Details for: TMEM14C

Gene ID: 51522

Symbol: TMEM14C

Ensembl ID: ENSG00000111843

Description: transmembrane protein 14C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 181.6724
    Cell Significance Index: -46.0800
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.7618
    Cell Significance Index: -27.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 153.9395
    Cell Significance Index: -63.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.7005
    Cell Significance Index: -66.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.9002
    Cell Significance Index: -65.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.0861
    Cell Significance Index: -67.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.8768
    Cell Significance Index: -59.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9894
    Cell Significance Index: -50.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.0398
    Cell Significance Index: -67.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.0227
    Cell Significance Index: -43.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 11.4829
    Cell Significance Index: 286.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6122
    Cell Significance Index: -16.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.1030
    Cell Significance Index: 71.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9963
    Cell Significance Index: 411.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.8536
    Cell Significance Index: 36.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7493
    Cell Significance Index: 37.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7444
    Cell Significance Index: 74.7000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4585
    Cell Significance Index: 27.9300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.4398
    Cell Significance Index: 19.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4071
    Cell Significance Index: 112.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1741
    Cell Significance Index: 75.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0252
    Cell Significance Index: 42.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9896
    Cell Significance Index: 244.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8298
    Cell Significance Index: 329.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7996
    Cell Significance Index: 84.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7289
    Cell Significance Index: 944.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6399
    Cell Significance Index: 43.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5594
    Cell Significance Index: 116.2200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4074
    Cell Significance Index: 15.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3664
    Cell Significance Index: 70.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2652
    Cell Significance Index: 559.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2388
    Cell Significance Index: 87.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2329
    Cell Significance Index: 158.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1739
    Cell Significance Index: 151.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1695
    Cell Significance Index: 10.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5203
    Cell Significance Index: 61.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4592
    Cell Significance Index: 8.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4008
    Cell Significance Index: 39.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3758
    Cell Significance Index: 64.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3696
    Cell Significance Index: 9.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3591
    Cell Significance Index: 103.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3278
    Cell Significance Index: 295.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3063
    Cell Significance Index: 19.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2397
    Cell Significance Index: 47.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2181
    Cell Significance Index: 41.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2160
    Cell Significance Index: 11.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1906
    Cell Significance Index: 38.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1862
    Cell Significance Index: 5.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1840
    Cell Significance Index: 11.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1657
    Cell Significance Index: 26.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1267
    Cell Significance Index: 2.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1199
    Cell Significance Index: 90.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1074
    Cell Significance Index: 78.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0895
    Cell Significance Index: 2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0720
    Cell Significance Index: 3.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0199
    Cell Significance Index: 7.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0102
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0357
    Cell Significance Index: -22.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0371
    Cell Significance Index: -68.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0426
    Cell Significance Index: -65.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0533
    Cell Significance Index: -72.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0616
    Cell Significance Index: -34.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0691
    Cell Significance Index: -43.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0814
    Cell Significance Index: -3.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1158
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1226
    Cell Significance Index: -55.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1238
    Cell Significance Index: -3.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1289
    Cell Significance Index: -27.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1417
    Cell Significance Index: -3.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1631
    Cell Significance Index: -19.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1716
    Cell Significance Index: -6.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1976
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2368
    Cell Significance Index: -27.1400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2982
    Cell Significance Index: -1.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3060
    Cell Significance Index: -7.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3111
    Cell Significance Index: -12.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3146
    Cell Significance Index: -6.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3372
    Cell Significance Index: -7.3100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3424
    Cell Significance Index: -39.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3451
    Cell Significance Index: -50.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3473
    Cell Significance Index: -4.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3739
    Cell Significance Index: -20.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3839
    Cell Significance Index: -10.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3895
    Cell Significance Index: -10.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3921
    Cell Significance Index: -5.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4290
    Cell Significance Index: -11.5000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.4953
    Cell Significance Index: -3.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5872
    Cell Significance Index: -46.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6048
    Cell Significance Index: -5.0800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.6142
    Cell Significance Index: -3.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6260
    Cell Significance Index: -43.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6381
    Cell Significance Index: -66.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7377
    Cell Significance Index: -56.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7645
    Cell Significance Index: -14.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7989
    Cell Significance Index: -47.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0426
    Cell Significance Index: -10.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0879
    Cell Significance Index: -66.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1628
    Cell Significance Index: -34.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TMEM14C is a transmembrane protein with a unique structure, consisting of a single transmembrane domain and a cytoplasmic tail. Its expression is largely restricted to hematopoietic and immune cells, suggesting a specialized role in cell differentiation and immune function. TMEM14C has been implicated in the regulation of heme biosynthesis, a critical process in erythropoiesis, where heme is synthesized from iron and succinyl-CoA. **Pathways and Functions** TMEM14C is involved in several cellular pathways, including: 1. **Erythrocyte differentiation**: TMEM14C regulates the expression of genes involved in erythropoiesis, promoting the differentiation of hematopoietic progenitor cells into erythrocytes. 2. **Heme biosynthetic process**: TMEM14C modulates the activity of enzymes involved in heme synthesis, ensuring the proper production of heme, a critical component of hemoglobin. 3. **Mitochondrial inner membrane**: TMEM14C interacts with mitochondrial proteins, regulating the transport of ions and molecules across the mitochondrial inner membrane. 4. **Mitochondrial membrane**: TMEM14C is involved in the regulation of mitochondrial membrane dynamics, ensuring the proper functioning of mitochondria. **Clinical Significance** TMEM14C dysregulation has been implicated in various hematological disorders, including: 1. **Anemia**: Abnormal expression of TMEM14C has been linked to anemia, a condition characterized by a decrease in red blood cell mass or hemoglobin levels. 2. **Leukemia**: TMEM14C mutations have been identified in some cases of leukemia, a type of cancer that affects the blood and bone marrow. 3. **Immune disorders**: TMEM14C dysregulation has been implicated in various immune disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, TMEM14C is a critical protein involved in erythrocyte differentiation and heme biosynthesis. Its dysregulation has significant implications for hematological and immune disorders, highlighting the importance of further research into the molecular mechanisms underlying TMEM14C function.

Genular Protein ID: 492725948

Symbol: TM14C_HUMAN

Name: Transmembrane protein 14C

UniProtKB Accession Codes:

Q9P0S9 Q5T4I6

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 22609626

Title: Facile backbone structure determination of human membrane proteins by NMR spectroscopy.

PubMed ID: 22609626

DOI: 10.1038/nmeth.2033

Sequence Information:

  • Length: 112
  • Mass: 11565
  • Checksum: 0C54AD12A50A96E0
  • Sequence:
    • MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL GAYQLSQDPR 
NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV AKVGVSMFNR PH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.