Details for: UFC1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 371.2104
Cell Significance Index: -57.7400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 172.9832
Cell Significance Index: -71.2600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 157.5243
Cell Significance Index: -39.9600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 150.8897
Cell Significance Index: -61.3000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 143.7974
Cell Significance Index: -67.8900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 132.4882
Cell Significance Index: -68.1500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 101.4423
Cell Significance Index: -68.0700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 65.0751
Cell Significance Index: -62.1300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 53.3596
Cell Significance Index: -65.7900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.8964
Cell Significance Index: -70.6200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.5264
Cell Significance Index: -50.7600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.8189
Cell Significance Index: -34.3400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.6533
Cell Significance Index: -16.7500 - Cell Name: peg cell (CL4033014)
Fold Change: 3.5696
Cell Significance Index: 82.4700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.7415
Cell Significance Index: 176.8700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.6235
Cell Significance Index: 122.3200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.5115
Cell Significance Index: 187.1800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.3641
Cell Significance Index: 69.4300 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.2860
Cell Significance Index: 25.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.1040
Cell Significance Index: 288.9400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.0830
Cell Significance Index: 97.9000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.9780
Cell Significance Index: 255.5400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.9643
Cell Significance Index: 1072.7300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.8298
Cell Significance Index: 16.8500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.6832
Cell Significance Index: 44.2600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.6487
Cell Significance Index: 34.5100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6388
Cell Significance Index: 85.1300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4413
Cell Significance Index: 39.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4322
Cell Significance Index: 49.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.4175
Cell Significance Index: 255.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.3890
Cell Significance Index: 170.7900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.2470
Cell Significance Index: 551.3400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.2429
Cell Significance Index: 10.4400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.2236
Cell Significance Index: 7.5300 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.1213
Cell Significance Index: 143.7400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.0619
Cell Significance Index: 18.7700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9655
Cell Significance Index: 68.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.9091
Cell Significance Index: 155.2300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8376
Cell Significance Index: 98.7800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.6053
Cell Significance Index: 6.5800 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.5937
Cell Significance Index: 4.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5453
Cell Significance Index: 14.5600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5389
Cell Significance Index: 87.6500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5014
Cell Significance Index: 26.1200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4952
Cell Significance Index: 447.1100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4524
Cell Significance Index: 89.7800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4403
Cell Significance Index: 12.6900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3716
Cell Significance Index: 36.7600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2194
Cell Significance Index: 2.8100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2191
Cell Significance Index: 41.7100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2042
Cell Significance Index: 12.8700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1758
Cell Significance Index: 3.2500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1537
Cell Significance Index: 30.8300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1379
Cell Significance Index: 7.2400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0921
Cell Significance Index: 69.7100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0449
Cell Significance Index: 32.9300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0341
Cell Significance Index: 0.5700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0113
Cell Significance Index: 0.5100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0038
Cell Significance Index: -0.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0047
Cell Significance Index: -3.4600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0094
Cell Significance Index: -0.9600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0203
Cell Significance Index: -38.1400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0366
Cell Significance Index: -67.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0406
Cell Significance Index: -25.3800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0452
Cell Significance Index: -69.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0644
Cell Significance Index: -87.5300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0645
Cell Significance Index: -23.1400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0788
Cell Significance Index: -50.0600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0849
Cell Significance Index: -47.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1352
Cell Significance Index: -61.3500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1399
Cell Significance Index: -29.4600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1455
Cell Significance Index: -2.2100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1554
Cell Significance Index: -17.8000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1930
Cell Significance Index: -4.9300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2088
Cell Significance Index: -60.0800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2394
Cell Significance Index: -6.6900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2429
Cell Significance Index: -28.3100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3185
Cell Significance Index: -8.5200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4020
Cell Significance Index: -58.4400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4333
Cell Significance Index: -49.4600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4437
Cell Significance Index: -35.1400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4611
Cell Significance Index: -9.8200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.5365
Cell Significance Index: -6.4000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5531
Cell Significance Index: -19.4400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5852
Cell Significance Index: -35.9700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6616
Cell Significance Index: -21.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6764
Cell Significance Index: -70.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7469
Cell Significance Index: -41.9100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7528
Cell Significance Index: -11.2800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8216
Cell Significance Index: -11.2100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8620
Cell Significance Index: -66.1500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8702
Cell Significance Index: -58.5100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.9148
Cell Significance Index: -9.4700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0447
Cell Significance Index: -64.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0801
Cell Significance Index: -27.0000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.1422
Cell Significance Index: -19.6900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -1.1936
Cell Significance Index: -16.7300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.2180
Cell Significance Index: -35.8800 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.2956
Cell Significance Index: -8.0500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.3430
Cell Significance Index: -29.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3036255685
Symbol: UFC1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15071506
Title: A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.
PubMed ID: 15071506
PubMed ID: 10810093
Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
PubMed ID: 10810093
DOI: 10.1101/gr.10.5.703
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 20018847
Title: A novel type of E3 ligase for the Ufm1 conjugation system.
PubMed ID: 20018847
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25902260
Title: Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment.
PubMed ID: 25902260
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27653677
Title: Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 Complex.
PubMed ID: 27653677
PubMed ID: 27351204
Title: Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.
PubMed ID: 27351204
DOI: 10.7554/elife.17290
PubMed ID: 29868776
Title: Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.
PubMed ID: 29868776
DOI: 10.1093/brain/awy135
PubMed ID: 30886146
Title: UFL1 promotes histone H4 ufmylation and ATM activation.
PubMed ID: 30886146
PubMed ID: 30626644
Title: Ribosomal protein RPL26 is the principal target of UFMylation.
PubMed ID: 30626644
PubMed ID: 32160526
Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.
PubMed ID: 32160526
PubMed ID: 35926457
Title: Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.
PubMed ID: 35926457
PubMed ID: 36121123
Title: A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
PubMed ID: 36121123
PubMed ID: 35394863
Title: Signaling from the RNA sensor RIG-I is regulated by ufmylation.
PubMed ID: 35394863
PubMed ID: 37988244
Title: Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation.
PubMed ID: 37988244
PubMed ID: 37036982
Title: RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum.
PubMed ID: 37036982
PubMed ID: 16132835
Title: GFT NMR based resonance assignment for the 21 kDa human protein UFC1.
PubMed ID: 16132835
PubMed ID: 17825256
Title: Crystal structure of Ufc1, the Ufm1-conjugating enzyme.
PubMed ID: 17825256
PubMed ID: 19101823
Title: NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
PubMed ID: 19101823
PubMed ID: 34299007
Title: A concerted action of UBA5 C-terminal unstructured regions is important for transfer of activated UFM1 to UFC1.
PubMed ID: 34299007
DOI: 10.3390/ijms22147390
PubMed ID: 34588452
Title: Structural basis for UFM1 transfer from UBA5 to UFC1.
PubMed ID: 34588452
PubMed ID: 38383789
Title: The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
PubMed ID: 38383789
Sequence Information:
- Length: 167
- Mass: 19458
- Checksum: 1675D9187DC43E14
- Sequence:
MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCNQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.