PIAS4 | ENSG00000105229 | NCBI 51588

Details for: PIAS4

Gene ID: 51588

Symbol: PIAS4

Ensembl ID: ENSG00000105229

Description: protein inhibitor of activated STAT 4

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna repair
(R-HSA-73894)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Post-translational protein modification
(R-HSA-597592)
Processing of dna double-strand break ends
(R-HSA-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of immune response proteins
(R-HSA-4755510)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Sumoylation of transcription factors
(R-HSA-3232118)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Vitamin d (calciferol) metabolism
(R-HSA-196791)
Central nervous system development
(GO:0007417)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Double-strand break repair
(GO:0006302)
Hair follicle development
(GO:0001942)
Limb epidermis development
(GO:0060887)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein localization to chromatin
(GO:0120186)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902231)
Positive regulation of keratinocyte apoptotic process
(GO:1902174)
Positive regulation of protein sumoylation
(GO:0033235)
Protein binding
(GO:0005515)
Protein sumoylation
(GO:0016925)
Regulation of mrna stability
(GO:0043488)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sumo ligase activity
(GO:0061665)
Sumo transferase activity
(GO:0019789)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transferase complex
(GO:1990234)
Ubiquitin protein ligase binding
(GO:0031625)
Vitamin d metabolic process
(GO:0042359)
Wnt signaling pathway
(GO:0016055)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 107.7500
Cell Significance Index: -16.7600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 65.6828
Cell Significance Index: -16.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 37.9316
Cell Significance Index: -15.4100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.2557
Cell Significance Index: -15.5200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.2746
Cell Significance Index: -17.6000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.2751
Cell Significance Index: -16.8100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.1441
Cell Significance Index: -15.8000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.5235
Cell Significance Index: -17.8500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2702
Cell Significance Index: 148.0300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9951
Cell Significance Index: 898.4700
Cell Name: germ cell (CL0000586)
Fold Change: 0.7880
Cell Significance Index: 5.9500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7199
Cell Significance Index: 43.2200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6655
Cell Significance Index: 9.0800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6526
Cell Significance Index: 106.1400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5727
Cell Significance Index: 19.9000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5695
Cell Significance Index: 114.2500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4258
Cell Significance Index: 84.5000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3955
Cell Significance Index: 24.9300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3833
Cell Significance Index: 26.5100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3614
Cell Significance Index: 7.8300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3544
Cell Significance Index: 10.2100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2974
Cell Significance Index: 13.4800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2566
Cell Significance Index: 6.8800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2478
Cell Significance Index: 12.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2338
Cell Significance Index: 44.5000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2191
Cell Significance Index: 5.8500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2125
Cell Significance Index: 38.3000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2090
Cell Significance Index: 74.9500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1972
Cell Significance Index: 4.9300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1816
Cell Significance Index: 9.4600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1761
Cell Significance Index: 4.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1739
Cell Significance Index: 94.9600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1552
Cell Significance Index: 19.0900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1437
Cell Significance Index: 6.7000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1421
Cell Significance Index: 19.5200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1285
Cell Significance Index: 56.8300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1115
Cell Significance Index: 13.1500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0720
Cell Significance Index: 2.5300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0612
Cell Significance Index: 42.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0605
Cell Significance Index: 4.5100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0592
Cell Significance Index: 2.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0563
Cell Significance Index: 5.5700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0459
Cell Significance Index: 1.2500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0454
Cell Significance Index: 0.7600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0430
Cell Significance Index: 0.9000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0378
Cell Significance Index: 4.8500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0218
Cell Significance Index: 1.6700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0160
Cell Significance Index: 0.3400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0125
Cell Significance Index: 19.1900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0094
Cell Significance Index: 17.3800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0093
Cell Significance Index: 0.1600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0083
Cell Significance Index: 15.5900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0043
Cell Significance Index: 0.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0040
Cell Significance Index: 0.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0032
Cell Significance Index: 4.3200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0068
Cell Significance Index: -5.0200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0088
Cell Significance Index: -5.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0151
Cell Significance Index: -11.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0197
Cell Significance Index: -14.6000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0219
Cell Significance Index: -1.4100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0224
Cell Significance Index: -10.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0268
Cell Significance Index: -15.1300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0327
Cell Significance Index: -20.4400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0393
Cell Significance Index: -4.0100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0434
Cell Significance Index: -1.1400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0440
Cell Significance Index: -2.4700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0501
Cell Significance Index: -14.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0529
Cell Significance Index: -2.7800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0554
Cell Significance Index: -3.9200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0621
Cell Significance Index: -1.3600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0669
Cell Significance Index: -4.5000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0784
Cell Significance Index: -11.4000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0846
Cell Significance Index: -5.2000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0938
Cell Significance Index: -19.7600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1032
Cell Significance Index: -1.2300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1042
Cell Significance Index: -11.9400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1146
Cell Significance Index: -3.6700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1491
Cell Significance Index: -6.6000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1616
Cell Significance Index: -16.8300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1662
Cell Significance Index: -1.7200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1821
Cell Significance Index: -14.4200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1988
Cell Significance Index: -5.1100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2013
Cell Significance Index: -12.3400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2103
Cell Significance Index: -7.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2292
Cell Significance Index: -6.7300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2681
Cell Significance Index: -6.8500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2737
Cell Significance Index: -7.8100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2906
Cell Significance Index: -2.3700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3099
Cell Significance Index: -4.6700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3192
Cell Significance Index: -5.9000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3636
Cell Significance Index: -11.5800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3746
Cell Significance Index: -5.3700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3903
Cell Significance Index: -12.7800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4029
Cell Significance Index: -11.5500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4073
Cell Significance Index: -14.2700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4133
Cell Significance Index: -8.8400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4236
Cell Significance Index: -15.5500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4426
Cell Significance Index: -22.3700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4466
Cell Significance Index: -13.1600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.4552
Cell Significance Index: -5.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PIAS4 is a member of the PIAS (Protein Inhibitor of Activated STAT) family, which consists of four proteins that regulate the activity of activated STAT transcription factors. PIAS4 is specifically known for its ability to inhibit the activation of STAT 4, a transcription factor involved in the regulation of immune responses and cell growth. PIAS4 is also involved in the regulation of various cellular processes, including DNA repair, transcriptional control, and protein sumoylation. **Pathways and Functions:** PIAS4 is involved in multiple signaling pathways, including: 1. **DNA Damage Response:** PIAS4 regulates the activity of DNA damage response proteins, such as ATM (Ataxia-Telangiectasia Mutated) and BRCA1 (Breast Cancer 1), which are essential for maintaining genomic stability. 2. **Transcriptional Control:** PIAS4 modulates the activity of transcription factors, including STAT 4, NF-κB, and p53, which are involved in regulating cell growth, differentiation, and survival. 3. **Immune Function:** PIAS4 is involved in the regulation of immune responses, including the activation of T cells and the regulation of cytokine production. 4. **Protein Sumoylation:** PIAS4 is a sumo E3 ligase, which means it can regulate the sumoylation of target proteins, including transcription factors and DNA damage response proteins. **Clinical Significance:** The dysregulation of PIAS4 has been implicated in various diseases, including: 1. **Cancer:** PIAS4 mutations have been identified in several types of cancer, including breast, lung, and colon cancer, where it is thought to contribute to tumor progression and metastasis. 2. **Autoimmune Diseases:** PIAS4 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders:** PIAS4 has been implicated in the regulation of neuronal function and has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PIAS4 is a multifunctional gene that plays a crucial role in regulating various cellular processes, including DNA damage response, transcriptional control, and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of PIAS4 in maintaining cellular homeostasis. Further research is needed to fully understand the role of PIAS4 in human disease and to explore potential therapeutic strategies for its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein inhibitor of activated STAT protein 4
B3KMR4_HUMAN

Genular Protein ID: 1327407668

Symbol: PIAS4_HUMAN

Name: Protein inhibitor of activated STAT protein 4

UniProtKB Accession Codes:

Q8N2W9 O75926 Q96G19 Q9UN16

Database IDs:

Citations:

PubMed ID: 9724754

Title: Inhibition of Stat1-mediated gene activation by PIAS1.

PubMed ID: 9724754

DOI: 10.1073/pnas.95.18.10626

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11388671

Title: A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.

PubMed ID: 11388671

DOI: 10.1023/a:1011392811628

PubMed ID: 11248056

Title: A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.

PubMed ID: 11248056

DOI: 10.1073/pnas.051489598

PubMed ID: 11439351

Title: Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.

PubMed ID: 11439351

DOI: 10.1038/sj.onc.1204489

PubMed ID: 12223491

Title: SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

PubMed ID: 12223491

DOI: 10.1074/jbc.m208099200

PubMed ID: 12750312

Title: Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.

PubMed ID: 12750312

DOI: 10.1161/01.res.0000076893.70898.36

PubMed ID: 12727872

Title: Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.

PubMed ID: 12727872

DOI: 10.1093/emboj/cdg204

PubMed ID: 12631292

Title: Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.

PubMed ID: 12631292

DOI: 10.1046/j.1432-1033.2003.03504.x

PubMed ID: 12511558

Title: A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.

PubMed ID: 12511558

DOI: 10.1074/jbc.m210440200

PubMed ID: 15251447

Title: PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

PubMed ID: 15251447

DOI: 10.1016/j.febslet.2004.05.081

PubMed ID: 15831457

Title: SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.

PubMed ID: 15831457

DOI: 10.1128/mcb.25.9.3506-3518.2005

PubMed ID: 15976810

Title: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities.

PubMed ID: 15976810

DOI: 10.1038/sj.cdd.4401704

PubMed ID: 16617055

Title: Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.

PubMed ID: 16617055

DOI: 10.1074/jbc.m513135200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 22508508

Title: DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.

PubMed ID: 22508508

DOI: 10.1083/jcb.201106152

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28842558

Title: HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PubMed ID: 28842558

DOI: 10.1038/s41467-017-00476-w

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32832608

Title: TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.

PubMed ID: 32832608

DOI: 10.1126/sciadv.aba7822

PubMed ID: 35013556

Title: The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

PubMed ID: 35013556

DOI: 10.1038/s41556-021-00807-6

PubMed ID: 34048572

Title: Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.

PubMed ID: 34048572

DOI: 10.1093/nar/gkab415

Sequence Information:

Length: 510
Mass: 56504
Checksum: 26AAA18246E1ACE3
Sequence:

MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 
LYETRYAKKN SEPAPQPHRP LDPLTMHSTY DRAGAVPRTP LAGPNIDYPV LYGKYLNGLG 
RLPAKTLKPE VRLVKLPFFN MLDELLKPTE LVPQNNEKLQ ESPCIFALTP RQVELIRNSR 
ELQPGVKAVQ VVLRICYSDT SCPQEDQYPP NIAVKVNHSY CSVPGYYPSN KPGVEPKRPC 
RPINLTHLMY LSSATNRITV TWGNYGKSYS VALYLVRQLT SSELLQRLKT IGVKHPELCK 
ALVKEKLRLD PDSEIATTGV RVSLICPLVK MRLSVPCRAE TCAHLQCFDA VFYLQMNEKK 
PTWMCPVCDK PAPYDQLIID GLLSKILSEC EDADEIEYLV DGSWCPIRAE KERSCSPQGA 
ILVLGPSDAN GLLPAPSVNG SGALGSTGGG GPVGSMENGK PGADVVDLTL DSSSSSEDEE 
EEEEEEEDED EEGPRPKRRC PFQKGLVPAC

Genular Protein ID: 2008637024

Symbol: B3KMR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMR4

Database IDs:

Sequence Information:

Length: 510
Mass: 56432
Checksum: C39489146F83E193
Sequence:

MAAELVEAKN MVMSFRVSDL QMLLGFVGRS KSGLKHELVT RALQLVQFDC SPELFKKIKE 
LYETRYAKKN SEPAPQPHRP LDPLTMHSTY DRAGAVPRTP LAGPNIDYPV LYGKYLNGLG 
RLPAKTLKPE VRLVKLPFFN MLDELLKPTE LVPQNNGKLQ ESPCIFALTP RQVELIRNSR 
ELQPGVKAVQ VVLRICYSDT SCPQEDQYPP NIAVKVNHSY CSVPGYYPSN KPGVEPKRPC 
RPINLTHLMY LSSATNRITV TWGNYGKSYS VALYLVRQLT SSELLQRLKT IGVKHPELCK 
ALVKEKLRLD PDSEIATTGV RVSLICPLVK MRLSVPCRAE TCAHLQCFDA VFYLQMNEKK 
PTWMCPVCDK PAPYDQLIID GLLSKILSEC EDADEIEYLV DGSWCPIRAE KERSCSPQGA 
ILVLGPSDAN GLLPAPSVNG SGALGSTGGG GPVGSMENGK PGADVVDLTL DSSSSSEDEE 
EEEEEEEDED EEGPRPKRRC PFQKGLVPAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIAS4

Associated with

Cells (max top 100)

Other Information

Inhibition of Stat1-mediated gene activation by PIAS1. PubMed ID: 9724754

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. PubMed ID: 11388671

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif. PubMed ID: 11248056

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. PubMed ID: 11439351

SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. PubMed ID: 12223491

Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. PubMed ID: 12750312

Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. PubMed ID: 12727872

Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. PubMed ID: 12631292

A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3. PubMed ID: 12511558

PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis. PubMed ID: 15251447

SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. PubMed ID: 15831457

Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. PubMed ID: 15976810

Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. PubMed ID: 16617055

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. PubMed ID: 21965678

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. PubMed ID: 22508508

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. PubMed ID: 28842558

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy. PubMed ID: 32832608

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. PubMed ID: 35013556

Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response. PubMed ID: 34048572