Details for: NOP58

Gene ID: 51602

Symbol: NOP58

Ensembl ID: ENSG00000055044

Description: NOP58 ribonucleoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 326.7860
    Cell Significance Index: -50.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 189.6560
    Cell Significance Index: -48.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 154.8983
    Cell Significance Index: -63.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.1945
    Cell Significance Index: -56.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 135.2826
    Cell Significance Index: -63.8700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.3706
    Cell Significance Index: -63.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 95.3024
    Cell Significance Index: -63.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.2358
    Cell Significance Index: -56.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.3391
    Cell Significance Index: -59.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.2694
    Cell Significance Index: -51.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.7474
    Cell Significance Index: -62.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.6831
    Cell Significance Index: -48.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3955
    Cell Significance Index: -24.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7623
    Cell Significance Index: 548.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.4568
    Cell Significance Index: 65.6000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5465
    Cell Significance Index: 43.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4630
    Cell Significance Index: 172.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3895
    Cell Significance Index: 278.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2970
    Cell Significance Index: 210.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0214
    Cell Significance Index: 140.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9874
    Cell Significance Index: 69.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9360
    Cell Significance Index: 43.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9317
    Cell Significance Index: 334.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9143
    Cell Significance Index: 164.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9095
    Cell Significance Index: 111.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9026
    Cell Significance Index: 26.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9002
    Cell Significance Index: 398.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8519
    Cell Significance Index: 22.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8283
    Cell Significance Index: 9.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7938
    Cell Significance Index: 51.2200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7835
    Cell Significance Index: 8.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7338
    Cell Significance Index: 41.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7299
    Cell Significance Index: 398.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7112
    Cell Significance Index: 642.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6617
    Cell Significance Index: 18.0100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6025
    Cell Significance Index: 9.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5827
    Cell Significance Index: 403.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5438
    Cell Significance Index: 70.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5282
    Cell Significance Index: 36.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5229
    Cell Significance Index: 18.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5020
    Cell Significance Index: 64.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3568
    Cell Significance Index: 7.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3490
    Cell Significance Index: 18.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3457
    Cell Significance Index: 15.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3176
    Cell Significance Index: 23.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2485
    Cell Significance Index: 4.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2202
    Cell Significance Index: 4.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2171
    Cell Significance Index: 16.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2142
    Cell Significance Index: 13.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1887
    Cell Significance Index: 32.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1512
    Cell Significance Index: 284.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1413
    Cell Significance Index: 2.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1303
    Cell Significance Index: 24.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0822
    Cell Significance Index: 2.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0705
    Cell Significance Index: 1.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0627
    Cell Significance Index: 96.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0589
    Cell Significance Index: 3.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0381
    Cell Significance Index: 24.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0350
    Cell Significance Index: 64.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0268
    Cell Significance Index: 1.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0219
    Cell Significance Index: 29.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0106
    Cell Significance Index: 4.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0017
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0159
    Cell Significance Index: -12.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0430
    Cell Significance Index: -31.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0451
    Cell Significance Index: -6.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0748
    Cell Significance Index: -42.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0944
    Cell Significance Index: -9.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0976
    Cell Significance Index: -9.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1309
    Cell Significance Index: -1.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1465
    Cell Significance Index: -3.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1551
    Cell Significance Index: -8.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1688
    Cell Significance Index: -35.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1832
    Cell Significance Index: -52.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1867
    Cell Significance Index: -4.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1908
    Cell Significance Index: -3.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2286
    Cell Significance Index: -26.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2378
    Cell Significance Index: -10.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2389
    Cell Significance Index: -7.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2418
    Cell Significance Index: -12.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2686
    Cell Significance Index: -30.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2873
    Cell Significance Index: -32.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3061
    Cell Significance Index: -19.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3109
    Cell Significance Index: -6.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3618
    Cell Significance Index: -6.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3924
    Cell Significance Index: -42.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3980
    Cell Significance Index: -15.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4452
    Cell Significance Index: -2.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4533
    Cell Significance Index: -11.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4853
    Cell Significance Index: -11.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4893
    Cell Significance Index: -50.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5052
    Cell Significance Index: -5.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5548
    Cell Significance Index: -7.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6494
    Cell Significance Index: -5.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6718
    Cell Significance Index: -19.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6819
    Cell Significance Index: -17.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6999
    Cell Significance Index: -10.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7040
    Cell Significance Index: -55.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NOP58 is a 57-kDa protein that belongs to the Nop58 family of nucleolar proteins. It is a multifunctional protein that interacts with various RNA-binding proteins, transcription factors, and sumoylation enzymes, and is involved in several key cellular processes, including: * RNA processing and modification: NOP58 is involved in the biogenesis of small ribosomal subunits, and participates in RNA modification, including box C/D methylation and sumoylation. * Protein modification: NOP58 is a substrate for sumoylation, a post-translational modification that regulates protein function and localization. * Transcription regulation: NOP58 interacts with transcription factors and RNA-binding proteins to regulate gene expression. **Pathways and Functions** NOP58 is involved in several key cellular pathways, including: * RNA processing and biogenesis: NOP58 is involved in the biogenesis of small ribosomal subunits, and participates in RNA modification, including box C/D methylation and sumoylation. * Protein modification: NOP58 is a substrate for sumoylation, a post-translational modification that regulates protein function and localization. * Transcription regulation: NOP58 interacts with transcription factors and RNA-binding proteins to regulate gene expression. * Sumoylation: NOP58 is a substrate for sumoylation, a post-translational modification that regulates protein function and localization. * Cajal body: NOP58 is involved in the formation and maintenance of Cajal bodies, small nucleolar structures that regulate RNA processing and modification. **Clinical Significance** NOP58 has been implicated in several diseases and disorders, including: * Leukemia: NOP58 has been shown to be overexpressed in certain types of leukemia, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). * Lymphoma: NOP58 has been shown to be overexpressed in certain types of lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma. * Cancer: NOP58 has been implicated in the development and progression of various types of cancer, including breast cancer, lung cancer, and colon cancer. * Neurological disorders: NOP58 has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). In summary, NOP58 is a multifunctional ribonucleoprotein that plays a crucial role in various cellular processes, including RNA processing, protein modification, and transcription regulation. Its dysregulation has been implicated in several diseases and disorders, including leukemia, lymphoma, cancer, and neurological disorders. Further research is needed to fully understand the role of NOP58 in human health and disease.

Genular Protein ID: 60875924

Symbol: NOP58_HUMAN

Name: Nucleolar protein 5

UniProtKB Accession Codes:

Q9Y2X3 Q53SA4 Q6PK08 Q9P036 Q9UFN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10606270

Title: Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins.

PubMed ID: 10606270

DOI: 10.1017/s1355838299991288

PubMed ID: 10925205

Title: Isolation and characterization of a novel PDGF-induced human gene.

PubMed ID: 10925205

DOI: 10.1016/s0378-1119(00)00232-8

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 12417735

Title: Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.

PubMed ID: 12417735

DOI: 10.1128/mcb.22.23.8342-8352.2002

PubMed ID: 15574333

Title: Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex.

PubMed ID: 15574333

DOI: 10.1016/j.molcel.2004.11.012

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17636026

Title: A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.

PubMed ID: 17636026

DOI: 10.1128/mcb.01097-07

PubMed ID: 17709390

Title: Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis.

PubMed ID: 17709390

DOI: 10.1128/mcb.00516-07

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19620283

Title: Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.

PubMed ID: 19620283

DOI: 10.1128/mcb.00752-09

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20797632

Title: A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.

PubMed ID: 20797632

DOI: 10.1016/j.molcel.2010.07.025

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33367824

Title: NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis.

PubMed ID: 33367824

DOI: 10.1093/nar/gkaa1226

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 529
  • Mass: 59578
  • Checksum: 27CD73CFF5B9A556
  • Sequence:
    • MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF 
TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE KLNLSCIHSP VVNELMRGIR 
SQMDGLIPGV EPREMAAMCL GLAHSLSRYR LKFSADKVDT MIVQAISLLD DLDKELNNYI 
MRCREWYGWH FPELGKIISD NLTYCKCLQK VGDRKNYASA KLSELLPEEV EAEVKAAAEI 
SMGTEVSEED ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA 
HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT SPKHKGKISR 
MLAAKTVLAI RYDAFGEDSS SAMGVENRAK LEARLRTLED RGIRKISGTG KALAKTEKYE 
HKSEVKTYDP SGDSTLPTCS KKRKIEQVDK EDEITEKKAK KAKIKVKVEE EEEEKVAEEE 
ETSVKKKKKR GKKKHIKEEP LSEEEPCTST AIASPEKKKK KKKKRENED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.