Details for: RTF2

Gene ID: 51507

Symbol: RTF2

Ensembl ID: ENSG00000022277

Description: replication termination factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.3025
    Cell Significance Index: -52.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.2545
    Cell Significance Index: -53.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.4903
    Cell Significance Index: -45.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.0636
    Cell Significance Index: -52.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.8930
    Cell Significance Index: -53.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.4528
    Cell Significance Index: -46.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2146
    Cell Significance Index: -35.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.4148
    Cell Significance Index: -35.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0988
    Cell Significance Index: -17.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3345
    Cell Significance Index: 183.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3054
    Cell Significance Index: 17.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2474
    Cell Significance Index: 80.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2179
    Cell Significance Index: 219.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2130
    Cell Significance Index: 11.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0915
    Cell Significance Index: 134.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0780
    Cell Significance Index: 31.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0244
    Cell Significance Index: 101.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9700
    Cell Significance Index: 529.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9405
    Cell Significance Index: 120.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9013
    Cell Significance Index: 106.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8999
    Cell Significance Index: 178.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8784
    Cell Significance Index: 45.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8730
    Cell Significance Index: 385.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8574
    Cell Significance Index: 9.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8494
    Cell Significance Index: 23.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7993
    Cell Significance Index: 160.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7466
    Cell Significance Index: 34.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7319
    Cell Significance Index: 15.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6921
    Cell Significance Index: 89.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6872
    Cell Significance Index: 48.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6746
    Cell Significance Index: 42.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5801
    Cell Significance Index: 30.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5329
    Cell Significance Index: 36.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5222
    Cell Significance Index: 38.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4648
    Cell Significance Index: 21.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4647
    Cell Significance Index: 12.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4071
    Cell Significance Index: 14.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3325
    Cell Significance Index: 3.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3045
    Cell Significance Index: 15.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2749
    Cell Significance Index: 5.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2504
    Cell Significance Index: 11.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2413
    Cell Significance Index: 86.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2400
    Cell Significance Index: 5.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1807
    Cell Significance Index: 5.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1486
    Cell Significance Index: 28.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1419
    Cell Significance Index: 98.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1122
    Cell Significance Index: 5.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0664
    Cell Significance Index: 11.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0303
    Cell Significance Index: 0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0161
    Cell Significance Index: 11.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0116
    Cell Significance Index: 8.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0087
    Cell Significance Index: -16.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0174
    Cell Significance Index: -26.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0307
    Cell Significance Index: -3.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0309
    Cell Significance Index: -42.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0367
    Cell Significance Index: -27.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0387
    Cell Significance Index: -24.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0663
    Cell Significance Index: -30.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0743
    Cell Significance Index: -41.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0744
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0977
    Cell Significance Index: -61.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0981
    Cell Significance Index: -11.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1098
    Cell Significance Index: -17.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1292
    Cell Significance Index: -3.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1461
    Cell Significance Index: -42.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1864
    Cell Significance Index: -10.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2005
    Cell Significance Index: -15.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2115
    Cell Significance Index: -30.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2247
    Cell Significance Index: -26.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2552
    Cell Significance Index: -53.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2577
    Cell Significance Index: -15.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2977
    Cell Significance Index: -7.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3925
    Cell Significance Index: -12.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4176
    Cell Significance Index: -11.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4360
    Cell Significance Index: -34.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4365
    Cell Significance Index: -12.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4686
    Cell Significance Index: -31.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4813
    Cell Significance Index: -10.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4819
    Cell Significance Index: -50.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5010
    Cell Significance Index: -22.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5469
    Cell Significance Index: -8.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5674
    Cell Significance Index: -4.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5700
    Cell Significance Index: -34.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6282
    Cell Significance Index: -23.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6827
    Cell Significance Index: -27.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8588
    Cell Significance Index: -52.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.8602
    Cell Significance Index: -6.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8615
    Cell Significance Index: -10.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8628
    Cell Significance Index: -16.8400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8726
    Cell Significance Index: -7.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8825
    Cell Significance Index: -22.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9515
    Cell Significance Index: -12.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0710
    Cell Significance Index: -27.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1172
    Cell Significance Index: -41.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1289
    Cell Significance Index: -33.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RTF2 is a non-coding RNA gene that has been implicated in the regulation of DNA replication termination. It is a member of the replication termination factor family, which is responsible for unwinding and resolving the replication fork during DNA replication. RTF2 has been shown to interact with other proteins involved in DNA replication, including topoisomerase II and histone chaperones. The gene is highly expressed in cells that are actively replicating their DNA, such as embryonic stem cells and smooth muscle fibers. RTF2 has also been found to be involved in the regulation of DNA stability and repair, suggesting a broader role in maintaining genome integrity. **Pathways and Functions:** RTF2 is involved in several key pathways, including: 1. **Mitotic DNA Replication Termination:** RTF2 plays a crucial role in the resolution of the replication fork during mitosis, ensuring accurate and efficient DNA replication. 2. **Cellular Response to Hydroxyurea:** RTF2 has been shown to be involved in the cellular response to hydroxyurea, a chemotherapeutic agent that inhibits DNA synthesis. RTF2 helps to regulate the expression of genes involved in DNA repair and cell cycle arrest. 3. **DNA Binding:** RTF2 has been shown to interact with DNA-binding proteins, such as topoisomerase II, to regulate DNA replication and repair. 4. **Regulation of DNA Stability:** RTF2 has been implicated in the regulation of DNA stability and repair, suggesting a broader role in maintaining genome integrity. **Clinical Significance:** The dysregulation of RTF2 has been implicated in various diseases, including: 1. **Cancer:** RTF2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. This overexpression may contribute to the development and progression of cancer. 2. **Genetic Disorders:** RTF2 has been implicated in genetic disorders such as Fanconi anemia, a rare genetic disorder characterized by bone marrow failure and increased risk of cancer. 3. **Immunological Disorders:** RTF2 has been shown to play a role in the regulation of immune responses, particularly in the context of T cell activation and differentiation. In conclusion, RTF2 is a critical gene that plays a pivotal role in the regulation of DNA replication and stability. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms by which RTF2 functions and its potential as a therapeutic target.

Genular Protein ID: 1509514432

Symbol: RTF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29290612

Title: Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.

PubMed ID: 29290612

DOI: 10.1016/j.molcel.2017.11.035

Sequence Information:

  • Length: 306
  • Mass: 33887
  • Checksum: 41EBAB29F7D535BF
  • Sequence:
  • MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD 
    AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI 
    CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD 
    VLKTRMEERR LRAKLEKKTK KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT 
    NLAPKSTAMN ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT 
    HTSYCF

Genular Protein ID: 189624358

Symbol: A2A2L6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 230
  • Mass: 26074
  • Checksum: 2B5EED38670B039A
  • Sequence:
  • MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD 
    AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI 
    CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD 
    VLKTRMEERR LRAKLEKKPQ GHQKLRQGSL KKPALILERR KPTWLPKAQQ

Genular Protein ID: 523482018

Symbol: B4DXL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 336
  • Mass: 37500
  • Checksum: CE36B55F63389E21
  • Sequence:
  • MGCDGGTIPK RHELVKGPKK VEKIWHLKNG KEWCSLHSEG KNKNGKEWDM EYDVDKDAEL 
    VAQWNYCTLS QEILRRPIVA CELGRLYNKD AVIEFLLDKS AEKALGKAAS HIKSIKNVTE 
    LKLSDNPAWE GDKGNTKGDK HDDLQRARFI CPVVGLEMNG RHRFCFLRCC GCVFSERALK 
    EIKAEVCHTC GAAFQEDDVI VLNGTKEDVD VLKTRMEERR LRAKLEKKTK KPKAAESVSK 
    PDVSEEAPGP SKVKTGKPEE ASLDSREKKT NLAPKSTAMN ESSSGKAGKP PCGATKRSIA 
    DSEESEAYKS LFTTHSSAKR SKEESAHWVT HTSYCF

Genular Protein ID: 1031486909

Symbol: A0A0A0MQR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 336
  • Mass: 37532
  • Checksum: 483B025F63252928
  • Sequence:
  • MGCDGGTIPK RHELVKGPKK VEKIWHLKNG KEWCSLHSEG KNKNGKEWDM EYDVDKDAEL 
    VAQWNYCTLS QEILRRPIVA CELGRLYNKD AVIEFLLDKS AEKALGKAAS HIKSIKNVTE 
    LKLSDNPAWE GDKGNTKGDK HDDLQRARFI CPVVGLEMNG RHRFCFLRCC GCVFSERALK 
    EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD VLKTRMEERR LRAKLEKKTK KPKAAESVSK 
    PDVSEEAPGP SKVKTGKPEE ASLDSREKKT NLAPKSTAMN ESSSGKAGKP PCGATKRSIA 
    DSEESEAYKS LFTTHSSAKR SKEESAHWVT HTSYCF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.