Details for: ESF1

Gene ID: 51575

Symbol: ESF1

Ensembl ID: ENSG00000089048

Description: ESF1 nucleolar pre-rRNA processing protein homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 346.6516
    Cell Significance Index: -53.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.1415
    Cell Significance Index: -49.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.8964
    Cell Significance Index: -57.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 126.0901
    Cell Significance Index: -59.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 109.1789
    Cell Significance Index: -56.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.9986
    Cell Significance Index: -59.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.6825
    Cell Significance Index: -57.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.8405
    Cell Significance Index: -53.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8731
    Cell Significance Index: -58.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9906
    Cell Significance Index: -39.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.7786
    Cell Significance Index: -23.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8904
    Cell Significance Index: 199.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3254
    Cell Significance Index: 461.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6486
    Cell Significance Index: 179.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6433
    Cell Significance Index: 22.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5136
    Cell Significance Index: 246.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4889
    Cell Significance Index: 298.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4380
    Cell Significance Index: 39.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2629
    Cell Significance Index: 33.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1660
    Cell Significance Index: 32.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1344
    Cell Significance Index: 155.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0295
    Cell Significance Index: 57.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0284
    Cell Significance Index: 126.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9856
    Cell Significance Index: 435.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9307
    Cell Significance Index: 65.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9217
    Cell Significance Index: 166.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7628
    Cell Significance Index: 273.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7542
    Cell Significance Index: 21.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7089
    Cell Significance Index: 44.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5844
    Cell Significance Index: 319.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5817
    Cell Significance Index: 74.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5718
    Cell Significance Index: 108.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5513
    Cell Significance Index: 11.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4812
    Cell Significance Index: 36.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4623
    Cell Significance Index: 319.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4604
    Cell Significance Index: 20.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4292
    Cell Significance Index: 26.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3698
    Cell Significance Index: 17.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3450
    Cell Significance Index: 18.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3390
    Cell Significance Index: 17.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3324
    Cell Significance Index: 42.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2888
    Cell Significance Index: 3.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2536
    Cell Significance Index: 1.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2498
    Cell Significance Index: 225.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2052
    Cell Significance Index: 15.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1727
    Cell Significance Index: 7.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1546
    Cell Significance Index: 26.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1460
    Cell Significance Index: 2.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1426
    Cell Significance Index: 1.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1085
    Cell Significance Index: 4.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0990
    Cell Significance Index: 6.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0837
    Cell Significance Index: 8.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0797
    Cell Significance Index: 5.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0702
    Cell Significance Index: 1.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0513
    Cell Significance Index: 96.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0461
    Cell Significance Index: 1.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0305
    Cell Significance Index: 1.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0130
    Cell Significance Index: 8.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0062
    Cell Significance Index: 11.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0180
    Cell Significance Index: -11.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0201
    Cell Significance Index: -9.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0202
    Cell Significance Index: -15.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0265
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0269
    Cell Significance Index: -19.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0450
    Cell Significance Index: -25.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0631
    Cell Significance Index: -7.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0719
    Cell Significance Index: -10.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0834
    Cell Significance Index: -2.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0899
    Cell Significance Index: -9.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1126
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1413
    Cell Significance Index: -29.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1656
    Cell Significance Index: -47.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1728
    Cell Significance Index: -20.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2072
    Cell Significance Index: -3.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2090
    Cell Significance Index: -5.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2798
    Cell Significance Index: -31.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2921
    Cell Significance Index: -33.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3288
    Cell Significance Index: -8.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3867
    Cell Significance Index: -9.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4331
    Cell Significance Index: -13.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4970
    Cell Significance Index: -11.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5101
    Cell Significance Index: -53.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5233
    Cell Significance Index: -12.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5703
    Cell Significance Index: -8.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5900
    Cell Significance Index: -46.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6318
    Cell Significance Index: -18.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6505
    Cell Significance Index: -3.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6529
    Cell Significance Index: -16.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8143
    Cell Significance Index: -14.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8336
    Cell Significance Index: -9.4700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8573
    Cell Significance Index: -7.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8754
    Cell Significance Index: -53.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8902
    Cell Significance Index: -19.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.9522
    Cell Significance Index: -7.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1090
    Cell Significance Index: -27.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1140
    Cell Significance Index: -35.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1330
    Cell Significance Index: -24.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ESF1 gene is a member of the nucleolar pre-rRNA processing protein family, which is involved in the processing of rRNA in the nucleolus. ESF1 is specifically expressed in cells that require high levels of rRNA production, such as hematopoietic stem cells, embryonic stem cells, and smooth muscle fibers. The gene is highly conserved across species, suggesting its essential role in rRNA processing and ribosome biogenesis. **Pathways and Functions:** ESF1 is involved in the processing of pre-rRNA in the nucleolus, where it interacts with other RNA processing proteins to facilitate the maturation of rRNA. The ESF1 protein is localized to the nucleolus and is required for the assembly and function of ribosomes. In addition, ESF1 has been implicated in the regulation of cell growth and proliferation, particularly in cells of hematopoietic origin. **Clinical Significance:** Dysregulation of ESF1 expression has been implicated in various diseases, including hematological malignancies. For example, altered ESF1 expression has been observed in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), suggesting its potential as a diagnostic or prognostic marker. Furthermore, ESF1 has been shown to play a role in the regulation of cell growth and proliferation, making it a potential target for the treatment of cancer. In addition to its role in hematological malignancies, ESF1 has also been implicated in other diseases, including inflammatory bowel disease and autoimmune disorders. For example, ESF1 expression has been shown to be altered in patients with inflammatory bowel disease, suggesting its potential as a biomarker for disease diagnosis or prognosis. **Conclusion:** In conclusion, the ESF1 gene plays a critical role in the processing of rRNA and the assembly and function of ribosomes. Its dysregulation has been implicated in various diseases, including hematological malignancies and inflammatory bowel disease. Further research is needed to fully understand the clinical significance of ESF1 and its potential as a diagnostic or prognostic marker for these diseases. **Recommendations:** 1. Further studies are needed to fully understand the role of ESF1 in rRNA processing and ribosome biogenesis. 2. The development of ESF1 as a diagnostic or prognostic marker for hematological malignancies and inflammatory bowel disease is warranted. 3. The potential of ESF1 as a therapeutic target for cancer treatment should be further investigated. **Limitations:** The current review is limited by the availability of data on ESF1 expression and function in various diseases. Further studies are needed to fully understand the clinical significance of ESF1 and its potential as a diagnostic or prognostic marker. **Future Directions:** Future studies should focus on the development of ESF1 as a diagnostic or prognostic marker for hematological malignancies and inflammatory bowel disease. Additionally, the potential of ESF1 as a therapeutic target for cancer treatment should be further investigated.

Genular Protein ID: 1475068377

Symbol: ESF1_HUMAN

Name: ESF1 homolog

UniProtKB Accession Codes:

Q9H501 Q86X92 Q9H9Q5 Q9HA35 Q9NX93 Q9P1S6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 851
  • Mass: 98796
  • Checksum: 1BA283E7A0A65432
  • Sequence:
    • MSSKQEIMSD QRFRRVAKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN YAVDKRGRPI 
SHSTTEDLKR FYDLSDSDSN LSGEDSKALS QKKIKKKKTQ TKKEIDSKNL VEKKKETKKA 
NHKGSENKTD LDNSIGIKKM KTSCKFKIDS NISPKKDSKE FTQKNKKEKK NIVQHTTDSS 
LEEKQRTLDS GTSEIVKSPR IECSKTRREM QSVVQLIMTR DSDGYENSTD GEMCDKDALE 
EDSESVSEIG SDEESENEIT SVGRASGDDD GSEDDEEEDE DEEEDEDEDS EDDDKSDSGP 
DLARGKGNIE TSSEDEDDTA DLFPEESGFE HAWRELDKDA PRADEITRRL AVCNMDWDRL 
KAKDLLALFN SFKPKGGVIF SVKIYPSEFG KERMKEEQVQ GPVELLSIPE DAPEKDWTSR 
EKLRDYQFKR LKYYYAVVDC DSPETASKIY EDCDGLEFES SCSFIDLRFI PDDITFDDEP 
KDVASEVNLT AYKPKYFTSA AMGTSTVEIT WDETDHERIT MLNRKFKKEE LLDMDFQAYL 
ASSSEDEEEI EEELQGDDGV NVEEDGKTKK SQKDDEEQIA KYRQLLQVIQ EKEKKGKEND 
MEMEIKWVPG LKESAEEMVK NKLEGKDKLT PWEQFLEKKK EKKRLKRKQK ALAEEASEEE 
LPSDVDLNDP YFAEEVKQIG INKKSVKSAK DGTSPEEEIE IERQKAEMAL LMMDEDEDSK 
KHFNYNKIVE HQNLSKKKKK QLMKKKELIE DDFEVNVNDA RFQAMYTSHL FNLDPSDPNF 
KKTKAMEKIL EEKARQRERK EQELTQAIKK KESEIEKESQ RKSIDPALSM LIKSIKTKTE 
QFQARKKQKV K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.