Details for: HECA

Gene ID: 51696

Symbol: HECA

Ensembl ID: ENSG00000112406

Description: hdc homolog, cell cycle regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 176.4117
    Cell Significance Index: -27.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.7246
    Cell Significance Index: -27.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.9805
    Cell Significance Index: -25.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.7636
    Cell Significance Index: -29.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 55.0366
    Cell Significance Index: -28.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.4561
    Cell Significance Index: -29.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.3933
    Cell Significance Index: -27.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3626
    Cell Significance Index: -27.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1337
    Cell Significance Index: -28.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8446
    Cell Significance Index: -14.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5099
    Cell Significance Index: -20.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7646
    Cell Significance Index: 335.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4725
    Cell Significance Index: 20.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0004
    Cell Significance Index: 15.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9033
    Cell Significance Index: 89.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8984
    Cell Significance Index: 97.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8404
    Cell Significance Index: 136.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6403
    Cell Significance Index: 128.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6326
    Cell Significance Index: 32.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6206
    Cell Significance Index: 17.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4714
    Cell Significance Index: 32.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4615
    Cell Significance Index: 83.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4367
    Cell Significance Index: 53.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4245
    Cell Significance Index: 11.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3984
    Cell Significance Index: 9.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3585
    Cell Significance Index: 10.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3471
    Cell Significance Index: 153.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3204
    Cell Significance Index: 24.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2963
    Cell Significance Index: 6.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2872
    Cell Significance Index: 13.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2777
    Cell Significance Index: 99.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2754
    Cell Significance Index: 12.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2580
    Cell Significance Index: 7.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2464
    Cell Significance Index: 15.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2221
    Cell Significance Index: 10.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1873
    Cell Significance Index: 129.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1650
    Cell Significance Index: 3.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1391
    Cell Significance Index: 75.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1373
    Cell Significance Index: 85.7600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1245
    Cell Significance Index: 1.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1019
    Cell Significance Index: 13.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0656
    Cell Significance Index: 13.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0410
    Cell Significance Index: 2.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0256
    Cell Significance Index: 3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0198
    Cell Significance Index: 3.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0163
    Cell Significance Index: 30.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0091
    Cell Significance Index: 5.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0024
    Cell Significance Index: 0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0217
    Cell Significance Index: -1.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0282
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0294
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0322
    Cell Significance Index: -23.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0406
    Cell Significance Index: -5.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0471
    Cell Significance Index: -6.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0499
    Cell Significance Index: -7.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0751
    Cell Significance Index: -21.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0779
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0852
    Cell Significance Index: -17.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0929
    Cell Significance Index: -10.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0961
    Cell Significance Index: -7.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1092
    Cell Significance Index: -11.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1117
    Cell Significance Index: -3.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1343
    Cell Significance Index: -2.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1437
    Cell Significance Index: -9.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2280
    Cell Significance Index: -4.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2383
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2389
    Cell Significance Index: -27.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2464
    Cell Significance Index: -25.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3098
    Cell Significance Index: -8.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3151
    Cell Significance Index: -6.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3171
    Cell Significance Index: -16.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3311
    Cell Significance Index: -26.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3441
    Cell Significance Index: -5.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3656
    Cell Significance Index: -5.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3796
    Cell Significance Index: -5.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3942
    Cell Significance Index: -24.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4164
    Cell Significance Index: -26.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4168
    Cell Significance Index: -21.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4217
    Cell Significance Index: -11.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4420
    Cell Significance Index: -19.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4523
    Cell Significance Index: -23.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4743
    Cell Significance Index: -4.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4928
    Cell Significance Index: -18.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5230
    Cell Significance Index: -16.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5312
    Cell Significance Index: -17.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5397
    Cell Significance Index: -7.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5499
    Cell Significance Index: -17.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5526
    Cell Significance Index: -16.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5625
    Cell Significance Index: -14.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5642
    Cell Significance Index: -13.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5653
    Cell Significance Index: -20.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5906
    Cell Significance Index: -25.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The HECA gene is a homolog of the human Headcase protein (HDC), which is involved in the regulation of the cell cycle. HECA is significantly expressed in several cell types, including: * Hematopoietic oligopotent progenitor cells * Polychromatophilic erythroblasts * Mucosal type mast cells * Smooth muscle fibers of the ileum * Peripheral blood mononuclear cells * Ileal goblet cells * Orthochromatic erythroblasts * CD8-alpha-beta-positive, alpha-beta intraepithelial T cells * Stromal cells of bone marrow * Epidermal Langerhans cells **Pathways and Functions:** The HECA gene is involved in the negative regulation of the mitotic cell cycle, which is essential for maintaining tissue homeostasis and preventing uncontrolled cell proliferation. The pathways and functions of HECA can be summarized as follows: * **Negative regulation of mitotic cell cycle:** HECA acts as a brake on the cell cycle, preventing excessive cell division and maintaining tissue homeostasis. * **Cell cycle regulation:** HECA is involved in regulating the cell cycle, particularly in the G2/M phase, where it inhibits the progression of cells from the G2 phase to the M phase. * **Apoptosis:** HECA may also play a role in regulating apoptosis, which is the process of programmed cell death. Dysregulation of apoptosis can lead to cancer and other diseases. **Clinical Significance:** The HECA gene has significant implications in various diseases, including: * **Cancer:** Dysregulation of the HECA gene can lead to uncontrolled cell proliferation and cancer. * **Autoimmune diseases:** HECA may play a role in regulating the immune response, and dysregulation of the gene may contribute to autoimmune diseases. * **Inflammatory diseases:** HECA may also be involved in regulating inflammation, and dysregulation of the gene may contribute to inflammatory diseases. * **Regenerative medicine:** HECA may have potential applications in regenerative medicine, where it can be used to regulate cell proliferation and tissue repair. In conclusion, the HECA gene plays a crucial role in regulating the cell cycle, particularly in mitotic processes. Its dysregulation can lead to various diseases, including cancer, autoimmune diseases, and inflammatory diseases. Further research is needed to fully understand the function of HECA and its implications in disease.

Genular Protein ID: 1101834231

Symbol: HDC_HUMAN

Name: Headcase protein homolog

UniProtKB Accession Codes:

Q9UBI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11696983

Title: Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.

PubMed ID: 11696983

DOI: 10.3109/10425170109041340

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 543
  • Mass: 58837
  • Checksum: A161B7F4C57EF0D1
  • Sequence:
    • MPNPKNSKGG RKNKRANSSG DEQENGAGAL AAAGAAGAAA GGALAAAAGC GAAAAGAPGA 
GGAAGAGGAG TGAANAAAAA GAAAAGDAKN EAPCATPLIC SFGRPVDLEK DDYQKVVCNN 
EHCPCSTWMH LQCFYEWESS ILVQFNCIGR ARSWNEKQCR QNMWTKKGYD LAFRFCSCRC 
GQGHLKKDTD WYQVKRMQDE KKKKSGSEKN TGRPPGEAAE EAKKCRPPNK PQKGPSHDLP 
RRHSMDRQNS QEKAVGAAAY GARSPGGSPG QSPPTGYSIL SPAHFSGPRS SRYLGEFLKN 
AIHLEPHKKA MAGGHVFRNA HFDYSPAGLA VHRGGHFDTP VQFLRRLDLS ELLTHIPRHK 
LNTFHVRMED DAQVGQGEDL RKFILAALSA SHRNVVNCAL CHRALPVFEQ FPLVDGTLFL 
SPSRHDEIEY DVPCHLQGRL MHLYAVCVDC LEGVHKIICI KCKSRWDGSW HQLGTMYTYD 
ILAASPCCQA RLNCKHCGKP VIDVRIGMQY FSEYSNVQQC PHCGNLDYHF VKPFSSFKVL 
EAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.