Details for: COMMD10

Gene ID: 51397

Symbol: COMMD10

Ensembl ID: ENSG00000145781

Description: COMM domain containing 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 362.5312
    Cell Significance Index: -56.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 215.9331
    Cell Significance Index: -54.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 138.0273
    Cell Significance Index: -56.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.7769
    Cell Significance Index: -58.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 120.9086
    Cell Significance Index: -49.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.0987
    Cell Significance Index: -55.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.5113
    Cell Significance Index: -49.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.6416
    Cell Significance Index: -58.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.5382
    Cell Significance Index: -52.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2296
    Cell Significance Index: -35.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.0024
    Cell Significance Index: -59.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6441
    Cell Significance Index: 93.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.3918
    Cell Significance Index: 260.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.2856
    Cell Significance Index: 184.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1551
    Cell Significance Index: 427.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9438
    Cell Significance Index: 316.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9158
    Cell Significance Index: 37.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6729
    Cell Significance Index: 44.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6481
    Cell Significance Index: 330.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4571
    Cell Significance Index: 40.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3013
    Cell Significance Index: 466.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1871
    Cell Significance Index: 129.1200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1855
    Cell Significance Index: 17.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9927
    Cell Significance Index: 686.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9369
    Cell Significance Index: 22.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8379
    Cell Significance Index: 17.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5541
    Cell Significance Index: 8.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4845
    Cell Significance Index: 22.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4833
    Cell Significance Index: 32.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4811
    Cell Significance Index: 21.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4592
    Cell Significance Index: 250.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4460
    Cell Significance Index: 30.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4157
    Cell Significance Index: 15.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3338
    Cell Significance Index: 60.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3213
    Cell Significance Index: 2.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3180
    Cell Significance Index: 39.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2797
    Cell Significance Index: 177.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2742
    Cell Significance Index: 516.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2498
    Cell Significance Index: 11.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2474
    Cell Significance Index: 6.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2111
    Cell Significance Index: 324.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2099
    Cell Significance Index: 95.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1943
    Cell Significance Index: 358.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1866
    Cell Significance Index: 11.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1789
    Cell Significance Index: 8.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1585
    Cell Significance Index: 18.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1274
    Cell Significance Index: 17.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1096
    Cell Significance Index: 48.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0561
    Cell Significance Index: 76.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0445
    Cell Significance Index: 0.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0247
    Cell Significance Index: 2.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0346
    Cell Significance Index: -5.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0408
    Cell Significance Index: -29.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0474
    Cell Significance Index: -0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0531
    Cell Significance Index: -40.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0639
    Cell Significance Index: -47.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0916
    Cell Significance Index: -1.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0916
    Cell Significance Index: -11.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0952
    Cell Significance Index: -16.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0980
    Cell Significance Index: -10.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0990
    Cell Significance Index: -55.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1047
    Cell Significance Index: -65.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1251
    Cell Significance Index: -23.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1586
    Cell Significance Index: -20.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1675
    Cell Significance Index: -12.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1803
    Cell Significance Index: -51.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2242
    Cell Significance Index: -26.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2242
    Cell Significance Index: -14.1300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2518
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2914
    Cell Significance Index: -33.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2971
    Cell Significance Index: -62.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2980
    Cell Significance Index: -5.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3024
    Cell Significance Index: -15.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3160
    Cell Significance Index: -6.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3214
    Cell Significance Index: -11.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3492
    Cell Significance Index: -2.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3800
    Cell Significance Index: -39.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4976
    Cell Significance Index: -35.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5425
    Cell Significance Index: -35.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5430
    Cell Significance Index: -28.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5783
    Cell Significance Index: -45.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6430
    Cell Significance Index: -18.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6580
    Cell Significance Index: -15.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6622
    Cell Significance Index: -21.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6890
    Cell Significance Index: -10.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7121
    Cell Significance Index: -37.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7134
    Cell Significance Index: -11.9400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.7464
    Cell Significance Index: -7.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7771
    Cell Significance Index: -20.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8118
    Cell Significance Index: -49.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8580
    Cell Significance Index: -23.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9046
    Cell Significance Index: -8.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9525
    Cell Significance Index: -9.8600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.9557
    Cell Significance Index: -15.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9647
    Cell Significance Index: -12.0300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.0263
    Cell Significance Index: -10.6300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.0340
    Cell Significance Index: -12.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0809
    Cell Significance Index: -54.6300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.0919
    Cell Significance Index: -13.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1092
    Cell Significance Index: -35.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** COMMD10 is a gene that encodes a protein containing a COMM domain, a conserved structural motif known to interact with various proteins and regulate their activity. The gene is ubiquitously expressed across different cell types, including hematopoietic cells, embryonic stem cells, and epithelial cells. Its expression is particularly notable in cells involved in immune responses, such as peripheral blood mononuclear cells and CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. **Pathways and Functions:** COMMD10 is involved in several cellular pathways, including: 1. **Neddylation**: COMMD10 interacts with the E3 ubiquitin ligase, NEDD8-activating enzyme (NAE), to regulate the neddylation process, which is crucial for protein degradation and modification. 2. **Protein Binding**: The COMM domain of COMMD10 facilitates the interaction with various proteins, including those involved in protein modification, metabolism, and immune responses. 3. **Metabolism of Proteins**: COMMD10 is involved in the regulation of protein metabolism, including protein degradation and synthesis. 4. **Post-Translational Protein Modification**: COMMD10 regulates the activity of enzymes involved in post-translational protein modification, such as ubiquitination and neddylation. **Clinical Significance:** COMMD10 has been implicated in various human diseases, including: 1. **Immune Disorders**: Alterations in COMMD10 expression have been linked to immune disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders**: COMMD10 has been associated with neurological disorders, including Parkinson's disease and Alzheimer's disease. 3. **Cancer**: COMMD10 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. In conclusion, COMMD10 is a multifunctional gene that plays a critical role in various cellular processes, including protein modification, metabolism, and immune responses. Further research is necessary to fully elucidate the molecular mechanisms underlying the biological activities of COMMD10 and its clinical implications in human diseases. **Recommendations:** 1. **Further Research**: Conducting further studies to elucidate the molecular mechanisms underlying COMMD10 function and its clinical implications in human diseases. 2. **Therapeutic Applications**: Investigating the potential therapeutic applications of COMMD10 in immune disorders, neurological disorders, and cancer. 3. **Diagnostic Markers**: Developing diagnostic markers for COMMD10 expression to aid in the diagnosis and monitoring of human diseases.

Genular Protein ID: 2932847035

Symbol: COMDA_HUMAN

Name: COMM domain-containing protein 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15799966

Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.

PubMed ID: 15799966

DOI: 10.1074/jbc.m501928200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21778237

Title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

PubMed ID: 21778237

DOI: 10.1074/jbc.m111.278408

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23637203

Title: Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.

PubMed ID: 23637203

DOI: 10.1152/ajprenal.00158.2013

PubMed ID: 23563313

Title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.

PubMed ID: 23563313

DOI: 10.1172/jci66466

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 202
  • Mass: 22966
  • Checksum: 4D3C014FE59188CB
  • Sequence:
  • MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS EEEEEKLQAA 
    FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH LRQDKAEAFV NTWSSMGQET 
    VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS 
    HKELFDFYNK LETIQAQLDS LT

Genular Protein ID: 187400790

Symbol: D6RJ90_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 188
  • Mass: 21530
  • Checksum: 469DD968A64C8A70
  • Sequence:
  • MKKAVSLINA IDTGRFPRLL TRILQKLHLK AESSFSEEEE EKLQAAFSLE KQDLHLVLET 
    ISFILEQAVY HNVKPAALQQ QLENIHLRQD KAEAFVNTWS SMGQETVEKF RQRILAPCKL 
    ETVGWQLNLQ MAHSAQAKLK SPQAVLQLGV NNEDSKSLEK VLVEFSHKEL FDFYNKLETI 
    QAQLDSLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.