Details for: HIKESHI

Gene ID: 51501

Symbol: HIKESHI

Ensembl ID: ENSG00000149196

Description: heat shock protein nuclear import factor hikeshi

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.3633
    Cell Significance Index: -44.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.8049
    Cell Significance Index: -50.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.6320
    Cell Significance Index: -41.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.5243
    Cell Significance Index: -48.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.2844
    Cell Significance Index: -50.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2842
    Cell Significance Index: -42.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2262
    Cell Significance Index: -38.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0311
    Cell Significance Index: -30.8100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.2691
    Cell Significance Index: 19.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1887
    Cell Significance Index: 355.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2930
    Cell Significance Index: 34.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2814
    Cell Significance Index: 13.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2452
    Cell Significance Index: 43.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2288
    Cell Significance Index: 25.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0809
    Cell Significance Index: 64.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0021
    Cell Significance Index: 137.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8494
    Cell Significance Index: 100.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7601
    Cell Significance Index: 152.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6623
    Cell Significance Index: 361.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6546
    Cell Significance Index: 289.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6121
    Cell Significance Index: 75.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5980
    Cell Significance Index: 107.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5869
    Cell Significance Index: 41.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5723
    Cell Significance Index: 29.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5698
    Cell Significance Index: 73.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5513
    Cell Significance Index: 35.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5499
    Cell Significance Index: 16.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5042
    Cell Significance Index: 100.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4713
    Cell Significance Index: 46.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4449
    Cell Significance Index: 23.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4151
    Cell Significance Index: 148.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3836
    Cell Significance Index: 10.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3645
    Cell Significance Index: 2.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3106
    Cell Significance Index: 14.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3054
    Cell Significance Index: 19.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2660
    Cell Significance Index: 50.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.2397
    Cell Significance Index: 3.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2046
    Cell Significance Index: 10.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1559
    Cell Significance Index: 10.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1546
    Cell Significance Index: 7.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1328
    Cell Significance Index: 17.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1315
    Cell Significance Index: 90.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1293
    Cell Significance Index: 9.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0644
    Cell Significance Index: 1.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0241
    Cell Significance Index: 18.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0177
    Cell Significance Index: 33.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0115
    Cell Significance Index: 0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0055
    Cell Significance Index: -0.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0067
    Cell Significance Index: -0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0129
    Cell Significance Index: -8.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0256
    Cell Significance Index: -34.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0317
    Cell Significance Index: -14.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0338
    Cell Significance Index: -2.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0485
    Cell Significance Index: -35.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0545
    Cell Significance Index: -40.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0588
    Cell Significance Index: -6.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0705
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0798
    Cell Significance Index: -45.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0812
    Cell Significance Index: -11.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0849
    Cell Significance Index: -53.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0871
    Cell Significance Index: -14.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1257
    Cell Significance Index: -6.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1346
    Cell Significance Index: -38.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1479
    Cell Significance Index: -17.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2070
    Cell Significance Index: -5.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2193
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2309
    Cell Significance Index: -26.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2525
    Cell Significance Index: -6.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2527
    Cell Significance Index: -8.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2534
    Cell Significance Index: -53.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3120
    Cell Significance Index: -14.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3503
    Cell Significance Index: -3.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3623
    Cell Significance Index: -7.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3702
    Cell Significance Index: -8.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4411
    Cell Significance Index: -45.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5311
    Cell Significance Index: -23.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5571
    Cell Significance Index: -44.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5908
    Cell Significance Index: -13.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6419
    Cell Significance Index: -11.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6662
    Cell Significance Index: -25.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7160
    Cell Significance Index: -21.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7233
    Cell Significance Index: -18.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7594
    Cell Significance Index: -46.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8329
    Cell Significance Index: -34.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8353
    Cell Significance Index: -23.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8578
    Cell Significance Index: -10.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8724
    Cell Significance Index: -12.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8998
    Cell Significance Index: -16.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9031
    Cell Significance Index: -28.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9220
    Cell Significance Index: -12.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9401
    Cell Significance Index: -16.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9621
    Cell Significance Index: -31.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9713
    Cell Significance Index: -30.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0183
    Cell Significance Index: -37.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0286
    Cell Significance Index: -36.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0381
    Cell Significance Index: -20.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HIKESHI is a nuclear import factor that mediates the entry of HSP70 into the nucleus, where it can regulate the expression of heat shock-responsive genes. The gene is significantly expressed in cells that are exposed to heat stress, suggesting its role in protecting against thermal damage. HIKESHI is also involved in the regulation of the heat shock factor 1 (HSF1)-mediated heat shock response, a critical pathway that coordinates the expression of HSPs in response to stress. Furthermore, HIKESHI is expressed in various immune cells, including T cells, mast cells, and dendritic cells, highlighting its potential role in immune function and response to stress. **Pathways and Functions:** The HIKESHI pathway is involved in the regulation of HSP70 expression, which is a key player in the cellular response to stress. HIKESHI mediates the nuclear import of HSP70, allowing it to regulate the expression of heat shock-responsive genes. The HIKESHI pathway is also involved in the regulation of the HSF1-mediated heat shock response, a critical pathway that coordinates the expression of HSPs in response to stress. Additionally, HIKESHI has been shown to interact with other proteins, including HSP70 and heat shock transcription factor 1 (HSF1), to regulate the expression of heat shock-responsive genes. **Clinical Significance:** The identification of HIKESHI as a nuclear import factor involved in the regulation of HSP70 expression has significant implications for our understanding of cellular stress response and immune function. HIKESHI's role in regulating the HSF1-mediated heat shock response makes it a potential target for the development of novel therapeutic strategies for diseases characterized by stress-induced tissue damage, such as heat shock injury, cancer, and inflammatory disorders. Furthermore, the expression of HIKESHI in immune cells highlights its potential role in regulating immune responses and modulating inflammation. In conclusion, the discovery of HIKESHI as a nuclear import factor involved in the regulation of HSP70 expression has significant implications for our understanding of cellular stress response and immune function. Further research is needed to fully elucidate the mechanisms by which HIKESHI regulates HSP70 expression and the HSF1-mediated heat shock response, with potential applications in the development of novel therapeutic strategies for diseases characterized by stress-induced tissue damage. **Future Directions:** Future research should focus on: 1. Elucidating the mechanisms by which HIKESHI regulates HSP70 expression and the HSF1-mediated heat shock response. 2. Investigating the role of HIKESHI in regulating immune responses and modulating inflammation. 3. Exploring the potential therapeutic applications of HIKESHI as a target for the development of novel treatments for diseases characterized by stress-induced tissue damage. 4. Investigating the expression patterns and functions of HIKESHI in various cell types and tissues. By advancing our understanding of HIKESHI's role in cellular stress response and immune function, we can unlock new avenues for the development of novel therapeutic strategies for diseases characterized by stress-induced tissue damage.

Genular Protein ID: 2147141492

Symbol: HIKES_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FT3 Q8WVE8 Q9NVQ2 Q9NZZ1 Q9P022 Q9P0N1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22541429

Title: Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage.

PubMed ID: 22541429

DOI: 10.1016/j.cell.2012.02.058

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25760597

Title: Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s.

PubMed ID: 25760597

DOI: 10.1107/s1399004714026881

PubMed ID: 26545878

Title: Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.

PubMed ID: 26545878

DOI: 10.1136/jmedgenet-2015-103232

Sequence Information:

  • Length: 197
  • Mass: 21628
  • Checksum: 4FA524439B630511
  • Sequence:
    • MFGCLVAGRL VQTAAQQVAE DKFVFDLPDY ESINHVVVFM LGTIPFPEGM GGSVYFSYPD 
SNGMPVWQLL GFVTNGKPSA IFKISGLKSG EGSQHPFGAM NIVRTPSVAQ IGISVELLDS 
MAQQTPVGNA AVSSVDSFTQ FTQKMLDNFY NFASSFAVSQ AQMTPSPSEM FIPANVVLKW 
YENFQRRLAQ NPLFWKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.