Details for: AMOTL2

Gene ID: 51421

Symbol: AMOTL2

Ensembl ID: ENSG00000114019

Description: angiomotin like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.4844
    Cell Significance Index: -27.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 73.5530
    Cell Significance Index: -30.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.7159
    Cell Significance Index: -24.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.2899
    Cell Significance Index: -27.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4100
    Cell Significance Index: -24.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9285
    Cell Significance Index: -27.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1738
    Cell Significance Index: 9.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1682
    Cell Significance Index: 136.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7734
    Cell Significance Index: 21.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7259
    Cell Significance Index: 71.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6741
    Cell Significance Index: 14.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6589
    Cell Significance Index: 594.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6051
    Cell Significance Index: 330.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4434
    Cell Significance Index: 11.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4076
    Cell Significance Index: 8.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3945
    Cell Significance Index: 64.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3877
    Cell Significance Index: 11.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3589
    Cell Significance Index: 39.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3082
    Cell Significance Index: 8.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2971
    Cell Significance Index: 36.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2820
    Cell Significance Index: 16.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2782
    Cell Significance Index: 14.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2682
    Cell Significance Index: 13.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2503
    Cell Significance Index: 34.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2355
    Cell Significance Index: 6.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2305
    Cell Significance Index: 10.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2239
    Cell Significance Index: 99.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2078
    Cell Significance Index: 14.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1871
    Cell Significance Index: 23.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1816
    Cell Significance Index: 1.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1804
    Cell Significance Index: 34.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1718
    Cell Significance Index: 5.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1669
    Cell Significance Index: 11.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1586
    Cell Significance Index: 31.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1533
    Cell Significance Index: 17.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1498
    Cell Significance Index: 53.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1497
    Cell Significance Index: 8.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1260
    Cell Significance Index: 1.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1173
    Cell Significance Index: 2.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0696
    Cell Significance Index: 1.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0555
    Cell Significance Index: 0.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0531
    Cell Significance Index: 97.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0482
    Cell Significance Index: 3.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0422
    Cell Significance Index: 7.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0410
    Cell Significance Index: 0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0390
    Cell Significance Index: 2.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0341
    Cell Significance Index: 23.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0251
    Cell Significance Index: 38.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0235
    Cell Significance Index: 4.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0083
    Cell Significance Index: 1.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0089
    Cell Significance Index: -1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0108
    Cell Significance Index: -6.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0231
    Cell Significance Index: -31.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0337
    Cell Significance Index: -19.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0340
    Cell Significance Index: -21.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0381
    Cell Significance Index: -2.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0539
    Cell Significance Index: -15.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0649
    Cell Significance Index: -29.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0649
    Cell Significance Index: -7.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0666
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0811
    Cell Significance Index: -17.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0854
    Cell Significance Index: -1.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1060
    Cell Significance Index: -10.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1067
    Cell Significance Index: -4.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1409
    Cell Significance Index: -7.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1714
    Cell Significance Index: -10.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1860
    Cell Significance Index: -27.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1951
    Cell Significance Index: -11.9900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1976
    Cell Significance Index: -0.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2068
    Cell Significance Index: -4.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2458
    Cell Significance Index: -28.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2661
    Cell Significance Index: -27.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2998
    Cell Significance Index: -1.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3170
    Cell Significance Index: -25.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3596
    Cell Significance Index: -10.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4012
    Cell Significance Index: -26.9800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4602
    Cell Significance Index: -4.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4634
    Cell Significance Index: -13.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4708
    Cell Significance Index: -15.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4741
    Cell Significance Index: -11.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4831
    Cell Significance Index: -25.3700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.5393
    Cell Significance Index: -7.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5698
    Cell Significance Index: -8.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5952
    Cell Significance Index: -15.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6005
    Cell Significance Index: -9.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6006
    Cell Significance Index: -9.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6201
    Cell Significance Index: -27.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6437
    Cell Significance Index: -23.6300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.6523
    Cell Significance Index: -5.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6612
    Cell Significance Index: -6.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6826
    Cell Significance Index: -15.7700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7018
    Cell Significance Index: -9.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7055
    Cell Significance Index: -15.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7228
    Cell Significance Index: -27.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7350
    Cell Significance Index: -25.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AMOTL2 is a protein-coding gene that belongs to the angiomotin family of proteins. It is characterized by its ability to bind to actin filaments and regulate their organization, thereby influencing cell migration, shape, and morphology. The gene is also implicated in the regulation of transcription, particularly through the negative regulation of RNA polymerase II. Furthermore, AMOTL2 has been linked to various signaling pathways, including the Hippo, Wnt, and actin cytoskeleton organization pathways. **Pathways and Functions:** The AMOTL2 gene is involved in a diverse array of cellular processes, including: 1. **Actin Cytoskeleton Organization:** AMOTL2 regulates the organization of actin filaments, which is essential for cell migration, shape, and morphology. 2. **Cell Migration:** The gene's ability to regulate actin cytoskeleton organization enables it to influence cell migration, a critical process in tissue development and repair. 3. **Hippo Signaling Pathway:** AMOTL2 is a negative regulator of the Hippo signaling pathway, which plays a crucial role in regulating cell growth, proliferation, and apoptosis. 4. **Wnt Signaling Pathway:** The gene is also involved in the Wnt signaling pathway, which regulates cell proliferation, differentiation, and survival. 5. **Cell Polarity Establishment:** AMOTL2 is required for the establishment of cell polarity, a critical process in tissue development and morphogenesis. **Clinical Significance:** While AMOTL2's functions are still poorly understood, its dysregulation has been implicated in various diseases, including: 1. **Cancer:** Aberrant expression of AMOTL2 has been linked to cancer development and progression, highlighting its potential as a therapeutic target. 2. **Neurological Disorders:** The gene's involvement in actin cytoskeleton organization and cell migration suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Vascular Diseases:** AMOTL2's regulation of angiogenesis and endothelial cell morphogenesis makes it a potential target for the treatment of vascular diseases, such as atherosclerosis and cardiovascular disease. In conclusion, AMOTL2 is a multifaceted gene that plays a critical role in regulating actin cytoskeleton organization, cell migration, and signaling pathways. Further research is necessary to fully elucidate the gene's functions and its potential therapeutic applications.

Genular Protein ID: 2301330118

Symbol: AMOL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y2J4 A8K6F1 B7Z5Q1 E9PHW3 Q53EP1 Q96F99 Q9UKB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12406577

Title: Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.

PubMed ID: 12406577

DOI: 10.1016/s0378-1119(02)00928-9

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17293535

Title: Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.

PubMed ID: 17293535

DOI: 10.1242/dev.02782

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21205866

Title: Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.

PubMed ID: 21205866

DOI: 10.1101/gad.2000111

PubMed ID: 21937427

Title: Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.

PubMed ID: 21937427

DOI: 10.1074/jbc.m111.296806

PubMed ID: 22362771

Title: The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish.

PubMed ID: 22362771

DOI: 10.1074/jbc.m112.347419

PubMed ID: 23911299

Title: AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells.

PubMed ID: 23911299

DOI: 10.1016/j.gene.2013.07.015

PubMed ID: 23525008

Title: Amotl2 interacts with LL5beta, localizes to podosomes and regulates postsynaptic differentiation in muscle.

PubMed ID: 23525008

DOI: 10.1242/jcs.121327

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26598551

Title: Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.

PubMed ID: 26598551

DOI: 10.15252/embr.201540809

PubMed ID: 28842668

Title: The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching.

PubMed ID: 28842668

DOI: 10.1038/s41598-017-10102-w

PubMed ID: 34404733

Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.

PubMed ID: 34404733

DOI: 10.26508/lsa.202000953

Sequence Information:

  • Length: 779
  • Mass: 85764
  • Checksum: 665BE69FD7757CEF
  • Sequence:
    • MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 
EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 
QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 
SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 
HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 
SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 
AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 
AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS 
PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG 
SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TDRAPTEEPV VTAPPAAHAK 
HGSRDGSTQT EGPPDSTSTC LPPEPDSLLG CSSSQRAASL DSVATSRVQD LSDMVEILI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.