Details for: PEX1

Gene ID: 5189

Symbol: PEX1

Ensembl ID: ENSG00000127980

Description: peroxisomal biogenesis factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.59
    Marker Score: 504
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.5
    Marker Score: 627
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51119
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1924
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.25
    Marker Score: 47309
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24579
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.23
    Marker Score: 4756
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18064
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.2
    Marker Score: 1458
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10236
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.18
    Marker Score: 4924
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.16
    Marker Score: 4812
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71345
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10858
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10948
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.12
    Marker Score: 8576
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.11
    Marker Score: 4504
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.08
    Marker Score: 317
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.08
    Marker Score: 11130
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.05
    Marker Score: 1412
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.04
    Marker Score: 1817
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47956
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.99
    Marker Score: 270
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.96
    Marker Score: 304
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.95
    Marker Score: 554
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.92
    Marker Score: 19616
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 997
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13524
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4897
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.85
    Marker Score: 498
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.84
    Marker Score: 559
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.82
    Marker Score: 2820
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.8
    Marker Score: 420
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.8
    Marker Score: 365
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.78
    Marker Score: 3605
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.77
    Marker Score: 1701
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.77
    Marker Score: 1836
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.76
    Marker Score: 2046
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.76
    Marker Score: 1737
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.76
    Marker Score: 608
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.74
    Marker Score: 235
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.72
    Marker Score: 711
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.72
    Marker Score: 16014
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2966
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.7
    Marker Score: 6067
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.7
    Marker Score: 2471
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.68
    Marker Score: 233
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.68
    Marker Score: 738
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1582
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.67
    Marker Score: 329
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.66
    Marker Score: 370
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.66
    Marker Score: 197
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.66
    Marker Score: 819
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.65
    Marker Score: 2412
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.65
    Marker Score: 315
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.64
    Marker Score: 647
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.63
    Marker Score: 1593
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.63
    Marker Score: 663
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 921
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.62
    Marker Score: 201
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.62
    Marker Score: 770
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.62
    Marker Score: 798
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 534
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 152
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.6
    Marker Score: 637
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.58
    Marker Score: 449
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.58
    Marker Score: 601
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.57
    Marker Score: 659
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.57
    Marker Score: 385
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.56
    Marker Score: 384
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.56
    Marker Score: 19393
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.56
    Marker Score: 225
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.55
    Marker Score: 259
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.55
    Marker Score: 1170.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.55
    Marker Score: 779
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 502
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.54
    Marker Score: 1926
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.54
    Marker Score: 304
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.53
    Marker Score: 197
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.53
    Marker Score: 531
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 319
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.53
    Marker Score: 1015

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Other Information

**Key Characteristics:** PEX1 is a multifunctional protein that belongs to the PEX family of proteins, which are essential for peroxisome formation and function. The PEX1 protein is a member of the PEX5-like protein family and is characterized by its ability to bind to the peroxisomal membrane and interact with other proteins involved in peroxisomal biogenesis. PEX1 is primarily expressed in cells that require high levels of peroxisomal function, including retinal ganglion cells, cortical interneurons, and lens epithelial cells. **Pathways and Functions:** PEX1 plays a critical role in the assembly and targeting of peroxisomes to their correct location within the cell. The PEX1 protein interacts with other proteins involved in peroxisomal biogenesis, including PEX3, PEX4, and PEX19A, to form a complex that facilitates the import of peroxisomal proteins into the peroxisome matrix. PEX1 also regulates the localization of peroxisomal proteins to the peroxisomal membrane, ensuring proper peroxisomal function and maintaining cellular homeostasis. In addition to its role in peroxisomal biogenesis, PEX1 has been implicated in the regulation of cellular metabolism, including fatty acid oxidation and amino acid degradation. PEX1 has also been shown to interact with proteins involved in the regulation of cellular signaling pathways, including the PI3K/Akt and MAPK/ERK pathways. **Clinical Significance:** Mutations in the PEX1 gene have been linked to a range of clinical disorders, including peroxisomal biogenesis disorders (PBDs) and other metabolic disorders. PBDs are a group of rare and often fatal genetic disorders characterized by impaired peroxisomal function, leading to a range of clinical symptoms, including seizures, muscle weakness, and developmental delays. The identification of PEX1 mutations has provided valuable insights into the molecular mechanisms underlying PBDs and has led to the development of new therapeutic strategies for the treatment of these disorders. Furthermore, PEX1 has been implicated in the pathogenesis of other diseases, including cancer, neurodegenerative disorders, and metabolic disorders. The regulation of PEX1 by cellular stress and signaling pathways has been shown to have a significant impact on cellular function and survival, highlighting the importance of PEX1 in maintaining cellular homeostasis. In conclusion, PEX1 is a critical protein involved in peroxisomal biogenesis and function. The identification of PEX1 mutations has provided valuable insights into the molecular mechanisms underlying peroxisomal biogenesis disorders and has led to the development of new therapeutic strategies for the treatment of these disorders. Further research into the role of PEX1 in cellular function and disease will continue to shed light on the complex relationships between peroxisomal biogenesis and cellular health.

Genular Protein ID: 131270353

Symbol: PEX1_HUMAN

Name: Peroxisome biogenesis disorder protein 1

UniProtKB Accession Codes:

O43933 A4D1G3 A8KA90 B4DIM7 E9PE75 Q96S71 Q96S72 Q96S73 Q99994

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 8 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9398848

Title: Human PEX1 is mutated in complementation group 1 of the peroxisome biogenesis disorders.

PubMed ID: 9398848

DOI: 10.1038/ng1297-449

PubMed ID: 9398847

Title: Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders.

PubMed ID: 9398847

DOI: 10.1038/ng1297-445

PubMed ID: 9539740

Title: Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I.

PubMed ID: 9539740

DOI: 10.1073/pnas.95.8.4350

PubMed ID: 11439091

Title: Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction.

PubMed ID: 11439091

DOI: 10.1042/0264-6021:3570417

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12717447

Title: The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.

PubMed ID: 12717447

DOI: 10.1038/ncb982

PubMed ID: 16314507

Title: Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.

PubMed ID: 16314507

DOI: 10.1128/mcb.25.24.10822-10832.2005

PubMed ID: 16854980

Title: Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p.

PubMed ID: 16854980

DOI: 10.1074/jbc.m605159200

PubMed ID: 21362118

Title: Recruiting mechanism of the AAA peroxins, Pex1p and Pex6p, to Pex26p on the peroxisomal membrane.

PubMed ID: 21362118

DOI: 10.1111/j.1600-0854.2011.01182.x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19105186

Title: Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.

PubMed ID: 19105186

DOI: 10.1002/humu.20932

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29884772

Title: Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

PubMed ID: 29884772

DOI: 10.1074/jbc.ra118.003669

PubMed ID: 26387595

Title: Heimler syndrome is caused by hypomorphic mutations in the peroxisome-biogenesis genes PEX1 and PEX6.

PubMed ID: 26387595

DOI: 10.1016/j.ajhg.2015.08.011

PubMed ID: 16088892

Title: Novel PEX1 coding mutations and 5' UTR regulatory polymorphisms.

PubMed ID: 16088892

DOI: 10.1002/humu.9356

PubMed ID: 27302843

Title: Spectrum of PEX1 and PEX6 variants in Heimler syndrome.

PubMed ID: 27302843

DOI: 10.1038/ejhg.2016.62

PubMed ID: 32069232

Title: Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation.

PubMed ID: 32069232

DOI: 10.1515/jpem-2019-0194

PubMed ID: 33955040

Title: Compound heterozygous p. Arg949Trp and p. Gly970Ala mutations deteriorated the function of PEX1p: A study on PEX1 in a patient with Zellweger syndrome.

PubMed ID: 33955040

DOI: 10.1002/jcb.29945

PubMed ID: 33708531

Title: A Chinese newborn with Zellweger syndrome and compound heterozygous mutations novel in the PEX1 gene: a case report and literature review.

PubMed ID: 33708531

DOI: 10.21037/tp-20-167

Sequence Information:

  • Length: 1283
  • Mass: 142867
  • Checksum: 333CE0B15D2E2017
  • Sequence:
    • MWGSDRLAGA GGGGAAVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVV WSHQPAFLSW 
VEGRHFSDQG ENVAEINRQV GQKLGLSNGG QVFLKPCSHV VSCQQVEVEP LSADDWEILE 
LHAVSLEQHL LDQIRIVFPK AIFPVWVDQQ TYIFIQIVAL IPAASYGRLE TDTKLLIQPK 
TRRAKENTFS KADAEYKKLH SYGRDQKGMM KELQTKQLQS NTVGITESNE NESEIPVDSS 
SVASLWTMIG SIFSFQSEKK QETSWGLTEI NAFKNMQSKV VPLDNIFRVC KSQPPSIYNA 
SATSVFHKHC AIHVFPWDQE YFDVEPSFTV TYGKLVKLLS PKQQQSKTKQ NVLSPEKEKQ 
MSEPLDQKKI RSDHNEEDEK ACVLQVVWNG LEELNNAIKY TKNVEVLHLG KVWIPDDLRK 
RLNIEMHAVV RITPVEVTPK IPRSLKLQPR ENLPKDISEE DIKTVFYSWL QQSTTTMLPL 
VISEEEFIKL ETKDGLKEFS LSIVHSWEKE KDKNIFLLSP NLLQKTTIQV LLDPMVKEEN 
SEEIDFILPF LKLSSLGGVN SLGVSSLEHI THSLLGRPLS RQLMSLVAGL RNGALLLTGG 
KGSGKSTLAK AICKEAFDKL DAHVERVDCK ALRGKRLENI QKTLEVAFSE AVWMQPSVVL 
LDDLDLIAGL PAVPEHEHSP DAVQSQRLAH ALNDMIKEFI SMGSLVALIA TSQSQQSLHP 
LLVSAQGVHI FQCVQHIQPP NQEQRCEILC NVIKNKLDCD INKFTDLDLQ HVAKETGGFV 
ARDFTVLVDR AIHSRLSRQS ISTREKLVLT TLDFQKALRG FLPASLRSVN LHKPRDLGWD 
KIGGLHEVRQ ILMDTIQLPA KYPELFANLP IRQRTGILLY GPPGTGKTLL AGVIARESRM 
NFISVKGPEL LSKYIGASEQ AVRDIFIRAQ AAKPCILFFD EFESIAPRRG HDNTGVTDRV 
VNQLLTQLDG VEGLQGVYVL AATSRPDLID PALLRPGRLD KCVYCPPPDQ VSRLEILNVL 
SDSLPLADDV DLQHVASVTD SFTGADLKAL LYNAQLEALH GMLLSSGLQD GSSSSDSDLS 
LSSMVFLNHS SGSDDSAGDG ECGLDQSLVS LEMSEILPDE SKFNMYRLYF GSSYESELGN 
GTSSDLSSQC LSAPSSMTQD LPGVPGKDQL FSQPPVLRTA SQEGCQELTQ EQRDQLRADI 
SIIKGRYRSQ SGEDESMNQP GPIKTRLAIS QSHLMTALGH TRPSISEDDW KNFAELYESF 
QNPKRRKNQS GTMFRPGQKV TLA

Genular Protein ID: 2833730108

Symbol: A0A0C4DG33_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DG33

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 5 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 9 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 4 Proteomes 2 RefSeq 1 Rhea 2 SAM 1 SMART 2 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 1226
  • Mass: 136585
  • Checksum: 28125C8B785DA8E2
  • Sequence:
    • MWGSDRLAGA GGGGAAVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVV WSHQPAFLSW 
VEGRHFSDQG ENVAEINRQV GQKLGLSNGG QVFLKPCSHV VSCQQVEVEP LSADDWEILE 
LHAVSLEQHL LDQIRIVFPK AIFPVWVDQQ TYIFIQIVAL IPAASYGRLE TDTKLLIQPK 
TRRAKENTFS KADAEYKKLH SYGRDQKGMM KELQTKQLQS NTVGITESNE NESEIPVDSS 
SVASLWTMIG SIFSFQSEKK QETSWGLTEI NAFKNMQSKV VPLDNIFRVC KSQPPSIYNA 
SATSVFHKHC AIHVFPWDQE YFDVEPSFTV TYGKLVKLLS PKQQQSKTKQ NVLSPEKEKQ 
MSEPLDQKKI RSDHNEEDEK ACVLQVVWNG LEELNNAIKY TKNVEVLHLG KVWIPDDLRK 
RLNIEMHAVV RITPVEVTPK IPRSLKLQPR ENLPKDISEE DIKTVFYSWL QQSTTTMLPL 
VISEEEFIKL ETKDGLKEFS LSIVHSWEKE KDKNIFLLSP NLLQKTTIQV LLDPMVKEEN 
SEEIDFILPF LKLSSLGGVN SLGVSSLEHI THSLLGRPLS RQLMSLVAGL RNGALLLTGG 
KGSGKSTLAK AICKEAFDKL DAHVERVDCK ALRALNDMIK EFISMGSLVA LIATSQSQQS 
LHPLLVSAQG VHIFQCVQHI QPPNQEQRCE ILCNVIKNKL DCDINKFTDL DLQHVAKETG 
GFVARDFTVL VDRAIHSRLS RQSISTREKL VLTTLDFQKA LRGFLPASLR SVNLHKPRDL 
GWDKIGGLHE VRQILMDTIQ LPAKYPELFA NLPIRQRTGI LLYGPPGTGK TLLAGVIARE 
SRMNFISVKG PELLSKYIGA SEQAVRDIFI RAQAAKPCIL FFDEFESIAP RRGHDNTGVT 
DRVVNQLLTQ LDGVEGLQGV YVLAATSRPD LIDPALLRPG RLDKCVYCPP PDQVSRLEIL 
NVLSDSLPLA DDVDLQHVAS VTDSFTGADL KALLYNAQLE ALHGMLLSSG LQDGSSSSDS 
DLSLSSMVFL NHSSGSDDSA GDGECGLDQS LVSLEMSEIL PDESKFNMYR LYFGSSYESE 
LGNGTSSDLS SQCLSAPSSM TQDLPGVPGK DQLFSQPPVL RTASQEGCQE LTQEQRDQLR 
ADISIIKGRY RSQSGEDESM NQPGPIKTRL AISQSHLMTA LGHTRPSISE DDWKNFAELY 
ESFQNPKRRK NQSGTMFRPG QKVTLA

Genular Protein ID: 1907666925

Symbol: B4DER6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DER6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 1075
  • Mass: 119603
  • Checksum: 552FDAF55C371506
  • Sequence:
    • MMKELQTKQL QSNTVGITES NENESEIPVD SSSVASLWTM IGSIFSFQSE KKQETSWGLT 
EINAFKNMQS KVVPLDNIFR VCKSQPPSIY NASATSVFHK HCAIHVFPWD QEYFDVEPSF 
TVTYGKLVKL LSPKQQQSKT KQNVLSPEKE KQMSEPLDQK KIRSDHNEED EKACVLQVVW 
NGLEELNNAI KYTKNVEVLH LGKVWIPDDL RKRLNIEMHA VVRITPVEVT PKIPRSLKLQ 
PRENLPKDIS EEDIKTVFYS WLQQSTTTML PLVISEEEFI KLETKDGLKE FSLSIVHSWE 
KEKDKNIFLL SPNLLQKTTI QVLLDPMVKE ENSEEIDFIL PFLKLSSLGG VNSLGVSSLE 
HITHSLLGRP LSRQLMSLVA GLRNGALLLT GGKGSGKSTL AKAICKEAFD KLDAHVERVD 
CKALRGKRLE NIQKTLEVAF SEAVWMQPSV VLLDDLDLIA GLPAVPEHEH SPDAVQSQRL 
AHALNDMIKE FISMGSLVAL IATSQSQQSL HPLLVSAQGV HIFQCVQHIQ PPNQEQRCEI 
LCNVIKNKLD CDINKFTDLD LQHVAKETGG FVARDFTVLV DRAIHSRLSR QSISTREKLV 
LTTLDFQKAL RGFLPASLRS VNLHKPRDLG WDKIGGLHEV RQILMDTIQL PAKYPELFAN 
LPIRQRTGIL LYGPPGTGKT LLAGVIARES RMNFISVKGP ELLSKYIGAS EQAVRDIFIR 
AQAAKPCILF FDEFESIAPR RGHDNTGVTD RVVNQLLTQL DGVEGLQGVY VLAATSRPDL 
IDPALLRPGR LDKCVYCPPP DQVSRLEILN VLSDSLPLAD DVDLQHVASV TDSFTGADLK 
ALLYNAQLEA LHGMLLSSGL QDGSSSSDSD LSLSSMVFLN HSSGSDDSAG DGECGLDQSL 
VSLEMSEILP DESKFNMYRL YFGSSYESEL GNGTSSDLSS QCLSAPSSMT QDLPGVPGKD 
QLFSQPPVLR TASQEGCQEL TQEQRDQLRA DISIIKGRYR SQSGEDESMN QPGPIKTRLA 
ISQSHLMTAL GHTRPSISED DWKNFAELYE SFQNPKRRKN QSGTMFRPGQ KVTLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.