Details for: SELENOT

Gene ID: 51714

Symbol: SELENOT

Ensembl ID: ENSG00000198843

Description: selenoprotein T

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 164.5355
    Cell Significance Index: -67.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.6558
    Cell Significance Index: -62.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.1683
    Cell Significance Index: -71.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 135.1905
    Cell Significance Index: -69.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.1202
    Cell Significance Index: -71.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.4910
    Cell Significance Index: -47.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3345
    Cell Significance Index: -38.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7310
    Cell Significance Index: -16.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.6596
    Cell Significance Index: 426.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3466
    Cell Significance Index: 276.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4574
    Cell Significance Index: 76.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3678
    Cell Significance Index: 101.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3661
    Cell Significance Index: 40.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3056
    Cell Significance Index: 160.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2407
    Cell Significance Index: 33.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2280
    Cell Significance Index: 57.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1266
    Cell Significance Index: 615.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1040
    Cell Significance Index: 221.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0883
    Cell Significance Index: 196.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0057
    Cell Significance Index: 163.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8562
    Cell Significance Index: 109.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8017
    Cell Significance Index: 110.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7285
    Cell Significance Index: 47.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7256
    Cell Significance Index: 320.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6708
    Cell Significance Index: 42.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6448
    Cell Significance Index: 231.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6226
    Cell Significance Index: 80.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4446
    Cell Significance Index: 15.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4410
    Cell Significance Index: 22.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4219
    Cell Significance Index: 83.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4015
    Cell Significance Index: 18.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3722
    Cell Significance Index: 36.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2630
    Cell Significance Index: 18.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2492
    Cell Significance Index: 2.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1813
    Cell Significance Index: 30.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1356
    Cell Significance Index: 93.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0376
    Cell Significance Index: 0.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0357
    Cell Significance Index: 27.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0243
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0217
    Cell Significance Index: 0.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0050
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0014
    Cell Significance Index: 2.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0320
    Cell Significance Index: -20.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0340
    Cell Significance Index: -25.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0361
    Cell Significance Index: -66.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0390
    Cell Significance Index: -60.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0453
    Cell Significance Index: -20.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0489
    Cell Significance Index: -66.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0538
    Cell Significance Index: -1.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0572
    Cell Significance Index: -10.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0873
    Cell Significance Index: -49.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1094
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1276
    Cell Significance Index: -14.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1343
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1425
    Cell Significance Index: -88.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1938
    Cell Significance Index: -55.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1945
    Cell Significance Index: -2.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2079
    Cell Significance Index: -12.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2308
    Cell Significance Index: -12.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2369
    Cell Significance Index: -15.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2585
    Cell Significance Index: -37.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2820
    Cell Significance Index: -4.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3122
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3217
    Cell Significance Index: -24.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3371
    Cell Significance Index: -71.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3475
    Cell Significance Index: -9.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3993
    Cell Significance Index: -11.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4018
    Cell Significance Index: -14.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4344
    Cell Significance Index: -17.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5464
    Cell Significance Index: -4.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6240
    Cell Significance Index: -64.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6243
    Cell Significance Index: -20.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6566
    Cell Significance Index: -29.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6604
    Cell Significance Index: -16.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7612
    Cell Significance Index: -60.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7999
    Cell Significance Index: -20.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8395
    Cell Significance Index: -50.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8441
    Cell Significance Index: -31.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9173
    Cell Significance Index: -15.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9253
    Cell Significance Index: -24.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0109
    Cell Significance Index: -21.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0607
    Cell Significance Index: -30.2700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0854
    Cell Significance Index: -19.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1357
    Cell Significance Index: -15.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1524
    Cell Significance Index: -70.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.1714
    Cell Significance Index: -61.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3067
    Cell Significance Index: -32.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3864
    Cell Significance Index: -62.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3881
    Cell Significance Index: -32.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4354
    Cell Significance Index: -42.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4365
    Cell Significance Index: -21.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4528
    Cell Significance Index: -53.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4908
    Cell Significance Index: -48.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5391
    Cell Significance Index: -49.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.5594
    Cell Significance Index: -12.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5856
    Cell Significance Index: -12.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5888
    Cell Significance Index: -55.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.6253
    Cell Significance Index: -38.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Selenocysteine incorporation**: SELENOT contains a selenocysteine (Sec) residue, which is a unique amino acid that incorporates selenium into the protein structure. This is essential for the protein's redox activity and its ability to function in cellular processes. 2. **Thioredoxin-disulfide reductase activity**: SELENOT exhibits thioredoxin-disulfide reductase (TrxR) activity, which enables it to reduce oxidized thioredoxin and maintain the cellular redox balance. 3. **Cellular localization**: SELENOT is primarily found in the endoplasmic reticulum (ER) and ER membrane, where it plays a role in regulating the ER's redox environment. 4. **Regulation of cellular processes**: SELENOT is involved in various cellular processes, including glucose homeostasis, insulin secretion, and the regulation of cytosolic calcium ion concentration. **Pathways and Functions** 1. **Cell redox homeostasis**: SELENOT plays a crucial role in maintaining the cellular redox balance by regulating the activity of thioredoxin and other redox enzymes. 2. **Cellular oxidant detoxification**: SELENOT helps to detoxify oxidants and reactive oxygen species (ROS) in the ER, protecting cells from oxidative damage. 3. **Glucose homeostasis**: SELENOT is involved in regulating glucose homeostasis by influencing insulin secretion and glucose metabolism in pancreatic beta cells. 4. **Insulin secretion**: SELENOT is necessary for the proper functioning of insulin secretion in response to glucose stimuli. 5. **Positive regulation of cytosolic calcium ion concentration**: SELENOT helps to regulate the concentration of cytosolic calcium ions, which is essential for various cellular processes, including muscle contraction and neurotransmitter release. 6. **Positive regulation of growth hormone secretion**: SELENOT is involved in regulating the secretion of growth hormone, which is essential for growth and development. 7. **Response to glucose**: SELENOT responds to glucose stimuli by regulating insulin secretion and glucose metabolism. 8. **Selenium binding**: SELENOT contains a selenium-binding site, which is essential for its redox activity. 9. **Selenocysteine incorporation**: SELENOT incorporates selenocysteine into its structure, which is necessary for its redox activity. **Clinical Significance** 1. **Diabetes**: Mutations in the SELENOT gene have been associated with diabetes, highlighting its importance in glucose homeostasis and insulin secretion. 2. **Cancer**: SELENOT has been implicated in cancer development and progression, particularly in the context of oxidative stress and redox imbalance. 3. **Neurodegenerative diseases**: SELENOT may play a role in neurodegenerative diseases, such as Alzheimer's disease, where oxidative stress and redox imbalance are key factors. 4. **Infectious diseases**: SELENOT may be involved in the pathogenesis of infectious diseases, such as tuberculosis, where oxidative stress and redox imbalance are critical factors. In conclusion, SELENOT is a critical gene that plays a vital role in maintaining cellular redox homeostasis and regulating various cellular processes, including glucose homeostasis, insulin secretion, and the regulation of cytosolic calcium ion concentration. Its clinical significance highlights its importance in understanding the pathogenesis of various diseases, including diabetes, cancer, and neurodegenerative diseases.

Genular Protein ID: 581839010

Symbol: SELT_HUMAN

Name: N/A

UniProtKB Accession Codes:

P62341 O95904 Q8IY80 Q9CZ45 Q9NZJ3

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567350

Title: New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements.

PubMed ID: 10567350

DOI: 10.1074/jbc.274.48.33888

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23913443

Title: The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human beta-cells and its targeted inactivation impairs glucose tolerance.

PubMed ID: 23913443

DOI: 10.1210/en.2013-1167

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26866473

Title: Selenoprotein T exerts an essential oxidoreductase activity that protects dopaminergic neurons in mouse models of Parkinson's Disease.

PubMed ID: 26866473

DOI: 10.1089/ars.2015.6478

PubMed ID: 27645994

Title: Selenoprotein gene nomenclature.

PubMed ID: 27645994

DOI: 10.1074/jbc.m116.756155

Sequence Information:

  • Length: 195
  • Mass: 22324
  • Checksum: 5B7949FA7711AE9D
  • Sequence:
    • MRLLLLLLVA ASAMVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG YRRVFEEYMR 
VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI IVGKDPFAFF GMQAPSIWQW 
GQENKVYACM MVFFLSNMIE NQCMSTGAFE ITLNDVPVWS KLESGHLPSM QQLVQILDNE 
MKLNVHMDSI PHHRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.