:** 1. **V-ATPase complex**: The VATD protein is a key component of the V-ATPase complex, which is responsible for transporting protons across cellular membranes, thereby regulating cellular pH homeostasis. 2. **Immune responses**: The VATD protein plays a critical role in immune responses, including neutrophil degranulation and lysosomal lumen acidification. 3. **Regulation of cellular pH**: The VATD protein helps regulate cellular pH homeostasis by transporting protons across cellular membranes. 4. **Regulation of macroautophagy**: The VATD protein is involved in the regulation of macroautophagy, a process by which cells recycle damaged or dysfunctional cellular components. 5. **Regulation of mitf-m-dependent genes**: The VATD protein is involved in the regulation of mitf-m-dependent genes involved in lysosome biogenesis and autophagy. **Clinical Significance:** 1. **Immune disorders**: Mutations in the VATD gene have been associated with immune disorders, including neutrophil dysfunction and impaired lysosomal function. 2. **Cancer**: The VATD protein has been implicated in cancer, where it plays a role in regulating cellular pH homeostasis and immune responses. 3. **Neurological disorders**: The VATD protein has been implicated in neurological disorders, including Parkinson's disease, where it plays a role in regulating cellular pH homeostasis and immune responses. 4. **Gastrointestinal disorders**: The VATD protein has been implicated in gastrointestinal disorders, including inflammatory bowel disease, where it plays a role in regulating cellular pH homeostasis and immune responses. In conclusion, the ATP6V1D gene encodes for the VATD protein, a critical component of the V-ATPase complex, which plays a pivotal role in regulating cellular pH homeostasis, immune responses, and cellular processes. The VATD protein is predominantly expressed in cells involved in immune responses and hematopoiesis, and its dysregulation has been implicated in various diseases, including immune disorders, cancer, neurological disorders, and gastrointestinal disorders.

Genular Protein ID: 1818507226

Symbol: VATD_HUMAN

Name: V-type proton ATPase subunit D

UniProtKB Accession Codes:

Q9Y5K8 B2RE33 Q9Y688

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21844891

Title: A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.

PubMed ID: 21844891

DOI: 10.1038/cr.2011.134

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 247
  • Mass: 28263
  • Checksum: 4185E5F6A74EFB1C
  • Sequence:
    • MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE 
VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE 
LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI 
ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK 
DEDLLFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.