Details for: UFC1

Gene ID: 51506

Symbol: UFC1

Ensembl ID: ENSG00000143222

Description: ubiquitin-fold modifier conjugating enzyme 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 371.2104
    Cell Significance Index: -57.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 172.9832
    Cell Significance Index: -71.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 157.5243
    Cell Significance Index: -39.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 150.8897
    Cell Significance Index: -61.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.7974
    Cell Significance Index: -67.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 132.4882
    Cell Significance Index: -68.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 101.4423
    Cell Significance Index: -68.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.0751
    Cell Significance Index: -62.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.3596
    Cell Significance Index: -65.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.8964
    Cell Significance Index: -70.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5264
    Cell Significance Index: -50.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8189
    Cell Significance Index: -34.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6533
    Cell Significance Index: -16.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5696
    Cell Significance Index: 82.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7415
    Cell Significance Index: 176.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6235
    Cell Significance Index: 122.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5115
    Cell Significance Index: 187.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.3641
    Cell Significance Index: 69.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2860
    Cell Significance Index: 25.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1040
    Cell Significance Index: 288.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0830
    Cell Significance Index: 97.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9780
    Cell Significance Index: 255.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9643
    Cell Significance Index: 1072.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.8298
    Cell Significance Index: 16.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6832
    Cell Significance Index: 44.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6487
    Cell Significance Index: 34.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6388
    Cell Significance Index: 85.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4413
    Cell Significance Index: 39.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4322
    Cell Significance Index: 49.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4175
    Cell Significance Index: 255.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3890
    Cell Significance Index: 170.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2470
    Cell Significance Index: 551.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2429
    Cell Significance Index: 10.4400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2236
    Cell Significance Index: 7.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1213
    Cell Significance Index: 143.7400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0619
    Cell Significance Index: 18.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9655
    Cell Significance Index: 68.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9091
    Cell Significance Index: 155.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8376
    Cell Significance Index: 98.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6053
    Cell Significance Index: 6.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5937
    Cell Significance Index: 4.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5453
    Cell Significance Index: 14.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5389
    Cell Significance Index: 87.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5014
    Cell Significance Index: 26.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4952
    Cell Significance Index: 447.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4524
    Cell Significance Index: 89.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4403
    Cell Significance Index: 12.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3716
    Cell Significance Index: 36.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2194
    Cell Significance Index: 2.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2191
    Cell Significance Index: 41.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2042
    Cell Significance Index: 12.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1758
    Cell Significance Index: 3.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1537
    Cell Significance Index: 30.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1379
    Cell Significance Index: 7.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0921
    Cell Significance Index: 69.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0449
    Cell Significance Index: 32.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0341
    Cell Significance Index: 0.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0113
    Cell Significance Index: 0.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0203
    Cell Significance Index: -38.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0366
    Cell Significance Index: -67.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0406
    Cell Significance Index: -25.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0452
    Cell Significance Index: -69.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0644
    Cell Significance Index: -87.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0645
    Cell Significance Index: -23.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0788
    Cell Significance Index: -50.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0849
    Cell Significance Index: -47.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1352
    Cell Significance Index: -61.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1399
    Cell Significance Index: -29.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1455
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1554
    Cell Significance Index: -17.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1930
    Cell Significance Index: -4.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2088
    Cell Significance Index: -60.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2394
    Cell Significance Index: -6.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2429
    Cell Significance Index: -28.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3185
    Cell Significance Index: -8.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4020
    Cell Significance Index: -58.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4333
    Cell Significance Index: -49.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4437
    Cell Significance Index: -35.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4611
    Cell Significance Index: -9.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5365
    Cell Significance Index: -6.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5531
    Cell Significance Index: -19.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5852
    Cell Significance Index: -35.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6616
    Cell Significance Index: -21.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6764
    Cell Significance Index: -70.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7469
    Cell Significance Index: -41.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7528
    Cell Significance Index: -11.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8216
    Cell Significance Index: -11.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8620
    Cell Significance Index: -66.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8702
    Cell Significance Index: -58.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9148
    Cell Significance Index: -9.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0447
    Cell Significance Index: -64.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0801
    Cell Significance Index: -27.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1422
    Cell Significance Index: -19.6900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.1936
    Cell Significance Index: -16.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2180
    Cell Significance Index: -35.8800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.2956
    Cell Significance Index: -8.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3430
    Cell Significance Index: -29.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UFC1 is a ubiquitin-fold modifier conjugating enzyme that catalyzes the transfer of the Ufm1 tag to target proteins, which in turn affects their stability, localization, and activity. The Ufm1 conjugation pathway is distinct from other protein modification pathways, such as ubiquitination and phosphorylation. UFC1 is specifically expressed in various cell types, including hematopoietic cells, epithelial cells, and stem cells, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions:** The UFC1 gene is involved in several cellular pathways, including: 1. **Protein ufmylation**: The Ufm1 conjugation pathway is crucial for regulating protein stability, localization, and activity. This process is essential for maintaining cellular homeostasis and responding to ER stress. 2. **Regulation of type II interferon production**: UFC1 has been shown to regulate the production of type II interferons, which are essential for immune responses against viral infections. 3. **Response to endoplasmic reticulum stress**: UFC1 plays a critical role in responding to ER stress, which is a key factor in the development of various diseases, including cancer and autoimmune disorders. 4. **Reticulophagy**: UFC1 is involved in the regulation of reticulophagy, a process by which cells recycle damaged or dysfunctional organelles, including the ER. **Clinical Significance:** The UFC1 gene has significant implications for our understanding of various diseases, including: 1. **Cancer**: UFC1 dysregulation has been linked to the development of various cancers, including breast and lung cancer. 2. **Autoimmune disorders**: UFC1 plays a critical role in regulating immune responses, and dysregulation of this gene has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus. 3. **Endoplasmic reticulum stress**: UFC1 is essential for responding to ER stress, and dysregulation of this gene has been linked to various diseases, including metabolic disorders and neurodegenerative diseases. In conclusion, the UFC1 gene is a critical regulator of protein modification and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of ufmylation and its role in maintaining cellular homeostasis.

Genular Protein ID: 3036255685

Symbol: UFC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15071506

Title: A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.

PubMed ID: 15071506

DOI: 10.1038/sj.emboj.7600205

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20018847

Title: A novel type of E3 ligase for the Ufm1 conjugation system.

PubMed ID: 20018847

DOI: 10.1074/jbc.m109.036814

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25902260

Title: Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment.

PubMed ID: 25902260

DOI: 10.1371/journal.pone.0123106

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27653677

Title: Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 Complex.

PubMed ID: 27653677

DOI: 10.1016/j.celrep.2016.08.067

PubMed ID: 27351204

Title: Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.

PubMed ID: 27351204

DOI: 10.7554/elife.17290

PubMed ID: 29868776

Title: Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.

PubMed ID: 29868776

DOI: 10.1093/brain/awy135

PubMed ID: 30886146

Title: UFL1 promotes histone H4 ufmylation and ATM activation.

PubMed ID: 30886146

DOI: 10.1038/s41467-019-09175-0

PubMed ID: 30626644

Title: Ribosomal protein RPL26 is the principal target of UFMylation.

PubMed ID: 30626644

DOI: 10.1073/pnas.1816202116

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 35926457

Title: Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.

PubMed ID: 35926457

DOI: 10.1016/j.celrep.2022.111168

PubMed ID: 36121123

Title: A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.

PubMed ID: 36121123

DOI: 10.15252/embj.2022111015

PubMed ID: 35394863

Title: Signaling from the RNA sensor RIG-I is regulated by ufmylation.

PubMed ID: 35394863

DOI: 10.1073/pnas.2119531119

PubMed ID: 37988244

Title: Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation.

PubMed ID: 37988244

DOI: 10.15252/embr.202356920

PubMed ID: 37036982

Title: RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum.

PubMed ID: 37036982

DOI: 10.1073/pnas.2220340120

PubMed ID: 16132835

Title: GFT NMR based resonance assignment for the 21 kDa human protein UFC1.

PubMed ID: 16132835

DOI: 10.1007/s10858-005-7941-9

PubMed ID: 17825256

Title: Crystal structure of Ufc1, the Ufm1-conjugating enzyme.

PubMed ID: 17825256

DOI: 10.1016/j.bbrc.2007.08.129

PubMed ID: 19101823

Title: NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.

PubMed ID: 19101823

DOI: 10.1007/s10969-008-9054-7

PubMed ID: 34299007

Title: A concerted action of UBA5 C-terminal unstructured regions is important for transfer of activated UFM1 to UFC1.

PubMed ID: 34299007

DOI: 10.3390/ijms22147390

PubMed ID: 34588452

Title: Structural basis for UFM1 transfer from UBA5 to UFC1.

PubMed ID: 34588452

DOI: 10.1038/s41467-021-25994-6

PubMed ID: 38383789

Title: The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.

PubMed ID: 38383789

DOI: 10.1038/s41586-024-07093-w

Sequence Information:

  • Length: 167
  • Mass: 19458
  • Checksum: 1675D9187DC43E14
  • Sequence:
  • MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK 
    EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH 
    FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.