Details for: OSER1

Gene ID: 51526

Symbol: OSER1

Ensembl ID: ENSG00000132823

Description: oxidative stress responsive serine rich 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 206.7566
    Cell Significance Index: -32.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.7852
    Cell Significance Index: -30.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.6123
    Cell Significance Index: -33.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.4202
    Cell Significance Index: -30.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.3451
    Cell Significance Index: -35.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.2453
    Cell Significance Index: -34.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.3083
    Cell Significance Index: -35.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.2516
    Cell Significance Index: -33.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0103
    Cell Significance Index: -29.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0166
    Cell Significance Index: -35.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8144
    Cell Significance Index: -20.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6338
    Cell Significance Index: -12.3300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.3510
    Cell Significance Index: 12.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.5447
    Cell Significance Index: 413.0900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.9882
    Cell Significance Index: 18.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7419
    Cell Significance Index: 37.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6499
    Cell Significance Index: 75.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4033
    Cell Significance Index: 65.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6536
    Cell Significance Index: 268.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6333
    Cell Significance Index: 121.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6129
    Cell Significance Index: 75.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4825
    Cell Significance Index: 77.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4623
    Cell Significance Index: 1320.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2442
    Cell Significance Index: 160.7400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.2306
    Cell Significance Index: 7.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1627
    Cell Significance Index: 69.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0853
    Cell Significance Index: 28.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9615
    Cell Significance Index: 113.3900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.8413
    Cell Significance Index: 5.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7759
    Cell Significance Index: 35.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6367
    Cell Significance Index: 87.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5850
    Cell Significance Index: 71.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5844
    Cell Significance Index: 258.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5808
    Cell Significance Index: 14.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5770
    Cell Significance Index: 39.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5583
    Cell Significance Index: 14.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5440
    Cell Significance Index: 11.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5330
    Cell Significance Index: 105.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5072
    Cell Significance Index: 23.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4932
    Cell Significance Index: 7.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4781
    Cell Significance Index: 61.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4322
    Cell Significance Index: 42.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4031
    Cell Significance Index: 26.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3969
    Cell Significance Index: 216.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3828
    Cell Significance Index: 11.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3801
    Cell Significance Index: 6.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3785
    Cell Significance Index: 26.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3731
    Cell Significance Index: 9.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3660
    Cell Significance Index: 7.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3415
    Cell Significance Index: 61.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3309
    Cell Significance Index: 66.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2941
    Cell Significance Index: 7.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2657
    Cell Significance Index: 7.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2483
    Cell Significance Index: 8.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2373
    Cell Significance Index: 45.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2070
    Cell Significance Index: 2.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1702
    Cell Significance Index: 61.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1115
    Cell Significance Index: 2.0600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1103
    Cell Significance Index: 1.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0618
    Cell Significance Index: 116.2700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0598
    Cell Significance Index: 0.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0394
    Cell Significance Index: 27.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0131
    Cell Significance Index: 20.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0125
    Cell Significance Index: 22.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0063
    Cell Significance Index: -0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0251
    Cell Significance Index: -18.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0260
    Cell Significance Index: -19.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0357
    Cell Significance Index: -26.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0416
    Cell Significance Index: -18.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0443
    Cell Significance Index: -2.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0563
    Cell Significance Index: -31.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0567
    Cell Significance Index: -9.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0583
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0610
    Cell Significance Index: -38.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0716
    Cell Significance Index: -3.7600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0760
    Cell Significance Index: -0.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0913
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0924
    Cell Significance Index: -10.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1050
    Cell Significance Index: -30.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1586
    Cell Significance Index: -5.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1725
    Cell Significance Index: -9.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1747
    Cell Significance Index: -36.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1857
    Cell Significance Index: -2.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1966
    Cell Significance Index: -3.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2156
    Cell Significance Index: -1.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2403
    Cell Significance Index: -6.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2567
    Cell Significance Index: -15.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2884
    Cell Significance Index: -7.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2933
    Cell Significance Index: -30.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3575
    Cell Significance Index: -2.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3709
    Cell Significance Index: -29.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4040
    Cell Significance Index: -24.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4062
    Cell Significance Index: -27.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4087
    Cell Significance Index: -20.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4178
    Cell Significance Index: -21.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4289
    Cell Significance Index: -9.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OSER1 is a serine-rich protein, characterized by its high content of serine residues. This protein is responsive to oxidative stress, a condition caused by an imbalance between the production of reactive oxygen species (ROS) and the ability of the cell to detoxify these reactive intermediates. The presence of serine residues in OSER1 suggests that it may play a role in the regulation of protein-protein interactions, which are crucial for the proper functioning of various cellular processes. **Pathways and Functions:** OSER1 is involved in several cellular pathways, including the cellular response to hydrogen peroxide, a potent oxidizing agent. Hydrogen peroxide is a byproduct of the respiratory chain and can cause oxidative damage to cellular components. The expression of OSER1 in various cell types suggests that it may play a role in protecting these cells from oxidative stress. Furthermore, the involvement of OSER1 in protein binding pathways suggests that it may interact with other proteins to regulate cellular processes. **Possible Functions:** 1. **Oxidative Stress Response:** OSER1 may play a role in protecting cells from oxidative stress by regulating the activity of antioxidant enzymes or by modulating the expression of genes involved in the oxidative stress response. 2. **Immune Regulation:** The expression of OSER1 in immune cells such as T cells and mast cells suggests that it may play a role in regulating immune responses. OSER1 may interact with other proteins to modulate the activity of immune cells or to regulate the expression of genes involved in immune function. 3. **Cellular Protection:** OSER1 may also play a role in protecting cells from oxidative damage by regulating the activity of antioxidant enzymes or by modulating the expression of genes involved in cellular protection. **Clinical Significance:** The involvement of OSER1 in oxidative stress response and immune regulation makes it an attractive candidate for the study of various diseases, including: 1. **Oxidative Stress-Related Diseases:** OSER1 may play a role in the pathogenesis of diseases such as cancer, atherosclerosis, and neurodegenerative disorders, which are characterized by oxidative stress. 2. **Immune-Related Diseases:** The expression of OSER1 in immune cells suggests that it may play a role in the regulation of immune responses, which are involved in the pathogenesis of diseases such as autoimmune disorders and inflammatory diseases. 3. **Cancer:** OSER1 may also play a role in cancer, as it is involved in the regulation of oxidative stress response and immune regulation, which are critical processes in cancer development and progression. In conclusion, OSER1 is a serine-rich protein that plays a crucial role in the cellular response to oxidative stress and immune regulation. Further investigation of OSER1 is necessary to fully understand its functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3981630919

Symbol: OSER1_HUMAN

Name: Oxidative stress-responsive serine-rich protein 1

UniProtKB Accession Codes:

Q9NX31 B2RCK4 O95912 Q9NZ84 Q9P0R8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 GO 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 292
  • Mass: 31779
  • Checksum: 4DB0FFBA241FFEF4
  • Sequence:
    • MKSEAKDGEE ESLQTAFKKL RVDASGSVAS LSVGEGTGVR APVRTATDDT KPKTTCASKD 
SWHGSTRKSS RGAVRTQRRR RSKSPVLHPP KFIHCSTIAS SSSSQLKHKS QTDSPDGSSG 
LGISSPKEFS AGESSTSLDA NHTGAVVEPL RTSVPRLPSE SKKEDSSDAT QVPQASLKAS 
DLSDFQSVSK LNQGKPCTCI GKECQCKRWH DMEVYSFSGL QSVPPLAPER RSTLEDYSQS 
LHARTLSGSP RSCSEQARVF VDDVTIEDLS GYMEYYLYIP KKMSHMAEMM YT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.