Details for: PDHA1
Gene ID: 5160
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDHA1
Ensembl ID: ENSG00000131828
Description: pyruvate dehydrogenase E1 subunit alpha 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 22.44rCSI 26.36%PRS 47.48
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CSI 15.36rCSI 14.2%PRS 63.86
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CSI 14.18rCSI 13.67%PRS 34.81
-
CSI 14.09rCSI 19.97%PRS 40.84
-
CSI 13.7rCSI 18.31%PRS 66.01
-
CSI 12.38rCSI 11.92%PRS 44.27
-
CSI 11.93rCSI 24.5%PRS 65.9
-
CSI 11.02rCSI 39.16%PRS 79.44
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CSI 10.22rCSI 12.83%PRS 53.4
-
CSI 9.77rCSI 42.88%PRS 62.99
-
CSI 8.91rCSI 30.52%PRS 76.41
-
CSI 8.86rCSI 6.71%PRS 55.8
-
CSI 8.5rCSI 13.06%PRS 50.63
-
CSI 8.45rCSI 7.5%PRS 42.85
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CSI 8.31rCSI 18.64%PRS 29.41
-
CSI 8.08rCSI 12.91%PRS 47.45
-
CSI 7.88rCSI 59.2%PRS 63.96
-
CSI 7.73rCSI 20.5%PRS 57.16
-
CSI 7.45rCSI 12.07%PRS 42.38
-
CSI 7.34rCSI 9.22%PRS 57.22
-
CSI 7.02rCSI 10.6%PRS 45.72
-
CSI 6.93rCSI 8.93%PRS 29.65
-
CSI 6.64rCSI 11.84%PRS 59.34
-
CSI 6.35rCSI 11.22%PRS 27.78
-
CSI 6.33rCSI 10.05%PRS 54.26
-
CSI 6.23rCSI 16.8%PRS 52.6
-
CSI 6.14rCSI 17.61%PRS 61.08
-
CSI 6.1rCSI 27.11%PRS 42.51
-
CSI 5.88rCSI 21.14%PRS 27.68
-
CSI 5.83rCSI 6.11%PRS 41.11
-
CSI 5.75rCSI 60.95%PRS 45.24
-
CSI 5.74rCSI 7.84%PRS 48.56
-
CSI 5.59rCSI 12.49%PRS 50.2
-
CSI 5.52rCSI 4.99%PRS 40.49
-
CSI 5.4rCSI 17.5%PRS 46.64
-
CSI 5.3rCSI 10.3%PRS 45.74
-
CSI 5.25rCSI 7.27%PRS 48.77
-
CSI 5.24rCSI 4.12%PRS 50.13
-
CSI 4.96rCSI 7.99%PRS 34.88
-
CSI 4.8rCSI 4.79%PRS 38.22
-
CSI 4.71rCSI 12.24%PRS 49
-
CSI 4.71rCSI 3.54%PRS 47.06
-
CSI 4.69rCSI 3.76%PRS 65.21
-
CSI 4.63rCSI 11.3%PRS 40.03
-
CSI 4.59rCSI 4.73%PRS 61.36
-
CSI 4.49rCSI 17.48%PRS 63.99
-
CSI 4.4rCSI 23.74%PRS 58.32
-
CSI 4.35rCSI 3.22%PRS 37.63
-
CSI 4.13rCSI 3.47%PRS 61.01
-
CSI 4.1rCSI 6.05%PRS 61.16
-
CSI 3.98rCSI 10.5%PRS 51.16
-
CSI 3.92rCSI 3.19%PRS 44.56
-
CSI 3.88rCSI 3.21%PRS 44.69
-
CSI 3.77rCSI 9.57%PRS 39.93
-
CSI 3.71rCSI 5.05%PRS 37.47
-
CSI 3.69rCSI 21.15%PRS 54.38
-
CSI 3.69rCSI 5.94%PRS 52.72
-
CSI 3.65rCSI 28.6%PRS 60.3
-
CSI 3.64rCSI 5.41%PRS 46.27
-
CSI 3.64rCSI 3.44%PRS 44.77
-
CSI 3.61rCSI 4.59%PRS 48.97
-
CSI 3.57rCSI 2.89%PRS 44.32
-
CSI 3.54rCSI 4.74%PRS 52.08
-
CSI 3.53rCSI 5.45%PRS 41.7
-
CSI 3.47rCSI 2.43%PRS 45.45
-
CSI 3.46rCSI 5.31%PRS 46.06
-
CSI 3.41rCSI 3.55%PRS 44.49
-
CSI 3.19rCSI 2.12%PRS 47.6
-
CSI 3.18rCSI 9.39%PRS 47.74
-
CSI 3.16rCSI 7.29%PRS 35.95
-
CSI 3rCSI 2.37%PRS 32.07
-
CSI 2.96rCSI 4.04%PRS 46.35
-
CSI 2.95rCSI 18.42%PRS 36.57
-
CSI 2.91rCSI 4.64%PRS 37.88
-
CSI 2.89rCSI 7.3%PRS 51.92
-
CSI 2.87rCSI 8.04%PRS 58.3
-
CSI 2.86rCSI 2.99%PRS 43.36
-
CSI 2.82rCSI 3.77%PRS 45.3
-
CSI 2.8rCSI 2.6%PRS 43.59
-
CSI 2.76rCSI 17.79%PRS 65.9
-
CSI 2.76rCSI 18.12%PRS 76.62
-
CSI 2.74rCSI 4.35%PRS 37.18
-
CSI 2.63rCSI 2.58%PRS 46.01
-
CSI 2.62rCSI 28.5%PRS 64.32
-
CSI 2.6rCSI 7.4%PRS 43.82
-
CSI 2.6rCSI 7.48%PRS 61.48
-
CSI 2.6rCSI 2.66%PRS 62.32
-
CSI 2.56rCSI 2.21%PRS 47.41
-
CSI 2.49rCSI 3.65%PRS 54.8
-
CSI 2.49rCSI 3.57%PRS 51.14
-
CSI 2.48rCSI 4.25%PRS 52.96
-
CSI 2.48rCSI 3.56%PRS 35.5
-
CSI 2.47rCSI 5.92%PRS 59.61
-
CSI 2.46rCSI 2.84%PRS 38.34
-
CSI 2.42rCSI 12.15%PRS 54.57
-
CSI 2.41rCSI 2.11%PRS 48.66
-
CSI 2.38rCSI 1.71%PRS 56.59
-
CSI 2.35rCSI 3.47%PRS 48.68
-
CSI 2.33rCSI 3.23%PRS 43.25
-
CSI 2.33rCSI 1.57%PRS 53.82
-
CSI 0.2rCSI 1.9%PRS 70.8%
-
CSI 0.3rCSI 5.0%PRS 77.7%
-
CSI 0.4rCSI 1.1%PRS 29.9%
-
CSI 0.4rCSI 1.1%PRS 35.6%
-
CSI 0.4rCSI 1.0%PRS 42.5%
-
CSI 0.5rCSI 6.8%PRS 67.8%
-
CSI 0.6rCSI 2.8%PRS 67.5%
-
CSI 0.6rCSI 2.7%PRS 85.0%
-
CSI 0.7rCSI 1.6%PRS 27.9%
-
CSI 0.7rCSI 1.8%PRS 34.7%
-
CSI 0.8rCSI 2.3%PRS 58.3%
-
CSI 0.9rCSI 5.2%PRS 54.7%
-
CSI 0.9rCSI 2.8%PRS 66.6%
-
CSI 0.9rCSI 3.2%PRS 59.2%
-
CSI 0.9rCSI 3.0%PRS 51.3%
-
CSI 1.0rCSI 1.8%PRS 67.0%
-
CSI 1.0rCSI 2.3%PRS 56.1%
-
CSI 1.0rCSI 2.2%PRS 41.1%
-
CSI 1.1rCSI 2.3%PRS 53.7%
-
CSI 1.1rCSI 1.6%PRS 60.0%
-
CSI 1.1rCSI 2.6%PRS 46.0%
-
CSI 1.1rCSI 4.4%PRS 42.3%
-
CSI 1.1rCSI 2.5%PRS 32.7%
-
CSI 1.1rCSI 1.7%PRS 46.7%
-
CSI 1.1rCSI 1.0%PRS 51.0%
-
CSI 1.1rCSI 2.7%PRS 61.5%
-
CSI 1.1rCSI 2.4%PRS 58.8%
-
CSI 1.2rCSI 6.1%PRS 80.8%
-
CSI 1.2rCSI 1.4%PRS 66.5%
-
CSI 1.2rCSI 1.8%PRS 53.7%
-
CSI 1.2rCSI 2.1%PRS 28.7%
-
CSI 1.3rCSI 2.3%PRS 42.2%
-
CSI 1.3rCSI 2.2%PRS 49.3%
-
CSI 1.3rCSI 2.5%PRS 53.9%
-
CSI 1.3rCSI 3.2%PRS 53.9%
-
CSI 1.3rCSI 1.4%PRS 58.9%
-
CSI 1.4rCSI 1.6%PRS 34.3%
-
CSI 1.4rCSI 3.5%PRS 40.1%
-
CSI 1.4rCSI 3.6%PRS 52.2%
-
CSI 1.4rCSI 5.2%PRS 29.7%
-
CSI 1.4rCSI 2.0%PRS 57.3%
-
CSI 1.4rCSI 2.0%PRS 46.4%
-
CSI 1.4rCSI 22.0%PRS 69.5%
-
CSI 1.4rCSI 43.0%PRS 68.6%
-
CSI 1.5rCSI 5.3%PRS 62.9%
-
CSI 1.5rCSI 2.0%PRS 48.4%
-
CSI 1.5rCSI 4.4%PRS 46.2%
-
CSI 1.6rCSI 2.4%PRS 44.4%
-
CSI 1.6rCSI 2.8%PRS 42.2%
-
CSI 1.6rCSI 4.9%PRS 32.1%
-
CSI 1.6rCSI 2.5%PRS 40.6%
-
CSI 1.7rCSI 2.0%PRS 28.7%
-
CSI 1.7rCSI 2.5%PRS 48.3%
-
CSI 1.7rCSI 2.6%PRS 44.7%
-
CSI 1.7rCSI 3.1%PRS 34.0%
-
CSI 1.7rCSI 14.4%PRS 81.6%
-
CSI 1.7rCSI 4.2%PRS 41.8%
-
CSI 1.7rCSI 2.9%PRS 34.9%
-
CSI 1.8rCSI 4.0%PRS 49.3%
-
CSI 1.8rCSI 2.2%PRS 27.3%
-
CSI 1.8rCSI 1.8%PRS 49.5%
-
CSI 1.8rCSI 11.2%PRS 73.4%
-
CSI 1.8rCSI 1.6%PRS 33.4%
-
CSI 1.9rCSI 2.3%PRS 51.3%
-
CSI 1.9rCSI 2.1%PRS 60.0%
-
CSI 1.9rCSI 2.2%PRS 41.9%
-
CSI 1.9rCSI 1.4%PRS 42.5%
-
CSI 1.9rCSI 3.4%PRS 37.4%
-
CSI 1.9rCSI 2.9%PRS 52.7%
-
CSI 1.9rCSI 12.7%PRS 74.5%
-
CSI 2.0rCSI 2.9%PRS 43.4%
-
CSI 2.0rCSI 1.7%PRS 48.8%
-
CSI 2.0rCSI 2.6%PRS 48.5%
-
CSI 2.1rCSI 2.2%PRS 46.4%
-
CSI 2.1rCSI 2.5%PRS 39.8%
-
CSI 2.1rCSI 2.3%PRS 47.5%
-
CSI 2.1rCSI 9.1%PRS 37.6%
-
CSI 2.1rCSI 1.7%PRS 42.3%
-
CSI 2.1rCSI 2.6%PRS 46.4%
-
CSI 2.1rCSI 12.6%PRS 30.1%
-
CSI 2.2rCSI 2.0%PRS 44.7%
-
CSI 2.2rCSI 7.1%PRS 43.1%
-
CSI 2.2rCSI 2.4%PRS 41.8%
-
CSI 2.2rCSI 3.4%PRS 70.8%
-
CSI 2.2rCSI 4.7%PRS 47.9%
-
CSI 2.2rCSI 2.9%PRS 41.9%
-
CSI 2.3rCSI 52.8%PRS 66.6%
-
CSI 2.3rCSI 8.6%PRS 37.2%
-
CSI 2.3rCSI 4.6%PRS 34.1%
-
CSI 2.3rCSI 1.6%PRS 53.8%
-
CSI 2.3rCSI 3.2%PRS 43.3%
-
CSI 2.4rCSI 3.5%PRS 48.7%
-
CSI 2.4rCSI 1.7%PRS 56.6%
-
CSI 2.4rCSI 2.1%PRS 48.7%
-
CSI 2.4rCSI 12.2%PRS 54.6%
-
CSI 2.5rCSI 2.8%PRS 38.3%
-
CSI 2.5rCSI 5.9%PRS 59.6%
-
CSI 2.5rCSI 3.6%PRS 35.5%
-
CSI 2.5rCSI 4.3%PRS 53.0%
-
CSI 2.5rCSI 3.6%PRS 51.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4228403840
Symbol: ODPA_HUMAN
Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2227443
Title: Characterization and nucleotide sequence of the gene encoding the human pyruvate dehydrogenase alpha-subunit.
PubMed ID: 2227443
PubMed ID: 2748588
Title: Characterization of cDNAs encoding human pyruvate dehydrogenase alpha subunit.
PubMed ID: 2748588
PubMed ID: 3034892
Title: The human pyruvate dehydrogenase complex. Isolation of cDNA clones for the E1 alpha subunit, sequence analysis, and characterization of the mRNA.
PubMed ID: 3034892
PubMed ID: 2745444
Title: Structural organization of the gene for the E1 alpha subunit of the human pyruvate dehydrogenase complex.
PubMed ID: 2745444
PubMed ID: 2828359
Title: Isolation of a full-length complementary DNA coding for human E1 alpha subunit of the pyruvate dehydrogenase complex.
PubMed ID: 2828359
PubMed ID: 3422424
Title: Cloning and sequencing of cDNAs encoding alpha and beta subunits of human pyruvate dehydrogenase.
PubMed ID: 3422424
DOI: 10.1073/pnas.85.1.41
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 23146587
Title: Experimental determination of organelle targeting-peptide cleavage sites using transient expression of green fluorescent protein translational fusions.
PubMed ID: 23146587
PubMed ID: 10077682
Title: X chromosome evidence for ancient human histories.
PubMed ID: 10077682
PubMed ID: 1338114
Title: Mutation of E1 alpha gene in a female patient with pyruvate dehydrogenase deficiency due to rapid degradation of E1 protein.
PubMed ID: 1338114
DOI: 10.1007/bf01800220
PubMed ID: 7782287
Title: Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation.
PubMed ID: 7782287
PubMed ID: 11486000
Title: Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.
PubMed ID: 11486000
PubMed ID: 14638692
Title: Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
PubMed ID: 14638692
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12651851
Title: Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase.
PubMed ID: 12651851
PubMed ID: 17474719
Title: Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex.
PubMed ID: 17474719
DOI: 10.1021/bi700083z
PubMed ID: 19081061
Title: Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
PubMed ID: 19081061
PubMed ID: 29970614
Title: Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the alphaV138M variant of human pyruvate dehydrogenase.
PubMed ID: 29970614
PubMed ID: 1301207
Title: Mutations and polymorphisms in the pyruvate dehydrogenase E1 alpha gene.
PubMed ID: 1301207
PubMed ID: 1909401
Title: Characterization of the mutations in three patients with pyruvate dehydrogenase E1 alpha deficiency.
PubMed ID: 1909401
DOI: 10.1007/bf01800586
PubMed ID: 1551669
Title: Pyruvate dehydrogenase (PDH) deficiency caused by a 21-base pair insertion mutation in the E1 alpha subunit.
PubMed ID: 1551669
DOI: 10.1007/bf02265291
PubMed ID: 1293379
Title: X-linked pyruvate dehydrogenase E1 alpha subunit deficiency in heterozygous females: variable manifestation of the same mutation.
PubMed ID: 1293379
DOI: 10.1007/bf01800219
PubMed ID: 8498846
Title: Molecular genetic characterization of an X-linked form of Leigh's syndrome.
PubMed ID: 8498846
PubMed ID: 8504306
Title: Mutations in the X-linked E1 alpha subunit of pyruvate dehydrogenase leading to deficiency of the pyruvate dehydrogenase complex.
PubMed ID: 8504306
DOI: 10.1093/hmg/2.4.449
PubMed ID: 8032855
Title: Pyruvate dehydrogenase deficiency. Clinical presentation and molecular genetic characterization of five new patients.
PubMed ID: 8032855
PubMed ID: 7545958
Title: Pyruvate dehydrogenase deficiency caused by a 33 base pair duplication in the PDH E1 alpha subunit.
PubMed ID: 7545958
DOI: 10.1093/hmg/3.6.1021
PubMed ID: 8199595
Title: Pyruvate dehydrogenase deficiency in a male caused by a point mutation (F205L) in the E1 alpha subunit.
PubMed ID: 8199595
PubMed ID: 7967473
Title: Characterization of a point mutation in the pyruvate dehydrogenase E1 alpha gene from two boys with primary lactic acidaemia.
PubMed ID: 7967473
DOI: 10.1007/bf00711616
PubMed ID: 7887409
Title: Mutations in the X-linked E1 alpha subunit of pyruvate dehydrogenase: exon skipping, insertion of duplicate sequence, and missense mutations leading to the deficiency of the pyruvate dehydrogenase complex.
PubMed ID: 7887409
PubMed ID: 7573035
Title: An amino acid substitution in the pyruvate dehydrogenase E1 alpha gene, affecting mitochondrial import of the precursor protein.
PubMed ID: 7573035
PubMed ID: 7757088
Title: Pyruvate dehydrogenase complex deficiency due to a point mutation (P188L) within the thiamine pyrophosphate binding loop of the E1 alpha subunit.
PubMed ID: 7757088
DOI: 10.1093/hmg/4.2.315
PubMed ID: 8664900
Title: Mutation analysis of the pyruvate dehydrogenase E1 alpha gene in eight patients with a pyruvate dehydrogenase complex deficiency.
PubMed ID: 8664900
DOI: 10.1002/(sici)1098-1004(1996)7:1<46::aid-humu6>3.0.co;2-n
PubMed ID: 8844217
Title: Three new mutations of the pyruvate dehydrogenase alpha subunit: a point mutation (M181V), 3 bp deletion (-R282), and 16 bp insertion/frameshift (K358SVS-->TVDQS).
PubMed ID: 8844217
DOI: 10.1002/(sici)1098-1004(1996)8:2<180::aid-humu11>3.0.co;2-z
PubMed ID: 9266390
Title: Biochemical and molecular analysis of an X-linked case of Leigh syndrome associated with thiamin-responsive pyruvate dehydrogenase deficiency.
PubMed ID: 9266390
PubMed ID: 9671272
Title: Arginine 302 mutations in the pyruvate dehydrogenase E1alpha subunit gene: identification of further patients and in vitro demonstration of pathogenicity.
PubMed ID: 9671272
DOI: 10.1002/(sici)1098-1004(1998)12:2<114::aid-humu6>3.0.co;2-#
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 27864847
Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.
PubMed ID: 27864847
DOI: 10.1002/humu.23149
Sequence Information:
- Length: 390
- Mass: 43296
- Checksum: 4D685BBE44A92D4B
- Sequence:
MRKMLAAVSR VLSGASQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP PVTTVLTRED GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQEAC CVGLEAGINP TDHLITAYRA HGFTFTRGLS VREILAELTG RKGGCAKGKG GSMHMYAKNF YGGNGIVGAQ VPLGAGIALA CKYNGKDEVC LTLYGDGAAN QGQIFEAYNM AALWKLPCIF ICENNRYGMG TSVERAAAST DYYKRGDFIP GLRVDGMDIL CVREATRFAA AYCRSGKGPI LMELQTYRYH GHSMSDPGVS YRTREEIQEV RSKSDPIMLL KDRMVNSNLA SVEELKEIDV EVRKEIEDAA QFATADPEPP LEELGYHIYS SDPPFEVRGA NQWIKFKSVS