Details for: RTCB

Gene ID: 51493

Symbol: RTCB

Ensembl ID: ENSG00000100220

Description: RNA 2',3'-cyclic phosphate and 5'-OH ligase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.5644
    Cell Significance Index: -42.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.8273
    Cell Significance Index: -38.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 120.8163
    Cell Significance Index: -49.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.4567
    Cell Significance Index: -47.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.4322
    Cell Significance Index: -38.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.8451
    Cell Significance Index: -46.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.0372
    Cell Significance Index: -39.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.1319
    Cell Significance Index: -47.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2999
    Cell Significance Index: -38.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1793
    Cell Significance Index: -48.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9432
    Cell Significance Index: -30.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8727
    Cell Significance Index: -17.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8493
    Cell Significance Index: 17.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4354
    Cell Significance Index: 1296.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0846
    Cell Significance Index: 37.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0717
    Cell Significance Index: 55.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9805
    Cell Significance Index: 26.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9272
    Cell Significance Index: 69.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9012
    Cell Significance Index: 162.4700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8840
    Cell Significance Index: 9.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8811
    Cell Significance Index: 113.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8785
    Cell Significance Index: 142.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8701
    Cell Significance Index: 18.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8228
    Cell Significance Index: 163.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7921
    Cell Significance Index: 36.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7835
    Cell Significance Index: 427.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7569
    Cell Significance Index: 93.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7488
    Cell Significance Index: 331.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7326
    Cell Significance Index: 146.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7145
    Cell Significance Index: 98.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7018
    Cell Significance Index: 14.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5844
    Cell Significance Index: 27.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5099
    Cell Significance Index: 36.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4499
    Cell Significance Index: 29.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4101
    Cell Significance Index: 52.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3925
    Cell Significance Index: 24.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3704
    Cell Significance Index: 19.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3498
    Cell Significance Index: 9.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3178
    Cell Significance Index: 60.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3007
    Cell Significance Index: 107.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2828
    Cell Significance Index: 12.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2377
    Cell Significance Index: 6.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2183
    Cell Significance Index: 1.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2118
    Cell Significance Index: 12.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1803
    Cell Significance Index: 21.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1228
    Cell Significance Index: 12.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1213
    Cell Significance Index: 3.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0963
    Cell Significance Index: 66.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0746
    Cell Significance Index: 2.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0510
    Cell Significance Index: 3.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0237
    Cell Significance Index: 4.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0162
    Cell Significance Index: 30.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0107
    Cell Significance Index: 6.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0075
    Cell Significance Index: 11.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 9.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0055
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0226
    Cell Significance Index: -0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0242
    Cell Significance Index: -18.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0412
    Cell Significance Index: -4.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0528
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0529
    Cell Significance Index: -39.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0532
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0554
    Cell Significance Index: -8.0500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0576
    Cell Significance Index: -0.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0612
    Cell Significance Index: -3.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0724
    Cell Significance Index: -40.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0870
    Cell Significance Index: -54.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0912
    Cell Significance Index: -2.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1348
    Cell Significance Index: -15.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1362
    Cell Significance Index: -39.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2283
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2510
    Cell Significance Index: -52.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2550
    Cell Significance Index: -29.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2707
    Cell Significance Index: -16.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3408
    Cell Significance Index: -10.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3670
    Cell Significance Index: -24.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3746
    Cell Significance Index: -9.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4227
    Cell Significance Index: -33.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4315
    Cell Significance Index: -7.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4346
    Cell Significance Index: -45.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4656
    Cell Significance Index: -12.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5250
    Cell Significance Index: -11.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5262
    Cell Significance Index: -15.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5517
    Cell Significance Index: -16.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5560
    Cell Significance Index: -34.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5638
    Cell Significance Index: -13.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5682
    Cell Significance Index: -15.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5835
    Cell Significance Index: -10.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5972
    Cell Significance Index: -15.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6339
    Cell Significance Index: -3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6442
    Cell Significance Index: -28.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6544
    Cell Significance Index: -9.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7740
    Cell Significance Index: -29.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7878
    Cell Significance Index: -8.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9196
    Cell Significance Index: -16.2500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9332
    Cell Significance Index: -15.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RTCB is a type of RNA ligase that catalyzes the formation of cyclic phosphodiester bonds between 2',3'-cyclic phosphate groups and 5'-OH groups of RNA molecules. This enzyme is essential for the processing and maturation of various RNAs, including tRNAs, rRNAs, and mRNAs. RTCB's unique ability to form these cyclic bonds allows it to regulate RNA stability, localization, and function, ultimately influencing cellular behavior and response to environmental cues. **Pathways and Functions:** RTCB is involved in several critical pathways, including: 1. **RNA processing and modification**: RTCB plays a crucial role in the processing and maturation of tRNAs, rRNAs, and mRNAs, regulating their stability, localization, and function. 2. **Cell development and differentiation**: RTCB is essential for the proper development and differentiation of various cell types, including hematopoietic cells, embryonic stem cells, and smooth muscle fibers. 3. **RNA metabolism**: RTCB influences the regulation of RNA metabolism, including the degradation and translation of RNAs, thereby controlling cellular behavior and response to environmental cues. 4. **Cell signaling and communication**: RTCB is involved in the regulation of cell signaling and communication pathways, including the formation of cyclic phosphodiester bonds that modulate protein-RNA interactions. **Clinical Significance:** RTCB's role in RNA processing and modification has significant implications for various diseases and disorders, including: 1. **Hematological disorders**: RTCB mutations or dysregulation have been linked to various hematological disorders, such as leukemia and lymphoma. 2. **Neurological disorders**: RTCB's involvement in RNA processing and modification may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: RTCB's dysregulation has been implicated in the development and progression of various cancers, including leukemia and solid tumors. In conclusion, RTCB is a critical enzyme involved in RNA processing and modification, playing a pivotal role in cellular processes such as cell development, differentiation, and function. Further research on RTCB's role in disease pathology and its potential as a therapeutic target will provide valuable insights into the regulation of RNA metabolism and the development of novel treatments for various diseases.

Genular Protein ID: 304766740

Symbol: RTCB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y3I0 B2R6A8 Q6IAI0 Q9BWL4 Q9NTH1 Q9P037 Q9P0J3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 27 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 13 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12529303

Title: Reevaluating human gene annotation: a second-generation analysis of chromosome 22.

PubMed ID: 12529303

DOI: 10.1101/gr.695703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15312650

Title: Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.

PubMed ID: 15312650

DOI: 10.1016/j.neuron.2004.07.022

PubMed ID: 16236267

Title: Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.

PubMed ID: 16236267

DOI: 10.1016/j.bbrc.2005.09.191

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21311021

Title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

PubMed ID: 21311021

DOI: 10.1126/science.1197847

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24870230

Title: Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.

PubMed ID: 24870230

DOI: 10.1038/nature13284

PubMed ID: 24608264

Title: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

PubMed ID: 24608264

DOI: 10.1371/journal.pone.0090957

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 505
  • Mass: 55210
  • Checksum: C7C0CC2C95BDD27B
  • Sequence:
    • MSRSYNDELQ FLEKINKNCW RIKKGFVPNM QVEGVFYVND ALEKLMFEEL RNACRGGGVG 
GFLPAMKQIG NVAALPGIVH RSIGLPDVHS GYGFAIGNMA AFDMNDPEAV VSPGGVGFDI 
NCGVRLLRTN LDESDVQPVK EQLAQAMFDH IPVGVGSKGV IPMNAKDLEE ALEMGVDWSL 
REGYAWAEDK EHCEEYGRML QADPNKVSAR AKKRGLPQLG TLGAGNHYAE IQVVDEIFNE 
YAAKKMGIDH KGQVCVMIHS GSRGLGHQVA TDALVAMEKA MKRDKIIVND RQLACARIAS 
PEGQDYLKGM AAAGNYAWVN RSSMTFLTRQ AFAKVFNTTP DDLDLHVIYD VSHNIAKVEQ 
HVVDGKERTL LVHRKGSTRA FPPHHPLIAV DYQLTGQPVL IGGTMGTCSY VLTGTEQGMT 
ETFGTTCHGA GRALSRAKSR RNLDFQDVLD KLADMGIAIR VASPKLVMEE APESYKNVTD 
VVNTCHDAGI SKKAIKLRPI AVIKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.