Details for: LIMA1

Gene ID: 51474

Symbol: LIMA1

Ensembl ID: ENSG00000050405

Description: LIM domain and actin binding 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 429.5214
    Cell Significance Index: -66.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 255.0037
    Cell Significance Index: -64.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.3134
    Cell Significance Index: -69.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 140.3791
    Cell Significance Index: -57.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 104.2290
    Cell Significance Index: -69.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.9455
    Cell Significance Index: -57.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.7059
    Cell Significance Index: -67.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.4325
    Cell Significance Index: -68.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.9476
    Cell Significance Index: -39.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1691
    Cell Significance Index: -67.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4892
    Cell Significance Index: -38.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.7511
    Cell Significance Index: 210.9800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 7.6579
    Cell Significance Index: 96.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.4328
    Cell Significance Index: 125.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 5.2091
    Cell Significance Index: 139.0900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.2905
    Cell Significance Index: 12.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.6304
    Cell Significance Index: 446.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2291
    Cell Significance Index: 582.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.8325
    Cell Significance Index: 43.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7425
    Cell Significance Index: 142.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.6014
    Cell Significance Index: 282.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4242
    Cell Significance Index: 52.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2441
    Cell Significance Index: 20.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0758
    Cell Significance Index: 94.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7059
    Cell Significance Index: 120.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5390
    Cell Significance Index: 43.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4993
    Cell Significance Index: 34.6400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.4533
    Cell Significance Index: 9.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4279
    Cell Significance Index: 196.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3661
    Cell Significance Index: 20.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1027
    Cell Significance Index: 487.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0463
    Cell Significance Index: 375.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9752
    Cell Significance Index: 532.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9053
    Cell Significance Index: 42.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8627
    Cell Significance Index: 171.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8197
    Cell Significance Index: 105.0800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8190
    Cell Significance Index: 7.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5919
    Cell Significance Index: 12.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5630
    Cell Significance Index: 12.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5336
    Cell Significance Index: 32.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5258
    Cell Significance Index: 9.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4963
    Cell Significance Index: 49.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4934
    Cell Significance Index: 98.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4911
    Cell Significance Index: 36.6000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.4652
    Cell Significance Index: 2.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4045
    Cell Significance Index: 365.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3527
    Cell Significance Index: 10.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3148
    Cell Significance Index: 217.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2931
    Cell Significance Index: 8.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2504
    Cell Significance Index: 15.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2365
    Cell Significance Index: 8.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2240
    Cell Significance Index: 2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1842
    Cell Significance Index: 31.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1670
    Cell Significance Index: 314.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1377
    Cell Significance Index: 62.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1055
    Cell Significance Index: 20.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0112
    Cell Significance Index: 0.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0033
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0173
    Cell Significance Index: -31.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0243
    Cell Significance Index: -15.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0247
    Cell Significance Index: -37.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0362
    Cell Significance Index: -26.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0385
    Cell Significance Index: -52.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0413
    Cell Significance Index: -30.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0461
    Cell Significance Index: -34.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0727
    Cell Significance Index: -1.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0821
    Cell Significance Index: -46.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0925
    Cell Significance Index: -11.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1260
    Cell Significance Index: -1.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1870
    Cell Significance Index: -39.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1975
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2073
    Cell Significance Index: -59.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2175
    Cell Significance Index: -22.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2176
    Cell Significance Index: -16.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2312
    Cell Significance Index: -10.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2404
    Cell Significance Index: -6.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2463
    Cell Significance Index: -7.8900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2481
    Cell Significance Index: -1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2557
    Cell Significance Index: -37.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2561
    Cell Significance Index: -29.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2701
    Cell Significance Index: -31.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2870
    Cell Significance Index: -14.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3660
    Cell Significance Index: -42.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3719
    Cell Significance Index: -9.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3803
    Cell Significance Index: -8.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4375
    Cell Significance Index: -45.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4491
    Cell Significance Index: -17.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4784
    Cell Significance Index: -24.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5428
    Cell Significance Index: -36.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6051
    Cell Significance Index: -17.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6147
    Cell Significance Index: -9.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7697
    Cell Significance Index: -60.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8834
    Cell Significance Index: -9.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9933
    Cell Significance Index: -64.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0183
    Cell Significance Index: -62.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0384
    Cell Significance Index: -58.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1580
    Cell Significance Index: -16.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2388
    Cell Significance Index: -65.0400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.2522
    Cell Significance Index: -10.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** LIMA1 is characterized by its unique LIM domain and actin-binding capabilities. The LIM domain is a conserved structural motif that enables the protein to interact with specific sequences within actin filaments, modulating their assembly and disassembly. This interaction is crucial for maintaining the integrity of the cytoskeleton and regulating cellular processes such as cell migration, adhesion, and signaling. **Pathways and Functions** LIMA1 is involved in various cellular pathways, including: 1. **Actin cytoskeleton dynamics**: LIMA1 modulates the assembly and disassembly of actin filaments, influencing the structure and organization of the cytoskeleton. 2. **Cell migration**: LIMA1 interacts with actin filaments, facilitating cell migration and tissue repair. 3. **Adhesion**: LIMA1 regulates cell adhesion by modulating the organization of actin filaments at the cell surface. 4. **Signaling**: LIMA1 interacts with various signaling molecules, influencing the transmission of signals within the cell. 5. **Cytosol and plasma membrane organization**: LIMA1 regulates the organization of cytosol and plasma membrane components, influencing cellular processes such as cell migration and adhesion. **Clinical Significance** Dysregulation of LIMA1 has been implicated in various diseases, including: 1. **Immunological disorders**: LIMA1 has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: LIMA1 has been implicated in the progression of various cancers, including colorectal and breast cancer. 3. **Neurological disorders**: LIMA1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, LIMA1 is a multifaceted gene that plays a crucial role in various cellular processes, including cytoskeletal dynamics, cell migration, adhesion, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of LIMA1 in maintaining cellular homeostasis and overall health. Further research is necessary to fully elucidate the mechanisms by which LIMA1 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1358393052

Symbol: LIMA1_HUMAN

Name: LIM domain and actin-binding protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10618726

Title: EPLIN, epithelial protein lost in neoplasm.

PubMed ID: 10618726

DOI: 10.1038/sj.onc.1203206

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

PubMed ID: 10806352

Title: Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms.

PubMed ID: 10806352

DOI: 10.1016/s0378-1119(00)00144-x

PubMed ID: 12566430

Title: EPLIN regulates actin dynamics by cross-linking and stabilizing filaments.

PubMed ID: 12566430

DOI: 10.1083/jcb.200212057

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24694988

Title: Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.

PubMed ID: 24694988

DOI: 10.1038/ki.2014.85

PubMed ID: 29880681

Title: A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

PubMed ID: 29880681

DOI: 10.1126/science.aao6575

Sequence Information:

  • Length: 759
  • Mass: 85226
  • Checksum: 996378AFD3B003D5
  • Sequence:
  • MESSPFNRRQ WTSLSLRVTA KELSLVNKNK SSAIVEIFSK YQKAAEETNM EKKRSNTENL 
    SQHFRKGTLT VLKKKWENPG LGAESHTDSL RNSSTEIRHR ADHPPAEVTS HAASGAKADQ 
    EEQIHPRSRL RSPPEALVQG RYPHIKDGED LKDHSTESKK MENCLGESRH EVEKSEISEN 
    TDASGKIEKY NVPLNRLKMM FEKGEPTQTK ILRAQSRSAS GRKISENSYS LDDLEIGPGQ 
    LSSSTFDSEK NESRRNLELP RLSETSIKDR MAKYQAAVSK QSSSTNYTNE LKASGGEIKI 
    HKMEQKENVP PGPEVCITHQ EGEKISANEN SLAVRSTPAE DDSRDSQVKS EVQQPVHPKP 
    LSPDSRASSL SESSPPKAMK KFQAPARETC VECQKTVYPM ERLLANQQVF HISCFRCSYC 
    NNKLSLGTYA SLHGRIYCKP HFNQLFKSKG NYDEGFGHRP HKDLWASKNE NEEILERPAQ 
    LANARETPHS PGVEDAPIAK VGVLAASMEA KASSQQEKED KPAETKKLRI AWPPPTELGS 
    SGSALEEGIK MSKPKWPPED EISKPEVPED VDLDLKKLRR SSSLKERSRP FTVAASFQST 
    SVKSPKTVSP PIRKGWSMSE QSEESVGGRV AERKQVENAK ASKKNGNVGK TTWQNKESKG 
    ETGKRSKEGH SLEMENENLV ENGADSDEDD NSFLKQQSPQ EPKSLNWSSF VDNTFAEEFT 
    TQNQKSQDVE LWEGEVVKEL SVEEQIKRNR YYDEDEDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.