Details for: MBIP

Gene ID: 51562

Symbol: MBIP

Ensembl ID: ENSG00000151332

Description: MAP3K12 binding inhibitory protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 161.8822
    Cell Significance Index: -25.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.9328
    Cell Significance Index: -24.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.1025
    Cell Significance Index: -29.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.5436
    Cell Significance Index: -24.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.0002
    Cell Significance Index: -24.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.4205
    Cell Significance Index: -24.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1581
    Cell Significance Index: -27.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5078
    Cell Significance Index: -25.4700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 7.9380
    Cell Significance Index: 84.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1287
    Cell Significance Index: -28.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9158
    Cell Significance Index: -18.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8046
    Cell Significance Index: 293.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5503
    Cell Significance Index: 1399.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3591
    Cell Significance Index: 158.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.2049
    Cell Significance Index: 18.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6722
    Cell Significance Index: 134.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6430
    Cell Significance Index: 13.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6214
    Cell Significance Index: 42.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5937
    Cell Significance Index: 16.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5819
    Cell Significance Index: 15.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5644
    Cell Significance Index: 112.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5484
    Cell Significance Index: 242.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5345
    Cell Significance Index: 73.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5222
    Cell Significance Index: 32.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5119
    Cell Significance Index: 4.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5027
    Cell Significance Index: 347.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4866
    Cell Significance Index: 265.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4772
    Cell Significance Index: 21.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4527
    Cell Significance Index: 15.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4237
    Cell Significance Index: 151.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4166
    Cell Significance Index: 23.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3630
    Cell Significance Index: 25.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3346
    Cell Significance Index: 42.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2961
    Cell Significance Index: 8.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2365
    Cell Significance Index: 42.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2000
    Cell Significance Index: 5.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1849
    Cell Significance Index: 18.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1772
    Cell Significance Index: 8.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1728
    Cell Significance Index: 12.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1654
    Cell Significance Index: 20.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1447
    Cell Significance Index: 18.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1358
    Cell Significance Index: 102.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1322
    Cell Significance Index: 3.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1125
    Cell Significance Index: 7.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0879
    Cell Significance Index: 4.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0815
    Cell Significance Index: 15.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0722
    Cell Significance Index: 3.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0706
    Cell Significance Index: 1.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0689
    Cell Significance Index: 8.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0488
    Cell Significance Index: 2.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0438
    Cell Significance Index: 82.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0271
    Cell Significance Index: 0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0212
    Cell Significance Index: 13.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0075
    Cell Significance Index: 13.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0065
    Cell Significance Index: 10.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0035
    Cell Significance Index: 1.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0205
    Cell Significance Index: -1.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0275
    Cell Significance Index: -0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0336
    Cell Significance Index: -4.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0343
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0378
    Cell Significance Index: -6.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0473
    Cell Significance Index: -26.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0505
    Cell Significance Index: -5.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0534
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0552
    Cell Significance Index: -34.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0594
    Cell Significance Index: -1.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0838
    Cell Significance Index: -24.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0921
    Cell Significance Index: -1.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1079
    Cell Significance Index: -6.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1243
    Cell Significance Index: -2.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1297
    Cell Significance Index: -1.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1461
    Cell Significance Index: -7.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1529
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1608
    Cell Significance Index: -33.8600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1669
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1713
    Cell Significance Index: -19.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1789
    Cell Significance Index: -2.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2039
    Cell Significance Index: -7.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2219
    Cell Significance Index: -23.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2617
    Cell Significance Index: -20.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2890
    Cell Significance Index: -5.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3520
    Cell Significance Index: -21.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3587
    Cell Significance Index: -9.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3654
    Cell Significance Index: -9.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3994
    Cell Significance Index: -24.4900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4081
    Cell Significance Index: -5.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4138
    Cell Significance Index: -11.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4206
    Cell Significance Index: -13.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4207
    Cell Significance Index: -4.3600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4352
    Cell Significance Index: -3.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4775
    Cell Significance Index: -10.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4913
    Cell Significance Index: -12.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5097
    Cell Significance Index: -14.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5211
    Cell Significance Index: -12.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5273
    Cell Significance Index: -4.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5364
    Cell Significance Index: -6.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MBIP1 is a protein that interacts with MAP3K12, a mitogen-activated protein kinase kinase kinase (MAP3K12), to inhibit its activity. This interaction has been shown to regulate the cell cycle, particularly during the G2/M phase, where MBIP1 acts as a negative regulator of cell proliferation. MBIP1 is highly expressed in various cell types, including hematopoietic oligopotent progenitor cells, polychromatophilic erythroblasts, and embryonic stem cells, suggesting its involvement in developmental processes and immune cell differentiation. **Pathways and Functions:** MBIP1 is involved in several key pathways, including: 1. **Epigenetic regulation of gene expression**: MBIP1 interacts with WDR5-containing histone-modifying complexes to regulate chromatin organization and gene expression. 2. **Cell cycle regulation**: MBIP1 acts as a negative regulator of the G2/M phase, inhibiting cell proliferation and promoting cell cycle arrest. 3. **Transcriptional regulation**: MBIP1 interacts with RNA polymerase II to regulate transcription, particularly in response to stress and DNA damage. 4. **Immune responses**: MBIP1 is highly expressed in immune cells, such as CD8-alpha-beta-positive T cells and mast cells, suggesting its involvement in immune cell function and regulation. **Clinical Significance:** MBIP1 has been implicated in various human diseases, including: 1. **Cancer**: MBIP1 is often downregulated in cancer cells, suggesting its role in tumor suppression and cell cycle regulation. 2. **Autoimmune diseases**: MBIP1 may play a role in regulating immune responses and preventing autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders**: MBIP1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation may contribute to disease pathogenesis. In conclusion, MBIP1 is a novel gene that plays a critical role in regulating gene expression, cell cycle control, and immune responses. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms underlying MBIP1 function and its potential therapeutic applications. **Future Directions:** 1. **Investigating MBIP1-mediated regulation of gene expression**: Further studies are needed to elucidate the mechanisms underlying MBIP1-mediated regulation of gene expression and its role in developmental processes. 2. **Exploring MBIP1's role in cancer and autoimmune diseases**: Research into MBIP1's role in cancer and autoimmune diseases will provide valuable insights into its therapeutic potential. 3. **Developing MBIP1-targeted therapies**: The development of MBIP1-targeted therapies may offer new avenues for treating human diseases, including cancer and autoimmune disorders.

Genular Protein ID: 2293397330

Symbol: MBIP1_HUMAN

Name: MAP3K12-binding inhibitory protein 1

UniProtKB Accession Codes:

Q9NS73 Q86TZ2 Q96AS5 Q9BS93 Q9NZE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 16 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10801814

Title: MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase.

PubMed ID: 10801814

DOI: 10.1074/jbc.m001488200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19103755

Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.

PubMed ID: 19103755

DOI: 10.1128/mcb.01599-08

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 344
  • Mass: 39281
  • Checksum: 9DABB35CA8695C02
  • Sequence:
    • MAAATELNRP SSGDRNLERR CRPNLSREVL YEIFRSLHTL VGQLDLRDDV VKITIDWNKL 
QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA VEEIGRTEMG NKNEVNDKFS 
IGDLQEEEKH KESDLRDVKK TQIHFDPEVV QIKAGKAEID RRISAFIERK QAEINENNVR 
EFCNVIDCNQ ENSCARTDAI FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML 
RDCGNQAVEE RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG 
KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP

Genular Protein ID: 2398533945

Symbol: B2RCV0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCV0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 344
  • Mass: 39236
  • Checksum: 2AF42F5C681A722F
  • Sequence:
    • MAAATEHNRP SSGDRNLERR CSPNLSREVL YEIFRSLHTL VGQLDLRDDV VKITIDWNKL 
QSLSAFQPAL LFSALEQHIL YLQPFLAKLQ SPIKEENTTA VEEIGRTEMG NKNEVNDKFS 
IGDLQEEEKH KESDLRDVKK TQIHFDPEVV QIKAGKAEID RRISAFIERK QAEINENNVR 
EFCNVIDCNQ ENSCARTDAI FTPYPGFKSH VKVSRVVNTY GPQTRPEGIP GSGHKPNSML 
RDCGNQAVEE RLQNIEAHLR LQTGGPVPRD IYQRIKKLED KILELEGISP EYFQSVSFSG 
KRRKVQPPQQ NYSLAELDEK ISALKQALLR KSREAESMAT HHLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.