Details for: LIMA1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 429.5214
Cell Significance Index: -66.8100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 255.0037
Cell Significance Index: -64.6800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 147.3134
Cell Significance Index: -69.5500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 140.3791
Cell Significance Index: -57.0300 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 104.2290
Cell Significance Index: -69.9400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.9455
Cell Significance Index: -57.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 54.7059
Cell Significance Index: -67.4500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.4325
Cell Significance Index: -68.1300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 17.9476
Cell Significance Index: -39.2800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.1691
Cell Significance Index: -67.7500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.4892
Cell Significance Index: -38.3600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 7.7511
Cell Significance Index: 210.9800 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 7.6579
Cell Significance Index: 96.4300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 6.4328
Cell Significance Index: 125.5500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 5.2091
Cell Significance Index: 139.0900 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 4.2905
Cell Significance Index: 12.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.6304
Cell Significance Index: 446.3900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.2291
Cell Significance Index: 582.1100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 2.8325
Cell Significance Index: 43.0200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.7425
Cell Significance Index: 142.4700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.6014
Cell Significance Index: 282.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.4242
Cell Significance Index: 52.5200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.2441
Cell Significance Index: 20.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.0758
Cell Significance Index: 94.0900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.7059
Cell Significance Index: 120.6500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5390
Cell Significance Index: 43.0100 - Cell Name: peg cell (CL4033014)
Fold Change: 1.4993
Cell Significance Index: 34.6400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.4533
Cell Significance Index: 9.0300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4279
Cell Significance Index: 196.0900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.3661
Cell Significance Index: 20.4700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1027
Cell Significance Index: 487.5500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0463
Cell Significance Index: 375.3000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9752
Cell Significance Index: 532.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.9053
Cell Significance Index: 42.2100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8627
Cell Significance Index: 171.2100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8197
Cell Significance Index: 105.0800 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.8190
Cell Significance Index: 7.2700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.5919
Cell Significance Index: 12.3900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5630
Cell Significance Index: 12.0400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5336
Cell Significance Index: 32.8000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.5258
Cell Significance Index: 9.0100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4963
Cell Significance Index: 49.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4934
Cell Significance Index: 98.9800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4911
Cell Significance Index: 36.6000 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.4652
Cell Significance Index: 2.8700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4045
Cell Significance Index: 365.2100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3527
Cell Significance Index: 10.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3148
Cell Significance Index: 217.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2931
Cell Significance Index: 8.4500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2504
Cell Significance Index: 15.7800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2365
Cell Significance Index: 8.3100 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2240
Cell Significance Index: 2.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1842
Cell Significance Index: 31.4500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1670
Cell Significance Index: 314.5100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1377
Cell Significance Index: 62.5200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1055
Cell Significance Index: 20.0700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0112
Cell Significance Index: 0.5300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0033
Cell Significance Index: 0.3800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0173
Cell Significance Index: -31.9800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0243
Cell Significance Index: -15.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0247
Cell Significance Index: -37.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0274
Cell Significance Index: -17.0800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0362
Cell Significance Index: -26.8300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0385
Cell Significance Index: -52.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0413
Cell Significance Index: -30.2900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0461
Cell Significance Index: -34.9300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0727
Cell Significance Index: -1.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0821
Cell Significance Index: -46.3100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0925
Cell Significance Index: -11.9600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1260
Cell Significance Index: -1.8100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1870
Cell Significance Index: -39.3900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1975
Cell Significance Index: -2.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2073
Cell Significance Index: -59.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2175
Cell Significance Index: -22.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2176
Cell Significance Index: -16.7000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2312
Cell Significance Index: -10.2300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2404
Cell Significance Index: -6.0100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2463
Cell Significance Index: -7.8900 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.2481
Cell Significance Index: -1.0800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2557
Cell Significance Index: -37.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2561
Cell Significance Index: -29.3400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2701
Cell Significance Index: -31.8500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2870
Cell Significance Index: -14.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3660
Cell Significance Index: -42.6500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3719
Cell Significance Index: -9.5600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3803
Cell Significance Index: -8.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4375
Cell Significance Index: -45.5500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4491
Cell Significance Index: -17.0100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4784
Cell Significance Index: -24.9200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5428
Cell Significance Index: -36.5000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6051
Cell Significance Index: -17.7700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.6147
Cell Significance Index: -9.5100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7697
Cell Significance Index: -60.9600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.8834
Cell Significance Index: -9.1500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.9933
Cell Significance Index: -64.0900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0183
Cell Significance Index: -62.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0384
Cell Significance Index: -58.2700 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.1580
Cell Significance Index: -16.6600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.2388
Cell Significance Index: -65.0400 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.2522
Cell Significance Index: -10.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1358393052
Symbol: LIMA1_HUMAN
Name: LIM domain and actin-binding protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10618726
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 11256614
Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
PubMed ID: 11256614
PubMed ID: 10806352
Title: Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms.
PubMed ID: 10806352
PubMed ID: 12566430
Title: EPLIN regulates actin dynamics by cross-linking and stabilizing filaments.
PubMed ID: 12566430
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24694988
Title: Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.
PubMed ID: 24694988
DOI: 10.1038/ki.2014.85
PubMed ID: 29880681
Title: A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.
PubMed ID: 29880681
Sequence Information:
- Length: 759
- Mass: 85226
- Checksum: 996378AFD3B003D5
- Sequence:
MESSPFNRRQ WTSLSLRVTA KELSLVNKNK SSAIVEIFSK YQKAAEETNM EKKRSNTENL SQHFRKGTLT VLKKKWENPG LGAESHTDSL RNSSTEIRHR ADHPPAEVTS HAASGAKADQ EEQIHPRSRL RSPPEALVQG RYPHIKDGED LKDHSTESKK MENCLGESRH EVEKSEISEN TDASGKIEKY NVPLNRLKMM FEKGEPTQTK ILRAQSRSAS GRKISENSYS LDDLEIGPGQ LSSSTFDSEK NESRRNLELP RLSETSIKDR MAKYQAAVSK QSSSTNYTNE LKASGGEIKI HKMEQKENVP PGPEVCITHQ EGEKISANEN SLAVRSTPAE DDSRDSQVKS EVQQPVHPKP LSPDSRASSL SESSPPKAMK KFQAPARETC VECQKTVYPM ERLLANQQVF HISCFRCSYC NNKLSLGTYA SLHGRIYCKP HFNQLFKSKG NYDEGFGHRP HKDLWASKNE NEEILERPAQ LANARETPHS PGVEDAPIAK VGVLAASMEA KASSQQEKED KPAETKKLRI AWPPPTELGS SGSALEEGIK MSKPKWPPED EISKPEVPED VDLDLKKLRR SSSLKERSRP FTVAASFQST SVKSPKTVSP PIRKGWSMSE QSEESVGGRV AERKQVENAK ASKKNGNVGK TTWQNKESKG ETGKRSKEGH SLEMENENLV ENGADSDEDD NSFLKQQSPQ EPKSLNWSSF VDNTFAEEFT TQNQKSQDVE LWEGEVVKEL SVEEQIKRNR YYDEDEDEE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.