Details for: PHAX

Gene ID: 51808

Symbol: PHAX

Ensembl ID: ENSG00000164902

Description: phosphorylated adaptor for RNA export

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.9921
    Cell Significance Index: -31.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.0217
    Cell Significance Index: -30.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.5124
    Cell Significance Index: -40.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 77.0774
    Cell Significance Index: -36.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.5087
    Cell Significance Index: -35.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7098
    Cell Significance Index: -28.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1408
    Cell Significance Index: -36.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.2046
    Cell Significance Index: -25.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6955
    Cell Significance Index: -12.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4572
    Cell Significance Index: 87.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3218
    Cell Significance Index: 130.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2887
    Cell Significance Index: 81.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2780
    Cell Significance Index: 139.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9330
    Cell Significance Index: 128.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8753
    Cell Significance Index: 157.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8676
    Cell Significance Index: 18.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7818
    Cell Significance Index: 96.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7596
    Cell Significance Index: 39.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7327
    Cell Significance Index: 25.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7326
    Cell Significance Index: 19.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6993
    Cell Significance Index: 140.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6798
    Cell Significance Index: 5.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6565
    Cell Significance Index: 45.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6426
    Cell Significance Index: 350.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6070
    Cell Significance Index: 5.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5878
    Cell Significance Index: 259.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5401
    Cell Significance Index: 107.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5122
    Cell Significance Index: 23.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5096
    Cell Significance Index: 460.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5057
    Cell Significance Index: 59.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5025
    Cell Significance Index: 35.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4917
    Cell Significance Index: 23.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4730
    Cell Significance Index: 60.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4421
    Cell Significance Index: 22.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4176
    Cell Significance Index: 11.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3688
    Cell Significance Index: 27.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3592
    Cell Significance Index: 8.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3464
    Cell Significance Index: 15.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3240
    Cell Significance Index: 116.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2420
    Cell Significance Index: 31.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2379
    Cell Significance Index: 14.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2106
    Cell Significance Index: 2.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2053
    Cell Significance Index: 39.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1746
    Cell Significance Index: 5.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1085
    Cell Significance Index: 7.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1004
    Cell Significance Index: 2.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0928
    Cell Significance Index: 15.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0753
    Cell Significance Index: 1.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0571
    Cell Significance Index: 1.3200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0474
    Cell Significance Index: 0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0378
    Cell Significance Index: 2.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0295
    Cell Significance Index: 20.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0068
    Cell Significance Index: 4.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0090
    Cell Significance Index: -5.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0139
    Cell Significance Index: -10.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0209
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0214
    Cell Significance Index: -39.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0224
    Cell Significance Index: -16.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0246
    Cell Significance Index: -37.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.3400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0266
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0286
    Cell Significance Index: -18.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0368
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0375
    Cell Significance Index: -21.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0407
    Cell Significance Index: -4.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0567
    Cell Significance Index: -25.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0752
    Cell Significance Index: -15.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0856
    Cell Significance Index: -9.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0990
    Cell Significance Index: -28.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1099
    Cell Significance Index: -8.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1378
    Cell Significance Index: -20.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1675
    Cell Significance Index: -19.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1744
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1778
    Cell Significance Index: -20.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1902
    Cell Significance Index: -3.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1916
    Cell Significance Index: -4.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2027
    Cell Significance Index: -13.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2041
    Cell Significance Index: -5.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2455
    Cell Significance Index: -7.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2574
    Cell Significance Index: -5.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2579
    Cell Significance Index: -2.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2954
    Cell Significance Index: -7.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3119
    Cell Significance Index: -24.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3314
    Cell Significance Index: -3.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3437
    Cell Significance Index: -8.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3447
    Cell Significance Index: -35.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4021
    Cell Significance Index: -5.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4397
    Cell Significance Index: -19.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4403
    Cell Significance Index: -10.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4425
    Cell Significance Index: -9.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4823
    Cell Significance Index: -6.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4825
    Cell Significance Index: -29.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5196
    Cell Significance Index: -13.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5436
    Cell Significance Index: -10.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5509
    Cell Significance Index: -20.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5684
    Cell Significance Index: -14.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6488
    Cell Significance Index: -5.1800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7205
    Cell Significance Index: -5.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphorylation-dependent function**: PHAX is a phosphorylated adaptor protein, which suggests that its activity is regulated by post-translational modifications. This phosphorylation event is crucial for its interaction with other proteins and its role in RNA export. 2. **RNA export**: PHAX is involved in the export of snRNAs from the nucleus, which are essential for the regulation of gene expression. The dysregulation of PHAX can lead to impaired RNA export, resulting in altered gene expression patterns. 3. **Cellular localization**: PHAX is localized to the nucleus and cytosol, where it interacts with other proteins and regulates RNA export. 4. **Significant expression in various cell types**: PHAX is expressed in a wide range of cell types, including hematopoietic cells, neuronal cells, and epithelial cells, suggesting its importance in various cellular processes. **Pathways and Functions:** 1. **Cajal body formation**: PHAX is involved in the formation of Cajal bodies, which are nuclear structures that regulate gene expression and RNA export. 2. **RNA polymerase II transcription**: PHAX interacts with RNA polymerase II to regulate the transcription of snRNAs. 3. **Metabolism of non-coding RNAs**: PHAX is involved in the regulation of the metabolism of non-coding RNAs, including snRNAs and other small RNAs. 4. **Protein binding**: PHAX interacts with various proteins, including RNA-binding proteins and other adaptors, to regulate RNA export. **Clinical Significance:** Dysregulation of the PHAX gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: PHAX mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer**: PHAX dysregulation has been linked to cancer development and progression, including leukemia and lymphoma. 3. **Neurological disorders**: PHAX mutations have been associated with neurological disorders, such as autism and schizophrenia. In conclusion, the PHAX gene plays a critical role in regulating RNA export and its dysregulation has significant implications in immunological and cellular processes. Further research is needed to fully understand the mechanisms of PHAX and its role in human disease.

Genular Protein ID: 470101098

Symbol: PHAX_HUMAN

Name: Phosphorylated adapter RNA export protein

UniProtKB Accession Codes:

Q9H814 Q9H8W1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15574332

Title: PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli.

PubMed ID: 15574332

DOI: 10.1016/j.molcel.2004.11.013

PubMed ID: 11333016

Title: The evolutionarily conserved region of the U snRNA export mediator PHAX is a novel RNA-binding domain that is essential for U snRNA export.

PubMed ID: 11333016

DOI: 10.1017/s1355838201002278

PubMed ID: 15574333

Title: Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex.

PubMed ID: 15574333

DOI: 10.1016/j.molcel.2004.11.012

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26382858

Title: mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.

PubMed ID: 26382858

DOI: 10.1038/ncomms9192

PubMed ID: 20430857

Title: Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.

PubMed ID: 20430857

DOI: 10.1261/rna.2009910

Sequence Information:

  • Length: 394
  • Mass: 44403
  • Checksum: 3513FA5081C6F7CA
  • Sequence:
    • MALEVGDMED GQLSDSDSDM TVAPSDRPLQ LPKVLGGDSA MRAFQNTATA CAPVSHYRAV 
ESVDSSEESF SDSDDDSCLW KRKRQKCFNP PPKPEPFQFG QSSQKPPVAG GKKINNIWGA 
VLQEQNQDAV ATELGILGME GTIDRSRQSE TYNYLLAKKL RKESQEHTKD LDKELDEYMH 
GGKKMGSKEE ENGQGHLKRK RPVKDRLGNR PEMNYKGRYE ITAEDSQEKV ADEISFRLQE 
PKKDLIARVV RIIGNKKAIE LLMETAEVEQ NGGLFIMNGS RRRTPGGVFL NLLKNTPSIS 
EEQIKDIFYI ENQKEYENKK AARKRRTQVL GKKMKQAIKS LNFQEDDDTS RETFASDTNE 
ALASLDESQE GHAEAKLEAE EAIEVDHSHD LDIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.