Details for: NOL7

Gene ID: 51406

Symbol: NOL7

Ensembl ID: ENSG00000225921

Description: nucleolar protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 380.5485
    Cell Significance Index: -59.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.6551
    Cell Significance Index: -56.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.8522
    Cell Significance Index: -72.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 148.8712
    Cell Significance Index: -60.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 136.3569
    Cell Significance Index: -70.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.8802
    Cell Significance Index: -72.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.0146
    Cell Significance Index: -61.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.1601
    Cell Significance Index: -68.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.6446
    Cell Significance Index: -52.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.0003
    Cell Significance Index: -71.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.6901
    Cell Significance Index: -45.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1984
    Cell Significance Index: -22.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.5301
    Cell Significance Index: 574.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8157
    Cell Significance Index: 41.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7480
    Cell Significance Index: 315.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7342
    Cell Significance Index: 111.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6973
    Cell Significance Index: 1532.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6544
    Cell Significance Index: 77.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6533
    Cell Significance Index: 203.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6517
    Cell Significance Index: 15.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5017
    Cell Significance Index: 206.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4699
    Cell Significance Index: 173.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4643
    Cell Significance Index: 68.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4600
    Cell Significance Index: 797.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2622
    Cell Significance Index: 558.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2517
    Cell Significance Index: 14.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2278
    Cell Significance Index: 63.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1696
    Cell Significance Index: 82.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1683
    Cell Significance Index: 87.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1183
    Cell Significance Index: 143.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1088
    Cell Significance Index: 30.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8400
    Cell Significance Index: 108.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8326
    Cell Significance Index: 37.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7299
    Cell Significance Index: 21.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7161
    Cell Significance Index: 14.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6933
    Cell Significance Index: 137.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6933
    Cell Significance Index: 18.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6799
    Cell Significance Index: 136.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6393
    Cell Significance Index: 17.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4977
    Cell Significance Index: 26.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4642
    Cell Significance Index: 32.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4627
    Cell Significance Index: 5.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3783
    Cell Significance Index: 11.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3711
    Cell Significance Index: 63.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3400
    Cell Significance Index: 21.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2813
    Cell Significance Index: 100.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2665
    Cell Significance Index: 28.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2459
    Cell Significance Index: 170.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2086
    Cell Significance Index: 5.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1378
    Cell Significance Index: 13.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1085
    Cell Significance Index: 6.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0627
    Cell Significance Index: 3.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0485
    Cell Significance Index: 35.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0339
    Cell Significance Index: 1.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0157
    Cell Significance Index: 11.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0038
    Cell Significance Index: 7.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0134
    Cell Significance Index: -24.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0352
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0403
    Cell Significance Index: -54.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0719
    Cell Significance Index: -45.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0830
    Cell Significance Index: -46.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1070
    Cell Significance Index: -1.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1094
    Cell Significance Index: -2.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1232
    Cell Significance Index: -55.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1449
    Cell Significance Index: -30.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1780
    Cell Significance Index: -20.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1788
    Cell Significance Index: -20.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1989
    Cell Significance Index: -37.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1993
    Cell Significance Index: -57.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2422
    Cell Significance Index: -8.4100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2748
    Cell Significance Index: -1.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3183
    Cell Significance Index: -4.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3696
    Cell Significance Index: -53.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4282
    Cell Significance Index: -10.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4315
    Cell Significance Index: -7.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4516
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4758
    Cell Significance Index: -54.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4771
    Cell Significance Index: -26.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4825
    Cell Significance Index: -38.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4847
    Cell Significance Index: -10.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4898
    Cell Significance Index: -37.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5860
    Cell Significance Index: -10.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6234
    Cell Significance Index: -16.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6581
    Cell Significance Index: -68.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6882
    Cell Significance Index: -9.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7156
    Cell Significance Index: -48.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8330
    Cell Significance Index: -26.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9459
    Cell Significance Index: -41.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9916
    Cell Significance Index: -11.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0107
    Cell Significance Index: -17.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0344
    Cell Significance Index: -63.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0927
    Cell Significance Index: -29.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1329
    Cell Significance Index: -28.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1473
    Cell Significance Index: -57.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2090
    Cell Significance Index: -45.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2799
    Cell Significance Index: -32.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.3328
    Cell Significance Index: -11.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NOL7 is a conserved nucleolar protein that belongs to the UTP-binding family of proteins. It is characterized by its ability to bind to UTP (uridine triphosphate) and other nucleotides, which suggests its involvement in nucleotide metabolism and RNA synthesis. NOL7 is also known to interact with other proteins, including ribosomal proteins and RNA-binding proteins, which further supports its role in ribosomal biogenesis and RNA processing. **Pathways and Functions:** NOL7 is involved in several cellular pathways, including: 1. **Ribosomal small subunit biogenesis:** NOL7 is required for the assembly of the ribosomal small subunit, which is a critical step in protein synthesis. It interacts with ribosomal proteins and other factors to facilitate the formation of the small subunit. 2. **Maturation of ssu-RNA:** NOL7 is involved in the maturation of small subunit RNA (ssu-RNA), which is essential for ribosomal function. 3. **Mitochondrial function:** NOL7 has been shown to interact with mitochondrial proteins and influence mitochondrial function, which suggests its role in energy metabolism. 4. **RNA binding:** NOL7 has RNA-binding capabilities, which allows it to interact with RNA molecules and influence RNA processing. **Clinical Significance:** NOL7 has been identified as a significantly expressed protein in various cell types, including hematopoietic cells, epithelial cells, and cells of the immune system. This suggests its potential role in several diseases, including: 1. **Cancer:** NOL7 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. Its role in ribosomal biogenesis and RNA processing makes it a potential target for cancer therapy. 2. **Autoimmune diseases:** NOL7 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where it may play a role in the dysregulation of immune responses. 3. **Neurological disorders:** NOL7 has been identified in the brain and spinal cord, where it may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, NOL7 is a multifunctional protein that plays a critical role in various cellular processes, including ribosomal biogenesis, RNA binding, and protein-protein interactions. Its clinical significance is evident in its involvement in several diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the role of NOL7 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3267935337

Symbol: UTP16_HUMAN

Name: Nucleolar protein 7

UniProtKB Accession Codes:

Q9UMY1 Q5T297 Q9Y3U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16205646

Title: NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype.

PubMed ID: 16205646

DOI: 10.1038/sj.onc.1209070

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11790298

Title: Directed proteomic analysis of the human nucleolus.

PubMed ID: 11790298

DOI: 10.1016/s0960-9822(01)00650-9

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 37246770

Title: Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing.

PubMed ID: 37246770

DOI: 10.1080/15476286.2023.2217392

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 257
  • Mass: 29426
  • Checksum: 84DB1906362263AF
  • Sequence:
    • MVQLRPRASR APASAEAMVD EGQLASEEEE AEHGLLLGQP SSGAAAEPLE EDEEGDDEFD 
DEAPEELTFA SAQAEAREEE RRVRETVRRD KTLLKEKRKR REELFIEQKK RKLLPDTILE 
KLTTASQTNI KKSPGKVKEV NLQKKNEDCE KGNDSKKVKV QKVQSVSQNK SYLAVRLKDQ 
DLRDSRQQAA QAFIHNSLYG PGTNRTTVNK FLSLANKRLP VKRAAVQFLN NAWGIQKKQN 
AKRFKRRWMV RKMKTKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.